PSMD10

From Wikipedia, the free encyclopedia


Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PDB rendering based on 1qym.
Available structures: 1qym, 1tr4, 1uoh, 2dvw
Identifiers
Symbol(s) PSMD10; dJ889N15.2; p28
External IDs OMIM: 603480 MGI: 1858898 HomoloGene: 39167
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5716 53380
Ensembl ENSG00000101843 ENSMUSG00000031429
Uniprot O75832 Q8R0G2
Refseq NM_002814 (mRNA)
NP_002805 (protein)		 NM_016883 (mRNA)
NP_058579 (protein)
Location Chr X: 107.21 - 107.22 Mb Chr X: 136.29 - 136.3 Mb
Pubmed search [1] [2]

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10, also known as PSMD10, is a human gene.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[1]

[edit] References

  1. ^ Entrez Gene: PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.

[edit] Further reading

  • Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196. 
  • Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281–3. PMID 12914693. 
  • Sastry L, Cao T, King CR (1997). "Multiple Grb2-protein complexes in human cancer cells.". Int. J. Cancer 70 (2): 208–13. PMID 9009162. 
  • Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.". J. Biol. Chem. 272 (13): 8145–8. PMID 9079628. 
  • Hori T, Kato S, Saeki M, et al. (1998). "cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome.". Gene 216 (1): 113–22. PMID 9714768. 
  • Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.". J. Virol. 72 (12): 10251–5. PMID 9811770. 
  • Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype.". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577. 
  • Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway.". J. Biol. Chem. 275 (38): 29749–53. doi:10.1074/jbc.M004670200. PMID 10893419. 
  • Dawson S, Apcher S, Mee M, et al. (2002). "Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome.". J. Biol. Chem. 277 (13): 10893–902. doi:10.1074/jbc.M107313200. PMID 11779854. 
  • Sheehy AM, Gaddis NC, Choi JD, Malim MH (2002). "Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.". Nature 418 (6898): 646–50. doi:10.1038/nature00939. PMID 12167863. 
  • Fu XY, Wang HY, Tan L, et al. (2002). "Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance.". World J. Gastroenterol. 8 (4): 638–43. PMID 12174370. 
  • Huang X, Seifert U, Salzmann U, et al. (2002). "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.". J. Mol. Biol. 323 (4): 771–82. PMID 12419264. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nagao T, Higashitsuji H, Nonoguchi K, et al. (2003). "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity.". J. Biol. Chem. 278 (12): 10668–74. doi:10.1074/jbc.M206104200. PMID 12525503. 
  • Gaddis NC, Chertova E, Sheehy AM, et al. (2003). "Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions.". J. Virol. 77 (10): 5810–20. PMID 12719574. 
  • Lecossier D, Bouchonnet F, Clavel F, Hance AJ (2003). "Hypermutation of HIV-1 DNA in the absence of the Vif protein.". Science 300 (5622): 1112. doi:10.1126/science.1083338. PMID 12750511. 
  • Zhang H, Yang B, Pomerantz RJ, et al. (2003). "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.". Nature 424 (6944): 94–8. doi:10.1038/nature01707. PMID 12808465. 
  • Mangeat B, Turelli P, Caron G, et al. (2003). "Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.". Nature 424 (6944): 99–103. doi:10.1038/nature01709. PMID 12808466. 
  • Harris RS, Bishop KN, Sheehy AM, et al. (2003). "DNA deamination mediates innate immunity to retroviral infection.". Cell 113 (6): 803–9. PMID 12809610. 
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