Pterin deaminase

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In enzymology, a pterin deaminase (EC 3.5.4.11) is an enzyme that catalyzes the chemical reaction

2-amino-4-hydroxypteridine + H₂O $\rightleftharpoons$ 2,4-dihydroxypteridine + NH₃

Thus, the two substrates of this enzyme are 2-amino-4-hydroxypteridine and H₂O, whereas its two products are 2,4-dihydroxypteridine and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 2-amino-4-hydroxypteridine aminohydrolase. This enzyme is also called acrasinase.

[edit] References

IUBMB entry for 3.5.4.11
BRENDA references for 3.5.4.11 (Recommended.)
PubMed references for 3.5.4.11
PubMed Central references for 3.5.4.11
Google Scholar references for 3.5.4.11
LEVENBERG B, HAYAISHI O (1959). "A bacterial pterin deaminase". J. Biol. Chem. 234: 955–61. PMID 13654299.
Rembold H, Simmersbach F (1969). "Catabolism of pteridine cofactors. II. A specific pterin deaminase in rat liver". Biochim. Biophys. Acta. 184: 589–96. PMID 5821022.