PSCA (gene)

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Prostate stem cell antigen
Identifiers
Symbol(s) PSCA; PRO232
External IDs OMIM: 602470 MGI: 1919623 HomoloGene: 4150
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8000 72373
Ensembl ENSG00000167653 ENSMUSG00000022598
Uniprot O43653 Q9D7U0
Refseq NM_005672 (mRNA)
NP_005663 (protein)		 NM_028216 (mRNA)
NP_082492 (protein)
Location Chr 8: 143.76 - 143.76 Mb Chr 15: 74.54 - 74.54 Mb
Pubmed search [1] [2]

Prostate stem cell antigen, also known as PSCA, is a human gene.[1]

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene has a nonsynonymous nucleotide polymorphism at its start codon.[1]

[edit] References

  1. ^ a b Entrez Gene: PSCA prostate stem cell antigen.

[edit] Further reading

  • Reiter RE, Gu Z, Watabe T, et al. (1998). "Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.". Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1735-40. PMID 9465086. 
  • Gu Z, Thomas G, Yamashiro J, et al. (2000). "Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer.". Oncogene 19 (10): 1288-96. doi:10.1038/sj.onc.1203426. PMID 10713670. 
  • Bahrenberg G, Brauers A, Joost HG, Jakse G (2000). "Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors.". Biochem. Biophys. Res. Commun. 275 (3): 783-8. doi:10.1006/bbrc.2000.3393. PMID 10973799. 
  • Amara N, Palapattu GS, Schrage M, et al. (2001). "Prostate stem cell antigen is overexpressed in human transitional cell carcinoma.". Cancer Res. 61 (12): 4660-5. PMID 11406532. 
  • Watabe T, Lin M, Ide H, et al. (2002). "Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 401-6. doi:10.1073/pnas.012574899. PMID 11752398. 
  • Ross S, Spencer SD, Holcomb I, et al. (2002). "Prostate stem cell antigen as therapy target: tissue expression and in vivo efficacy of an immunoconjugate.". Cancer Res. 62 (9): 2546-53. PMID 11980648. 
  • Jain A, Lam A, Vivanco I, et al. (2003). "Identification of an androgen-dependent enhancer within the prostate stem cell antigen gene.". Mol. Endocrinol. 16 (10): 2323-37. PMID 12351697. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tran CP, Lin C, Yamashiro J, Reiter RE (2003). "Prostate stem cell antigen is a marker of late intermediate prostate epithelial cells.". Mol. Cancer Res. 1 (2): 113-21. PMID 12496358. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Fraga MF, Ballestar E, Villar-Garea A, et al. (2005). "Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.". Nat. Genet. 37 (4): 391-400. doi:10.1038/ng1531. PMID 15765097. 
  • Lam JS, Yamashiro J, Shintaku IP, et al. (2005). "Prostate stem cell antigen is overexpressed in prostate cancer metastases.". Clin. Cancer Res. 11 (7): 2591-6. doi:10.1158/1078-0432.CCR-04-1842. PMID 15814638. 
  • Zhigang Z, Wenlu S (2006). "Complete androgen ablation suppresses prostate stem cell antigen (PSCA) mRNA expression in human prostate carcinoma.". Prostate 65 (4): 299-305. doi:10.1002/pros.20290. PMID 16015594. 
  • Wente MN, Jain A, Kono E, et al. (2006). "Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer.". Pancreas 31 (2): 119-25. PMID 16024997. 
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942-54. doi:10.1007/s00335-005-0075-2. PMID 16341674. 
  • Grubbs EG, Abdel-Wahab Z, Tyler DS, Pruitt SK (2007). "Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer.". Ann. Surg. Oncol. 13 (12): 1645-54. doi:10.1245/s10434-006-9029-5. PMID 16957968. 
  • Morgenroth A, Cartellieri M, Schmitz M, et al. (2007). "Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells.". Prostate 67 (10): 1121-31. doi:10.1002/pros.20608. PMID 17492652. 
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