Pulmonary surfactant-associated protein B

From Wikipedia, the free encyclopedia

Surfactant, pulmonary-associated protein B

Identifiers

SFTPB; PSP-B; SFTB3; SFTP3; SP-B

External IDs

OMIM: 178640 MGI: 109516 HomoloGene: 456

Gene ontology
Cellular Component:	• extracellular space • lysosome
Biological Process:	• lipid metabolic process • sphingolipid metabolic process • respiratory gaseous exchange • organ morphogenesis • regulation of liquid surface tension

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000542 (mRNA)
NP_000533 (protein)

XM_974249 (mRNA)
XP_979343 (protein)

Location

Chr 2: 85.74 - 85.75 Mb

Chr 6: 72.23 - 72.24 Mb

Pubmed search

[1]

[2]

Surfactant, pulmonary-associated protein B, also known as SFTPB, is a human gene.^[1]

Pulmonary surfactant-associated protein B' is a membrane protein which manufactures surfactant.

Humans and animals born with a congenital absence of SP-B suffer from intractable respiratory failure.

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Pulmonary_surfactant#Proteins

[edit] References

^ Entrez Gene: SFTPB surfactant, pulmonary-associated protein B.

[edit] Further reading

Pérez-Gil J (2002). "Lipid-protein interactions of hydrophobic proteins SP-B and SP-C in lung surfactant assembly and dynamics.". Pediatric pathology & molecular medicine 20 (6): 445–69. PMID 11699574.
Johansson J, Curstedt T, Robertson B (2002). "Artificial surfactants based on analogues of SP-B and SP-C.". Pediatric pathology & molecular medicine 20 (6): 501–18. PMID 11699576.
Nogee LM (2004). "Alterations in SP-B and SP-C expression in neonatal lung disease.". Annu. Rev. Physiol. 66: 601–23. doi:10.1146/annurev.physiol.66.032102.134711. PMID 14977415.
Moore KJ, D'Amore-Bruno MA, Korfhagen TR, et al. (1992). "Chromosomal localization of three pulmonary surfactant protein genes in the mouse.". Genomics 12 (2): 388–93. PMID 1346779.
Voorhout WF, Veenendaal T, Haagsman HP, et al. (1992). "Intracellular processing of pulmonary surfactant protein B in an endosomal/lysosomal compartment.". Am. J. Physiol. 263 (4 Pt 1): L479–86. PMID 1415726.
Johansson J, Jörnvall H, Curstedt T (1992). "Human surfactant polypeptide SP-B. Disulfide bridges, C-terminal end, and peptide analysis of the airway form.". FEBS Lett. 301 (2): 165–7. PMID 1568474.
Yu SH, Possmayer F (1992). "Effect of pulmonary surfactant protein B (SP-B) and calcium on phospholipid adsorption and squeeze-out of phosphatidylglycerol from binary phospholipid monolayers containing dipalmitoylphosphatidylcholine.". Biochim. Biophys. Acta 1126 (1): 26–34. PMID 1606172.
Weaver TE, Whitsett JA (1989). "Processing of hydrophobic pulmonary surfactant protein B in rat type II cells.". Am. J. Physiol. 257 (2 Pt 1): L100–8. PMID 2475034.
Pilot-Matias TJ, Kister SE, Fox JL, et al. (1989). "Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B.". DNA 8 (2): 75–86. PMID 2924687.
Glasser SW, Korfhagen TR, Weaver T, et al. (1987). "cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe).". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4007–11. PMID 3035561.
Revak SD, Merritt TA, Degryse E, et al. (1988). "Use of human surfactant low molecular weight apoproteins in the reconstitution of surfactant biologic activity.". J. Clin. Invest. 81 (3): 826–33. PMID 3343343.
Jacobs KA, Phelps DS, Steinbrink R, et al. (1987). "Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein.". J. Biol. Chem. 262 (20): 9808–11. PMID 3597440.
Vamvakopoulos NC, Modi WS, Floros J (1994). "Mapping the human pulmonary surfactant-associated protein B gene (SFTP3) to chromosome 2p12-->p11.2.". Cytogenet. Cell Genet. 68 (1-2): 8–10. PMID 7956367.
Nogee LM, Garnier G, Dietz HC, et al. (1994). "A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds.". J. Clin. Invest. 93 (4): 1860–3. PMID 8163685.
Stuhrmann M, Bohnhorst B, Peters U, et al. (1999). "Prenatal diagnosis of congenital alveolar proteinosis (surfactant protein B deficiency).". Prenat. Diagn. 18 (9): 953–5. PMID 9793979.
Wallot M, Wagenvoort C, deMello D, et al. (1999). "Congenital alveolar proteinosis caused by a novel mutation of the surfactant protein B gene and misalignment of lung vessels in consanguineous kindred infants.". Eur. J. Pediatr. 158 (6): 513–8. PMID 10378403.
Tredano M, van Elburg RM, Kaspers AG, et al. (2000). "Compound SFTPB 1549C-->GAA (121ins2) and 457delC heterozygosity in severe congenital lung disease and surfactant protein B (SP-B) deficiency.". Hum. Mutat. 14 (6): 502–9. doi:10.1002/(SICI)1098-1004(199912)14:6<502::AID-HUMU9>3.0.CO;2-C. PMID 10571948.
Korimilli A, Gonzales LW, Guttentag SH (2000). "Intracellular localization of processing events in human surfactant protein B biosynthesis.". J. Biol. Chem. 275 (12): 8672–9. PMID 10722708.
Gordon LM, Lee KY, Lipp MM, et al. (2000). "Conformational mapping of the N-terminal segment of surfactant protein B in lipid using 13C-enhanced Fourier transform infrared spectroscopy.". J. Pept. Res. 55 (4): 330–47. PMID 10798379.
Lin Z, Pearson C, Chinchilli V, et al. (2001). "Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS.". Clin. Genet. 58 (3): 181–91. PMID 11076040.