PTPRT

From Wikipedia, the free encyclopedia

Protein tyrosine phosphatase, receptor type, T

PDB rendering based on 2ooq.

Available structures: 2ooq

Identifiers

Symbol(s)

PTPRT; KIAA0283; RPTPrho

External IDs

OMIM: 608712 MGI: 1321152 HomoloGene: 56924

Gene ontology
Molecular Function:	• protein tyrosine phosphatase activity • receptor activity • transmembrane receptor protein tyrosine phosphatase activity • protein binding • hydrolase activity
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane
Biological Process:	• protein amino acid dephosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007050 (mRNA)
NP_008981 (protein)

NM_021464 (mRNA)
NP_067439 (protein)

Location

Chr 20: 40.13 - 41.25 Mb

Chr 2: 161.22 - 162.35 Mb

Pubmed search

[1]

[2]

Protein tyrosine phosphatase, receptor type, T, also known as PTPRT, is a human gene.^[1]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: PTPRT protein tyrosine phosphatase, receptor type, T.

[edit] Further reading

Zhang X, Guo A, Yu J, et al. (2007). "Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 4060–4. doi:10.1073/pnas.0611665104. PMID 17360477.
Lee JW, Jeong EG, Lee SH, et al. (2007). "Mutational analysis of PTPRT phosphatase domains in common human cancers.". APMIS 115 (1): 47–51. doi:10.1111/j.1600-0463.2007.apm_554.x. PMID 17223850.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Hu YF, Zhang HL, Cai T, et al. (2006). "The IA-2 interactome.". Diabetologia 48 (12): 2576–81. doi:10.1007/s00125-005-0037-y. PMID 16273344.
Wang Z, Shen D, Parsons DW, et al. (2004). "Mutational analysis of the tyrosine phosphatome in colorectal cancers.". Science 304 (5674): 1164–6. doi:10.1126/science.1096096. PMID 15155950.
Besco JA, Frostholm A, Popesco MC, et al. (2003). "Genomic organization and alternative splicing of the human and mouse RPTPrho genes: Correction.". BMC Genomics 2 (1): 5. PMID 11814386.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Besco JA, Frostholm A, Popesco MC, et al. (2003). "Genomic organization and alternative splicing of the human and mouse RPTPrho genes.". BMC Genomics 2 (1): 1. PMID 11423001.
McAndrew PE, Frostholm A, White RA, et al. (1999). "Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system.". Brain Res. Mol. Brain Res. 56 (1-2): 9–21. PMID 9602027.
McAndrew PE, Frostholm A, Evans JE, et al. (1998). "Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex.". J. Comp. Neurol. 391 (4): 444–55. PMID 9486824.
Ohara O, Nagase T, Ishikawa K, et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.". DNA Res. 4 (1): 53–9. PMID 9179496.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.