PSMB1

From Wikipedia, the free encyclopedia


Proteasome (prosome, macropain) subunit, beta type, 1
PDB rendering based on 1iru.
Available structures: 1iru
Identifiers
Symbol(s) PSMB1; PSC5; FLJ25321; HC5; KIAA1838; PMSB1
External IDs OMIM: 602017 MGI: 104884 HomoloGene: 2087
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5689 19170
Ensembl ENSG00000008018 ENSMUSG00000014769
Uniprot P20618 Q6RI64
Refseq NM_002793 (mRNA)
NP_002784 (protein)		 NM_011185 (mRNA)
NP_035315 (protein)
Location Chr 6: 170.69 - 170.7 Mb Chr 17: 15.18 - 15.2 Mb
Pubmed search [1] [2]

Proteasome (prosome, macropain) subunit, beta type, 1, also known as PSMB1, is a human gene.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species.[1]

[edit] References

  1. ^ Entrez Gene: PSMB1 proteasome (prosome, macropain) subunit, beta type, 1.

[edit] Further reading

  • Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801-47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196. 
  • Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281-3. PMID 12914693. 
  • Tamura T, Lee DH, Osaka F, et al. (1991). "Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes).". Biochim. Biophys. Acta 1089 (1): 95-102. PMID 2025653. 
  • Lee LW, Moomaw CR, Orth K, et al. (1990). "Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome).". Biochim. Biophys. Acta 1037 (2): 178-85. PMID 2306472. 
  • Okumura K, Nogami M, Taguchi H, et al. (1995). "The genes for the alpha-type HC3 (PMSA2) and beta-type HC5 (PMSB1) subunits of human proteasomes map to chromosomes 6q27 and 7p12-p13 by fluorescence in situ hybridization.". Genomics 27 (2): 377-9. doi:10.1006/geno.1995.1062. PMID 7558012. 
  • Kristensen P, Johnsen AH, Uerkvitz W, et al. (1995). "Human proteasome subunits from 2-dimensional gels identified by partial sequencing.". Biochem. Biophys. Res. Commun. 205 (3): 1785-9. PMID 7811265. 
  • Tamura T, Osaka F, Kawamura Y, et al. (1994). "Isolation and characterization of alpha-type HC3 and beta-type HC5 subunit genes of human proteasomes.". J. Mol. Biol. 244 (1): 117-24. doi:10.1006/jmbi.1994.1710. PMID 7966316. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.". J. Biol. Chem. 272 (13): 8145-8. PMID 9079628. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.". J. Virol. 72 (12): 10251-5. PMID 9811770. 
  • Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype.". Nat. Med. 4 (12): 1397-400. doi:10.1038/3987. PMID 9846577. 
  • Elenich LA, Nandi D, Kent AE, et al. (1999). "The complete primary structure of mouse 20S proteasomes.". Immunogenetics 49 (10): 835-42. PMID 10436176. 
  • Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway.". J. Biol. Chem. 275 (38): 29749-53. doi:10.1074/jbc.M004670200. PMID 10893419. 
  • Feng Y, Longo DL, Ferris DK (2001). "Polo-like kinase interacts with proteasomes and regulates their activity.". Cell Growth Differ. 12 (1): 29-37. PMID 11205743. 
  • Sheehy AM, Gaddis NC, Choi JD, Malim MH (2002). "Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.". Nature 418 (6898): 646-50. doi:10.1038/nature00939. PMID 12167863. 
  • Huang X, Seifert U, Salzmann U, et al. (2002). "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.". J. Mol. Biol. 323 (4): 771-82. PMID 12419264. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Suzumori N, Burns KH, Yan W, Matzuk MM (2003). "RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 550-5. doi:10.1073/pnas.0234474100. PMID 12525704. 
 This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.