PUF60

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Fuse-binding protein-interacting repressor
PDB rendering based on 2dny.
Available structures: 2dny
Identifiers
Symbol(s) SIAHBP1; FIR; FLJ31379; PUF60; RoBPI
External IDs OMIM: 604819 MGI: 1915209 HomoloGene: 8614
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 22827 67959
Ensembl ENSG00000179950 ENSMUSG00000002524
Refseq NM_014281 (mRNA)
NP_055096 (protein)		 NM_028364 (mRNA)
NP_082640 (protein)
Location Chr 8: 144.97 - 144.98 Mb Chr 15: 75.9 - 75.9 Mb
Pubmed search [1] [2]

Fuse-binding protein-interacting repressor, also known as SIAHBP1, is a human gene.[1]

The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: SIAHBP1 fuse-binding protein-interacting repressor.

[edit] Further reading

  • Page-McCaw PS, Amonlirdviman K, Sharp PA (2000). "PUF60: a novel U2AF65-related splicing activity.". RNA 5 (12): 1548-60. PMID 10606266. 
  • Bouffard P, Barbar E, Brière F, Boire G (2000). "Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins.". RNA 6 (1): 66-78. PMID 10668799. 
  • Poleev A, Hartmann A, Stamm S (2000). "A trans-acting factor, isolated by the three-hybrid system, that influences alternative splicing of the amyloid precursor protein minigene.". Eur. J. Biochem. 267 (13): 4002-10. PMID 10866799. 
  • Liu J, He L, Collins I, et al. (2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription.". Mol. Cell 5 (2): 331-41. PMID 10882074. 
  • Liu J, Akoulitchev S, Weber A, et al. (2001). "Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.". Cell 104 (3): 353-63. PMID 11239393. 
  • Sandrock B, Egly JM (2001). "A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH.". J. Biol. Chem. 276 (38): 35328-33. doi:10.1074/jbc.M105570200. PMID 11445587. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Liu J, Kouzine F, Nie Z, et al. (2006). "The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression.". EMBO J. 25 (10): 2119-30. doi:10.1038/sj.emboj.7601101. PMID 16628215. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Hastings ML, Allemand E, Duelli DM, et al. (2007). "Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF65.". PLoS ONE 2 (6): e538. doi:10.1371/journal.pone.0000538. PMID 17579712. 
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