PSMA6

From Wikipedia, the free encyclopedia

Proteasome (prosome, macropain) subunit, alpha type, 6

PDB rendering based on 1iru.

Available structures: 1iru

Identifiers

Symbol(s)

PSMA6; IOTA; MGC22756; MGC2333; MGC23846; PROS27; p27K

External IDs

OMIM: 602855 MGI: 1347006 HomoloGene: 2085

Gene ontology
Molecular Function:	• RNA binding • threonine endopeptidase activity • protein binding
Cellular Component:	• cytosol • proteasome core complex (sensu Eukaryota)
Biological Process:	• ubiquitin-dependent protein catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002791 (mRNA)
NP_002782 (protein)

NM_011968 (mRNA)
NP_036098 (protein)

Location

Chr 14: 34.83 - 34.86 Mb

Chr 12: 56.32 - 56.34 Mb

Pubmed search

[1]

[2]

Proteasome (prosome, macropain) subunit, alpha type, 6, also known as PSMA6, is a human gene.^[1]

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.^[1]

[edit] References

^ ^a ^b Entrez Gene: PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6.

[edit] Further reading

Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281–3. PMID 12914693.
DeMartino GN, Orth K, McCullough ML, et al. (1991). "The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous.". Biochim. Biophys. Acta 1079 (1): 29–38. PMID 1888762.
Bey F, Silva Pereira I, Coux O, et al. (1993). "The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family.". Mol. Gen. Genet. 237 (1-2): 193–205. PMID 7681138.
Kristensen P, Johnsen AH, Uerkvitz W, et al. (1995). "Human proteasome subunits from 2-dimensional gels identified by partial sequencing.". Biochem. Biophys. Res. Commun. 205 (3): 1785–9. PMID 7811265.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. PMID 7821789.
Nederlof PM, Wang HR, Baumeister W (1996). "Nuclear localization signals of human and Thermoplasma proteasomal alpha subunits are functional in vitro.". Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12060–4. PMID 8618844.
Bureau JP, Olink-Coux M, Brouard N, et al. (1997). "Characterization of prosomes in human lymphocyte subpopulations and their presence as surface antigens.". Exp. Cell Res. 231 (1): 50–60. doi:10.1006/excr.1996.3453. PMID 9056411.
Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation.". J. Biol. Chem. 272 (13): 8145–8. PMID 9079628.
Gerards WL, de Jong WW, Bloemendal H, Boelens W (1998). "The human proteasomal subunit HsC8 induces ring formation of other alpha-type subunits.". J. Mol. Biol. 275 (1): 113–21. doi:10.1006/jmbi.1997.1429. PMID 9451443.
Henry L, Baz A, Château MT, et al. (1998). "Proteasome (prosome) subunit variations during the differentiation of myeloid U937 cells.". Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 15 (3): 131–44. PMID 9497851.
Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.". J. Virol. 72 (12): 10251–5. PMID 9811770.
Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype.". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577.
Elenich LA, Nandi D, Kent AE, et al. (1999). "The complete primary structure of mouse 20S proteasomes.". Immunogenetics 49 (10): 835–42. PMID 10436176.
Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway.". J. Biol. Chem. 275 (38): 29749–53. doi:10.1074/jbc.M004670200. PMID 10893419.
Kleijnen MF, Shih AH, Zhou P, et al. (2000). "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.". Mol. Cell 6 (2): 409–19. PMID 10983987.
Feng Y, Longo DL, Ferris DK (2001). "Polo-like kinase interacts with proteasomes and regulates their activity.". Cell Growth Differ. 12 (1): 29–37. PMID 11205743.
Engidawork E, Juranville JF, Fountoulakis M, et al. (2002). "Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome.". J. Neural Transm. Suppl. (61): 117–30. PMID 11771738.
Sjakste T, Sjakste N, Scherrer K (2002). "Exon/intron organisation of human proteasome PROS-27 K gene.". DNA Seq. 12 (4): 261–5. PMID 11924531.