Pteridine reductase

From Wikipedia, the free encyclopedia

In enzymology, a pteridine reductase (EC 1.5.1.33) is an enzyme that catalyzes the chemical reaction

5,6,7,8-tetrahydrobiopterin + 2 NADP⁺ $\rightleftharpoons$ biopterin + 2 NADPH + 2 H⁺

Thus, the two substrates of this enzyme are 5,6,7,8-tetrahydrobiopterin and NADP⁺, whereas its 3 products are biopterin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase. Other names in common use include PTR1, and pteridine reductase 1.

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1W0C, 2BF7, 2BFA, 2BFM, 2BFO, 2BFP, and 2C7V.

[edit] References

IUBMB entry for 1.5.1.33
BRENDA references for 1.5.1.33 (Recommended.)
PubMed references for 1.5.1.33
PubMed Central references for 1.5.1.33
Google Scholar references for 1.5.1.33
Nare B, Hardy LW, Beverley SM (1997). "The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major". J. Biol. Chem. 272: 13883–91. doi:10.1074/jbc.272.21.13883. PMID 9153248.
SM, Hunter WN (2001). "Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites". Nat. Struct. Biol. 8: 521–5. doi:10.1038/88584. PMID 11373620.
Fitzpatrick PF (2000). "The aromatic amino acid hydroxylases". Adv. Enzymol. Relat. Areas. Mol. Biol. 74: 235–94. doi:10.1002/9780470123201.ch6. PMID 10800597.