PTK7

From Wikipedia, the free encyclopedia

PTK7 protein tyrosine kinase 7

Identifiers

PTK7; CCK4

External IDs

OMIM: 601890 MGI: 1918711 HomoloGene: 43672

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • receptor activity • vascular endothelial growth factor receptor activity • protein binding • ATP binding • kinase activity • transferase activity
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane
Biological Process:	• neural tube closure • protein amino acid phosphorylation • cell adhesion • signal transduction • establishment of epithelial cell polarity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002821 (mRNA)
NP_002812 (protein)

NM_175168 (mRNA)
NP_780377 (protein)

Location

Chr 6: 43.15 - 43.24 Mb

Chr 17: 46.03 - 46.05 Mb

Pubmed search

[1]

[2]

PTK7 protein tyrosine kinase 7, also known as PTK7, is a human gene.^[1]

Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PTK7 PTK7 protein tyrosine kinase 7.

[edit] Further reading

Mossie K, Jallal B, Alves F, et al. (1995). "Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family.". Oncogene 11 (10): 2179-84. PMID 7478540.
Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.". Oncogene 8 (12): 3403-10. PMID 8247543.
Park SK, Lee HS, Lee ST (1997). "Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.". J. Biochem. 119 (2): 235-9. PMID 8882711.
Banga SS, Ozer HL, Park SK, Lee ST (1997). "Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to human chromosome 6p21.1-->p12.2 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 76 (1-2): 43-4. PMID 9154124.
Jung JW, Ji AR, Lee J, et al. (2003). "Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA.". Biochim. Biophys. Acta 1579 (2-3): 153-63. PMID 12427550.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660-6. doi:10.1038/nbt827. PMID 12754519.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Kobus FJ, Fleming KG (2005). "The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions.". Biochemistry 44 (5): 1464-70. doi:10.1021/bi048076l. PMID 15683231.
Katoh M, Katoh M (2007). "Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells.". Int. J. Mol. Med. 20 (3): 405-9. PMID 17671748.