PRSS8

From Wikipedia, the free encyclopedia

Protease, serine, 8

Identifiers

PRSS8; CAP1; PROSTASIN

External IDs

OMIM: 600823 MGI: 1923810 HomoloGene: 20613

Gene ontology
Molecular Function:	• serine-type endopeptidase activity
Cellular Component:	• extracellular region • extracellular space • plasma membrane • integral to membrane
Biological Process:	• proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002773 (mRNA)
NP_002764 (protein)

NM_133351 (mRNA)
NP_579929 (protein)

Location

Chr 16: 31.05 - 31.05 Mb

Chr 7: 127.72 - 127.72 Mb

Pubmed search

[1]

[2]

Protease, serine, 8, also known as PRSS8, is a human gene.^[1]

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.^[1]

[edit] References

^ ^a ^b Entrez Gene: PRSS8 protease, serine, 8.

[edit] Further reading

Yu JX, Chao L, Chao J (1995). "Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA.". J. Biol. Chem. 270 (22): 13483–9. PMID 7768952.
Yu JX, Chao L, Chao J (1994). "Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland.". J. Biol. Chem. 269 (29): 18843–8. PMID 8034638.
Yu JX, Chao L, Ward DC, Chao J (1997). "Structure and chromosomal localization of the human prostasin (PRSS8) gene.". Genomics 32 (3): 334–40. doi:10.1006/geno.1996.0127. PMID 8838796.
Nelson PS, Gan L, Ferguson C, et al. (1999). "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 3114–9. PMID 10077646.
Chen LM, Skinner ML, Kauffman SW, et al. (2001). "Prostasin is a glycosylphosphatidylinositol-anchored active serine protease.". J. Biol. Chem. 276 (24): 21434–42. doi:10.1074/jbc.M011423200. PMID 11274175.
Donaldson SH, Hirsh A, Li DC, et al. (2002). "Regulation of the epithelial sodium channel by serine proteases in human airways.". J. Biol. Chem. 277 (10): 8338–45. doi:10.1074/jbc.M105044200. PMID 11756432.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wang C, Chao J, Chao L (2003). "Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats.". Am. J. Physiol. Regul. Integr. Comp. Physiol. 284 (4): R1031–6. doi:10.1152/ajpregu.00660.2002. PMID 12626364.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Tong Z, Illek B, Bhagwandin VJ, et al. (2004). "Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line.". Am. J. Physiol. Lung Cell Mol. Physiol. 287 (5): L928–35. doi:10.1152/ajplung.00160.2004. PMID 15246975.
Shipway A, Danahay H, Williams JA, et al. (2004). "Biochemical characterization of prostasin, a channel activating protease.". Biochem. Biophys. Res. Commun. 324 (2): 953–63. doi:10.1016/j.bbrc.2004.09.123. PMID 15474520.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Leyvraz C, Charles RP, Rubera I, et al. (2005). "The epidermal barrier function is dependent on the serine protease CAP1/Prss8.". J. Cell Biol. 170 (3): 487–96. doi:10.1083/jcb.200501038. PMID 16061697.
Fan B, Wu TD, Li W, Kirchhofer D (2005). "Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin.". J. Biol. Chem. 280 (41): 34513–20. doi:10.1074/jbc.M502119200. PMID 16103126.
Chen M, Chen LM, Chai KX (2006). "Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.". Prostate 66 (9): 911–20. doi:10.1002/pros.20325. PMID 16541421.
Rohan S, Tu JJ, Kao J, et al. (2007). "Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes.". Clin. Cancer Res. 12 (23): 6937–45. doi:10.1158/1078-0432.CCR-06-1268. PMID 17145811.
Chen M, Fu YY, Lin CY, et al. (2007). "Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3.". Biochim. Biophys. Acta 1773 (7): 1133–40. doi:10.1016/j.bbamcr.2007.04.013. PMID 17532063.