PTK2B

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PTK2B protein tyrosine kinase 2 beta
Identifiers
Symbol(s)	PTK2B; PKB; CADTK; CAKB; FADK2; FAK2; PTK; PYK2; RAFTK
External IDs	OMIM: 601212 MGI: 104908 HomoloGene: 23001
Gene ontology Molecular Function: • nucleotide binding • protein-tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • signal transducer activity • protein binding • ATP binding • transferase activity Cellular Component: • cytoplasm • cytoskeleton Biological Process: • protein complex assembly • protein amino acid phosphorylation • apoptosis • response to stress • cell adhesion • signal transduction • signal complex assembly • positive regulation of cell proliferation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2185	19229
Ensembl	ENSG00000120899	ENSMUSG00000059456
Uniprot	Q14289	Q3UDE9
Refseq	NM_004103 (mRNA) NP_004094 (protein)	XM_994666 (mRNA) XP_999760 (protein)
Location	Chr 8: 27.24 - 27.37 Mb	Chr 14: 65.11 - 65.24 Mb
Pubmed search	[1]	[2]

PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, is a human gene.

Contents 1 Protein 2 See also 3 References 4 Further reading

[edit] Protein

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.^[1]

[edit] See also

• Tyrosine kinase

[edit] References

[edit] Further reading