PSCD4

From Wikipedia, the free encyclopedia

Pleckstrin homology, Sec7 and coiled-coil domains 4

Identifiers

PSCD4; CYT4; DJ63G5.1

External IDs

OMIM: 606514 MGI: 2441702 HomoloGene: 22750

Gene ontology
Molecular Function:	• ARF guanyl-nucleotide exchange factor activity
Cellular Component:	• intracellular
Biological Process:	• regulation of ARF protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013385 (mRNA)
NP_037517 (protein)

NM_028195 (mRNA)
NP_082471 (protein)

Location

Chr 22: 36.01 - 36.04 Mb

Chr 15: 78.42 - 78.45 Mb

Pubmed search

[1]

[2]

Pleckstrin homology, Sec7 and coiled-coil domains 4, also known as PSCD4, is a human gene.^[1]

Pleckstrin homology, Sec7 and coiled/coil domains 4 (PSCD4) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The PSCD4 exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The PSCD4 and PSCD1 gene structures are very similar.^[1]

[edit] References

^ ^a ^b Entrez Gene: PSCD4 pleckstrin homology, Sec7 and coiled-coil domains 4.

[edit] Further reading

Morishige M, Hashimoto S, Ogawa E, et al. (2008). "GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.". Nat. Cell Biol. 10 (1): 85-92. doi:10.1038/ncb1672. PMID 18084281.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Venkateswarlu K (2003). "Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.". J. Biol. Chem. 278 (44): 43460-9. doi:10.1074/jbc.M304078200. PMID 12920129.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ogasawara M, Kim SC, Adamik R, et al. (2000). "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors.". J. Biol. Chem. 275 (5): 3221-30. PMID 10652308.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Trofatter JA, Long KR, Murrell JR, et al. (1996). "An expression-independent catalog of genes from human chromosome 22.". Genome Res. 5 (3): 214-24. PMID 8593609.