PTBP1

From Wikipedia, the free encyclopedia

Polypyrimidine tract binding protein 1

PDB rendering based on 1qm9.

Available structures: 1qm9, 1sjq, 1sjr, 2ad9, 2adb, 2adc, 2evz

Identifiers

Symbol(s)

PTBP1; HNRNPI; HNRPI; MGC10830; MGC8461; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; pPTB

External IDs

OMIM: 600693 MGI: 97791 HomoloGene: 49188

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA binding • protein binding • poly-pyrimidine tract binding
Cellular Component:	• nucleus • nucleoplasm • nucleolus • heterogeneous nuclear ribonucleoprotein complex
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002819 (mRNA)
NP_002810 (protein)

NM_001077363 (mRNA)
NP_001070831 (protein)

Location

Chr 19: 0.75 - 0.76 Mb

Chr 10: 79.26 - 79.27 Mb

Pubmed search

[1]

[2]

Polypyrimidine tract binding protein 1, also known as PTBP1, is a human gene.^[1]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: PTBP1 polypyrimidine tract binding protein 1.

[edit] Further reading

Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960-9. PMID 1286667.
Ghetti A, Piñol-Roma S, Michael WM, et al. (1992). "hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs.". Nucleic Acids Res. 20 (14): 3671-8. PMID 1641332.
Gil A, Sharp PA, Jamison SF, Garcia-Blanco MA (1991). "Characterization of cDNAs encoding the polypyrimidine tract-binding protein.". Genes Dev. 5 (7): 1224-36. PMID 1906035.
Patton JG, Mayer SA, Tempst P, Nadal-Ginard B (1991). "Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.". Genes Dev. 5 (7): 1237-51. PMID 1906036.
Raimondi E, Romanelli MG, Moralli D, et al. (1995). "Assignment of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein I (PTB) to chromosome 14q23-q24.1.". Genomics 27 (3): 553-5. doi:10.1006/geno.1995.1093. PMID 7558043.
Patton JG, Porro EB, Galceran J, et al. (1993). "Cloning and characterization of PSF, a novel pre-mRNA splicing factor.". Genes Dev. 7 (3): 393-406. PMID 8449401.
Wu-Baer F, Lane WS, Gaynor RB (1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.". J. Biol. Chem. 271 (8): 4201-8. PMID 8626763.
Black AC, Luo J, Chun S, et al. (1997). "Specific binding of polypyrimidine tract binding protein and hnRNP A1 to HIV-1 CRS elements.". Virus Genes 12 (3): 275-85. PMID 8883365.
Huang S, Deerinck TJ, Ellisman MH, Spector DL (1997). "The dynamic organization of the perinucleolar compartment in the cell nucleus.". J. Cell Biol. 137 (5): 965-74. PMID 9166399.
Oh YL, Hahm B, Kim YK, et al. (1998). "Determination of functional domains in polypyrimidine-tract-binding protein.". Biochem. J. 331 ( Pt 1): 169-75. PMID 9512476.
Hahm B, Cho OH, Kim JE, et al. (1998). "Polypyrimidine tract-binding protein interacts with HnRNP L.". FEBS Lett. 425 (3): 401-6. PMID 9563502.
Meissner M, Dechat T, Gerner C, et al. (2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB.". J. Cell. Biochem. 76 (4): 559-66. PMID 10653975.
Kim JH, Hahm B, Kim YK, et al. (2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm.". J. Mol. Biol. 298 (3): 395-405. doi:10.1006/jmbi.2000.3687. PMID 10772858.
Conte MR, Grüne T, Ghuman J, et al. (2000). "Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold.". EMBO J. 19 (12): 3132-41. doi:10.1093/emboj/19.12.3132. PMID 10856256.
Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.". Mol. Cell. Biol. 20 (20): 7463-79. PMID 11003644.
Romanelli MG, Lorenzi P, Morandi C (2000). "Organization of the human gene encoding heterogeneous nuclear ribonucleoprotein type I (hnRNP I) and characterization of hnRNP I related pseudogene.". Gene 255 (2): 267-72. PMID 11024286.
de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.". EMBO J. 19 (21): 5895-904. doi:10.1093/emboj/19.21.5895. PMID 11060040.
Zang WQ, Li B, Huang PY, et al. (2001). "Role of polypyrimidine tract binding protein in the function of the hepatitis B virus posttranscriptional regulatory element.". J. Virol. 75 (22): 10779-86. doi:10.1128/JVI.75.22.10779-10786.2001. PMID 11602719.
Hüttelmaier S, Illenberger S, Grosheva I, et al. (2002). "Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.". J. Cell Biol. 155 (5): 775-86. doi:10.1083/jcb.200105044. PMID 11724819.
Kamath RV, Leary DJ, Huang S (2002). "Nucleocytoplasmic shuttling of polypyrimidine tract-binding protein is uncoupled from RNA export.". Mol. Biol. Cell 12 (12): 3808-20. PMID 11739782.