PSCD3

From Wikipedia, the free encyclopedia

Pleckstrin homology, Sec7 and coiled-coil domains 3

PDB rendering based on 1bc9.

Available structures: 1bc9, 1fgy, 1fgz, 1fhw, 1fhx, 1u2b

Identifiers

Symbol(s)

PSCD3; ARNO3; GRP1

External IDs

OMIM: 605081 MGI: 1335107 HomoloGene: 3116

Gene ontology
Molecular Function:	• ARF guanyl-nucleotide exchange factor activity • protein binding • phosphatidylinositol binding • phosphatidylinositol-3,4,5-triphosphate binding • inositol-1,4,5-triphosphate receptor activity
Cellular Component:	• ruffle • intracellular • membrane fraction • cytoplasm • plasma membrane
Biological Process:	• vesicle-mediated transport • regulation of ARF protein signal transduction • positive regulation of cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004227 (mRNA)
NP_004218 (protein)

NM_011182 (mRNA)
NP_035312 (protein)

Location

Chr 7: 6.17 - 6.28 Mb

Chr 5: 143.88 - 143.97 Mb

Pubmed search

[1]

[2]

Pleckstrin homology, Sec7 and coiled-coil domains 3, also known as PSCD3, is a human gene.^[1]

This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.^[1]

[edit] References

^ ^a ^b Entrez Gene: PSCD3 pleckstrin homology, Sec7 and coiled-coil domains 3.

[edit] Further reading

Klarlund JK, Guilherme A, Holik JJ, et al. (1997). "Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains.". Science 275 (5308): 1927–30. PMID 9072969.
Franco M, Boretto J, Robineau S, et al. (1998). "ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9926–31. PMID 9707577.
Venkateswarlu K, Gunn-Moore F, Oatey PB, et al. (1998). "Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain.". Biochem. J. 335 ( Pt 1): 139–46. PMID 9742223.
Ogasawara M, Kim SC, Adamik R, et al. (2000). "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors.". J. Biol. Chem. 275 (5): 3221–30. PMID 10652308.
Nevrivy DJ, Peterson VJ, Avram D, et al. (2000). "Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors.". J. Biol. Chem. 275 (22): 16827–36. PMID 10828067.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Poirier MB, Hamann G, Domingue ME, et al. (2005). "General receptor for phosphoinositides 1, a novel repressor of thyroid hormone receptor action that prevents deoxyribonucleic acid binding.". Mol. Endocrinol. 19 (8): 1991–2005. doi:10.1210/me.2004-0449. PMID 15878955.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.