User:ProteinBoxBot/PBB Log Wiki 11-9-2007 A-2

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Contents 1 Log file for Protein Box Bot 2 Protein Status Quick Log - Date: 01:26, 10 November 2007 (UTC) 2.1 Proteins without matches (17) 2.2 Proteins with a High Potential Match (8) 2.3 Created (11) 2.4 Manual Inspection (Page not found) (14) 3 Protein Status Grid - Date: 01:26, 10 November 2007 (UTC) 4 Vebose Log - Date: 01:26, 10 November 2007 (UTC) 4.1 ADIPOR1 4.2 CD99 4.3 IL21 4.4 LIG4 4.5 LNPEP 4.6 LTBR 4.7 LTC4S 4.8 MAP4 4.9 MBD1 4.10 MTM1 4.11 MUT 4.12 NME2 4.13 NT5E 4.14 NTF3 4.15 OPRD1 4.16 P2RX1 4.17 PCBP1 4.18 PCBP2 4.19 PPP2R4 4.20 PSMB2 4.21 PSMD12 4.22 PSMD8 4.23 PTPN2 4.24 RPA2 4.25 UPF1

[edit] Log file for Protein Box Bot

Log page index: User:ProteinBoxBot/PBB_Log_Index

[edit] Protein Status Quick Log - Date: 01:26, 10 November 2007 (UTC)

[edit] Proteins without matches (17)

PCBP2	PCBP1	P2RX1	MTM1	OPRD1
PSMD8	ADIPOR1	RPA2	MAP4	LNPEP
PSMD12	NME2	NT5E	UPF1	PSMB2
LIG4	CD99

[edit] Proteins with a High Potential Match (8)

MBD1	PPP2R4	LTC4S	LTBR	PTPN2
MUT	NTF3	IL21

[edit] Created (11)

PCBP2	PCBP1	P2RX1	ADIPOR1	RPA2
MAP4	PSMD12	UPF1	PSMB2	LIG4
CD99

[edit] Manual Inspection (Page not found) (14)

MBD1	MTM1	OPRD1	PSMD8	PPP2R4
LTC4S	LTBR	LNPEP	PTPN2	NME2
NT5E	MUT	NTF3	IL21

[edit] Protein Status Grid - Date: 01:26, 10 November 2007 (UTC)

HUGO Symbol	Action Summary	Target page(s)	WP Symbol Search
PCBP2	Created	Other Pages: Poly binding protein 2 (No Data); PCBP2 (No Data); HNRPE2 (No Data); Hnrpe2 (No Data); MGC110998 (No Data); Mgc110998 (No Data); HnRNP-E2 (No Data); Hnrnp-e2 (No Data);	[1]
PCBP1	Created	Other Pages: Poly binding protein 1 (No Data); PCBP1 (No Data); HNRPE1 (No Data); Hnrpe1 (No Data); HNRPX (No Data); Hnrpx (No Data); HnRNP-E1 (No Data); Hnrnp-e1 (No Data); HnRNP-X (No Data); Hnrnp-x (No Data);	[2]
MBD1	Manual Inspection (Page not found)	Other Pages: Methyl-CpG binding domain protein 1 (No Data); MBD1 (Protein Template); CXXC3 (No Data); Cxxc3 (No Data); PCM1 (No Data); Pcm1 (No Data); RFT (DisAmbig); Rft (No Data);	[3]
P2RX1	Created	Other Pages: Purinergic receptor P2X (No Data); P2RX1 (No Data); P2X1 (No Data); P2x1 (No Data);	[4]
MTM1	Manual Inspection (Page not found)	Other Pages: Myotubularin 1 (No Data); MTM1 (No Data); CNM (DisAmbig); Cnm (No Data); MTMX (No Data); Mtmx (No Data); XLMTM (No Data); Xlmtm (No Data);	[5]
OPRD1	Manual Inspection (Page not found)	Other Pages: Opioid receptor (Unknown Data); OPRD1 (No Data); OPRD (No Data); Oprd (No Data);	[6]
PSMD8	Manual Inspection (Page not found)	Other Pages: Proteasome 26S subunit (No Data); PSMD8 (No Data); HIP6 (No Data); Hip6 (No Data); HYPF (No Data); Hypf (No Data); MGC1660 (No Data); Mgc1660 (No Data); Nin1p (No Data); S14 (DisAmbig); P31 (No Data);	[7]
PPP2R4	Manual Inspection (Page not found)	Other Pages: Protein phosphatase 2A activator (No Data); PPP2R4 (No Data); MGC2184 (No Data); Mgc2184 (No Data); PP2A (Protein Template); Pp2a (No Data); PR53 (No Data); Pr53 (No Data); PTPA (No Data); Ptpa (No Data);	[8]
LTC4S	Manual Inspection (Page not found)	Other Pages: Leukotriene C4 synthase (Protein Template); LTC4S (No Data); MGC33147 (No Data); Mgc33147 (No Data);	[9]
ADIPOR1	Created	Other Pages: Adiponectin receptor 1 (No Data); ADIPOR1 (No Data); ACDCR1 (No Data); Acdcr1 (No Data); CGI-45 (No Data); Cgi-45 (No Data); CGI45 (No Data); Cgi45 (No Data); FLJ25385 (No Data); Flj25385 (No Data); FLJ42464 (No Data); Flj42464 (No Data); PAQR1 (No Data); Paqr1 (No Data); TESBP1A (No Data); Tesbp1a (No Data);	[10]
LTBR	Manual Inspection (Page not found)	Other Pages: Lymphotoxin beta receptor (Protein Template); LTBR (No Data); CD18 (Codes Found, but no match[skip]); Cd18 (Redirect -> CD18); D12S370 (No Data); D12s370 (No Data); LT-BETA-R (No Data); Lt-beta-r (No Data); TNF-R-III (No Data); Tnf-r-iii (No Data); TNFCR (No Data); Tnfcr (No Data); TNFR-RP (No Data); Tnfr-rp (No Data); TNFR2-RP (No Data); Tnfr2-rp (No Data); TNFRSF3 (No Data); Tnfrsf3 (No Data);	[11]
RPA2	Created	Other Pages: Replication protein A2 (No Data); RPA2 (No Data); REPA2 (No Data); Repa2 (No Data); RPA32 (No Data); Rpa32 (No Data);	[12]
MAP4	Created	Other Pages: Microtubule-associated protein 4 (No Data); MAP4 (No Data); DKFZp779A1753 (No Data); Dkfzp779a1753 (No Data); MGC8617 (No Data); Mgc8617 (No Data);	[13]
LNPEP	Manual Inspection (Page not found)	Other Pages: Leucyl/cystinyl aminopeptidase (No Data); LNPEP (No Data); PLAP (No Data); Plap (No Data); CAP (DisAmbig); Cap (Unknown Data); IRAP (DisAmbig); Irap (No Data); P-LAP (No Data); P-lap (No Data);	[14]
PSMD12	Created	Other Pages: Proteasome 26S subunit (No Data); PSMD12 (No Data); P55 (Redirect -> CD120); MGC75406 (No Data); Mgc75406 (No Data); CD120 (Codes Found, but no match[skip]);	[15]
PTPN2	Manual Inspection (Page not found)	Other Pages: Protein tyrosine phosphatase (Protein Template); PTPN2 (No Data); PTPT (No Data); Ptpt (No Data); TC-PTP (No Data); Tc-ptp (No Data); TCELLPTP (No Data); Tcellptp (No Data); TCPTP (No Data); Tcptp (No Data);	[16]
NME2	Manual Inspection (Page not found)	Other Pages: Non-metastatic cells 2 (No Data); NME2 (No Data); MGC111212 (No Data); Mgc111212 (No Data); NDPKB (No Data); Ndpkb (No Data); NM23-H2 (No Data); Nm23-h2 (No Data); NM23B (No Data); Nm23b (No Data); Puf (Redirect -> University Presses of France); University Presses of France (Unknown Data);	[17]
NT5E	Manual Inspection (Page not found)	Other Pages: 5'-nucleotidase (Redirect -> Liver function tests); NT5E (No Data); CD73 (No Data); Cd73 (No Data); E5NT (No Data); E5nt (No Data); NT (DisAmbig); Nt (Redirect -> NT); NT5 (Redirect -> Windows 2000); Nt5 (No Data); NTE (DisAmbig); Nte (Redirect -> NTE); EN (DisAmbig); En (Redirect -> EN); ENT (DisAmbig); Ent (Unknown Data); Liver function tests (Unknown Data); Windows 2000 (Unknown Data);	[18]
UPF1	Created	Other Pages: UPF1 regulator of nonsense transcripts homolog (No Data); UPF1 (No Data); FLJ43809 (No Data); Flj43809 (No Data); FLJ46894 (No Data); Flj46894 (No Data); HUPF1 (No Data); Hupf1 (No Data); KIAA0221 (No Data); Kiaa0221 (No Data); NORF1 (No Data); Norf1 (No Data); RENT1 (No Data); Rent1 (No Data); PNORF1 (No Data); Pnorf1 (No Data);	[19]
PSMB2	Created	Other Pages: Proteasome subunit (No Data); PSMB2 (No Data); HC7-I (No Data); Hc7-i (No Data); MGC104215 (No Data); Mgc104215 (No Data); MGC126885 (No Data); Mgc126885 (No Data);	[20]
MUT	Manual Inspection (Page not found)	Other Pages: Methylmalonyl Coenzyme A mutase (Redirect -> Methylmalonyl-CoA mutase); MUT (DisAmbig); MCM (DisAmbig); Mcm (No Data); Methylmalonyl-CoA mutase (Protein Template);	[21]
LIG4	Created	Other Pages: Ligase IV (No Data); LIG4 (No Data);	[22]
CD99	Created	Other Pages: CD99 molecule (No Data); CD99 (No Data); MIC2 (No Data); Mic2 (No Data); MIC2X (No Data); Mic2x (No Data); MIC2Y (No Data); Mic2y (No Data);	[23]
NTF3	Manual Inspection (Page not found)	Other Pages: Neurotrophin 3 (Redirect -> Neurotrophin-3); NTF3 (No Data); NT3 (No Data); Nt3 (No Data); HDNF (No Data); Hdnf (No Data); MGC129711 (No Data); Mgc129711 (No Data); NGF-2 (No Data); Ngf-2 (No Data); NGF2 (No Data); Ngf2 (No Data); Neurotrophin-3 (Protein Template);	[24]
IL21	Manual Inspection (Page not found)	Other Pages: Interleukin 21 (Protein Template); IL21 (No Data); IL-21 (Redirect -> interleukin 21); Il-21 (No Data); Za11 (No Data);	[25]

[edit] Vebose Log - Date: 01:26, 10 November 2007 (UTC)

[edit] ADIPOR1

• INFO: Beginning work on ADIPOR1... {November 9, 2007 5:17:00 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 5:17:44 PM PST}
• CREATED: Created new protein page: ADIPOR1 {November 9, 2007 5:17:51 PM PST}

[edit] CD99

• INFO: Beginning work on CD99... {November 9, 2007 5:00:48 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 5:01:46 PM PST}
• CREATED: Created new protein page: CD99 {November 9, 2007 5:01:53 PM PST}

[edit] IL21

• INFO: Beginning work on IL21... {November 9, 2007 5:17:51 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:18:31 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
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| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Interleukin 21
 | HGNCid = 6005
 | Symbol = IL21
 | AltSymbols =; IL-21; Za11
 | OMIM = 605384
 | ECnumber =  
 | Homologene = 11032
 | MGIid = 1890474
 | GeneAtlas_image1 = PBB_GE_IL21_221271_at_tn.png
 | Function = {{GNF_GO|id=GO:0005134 |text = interleukin-2 receptor binding}} 
 | Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} 
 | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0045078 |text = positive regulation of interferon-gamma biosynthetic process}} {{GNF_GO|id=GO:0048469 |text = cell maturation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 59067
    | Hs_Ensembl = ENSG00000138684
    | Hs_RefseqProtein = NP_068575
    | Hs_RefseqmRNA = NM_021803
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 123753221
    | Hs_GenLoc_end = 123761662
    | Hs_Uniprot = Q9HBE4
    | Mm_EntrezGene = 60505
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_021782
    | Mm_RefseqProtein = NP_068554
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Interleukin 21''', also known as '''IL21''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Sivakumar PV, Foster DC, Clegg CH |title=Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. |journal=Immunology |volume=112 |issue= 2 |pages= 177-82 |year= 2004 |pmid= 15147560 |doi= 10.1111/j.1365-2567.2004.01886.x }}
*{{cite journal  | author=Leonard WJ, Spolski R |title=Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. |journal=Nat. Rev. Immunol. |volume=5 |issue= 9 |pages= 688-98 |year= 2005 |pmid= 16138102 |doi= 10.1038/nri1688 }}
*{{cite journal  | author=Brandt K, Singh PB, Bulfone-Paus S, Rückert R |title=Interleukin-21: a new modulator of immunity, infection, and cancer. |journal=Cytokine Growth Factor Rev. |volume=18 |issue= 3-4 |pages= 223-32 |year= 2007 |pmid= 17509926 |doi= 10.1016/j.cytogfr.2007.04.003 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] LIG4

• INFO: Beginning work on LIG4... {November 9, 2007 4:56:59 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 4:57:33 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 4:57:41 PM PST}
• CREATED: Created new protein page: LIG4 {November 9, 2007 4:57:49 PM PST}

[edit] LNPEP

• INFO: Beginning work on LNPEP... {November 9, 2007 4:57:49 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:58:12 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Leucyl/cystinyl aminopeptidase
 | HGNCid = 6656
 | Symbol = LNPEP
 | AltSymbols =; PLAP; CAP; IRAP; P-LAP
 | OMIM = 151300
 | ECnumber =  
 | Homologene = 21148
 | MGIid = 2387123
 | Function = {{GNF_GO|id=GO:0004177 |text = aminopeptidase activity}} {{GNF_GO|id=GO:0004179 |text = membrane alanyl aminopeptidase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4012
    | Hs_Ensembl = ENSG00000113441
    | Hs_RefseqProtein = NP_005566
    | Hs_RefseqmRNA = NM_005575
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 96296924
    | Hs_GenLoc_end = 96398975
    | Hs_Uniprot = Q9UIQ6
    | Mm_EntrezGene = 240028
    | Mm_Ensembl = ENSMUSG00000023845
    | Mm_RefseqmRNA = NM_172827
    | Mm_RefseqProtein = NP_766415
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 17232341
    | Mm_GenLoc_end = 17329107
    | Mm_Uniprot =  
  }}
}}
'''Leucyl/cystinyl aminopeptidase''', also known as '''LNPEP''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: LNPEP leucyl/cystinyl aminopeptidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4012| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Albiston AL, Mustafa T, McDowall SG, ''et al.'' |title=AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement. |journal=Trends Endocrinol. Metab. |volume=14 |issue= 2 |pages= 72-7 |year= 2003 |pmid= 12591177 |doi=  }}
*{{cite journal  | author=Keller SR |title=The insulin-regulated aminopeptidase: a companion and regulator of GLUT4. |journal=Front. Biosci. |volume=8 |issue=  |pages= s410-20 |year= 2004 |pmid= 12700100 |doi=  }}
*{{cite journal  | author=Keller SR |title=Role of the insulin-regulated aminopeptidase IRAP in insulin action and diabetes. |journal=Biol. Pharm. Bull. |volume=27 |issue= 6 |pages= 761-4 |year= 2005 |pmid= 15187412 |doi=  }}
*{{cite journal  | author=Nomura S, Ito T, Yamamoto E, ''et al.'' |title=Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy. |journal=Biochim. Biophys. Acta |volume=1751 |issue= 1 |pages= 19-25 |year= 2005 |pmid= 15894523 |doi= 10.1016/j.bbapap.2005.04.006 }}
*{{cite journal  | author=Tsujimoto M, Hattori A |title=The oxytocinase subfamily of M1 aminopeptidases. |journal=Biochim. Biophys. Acta |volume=1751 |issue= 1 |pages= 9-18 |year= 2005 |pmid= 16054015 |doi= 10.1016/j.bbapap.2004.09.011 }}
*{{cite journal  | author=Mizutani S, Shibata K, Kikkawa F, ''et al.'' |title=Essential role of placental leucine aminopeptidase in gynecologic malignancy. |journal=Expert Opin. Ther. Targets |volume=11 |issue= 4 |pages= 453-61 |year= 2007 |pmid= 17373876 |doi= 10.1517/14728222.11.4.453 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] LTBR

• INFO: Beginning work on LTBR... {November 9, 2007 4:58:12 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:59:01 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Lymphotoxin beta receptor (TNFR superfamily, member 3)
 | HGNCid = 6718
 | Symbol = LTBR
 | AltSymbols =; CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFRSF3
 | OMIM = 600979
 | ECnumber =  
 | Homologene = 1753
 | MGIid = 104875
 | GeneAtlas_image1 = PBB_GE_LTBR_203005_at_tn.png
 | Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4055
    | Hs_Ensembl = ENSG00000111321
    | Hs_RefseqProtein = NP_002333
    | Hs_RefseqmRNA = NM_002342
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 6363595
    | Hs_GenLoc_end = 6370994
    | Hs_Uniprot = P36941
    | Mm_EntrezGene = 17000
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = XM_982227
    | Mm_RefseqProtein = XP_987321
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Lymphotoxin beta receptor (TNFR superfamily, member 3)''', also known as '''LTBR''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.<ref>{{cite web | title = Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4055| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Elewaut D, Ware CF |title=The unconventional role of LT alpha beta in T cell differentiation. |journal=Trends Immunol. |volume=28 |issue= 4 |pages= 169-75 |year= 2007 |pmid= 17336158 |doi= 10.1016/j.it.2007.02.005 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] LTC4S

• INFO: Beginning work on LTC4S... {November 9, 2007 4:59:01 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:59:14 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Leukotriene C4 synthase
 | HGNCid = 6719
 | Symbol = LTC4S
 | AltSymbols =; MGC33147
 | OMIM = 246530
 | ECnumber =  
 | Homologene = 7406
 | MGIid = 107498
 | Function = {{GNF_GO|id=GO:0004364 |text = glutathione transferase activity}} {{GNF_GO|id=GO:0004464 |text = leukotriene-C4 synthase activity}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0019370 |text = leukotriene biosynthetic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4056
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_665874
    | Hs_RefseqmRNA = NM_145867
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 17001
    | Mm_Ensembl = ENSMUSG00000020377
    | Mm_RefseqmRNA = NM_008521
    | Mm_RefseqProtein = NP_032547
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 50079885
    | Mm_GenLoc_end = 50081955
    | Mm_Uniprot = Q5SVR7
  }}
}}
'''Leukotriene C4 synthase''', also known as '''LTC4S''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.<ref>{{cite web | title = Entrez Gene: LTC4S leukotriene C4 synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4056| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Penrose JF |title=LTC4 synthase. Enzymology, biochemistry, and molecular characterization. |journal=Clinical reviews in allergy & immunology |volume=17 |issue= 1-2 |pages= 133-52 |year= 1999 |pmid= 10436863 |doi=  }}
*{{cite journal  | author=Penrose JF, Austen KF |title=The biochemical, molecular, and genomic aspects of leukotriene C4 synthase. |journal=Proc. Assoc. Am. Physicians |volume=111 |issue= 6 |pages= 537-46 |year= 2000 |pmid= 10591082 |doi=  }}
*{{cite journal  | author=Jakobsson PJ, Morgenstern R, Mancini J, ''et al.'' |title=Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily. |journal=Am. J. Respir. Crit. Care Med. |volume=161 |issue= 2 Pt 2 |pages= S20-4 |year= 2000 |pmid= 10673221 |doi=  }}
*{{cite journal  | author=Bigby TD |title=The leukotriene C(4) synthase gene and asthma. |journal=Am. J. Respir. Cell Mol. Biol. |volume=23 |issue= 3 |pages= 273-6 |year= 2000 |pmid= 10970815 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

[edit] MAP4

• INFO: Beginning work on MAP4... {November 9, 2007 4:59:14 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 4:59:28 PM PST}
• CREATED: Created new protein page: MAP4 {November 9, 2007 4:59:36 PM PST}

[edit] MBD1

• INFO: Beginning work on MBD1... {November 9, 2007 4:59:36 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 5:00:34 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:00:48 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_MBD1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d9n.
 | PDB = {{PDB2|1d9n}}, {{PDB2|1ig4}}
 | Name = Methyl-CpG binding domain protein 1
 | HGNCid = 6916
 | Symbol = MBD1
 | AltSymbols =; CXXC3; PCM1; RFT
 | OMIM = 156535
 | ECnumber =  
 | Homologene = 8414
 | MGIid = 1333811
 | GeneAtlas_image1 = PBB_GE_MBD1_203353_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_MBD1_208595_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008327 |text = methyl-CpG binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0000792 |text = heterochromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4152
    | Hs_Ensembl = ENSG00000141644
    | Hs_RefseqProtein = NP_002375
    | Hs_RefseqmRNA = NM_002384
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 46047254
    | Hs_GenLoc_end = 46061844
    | Hs_Uniprot = Q9UIS9
    | Mm_EntrezGene = 17190
    | Mm_Ensembl = ENSMUSG00000024561
    | Mm_RefseqmRNA = NM_013594
    | Mm_RefseqProtein = NP_038622
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 74393641
    | Mm_GenLoc_end = 74408054
    | Mm_Uniprot = Q9Z2E2
  }}
}}
'''Methyl-CpG binding domain protein 1''', also known as '''MBD1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters.  Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus.  All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity.  MBD1 and MBD2 map very close to each other on chromosome 18q21.<ref>{{cite web | title = Entrez Gene: MBD1 methyl-CpG binding domain protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4152| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

[edit] MTM1

• INFO: Beginning work on MTM1... {November 9, 2007 5:01:53 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:02:12 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Myotubularin 1
 | HGNCid = 7448
 | Symbol = MTM1
 | AltSymbols =; CNM; MTMX; XLMTM
 | OMIM = 300415
 | ECnumber =  
 | Homologene = 37279
 | MGIid = 1099452
 | Function = {{GNF_GO|id=GO:0004437 |text = inositol or phosphatidylinositol phosphatase activity}} {{GNF_GO|id=GO:0004722 |text = protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} 
 | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} 
 | Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0046839 |text = phospholipid dephosphorylation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4534
    | Hs_Ensembl = ENSG00000171100
    | Hs_RefseqProtein = NP_000243
    | Hs_RefseqmRNA = NM_000252
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 149487727
    | Hs_GenLoc_end = 149592453
    | Hs_Uniprot = Q13496
    | Mm_EntrezGene = 17772
    | Mm_Ensembl = ENSMUSG00000031337
    | Mm_RefseqmRNA = NM_019926
    | Mm_RefseqProtein = NP_064310
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 67471323
    | Mm_GenLoc_end = 67575845
    | Mm_Uniprot = Q5BKQ5
  }}
}}
'''Myotubularin 1''', also known as '''MTM1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is a member of a gene family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy.<ref>{{cite web | title = Entrez Gene: MTM1 myotubularin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4534| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Laporte J, Biancalana V, Tanner SM, ''et al.'' |title=MTM1 mutations in X-linked myotubular myopathy. |journal=Hum. Mutat. |volume=15 |issue= 5 |pages= 393-409 |year= 2000 |pmid= 10790201 |doi= 10.1002/(SICI)1098-1004(200005)15:5<393::AID-HUMU1>3.0.CO;2-R }}
*{{cite journal  | author=Wishart MJ, Dixon JE |title=PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. |journal=Trends Cell Biol. |volume=12 |issue= 12 |pages= 579-85 |year= 2003 |pmid= 12495846 |doi=  }}
*{{cite journal  | author=Laporte J, Bedez F, Bolino A, Mandel JL |title=Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases. |journal=Hum. Mol. Genet. |volume=12 Spec No 2 |issue=  |pages= R285-92 |year= 2004 |pmid= 12925573 |doi= 10.1093/hmg/ddg273 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] MUT

• INFO: Beginning work on MUT... {November 9, 2007 5:02:12 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:03:06 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Methylmalonyl Coenzyme A mutase
 | HGNCid = 7526
 | Symbol = MUT
 | AltSymbols =; MCM
 | OMIM = 609058
 | ECnumber =  
 | Homologene = 20097
 | MGIid = 97239
 | GeneAtlas_image1 = PBB_GE_MUT_202959_at_tn.png
 | GeneAtlas_image2 = PBB_GE_MUT_202960_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004494 |text = methylmalonyl-CoA mutase activity}} {{GNF_GO|id=GO:0031419 |text = cobalamin binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050897 |text = cobalt ion binding}} 
 | Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} 
 | Process = {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0009791 |text = post-embryonic development}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4594
    | Hs_Ensembl = ENSG00000146085
    | Hs_RefseqProtein = NP_000246
    | Hs_RefseqmRNA = NM_000255
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 49506958
    | Hs_GenLoc_end = 49538811
    | Hs_Uniprot = P22033
    | Mm_EntrezGene = 17850
    | Mm_Ensembl = ENSMUSG00000023921
    | Mm_RefseqmRNA = NM_008650
    | Mm_RefseqProtein = NP_032676
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 40398191
    | Mm_GenLoc_end = 40425133
    | Mm_Uniprot = Q3UFU2
  }}
}}
'''Methylmalonyl Coenzyme A mutase''', also known as '''MUT''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = MUT encodes the mitochondrial enzymne methylmalonyl Coenzyme A mutase. In humans, MUT is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in MUT may lead to various types of methylmalonic aciduria.<ref>{{cite web | title = Entrez Gene: MUT methylmalonyl Coenzyme A mutase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4594| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Ledley FD, Rosenblatt DS |title=Mutations in mut methylmalonic acidemia: clinical and enzymatic correlations. |journal=Hum. Mutat. |volume=9 |issue= 1 |pages= 1-6 |year= 1997 |pmid= 8990001 |doi= 10.1002/(SICI)1098-1004(1997)9:1<1::AID-HUMU1>3.0.CO;2-E }}
*{{cite journal  | author=Ludwig ML, Matthews RG |title=Structure-based perspectives on B12-dependent enzymes. |journal=Annu. Rev. Biochem. |volume=66 |issue=  |pages= 269-313 |year= 1997 |pmid= 9242908 |doi= 10.1146/annurev.biochem.66.1.269 }}
*{{cite journal  | author=Lubrano R, Elli M, Rossi M, ''et al.'' |title=Renal transplant in methylmalonic acidemia: could it be the best option? Report on a case at 10 years and review of the literature. |journal=Pediatr. Nephrol. |volume=22 |issue= 8 |pages= 1209-14 |year= 2007 |pmid= 17401587 |doi= 10.1007/s00467-007-0460-z }}
}}
{{refend}}

{{protein-stub}}
 

[edit] NME2

• INFO: Beginning work on NME2... {November 9, 2007 5:03:06 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 5:03:20 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:03:44 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_NME2_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1be4.
 | PDB = {{PDB2|1be4}}, {{PDB2|1bhn}}, {{PDB2|1nsk}}, {{PDB2|1nue}}
 | Name = Non-metastatic cells 2, protein (NM23B) expressed in
 | HGNCid = 7850
 | Symbol = NME2
 | AltSymbols =; MGC111212; NDPKB; NM23-H2; NM23B; puf
 | OMIM = 156491
 | ECnumber =  
 | Homologene = 39553
 | MGIid = 97356
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004550 |text = nucleoside diphosphate kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}} 
 | Process = {{GNF_GO|id=GO:0006183 |text = GTP biosynthetic process}} {{GNF_GO|id=GO:0006228 |text = UTP biosynthetic process}} {{GNF_GO|id=GO:0006241 |text = CTP biosynthetic process}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007595 |text = lactation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009117 |text = nucleotide metabolic process}} {{GNF_GO|id=GO:0009142 |text = nucleoside triphosphate biosynthetic process}} {{GNF_GO|id=GO:0030879 |text = mammary gland development}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4831
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_001018147
    | Hs_RefseqmRNA = NM_001018137
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 18103
    | Mm_Ensembl = ENSMUSG00000020857
    | Mm_RefseqmRNA = NM_001077529
    | Mm_RefseqProtein = NP_001070997
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 93765906
    | Mm_GenLoc_end = 93772346
    | Mm_Uniprot = Q5NC82
  }}
}}
'''Non-metastatic cells 2, protein (NM23B) expressed in''', also known as '''NME2''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) which encode a fusion protein comprised of sequence sharing identity with each individual gene product.<ref>{{cite web | title = Entrez Gene: NME2 non-metastatic cells 2, protein (NM23B) expressed in| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4831| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

[edit] NT5E

• INFO: Beginning work on NT5E... {November 9, 2007 5:03:44 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:04:39 PM PST}

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{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = 5'-nucleotidase, ecto (CD73)
 | HGNCid = 8021
 | Symbol = NT5E
 | AltSymbols =; CD73; E5NT; NT; NT5; NTE; eN; eNT
 | OMIM = 129190
 | ECnumber =  
 | Homologene = 1895
 | MGIid = 99782
 | GeneAtlas_image1 = PBB_GE_NT5E_203939_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0008253 |text = 5'-nucleotidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016788 |text = hydrolase activity, acting on ester bonds}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0009166 |text = nucleotide catabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4907
    | Hs_Ensembl = ENSG00000135318
    | Hs_RefseqProtein = NP_002517
    | Hs_RefseqmRNA = NM_002526
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 86216528
    | Hs_GenLoc_end = 86262215
    | Hs_Uniprot = P21589
    | Mm_EntrezGene = 23959
    | Mm_Ensembl = ENSMUSG00000032420
    | Mm_RefseqmRNA = NM_011851
    | Mm_RefseqProtein = NP_035981
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 88125533
    | Mm_GenLoc_end = 88169982
    | Mm_Uniprot = Q0VEE0
  }}
}}
'''5'-nucleotidase, ecto (CD73)''', also known as '''NT5E''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: NT5E 5'-nucleotidase, ecto (CD73)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4907| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Resta R, Thompson LF |title=T cell signalling through CD73. |journal=Cell. Signal. |volume=9 |issue= 2 |pages= 131-9 |year= 1997 |pmid= 9113412 |doi=  }}
*{{cite journal  | author=Kirchhoff C, Hale G |title=Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation. |journal=Mol. Hum. Reprod. |volume=2 |issue= 3 |pages= 177-84 |year= 1997 |pmid= 9238677 |doi=  }}
*{{cite journal  | author=Resta R, Yamashita Y, Thompson LF |title=Ecto-enzyme and signaling functions of lymphocyte CD73. |journal=Immunol. Rev. |volume=161 |issue=  |pages= 95-109 |year= 1998 |pmid= 9553767 |doi=  }}
*{{cite journal  | author=Rosi F, Carlucci F, Marinello E, Tabucchi A |title=Ecto-5'-nucleotidase in B-cell chronic lymphocytic leukemia. |journal=Biomed. Pharmacother. |volume=56 |issue= 2 |pages= 100-4 |year= 2002 |pmid= 12000134 |doi=  }}
*{{cite journal  | author=Babiychuk EB, Draeger A |title=Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement? |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 3 |pages= 374-6 |year= 2006 |pmid= 16709165 |doi= 10.1042/BST0340374 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] NTF3

• INFO: Beginning work on NTF3... {November 9, 2007 5:04:39 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 5:05:10 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:05:30 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_NTF3_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b8k.
 | PDB = {{PDB2|1b8k}}, {{PDB2|1bnd}}, {{PDB2|1nt3}}
 | Name = Neurotrophin 3
 | HGNCid = 8023
 | Symbol = NTF3
 | AltSymbols =; NT3; HDNF; MGC129711; NGF-2; NGF2
 | OMIM = 162660
 | ECnumber =  
 | Homologene = 1896
 | MGIid = 97380
 | GeneAtlas_image1 = PBB_GE_NTF3_206706_at_tn.png
 | Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}} 
 | Component = {{GNF_GO|id=GO:0016023 |text = cytoplasmic membrane-bound vesicle}} 
 | Process = {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007274 |text = neuromuscular synaptic transmission}} {{GNF_GO|id=GO:0007403 |text = glial cell fate determination}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0021675 |text = nerve development}} {{GNF_GO|id=GO:0042490 |text = mechanoreceptor differentiation}} {{GNF_GO|id=GO:0043523 |text = regulation of neuron apoptosis}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048484 |text = enteric nervous system development}} {{GNF_GO|id=GO:0048699 |text = generation of neurons}} {{GNF_GO|id=GO:0051145 |text = smooth muscle cell differentiation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4908
    | Hs_Ensembl = ENSG00000185652
    | Hs_RefseqProtein = NP_002518
    | Hs_RefseqmRNA = NM_002527
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 5473527
    | Hs_GenLoc_end = 5474725
    | Hs_Uniprot = P20783
    | Mm_EntrezGene = 18205
    | Mm_Ensembl = ENSMUSG00000049107
    | Mm_RefseqmRNA = NM_008742
    | Mm_RefseqProtein = NP_032768
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 126067031
    | Mm_GenLoc_end = 126130540
    | Mm_Uniprot = Q3V1A4
  }}
}}
'''Neurotrophin 3''', also known as '''NTF3''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.<ref>{{cite web | title = Entrez Gene: NTF3 neurotrophin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4908| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

[edit] OPRD1

• INFO: Beginning work on OPRD1... {November 9, 2007 5:05:30 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:06:04 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Opioid receptor, delta 1
 | HGNCid = 8153
 | Symbol = OPRD1
 | AltSymbols =; OPRD
 | OMIM = 165195
 | ECnumber =  
 | Homologene = 20252
 | MGIid = 97438
 | GeneAtlas_image1 = PBB_GE_OPRD1_207792_at_tn.png
 | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004986 |text = delta-opioid receptor activity}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} 
 | Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007600 |text = sensory perception}} {{GNF_GO|id=GO:0008344 |text = adult locomotory behavior}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4985
    | Hs_Ensembl = ENSG00000116329
    | Hs_RefseqProtein = NP_000902
    | Hs_RefseqmRNA = NM_000911
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 29011241
    | Hs_GenLoc_end = 29062795
    | Hs_Uniprot = P41143
    | Mm_EntrezGene = 18386
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = XM_973497
    | Mm_RefseqProtein = XP_978591
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Opioid receptor, delta 1''', also known as '''OPRD1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Narita M, Funada M, Suzuki T |title=Regulations of opioid dependence by opioid receptor types. |journal=Pharmacol. Ther. |volume=89 |issue= 1 |pages= 1-15 |year= 2001 |pmid= 11316510 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

[edit] P2RX1

• INFO: Beginning work on P2RX1... {November 9, 2007 5:06:04 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 5:06:35 PM PST}
• CREATED: Created new protein page: P2RX1 {November 9, 2007 5:06:43 PM PST}

[edit] PCBP1

• INFO: Beginning work on PCBP1... {November 9, 2007 5:06:43 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 5:07:18 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 5:07:37 PM PST}
• CREATED: Created new protein page: PCBP1 {November 9, 2007 5:07:45 PM PST}

[edit] PCBP2

• INFO: Beginning work on PCBP2... {November 9, 2007 5:07:45 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 5:09:00 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 5:09:13 PM PST}
• CREATED: Created new protein page: PCBP2 {November 9, 2007 5:09:21 PM PST}

[edit] PPP2R4

• INFO: Beginning work on PPP2R4... {November 9, 2007 5:09:21 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 5:10:38 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:10:55 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PPP2R4_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2g62.
 | PDB = {{PDB2|2g62}}, {{PDB2|2hv6}}, {{PDB2|2hv7}}, {{PDB2|2ixm}}
 | Name = Protein phosphatase 2A activator, regulatory subunit 4
 | HGNCid = 9308
 | Symbol = PPP2R4
 | AltSymbols =; MGC2184; PP2A; PR53; PTPA
 | OMIM = 600756
 | ECnumber =  
 | Homologene = 6149
 | MGIid = 1346006
 | GeneAtlas_image1 = PBB_GE_PPP2R4_208874_x_at_tn.png
 | GeneAtlas_image2 = PBB_GE_PPP2R4_206452_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_PPP2R4_216105_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0008160 |text = protein tyrosine phosphatase activator activity}} {{GNF_GO|id=GO:0008601 |text = protein phosphatase type 2A regulator activity}} {{GNF_GO|id=GO:0019211 |text = phosphatase activator activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}} 
 | Component = {{GNF_GO|id=GO:0000159 |text = protein phosphatase type 2A complex}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} 
 | Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5524
    | Hs_Ensembl = ENSG00000119383
    | Hs_RefseqProtein = NP_066954
    | Hs_RefseqmRNA = NM_021131
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 130913050
    | Hs_GenLoc_end = 130951046
    | Hs_Uniprot = Q15257
    | Mm_EntrezGene = 110854
    | Mm_Ensembl = ENSMUSG00000039515
    | Mm_RefseqmRNA = NM_138748
    | Mm_RefseqProtein = NP_620087
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 30238059
    | Mm_GenLoc_end = 30269813
    | Mm_Uniprot = Q543N6
  }}
}}
'''Protein phosphatase 2A activator, regulatory subunit 4''', also known as '''PPP2R4''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: PPP2R4 protein phosphatase 2A activator, regulatory subunit 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5524| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43-51 |year= 2005 |pmid= 15638722 |doi=  }}
*{{cite journal  | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
*{{cite journal  | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143-9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
*{{cite journal  | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270-86 |year= 2005 |pmid= 15817944 |doi=  }}
*{{cite journal  | author=Soprano KJ, Purev E, Vuocolo S, Soprano DR |title=Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid. |journal=Oncogene |volume=25 |issue= 38 |pages= 5315-25 |year= 2006 |pmid= 16936753 |doi= 10.1038/sj.onc.1209679 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] PSMB2

• INFO: Beginning work on PSMB2... {November 9, 2007 5:10:55 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 5:11:41 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 5:11:57 PM PST}
• CREATED: Created new protein page: PSMB2 {November 9, 2007 5:12:05 PM PST}

[edit] PSMD12

• INFO: Beginning work on PSMD12... {November 9, 2007 5:13:07 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 5:14:00 PM PST}
• CREATED: Created new protein page: PSMD12 {November 9, 2007 5:14:07 PM PST}

[edit] PSMD8

• INFO: Beginning work on PSMD8... {November 9, 2007 5:12:05 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:13:07 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
 | HGNCid = 9566
 | Symbol = PSMD8
 | AltSymbols =; HIP6; HYPF; MGC1660; Nin1p; S14; p31
 | OMIM =  
 | ECnumber =  
 | Homologene = 37686
 | MGIid = 1888669
 | GeneAtlas_image1 = PBB_GE_PSMD8_200820_at_tn.png
 | GeneAtlas_image2 = PBB_GE_PSMD8_gnf1h08609_s_at_tn.png
 | Function = 
 | Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005838 |text = proteasome regulatory particle (sensu Eukaryota)}} 
 | Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5714
    | Hs_Ensembl = ENSG00000099341
    | Hs_RefseqProtein = NP_002803
    | Hs_RefseqmRNA = NM_002812
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 43557061
    | Hs_GenLoc_end = 43566303
    | Hs_Uniprot = P48556
    | Mm_EntrezGene = 57296
    | Mm_Ensembl = ENSMUSG00000030591
    | Mm_RefseqmRNA = XM_001001968
    | Mm_RefseqProtein = XP_001001968
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 28883015
    | Mm_GenLoc_end = 28889291
    | Mm_Uniprot = Q3TG45
  }}
}}
'''Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8''', also known as '''PSMD8''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.  An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.<ref>{{cite web | title = Entrez Gene: PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5714| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue=  |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal  | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

[edit] PTPN2

• INFO: Beginning work on PTPN2... {November 9, 2007 5:14:07 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 5:14:24 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:14:39 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PTPN2_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1l8k.
 | PDB = {{PDB2|1l8k}}
 | Name = Protein tyrosine phosphatase, non-receptor type 2
 | HGNCid = 9650
 | Symbol = PTPN2
 | AltSymbols =; PTPT; TC-PTP; TCELLPTP; TCPTP
 | OMIM = 176887
 | ECnumber =  
 | Homologene = 7497
 | MGIid = 97806
 | Function = {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0008286 |text = insulin receptor signaling pathway}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5771
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_002819
    | Hs_RefseqmRNA = NM_002828
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 19255
    | Mm_Ensembl = ENSMUSG00000024539
    | Mm_RefseqmRNA = NM_008977
    | Mm_RefseqProtein = NP_033003
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 67797358
    | Mm_GenLoc_end = 67849964
    | Mm_Uniprot = Q06180
  }}
}}
'''Protein tyrosine phosphatase, non-receptor type 2''', also known as '''PTPN2''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.<ref>{{cite web | title = Entrez Gene: PTPN2 protein tyrosine phosphatase, non-receptor type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5771| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

[edit] RPA2

• INFO: Beginning work on RPA2... {November 9, 2007 5:16:09 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 5:16:41 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 5:16:53 PM PST}
• CREATED: Created new protein page: RPA2 {November 9, 2007 5:17:00 PM PST}

[edit] UPF1

• INFO: Beginning work on UPF1... {November 9, 2007 5:14:39 PM PST}
• UPLOAD: Added new Image to wiki: {November 9, 2007 5:15:34 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 5:16:00 PM PST}
• CREATED: Created new protein page: UPF1 {November 9, 2007 5:16:09 PM PST}

end log.