PSMB10

From Wikipedia, the free encyclopedia

Proteasome (prosome, macropain) subunit, beta type, 10

Identifiers

PSMB10; LMP10; MECL1; MGC1665

External IDs

OMIM: 176847 MGI: 1096380 HomoloGene: 20616

Gene ontology
Molecular Function:	• threonine endopeptidase activity
Cellular Component:	• cytosol • proteasome core complex (sensu Eukaryota)
Biological Process:	• proteolysis • ubiquitin-dependent protein catabolic process • humoral immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002801 (mRNA)
NP_002792 (protein)

NM_013640 (mRNA)
NP_038668 (protein)

Location

Chr 16: 66.53 - 66.53 Mb

Chr 8: 108.82 - 108.83 Mb

Pubmed search

[1]

[2]

Proteasome (prosome, macropain) subunit, beta type, 10, also known as PSMB10, is a human gene.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.^[1]

[edit] References

^ Entrez Gene: PSMB10 proteasome (prosome, macropain) subunit, beta type, 10.

[edit] Further reading

Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801-47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281-3. PMID 12914693.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Larsen F, Solheim J, Kristensen T, et al. (1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1.". Hum. Mol. Genet. 2 (10): 1589-95. PMID 8268911.
Hisamatsu H, Shimbara N, Saito Y, et al. (1996). "Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.". J. Exp. Med. 183 (4): 1807-16. PMID 8666937.
Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.". J. Biol. Chem. 272 (13): 8145-8. PMID 9079628.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Foss GS, Larsen F, Solheim J, Prydz H (1998). "Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1.". Biochim. Biophys. Acta 1402 (1): 17-28. PMID 9551082.
Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.". J. Virol. 72 (12): 10251-5. PMID 9811770.
Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype.". Nat. Med. 4 (12): 1397-400. doi:10.1038/3987. PMID 9846577.
Schmidt M, Zantopf D, Kraft R, et al. (1999). "Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex.". J. Mol. Biol. 288 (1): 117-28. doi:10.1006/jmbi.1999.2660. PMID 10329130.
Elenich LA, Nandi D, Kent AE, et al. (1999). "The complete primary structure of mouse 20S proteasomes.". Immunogenetics 49 (10): 835-42. PMID 10436176.
Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway.". J. Biol. Chem. 275 (38): 29749-53. doi:10.1074/jbc.M004670200. PMID 10893419.
Sheehy AM, Gaddis NC, Choi JD, Malim MH (2002). "Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.". Nature 418 (6898): 646-50. doi:10.1038/nature00939. PMID 12167863.
Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443-9. PMID 12417987.
Huang X, Seifert U, Salzmann U, et al. (2002). "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.". J. Mol. Biol. 323 (4): 771-82. PMID 12419264.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Miyagi T, Tatsumi T, Takehara T, et al. (2003). "Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells.". J. Gastroenterol. Hepatol. 18 (1): 32-40. PMID 12519221.
Gaddis NC, Chertova E, Sheehy AM, et al. (2003). "Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions.". J. Virol. 77 (10): 5810-20. PMID 12719574.