Pulmonary surfactant-associated protein C

From Wikipedia, the free encyclopedia

Surfactant, pulmonary-associated protein C

PDB rendering based on 1spf.

Available structures: 1spf

Identifiers

Symbol(s)

SFTPC; PSP-C; SFTP2; SP-C

External IDs

OMIM: 178620 MGI: 109517 HomoloGene: 2271

Gene ontology
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• respiratory gaseous exchange • regulation of liquid surface tension

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003018 (mRNA)
NP_003009 (protein)

NM_011359 (mRNA)
NP_035489 (protein)

Location

Chr 8: 22.08 - 22.08 Mb

Chr 14: 69.26 - 69.26 Mb

Pubmed search

[1]

[2]

Surfactant, pulmonary-associated protein C, also known as SFTPC, is a human gene.^[1]

Pulmonary surfactant-associated protein C is a membrane protein which manufactures surfactant.

Humans and animals born lacking SP-C tend to develop progressive interstitial pneumonitis.

1 References
2 Further reading
3 See also
4 External links

[edit] References

^ Entrez Gene: SFTPC surfactant, pulmonary-associated protein C.

[edit] Further reading

Pérez-Gil J (2002). "Lipid-protein interactions of hydrophobic proteins SP-B and SP-C in lung surfactant assembly and dynamics.". Pediatric pathology & molecular medicine 20 (6): 445–69. PMID 11699574.
Solarin KO, Wang WJ, Beers MF (2002). "Synthesis and post-translational processing of surfactant protein C.". Pediatric pathology & molecular medicine 20 (6): 471–500. PMID 11699575.
Johansson J, Curstedt T, Robertson B (2002). "Artificial surfactants based on analogues of SP-B and SP-C.". Pediatric pathology & molecular medicine 20 (6): 501–18. PMID 11699576.
Nogee LM (2004). "Alterations in SP-B and SP-C expression in neonatal lung disease.". Annu. Rev. Physiol. 66: 601–23. doi:10.1146/annurev.physiol.66.032102.134711. PMID 14977415.
Brasch F, Griese M, Tredano M, et al. (2005). "Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene.". Eur. Respir. J. 24 (1): 30–9. PMID 15293602.
Keller A, Eistetter HR, Voss T, Schäfer KP (1991). "The pulmonary surfactant protein C (SP-C) precursor is a type II transmembrane protein.". Biochem. J. 277 ( Pt 2): 493–9. PMID 1859376.
Curstedt T, Johansson J, Persson P, et al. (1990). "Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups.". Proc. Natl. Acad. Sci. U.S.A. 87 (8): 2985–9. PMID 2326260.
Simatos GA, Forward KB, Morrow MR, Keough KM (1990). "Interaction between perdeuterated dimyristoylphosphatidylcholine and low molecular weight pulmonary surfactant protein SP-C.". Biochemistry 29 (24): 5807–14. PMID 2383558.
Glasser SW, Korfhagen TR, Perme CM, et al. (1988). "Two SP-C genes encoding human pulmonary surfactant proteolipid.". J. Biol. Chem. 263 (21): 10326–31. PMID 2839484.
Glasser SW, Korfhagen TR, Weaver TE, et al. (1988). "cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal).". J. Biol. Chem. 263 (1): 9–12. PMID 3335510.
Johansson J, Jörnvall H, Eklund A, et al. (1988). "Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms.". FEBS Lett. 232 (1): 61–4. PMID 3366248.
Warr RG, Hawgood S, Buckley DI, et al. (1987). "Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences.". Proc. Natl. Acad. Sci. U.S.A. 84 (22): 7915–9. PMID 3479771.
Young WA (1966). "Familial fibrocystic pulmonary dysplasia: a new case in a known affected family.". Canadian Medical Association journal 94 (20): 1059–61. PMID 5942662.
Wood S, Yaremko ML, Schertzer M, et al. (1995). "Mapping of the pulmonary surfactant SP5 (SFTP2) locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas.". Genomics 24 (3): 597–600. doi:10.1006/geno.1994.1673. PMID 7713515.
Hatzis D, Deiter G, deMello DE, Floros J (1994). "Human surfactant protein-C: genetic homogeneity and expression in RDS; comparison with other species.". Exp. Lung Res. 20 (1): 57–72. PMID 8181452.
Nogee LM, Dunbar AE, Wert SE, et al. (2001). "A mutation in the surfactant protein C gene associated with familial interstitial lung disease.". N. Engl. J. Med. 344 (8): 573–9. PMID 11207353.
Glasser SW, Burhans MS, Korfhagen TR, et al. (2001). "Altered stability of pulmonary surfactant in SP-C-deficient mice.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6366–71. doi:10.1073/pnas.101500298. PMID 11344267.