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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 19:50, 19 November 2007 (UTC)
[edit] Proteins without matches (8)
[edit] Proteins with a High Potential Match (6)
[edit] Redirected Proteins (11)
[edit] Manual Inspection (Page not found) (14)
[edit] Updated (11)
[edit] Protein Status Grid - Date: 19:50, 19 November 2007 (UTC)
| HUGO Symbol |
Action Summary |
Target page(s) |
WP Symbol Search |
| IL10RA |
Updated |
Other Pages: Interleukin 10 receptor (No Data); IL10RA (Good Codes + Entrez Match); CDW210A (No Data); Cdw210a (No Data); HIL-10R (No Data); Hil-10r (No Data); IL-10R1 (No Data); Il-10r1 (No Data); IL10R (No Data); Il10r (No Data); |
[1] |
| MYOG |
Manual Inspection (Page not found) |
Other Pages: Myogenin (Protein Template); MYOG (No Data); MYF4 (No Data); Myf4 (No Data); MYOGENIN (No Data); |
[2] |
| ITGB7 |
Manual Inspection (Page not found) |
Other Pages: Integrin (Unknown Data); ITGB7 (No Data); |
[3] |
| MAGEA1 |
Updated |
Other Pages: Melanoma antigen family A (No Data); MAGEA1 (Good Codes + Entrez Match); MAGE1 (No Data); Mage1 (No Data); MGC9326 (No Data); Mgc9326 (No Data); |
[4] |
| ATP6 |
Updated |
Other Pages: ATP synthase F0 subunit 6 (No Data); ATP6 (Redirect -> ATP synthase chain A); MTATP6 (No Data); Mtatp6 (No Data); ATP synthase chain A (Good Codes + Entrez Match); |
[5] |
| MT1A |
Manual Inspection (Page not found) |
Other Pages: Metallothionein 1A (No Data); MT1A (No Data); MGC32848 (No Data); Mgc32848 (No Data); MT1 (No Data); Mt1 (No Data); MT1S (No Data); Mt1s (No Data); MTC (DisAmbig); Mtc (No Data); |
[6] |
| ALPP |
Manual Inspection (Page not found) |
Other Pages: Alkaline phosphatase (Protein Template); ALPP (No Data); ALP (Redirect -> Australian Labor Party); Alp (Unknown Data); PLAP (No Data); Plap (No Data); ALPG (No Data); Alpg (No Data); ALPPL (No Data); Alppl (No Data); GCAP (DisAmbig); Gcap (No Data); Australian Labor Party (Unknown Data); |
[7] |
| GP9 |
Manual Inspection (Page not found) |
Other Pages: Glycoprotein IX (No Data); GP9 (Redirect -> EMD GP9); CD42a (No Data); Cd42a (No Data); GPIX (No Data); Gpix (No Data); EMD GP9 (Unknown Data); |
[8] |
| MATK |
Manual Inspection (Page not found) |
Other Pages: Megakaryocyte-associated tyrosine kinase (No Data); MATK (No Data); CHK (DisAmbig); Chk (Redirect -> Chesapeake Energy); CTK (DisAmbig); Ctk (No Data); DKFZp434N1212 (No Data); Dkfzp434n1212 (No Data); HHYLTK (No Data); Hhyltk (No Data); HYL (No Data); Hyl (Redirect -> Slug (mass)); HYLTK (No Data); Hyltk (No Data); Lsk (No Data); MGC1708 (No Data); Mgc1708 (No Data); MGC2101 (No Data); Mgc2101 (No Data); Chesapeake Energy (Unknown Data); Slug (mass) (Unknown Data); |
[9] |
| GRP |
Manual Inspection (Page not found) |
Other Pages: Gastrin-releasing peptide (Redirect -> Gastrin releasing peptide); GRP (DisAmbig); BN (DisAmbig); Bn (Redirect -> BN); GRP-10 (No Data); Grp-10 (No Data); PreproGRP (No Data); Preprogrp (No Data); ProGRP (No Data); Progrp (No Data); Gastrin releasing peptide (Protein Template); |
[10] |
| KCND2 |
Manual Inspection (Page not found) |
Other Pages: Potassium voltage-gated channel (Redirect -> Voltage-gated potassium channel); KCND2 (No Data); KIAA1044 (No Data); Kiaa1044 (No Data); KV4.2 (No Data); Kv4.2 (No Data); MGC119702 (No Data); Mgc119702 (No Data); MGC119703 (No Data); Mgc119703 (No Data); RK5 (No Data); Rk5 (No Data); Voltage-gated potassium channel (Unknown Data); |
[11] |
| EXOSC2 |
Manual Inspection (Page not found) |
Other Pages: Exosome component 2 (No Data); EXOSC2 (No Data); RRP4 (No Data); Rrp4 (No Data); Rrp4p (No Data); HRrp4p (No Data); Hrrp4p (No Data); P7 (DisAmbig); |
[12] |
| EIF3S6 |
Updated |
Other Pages: Eukaryotic translation initiation factor 3 (No Data); EIF3S6 (Good Codes + Entrez Match); EIF3-P48 (No Data); Eif3-p48 (No Data); INT6 (No Data); Int6 (No Data); EIF3-p46 (No Data); Eif3-p46 (No Data); EIF3e (No Data); Eif3e (No Data); |
[13] |
| DDX58 |
Updated |
Other Pages: DEAD box polypeptide 58 (No Data); DDX58 (Good Codes + Entrez Match); DKFZp434J1111 (No Data); Dkfzp434j1111 (No Data); DKFZp686N19181 (No Data); Dkfzp686n19181 (No Data); FLJ13599 (No Data); Flj13599 (No Data); RIG-I (No Data); Rig-i (No Data); |
[14] |
| MCM4 |
Updated |
Other Pages: MCM4 minichromosome maintenance deficient 4 (No Data); MCM4 (Good Codes + Entrez Match); CDC21 (No Data); Cdc21 (No Data); CDC54 (No Data); Cdc54 (No Data); MGC33310 (No Data); Mgc33310 (No Data); P1-CDC21 (No Data); P1-cdc21 (No Data); HCdc21 (No Data); Hcdc21 (No Data); |
[15] |
| GFRA1 |
Updated |
Other Pages: GDNF family receptor alpha 1 (No Data); GFRA1 (Good Codes + Entrez Match); GDNFR (No Data); Gdnfr (No Data); GDNFRA (No Data); Gdnfra (No Data); GFR-ALPHA-1 (No Data); Gfr-alpha-1 (No Data); MGC23045 (No Data); Mgc23045 (No Data); RET1L (No Data); Ret1l (No Data); RETL1 (No Data); Retl1 (No Data); TRNR1 (No Data); Trnr1 (No Data); |
[16] |
| LALBA |
Manual Inspection (Page not found) |
Other Pages: Lactalbumin (Protein Template); LALBA (No Data); MGC138521 (No Data); Mgc138521 (No Data); MGC138523 (No Data); Mgc138523 (No Data); |
[17] |
| LBR |
Manual Inspection (Page not found) |
Other Pages: Lamin B receptor (Protein Template); LBR (DisAmbig); DHCR14B (No Data); Dhcr14b (No Data); LMN2R (No Data); Lmn2r (No Data); MGC9041 (No Data); Mgc9041 (No Data); PHA (DisAmbig); Pha (No Data); |
[18] |
| MB |
Manual Inspection (Page not found) |
Other Pages: Myoglobin (Unknown Data); MB (DisAmbig); MGC13548 (No Data); Mgc13548 (No Data); PVALB (No Data); Pvalb (No Data); |
[19] |
| GM2A |
Updated |
Other Pages: GM2 ganglioside activator (No Data); GM2A (Good Codes + Entrez Match); SAP-3 (No Data); Sap-3 (No Data); |
[20] |
| LIG1 |
Updated |
Other Pages: Ligase I (No Data); LIG1 (Good Codes + Entrez Match); MGC117397 (No Data); Mgc117397 (No Data); MGC130025 (No Data); Mgc130025 (No Data); |
[21] |
| GABPA |
Updated |
Other Pages: GA binding protein transcription factor (No Data); GABPA (Good Codes + Entrez Match); E4TF1-60 (No Data); E4tf1-60 (No Data); E4TF1A (No Data); E4tf1a (No Data); NFT2 (No Data); Nft2 (No Data); NRF2 (No Data); Nrf2 (No Data); NRF2A (No Data); Nrf2a (No Data); |
[22] |
| GGA2 |
Manual Inspection (Page not found) |
Other Pages: Golgi associated (No Data); GGA2 (No Data); FLJ20966 (No Data); Flj20966 (No Data); KIAA1080 (No Data); Kiaa1080 (No Data); VEAR (No Data); Vear (Unknown Data); |
[23] |
| HUS1 |
Updated |
Other Pages: HUS1 checkpoint homolog (No Data); HUS1 (Good Codes + Entrez Match); |
[24] |
| KRT7 |
Manual Inspection (Page not found) |
Other Pages: Keratin 7 (Protein Template); KRT7 (No Data); CK7 (No Data); Ck7 (No Data); K2C7 (No Data); K2c7 (No Data); K7 (DisAmbig); MGC129731 (No Data); Mgc129731 (No Data); MGC3625 (No Data); Mgc3625 (No Data); SCL (DisAmbig); Scl (Redirect -> SCL); |
[25] |
[edit] Vebose Log - Date: 19:50, 19 November 2007 (UTC)
- INFO: Beginning work on ALPP... {November 19, 2007 11:26:55 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:27:33 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ALPP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ew2.
| PDB = {{PDB2|1ew2}}, {{PDB2|1zeb}}, {{PDB2|1zed}}, {{PDB2|1zef}}, {{PDB2|2glq}}
| Name = Alkaline phosphatase, placental (Regan isozyme)
| HGNCid = 439
| Symbol = ALPP
| AltSymbols =; ALP; PLAP; ALPG; ALPPL; GCAP
| OMIM = 171800
| ECnumber =
| Homologene = 55592
| MGIid = 108009
| GeneAtlas_image1 = PBB_GE_ALPP_204664_at_tn.png
| GeneAtlas_image2 = PBB_GE_ALPP_211619_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ALPP_210431_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004035 |text = alkaline phosphatase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0016310 |text = phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 250
| Hs_Ensembl = ENSG00000163283
| Hs_RefseqProtein = NP_001623
| Hs_RefseqmRNA = NM_001632
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 232951627
| Hs_GenLoc_end = 232955832
| Hs_Uniprot = P05187
| Mm_EntrezGene = 11650
| Mm_Ensembl = ENSMUSG00000026246
| Mm_RefseqmRNA = NM_007433
| Mm_RefseqProtein = NP_031459
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 88917861
| Mm_GenLoc_end = 88921082
| Mm_Uniprot = Q3ULC9
}}
}}
'''Alkaline phosphatase, placental (Regan isozyme)''', also known as '''ALPP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ALPP alkaline phosphatase, placental (Regan isozyme)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=250| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.<ref name="entrez">{{cite web | title = Entrez Gene: ALPP alkaline phosphatase, placental (Regan isozyme)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=250| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nye KE, Riley GA, Pinching AJ |title=The defect seen in the phosphatidylinositol hydrolysis pathway in HIV-infected lymphocytes and lymphoblastoid cells is due to inhibition of the inositol 1,4,5-trisphosphate 1,3,4,5-tetrakisphosphate 5-phosphomonoesterase. |journal=Clin. Exp. Immunol. |volume=89 |issue= 1 |pages= 89-93 |year= 1992 |pmid= 1321014 |doi= }}
*{{cite journal | author=Lowe ME |title=Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein. |journal=J. Cell Biol. |volume=116 |issue= 3 |pages= 799-807 |year= 1992 |pmid= 1730777 |doi= }}
*{{cite journal | author=Micanovic R, Gerber LD, Berger J, ''et al.'' |title=Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 1 |pages= 157-61 |year= 1990 |pmid= 2153284 |doi= }}
*{{cite journal | author=Martin D, Spurr NK, Trowsdale J |title=RFLP of the human placental alkaline phosphatase gene (PLAP). |journal=Nucleic Acids Res. |volume=15 |issue= 21 |pages= 9104 |year= 1988 |pmid= 2891112 |doi= }}
*{{cite journal | author=Kam W, Clauser E, Kim YS, ''et al.'' |title=Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 24 |pages= 8715-9 |year= 1986 |pmid= 3001717 |doi= }}
*{{cite journal | author=Knoll BJ, Rothblum KN, Longley M |title=Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution. |journal=J. Biol. Chem. |volume=263 |issue= 24 |pages= 12020-7 |year= 1988 |pmid= 3042787 |doi= }}
*{{cite journal | author=Micanovic R, Bailey CA, Brink L, ''et al.'' |title=Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 5 |pages= 1398-402 |year= 1988 |pmid= 3422741 |doi= }}
*{{cite journal | author=Knoll BJ, Rothblum KN, Longley M |title=Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. |journal=Gene |volume=60 |issue= 2-3 |pages= 267-76 |year= 1988 |pmid= 3443302 |doi= }}
*{{cite journal | author=Ovitt CE, Strauss AW, Alpers DH, ''et al.'' |title=Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 11 |pages= 3781-5 |year= 1986 |pmid= 3459156 |doi= }}
*{{cite journal | author=Henthorn PS, Knoll BJ, Raducha M, ''et al.'' |title=Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 15 |pages= 5597-601 |year= 1986 |pmid= 3461452 |doi= }}
*{{cite journal | author=Millán JL |title=Molecular cloning and sequence analysis of human placental alkaline phosphatase. |journal=J. Biol. Chem. |volume=261 |issue= 7 |pages= 3112-5 |year= 1986 |pmid= 3512548 |doi= }}
*{{cite journal | author=Ezra E, Blacher R, Udenfriend S |title=Purification and partial sequencing of human placental alkaline phosphatase. |journal=Biochem. Biophys. Res. Commun. |volume=116 |issue= 3 |pages= 1076-83 |year= 1984 |pmid= 6651840 |doi= }}
*{{cite journal | author=Le Du MH, Stigbrand T, Taussig MJ, ''et al.'' |title=Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 9158-65 |year= 2001 |pmid= 11124260 |doi= 10.1074/jbc.M009250200 }}
*{{cite journal | author=Spurway TD, Dalley JA, High S, Bulleid NJ |title=Early events in glycosylphosphatidylinositol anchor addition. substrate proteins associate with the transamidase subunit gpi8p. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 15975-82 |year= 2001 |pmid= 11278620 |doi= 10.1074/jbc.M010128200 }}
*{{cite journal | author=Rump A, Kasper G, Hayes C, ''et al.'' |title=Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1. |journal=Genomics |volume=73 |issue= 1 |pages= 50-5 |year= 2001 |pmid= 11352565 |doi= 10.1006/geno.2000.6504 }}
*{{cite journal | author=Wennberg C, Kozlenkov A, Di Mauro S, ''et al.'' |title=Structure, genomic DNA typing, and kinetic characterization of the D allozyme of placental alkaline phosphatase (PLAP/ALPP). |journal=Hum. Mutat. |volume=19 |issue= 3 |pages= 258-67 |year= 2002 |pmid= 11857742 |doi= 10.1002/humu.10052 }}
*{{cite journal | author=Kozlenkov A, Manes T, Hoylaerts MF, Millán JL |title=Function assignment to conserved residues in mammalian alkaline phosphatases. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22992-9 |year= 2002 |pmid= 11937510 |doi= 10.1074/jbc.M202298200 }}
*{{cite journal | author=Tang J, Li W |title=[Methodological study on the assay of glycosylphosphatidylinositol-specific phospholipase D activity in serum] |journal=Hunan Yi Ke Da Xue Xue Bao |volume=24 |issue= 2 |pages= 119-22 |year= 2002 |pmid= 11938765 |doi= }}
*{{cite journal | author=Lehto MT, Sharom FJ |title=Proximity of the protein moiety of a GPI-anchored protein to the membrane surface: a FRET study. |journal=Biochemistry |volume=41 |issue= 26 |pages= 8368-76 |year= 2002 |pmid= 12081485 |doi= }}
*{{cite journal | author=Le Du MH, Millan JL |title=Structural evidence of functional divergence in human alkaline phosphatases. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49808-14 |year= 2003 |pmid= 12372831 |doi= 10.1074/jbc.M207394200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ATP6... {November 19, 2007 11:40:26 AM PST}
- SEARCH REDIRECT: Control Box Found: ATP synthase chain A {November 19, 2007 11:40:53 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:40:56 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:40:56 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:40:56 AM PST}
- UPDATED: Updated protein page: ATP synthase chain A {November 19, 2007 11:41:01 AM PST}
- INFO: Beginning work on DDX58... {November 19, 2007 11:42:40 AM PST}
- SEARCH REDIRECT: Control Box Found: DDX58 {November 19, 2007 11:43:26 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:43:29 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:43:29 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:43:29 AM PST}
- UPDATED: Updated protein page: DDX58 {November 19, 2007 11:43:35 AM PST}
- INFO: Beginning work on EIF3S6... {November 19, 2007 11:32:26 AM PST}
- SEARCH REDIRECT: Control Box Found: EIF3S6 {November 19, 2007 11:33:09 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:33:12 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:33:12 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:33:12 AM PST}
- UPDATED: Updated protein page: EIF3S6 {November 19, 2007 11:33:18 AM PST}
- INFO: Beginning work on EXOSC2... {November 19, 2007 11:42:04 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:42:40 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EXOSC2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2nn6.
| PDB = {{PDB2|2nn6}}
| Name = Exosome component 2
| HGNCid = 17097
| Symbol = EXOSC2
| AltSymbols =; RRP4; Rrp4p; hRrp4p; p7
| OMIM = 602238
| ECnumber =
| Homologene = 6095
| MGIid = 2385133
| GeneAtlas_image1 = PBB_GE_EXOSC2_214507_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EXOSC2_209527_at_tn.png
| Function = {{GNF_GO|id=GO:0000175 |text = 3'-5'-exoribonuclease activity}} {{GNF_GO|id=GO:0004527 |text = exonuclease activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008312 |text = 7S RNA binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0000178 |text = exosome (RNase complex)}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23404
| Hs_Ensembl = ENSG00000130713
| Hs_RefseqProtein = NP_055100
| Hs_RefseqmRNA = NM_014285
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 132558929
| Hs_GenLoc_end = 132570069
| Hs_Uniprot = Q13868
| Mm_EntrezGene = 227715
| Mm_Ensembl = ENSMUSG00000039356
| Mm_RefseqmRNA = XM_979843
| Mm_RefseqProtein = XP_984937
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 31492724
| Mm_GenLoc_end = 31503314
| Mm_Uniprot = Q3TKQ3
}}
}}
'''Exosome component 2''', also known as '''EXOSC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EXOSC2 exosome component 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23404| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Adams MD, Dubnick M, Kerlavage AR, ''et al.'' |title=Sequence identification of 2,375 human brain genes. |journal=Nature |volume=355 |issue= 6361 |pages= 632-4 |year= 1992 |pmid= 1538749 |doi= 10.1038/355632a0 }}
*{{cite journal | author=Morris CM, Heisterkamp N, Groffen J, Fitzgerald PH |title=Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia. |journal=Blood |volume=78 |issue= 4 |pages= 1078-84 |year= 1991 |pmid= 1868241 |doi= }}
*{{cite journal | author=Zhu QS, Heisterkamp N, Groffen J |title=Characterization of the human ABL promoter regions. |journal=Oncogene |volume=5 |issue= 6 |pages= 885-91 |year= 1990 |pmid= 2163052 |doi= }}
*{{cite journal | author=Soekarman D, van Denderen J, Hoefsloot L, ''et al.'' |title=A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia. |journal=Leukemia |volume=4 |issue= 6 |pages= 397-403 |year= 1990 |pmid= 2193202 |doi= }}
*{{cite journal | author=Chen SJ, Chen Z, Font MP, ''et al.'' |title=Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation. |journal=Nucleic Acids Res. |volume=17 |issue= 19 |pages= 7631-42 |year= 1989 |pmid= 2678002 |doi= }}
*{{cite journal | author=Heisterkamp N, Stam K, Groffen J, ''et al.'' |title=Structural organization of the bcr gene and its role in the Ph' translocation. |journal=Nature |volume=315 |issue= 6022 |pages= 758-61 |year= 1985 |pmid= 2989703 |doi= }}
*{{cite journal | author=Shtivelman E, Lifshitz B, Gale RP, ''et al.'' |title=Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene. |journal=Cell |volume=47 |issue= 2 |pages= 277-84 |year= 1986 |pmid= 3021337 |doi= }}
*{{cite journal | author=Grosveld G, Verwoerd T, van Agthoven T, ''et al.'' |title=The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript. |journal=Mol. Cell. Biol. |volume=6 |issue= 2 |pages= 607-16 |year= 1987 |pmid= 3023859 |doi= }}
*{{cite journal | author=Bernards A, Rubin CM, Westbrook CA, ''et al.'' |title=The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia. |journal=Mol. Cell. Biol. |volume=7 |issue= 9 |pages= 3231-6 |year= 1987 |pmid= 3313010 |doi= }}
*{{cite journal | author=Groffen J, Heisterkamp N, Grosveld F, ''et al.'' |title=Isolation of human oncogene sequences (v-fes homolog) from a cosmid library. |journal=Science |volume=216 |issue= 4550 |pages= 1136-8 |year= 1982 |pmid= 6281890 |doi= }}
*{{cite journal | author=Heisterkamp N, Groffen J, Stephenson JR |title=The human v-abl cellular homologue. |journal=J. Mol. Appl. Genet. |volume=2 |issue= 1 |pages= 57-68 |year= 1983 |pmid= 6302194 |doi= }}
*{{cite journal | author=Heisterkamp N, Stephenson JR, Groffen J, ''et al.'' |title=Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. |journal=Nature |volume=306 |issue= 5940 |pages= 239-42 |year= 1984 |pmid= 6316147 |doi= }}
*{{cite journal | author=Groffen J, Stephenson JR, Heisterkamp N, ''et al.'' |title=Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. |journal=Cell |volume=36 |issue= 1 |pages= 93-9 |year= 1984 |pmid= 6319012 |doi= }}
*{{cite journal | author=Chissoe SL, Bodenteich A, Wang YF, ''et al.'' |title=Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. |journal=Genomics |volume=27 |issue= 1 |pages= 67-82 |year= 1995 |pmid= 7665185 |doi= }}
*{{cite journal | author=Litz CE, McClure JS, Copenhaver CM, Brunning RD |title=Duplication of small segments within the major breakpoint cluster region in chronic myelogenous leukemia. |journal=Blood |volume=81 |issue= 6 |pages= 1567-72 |year= 1993 |pmid= 8453102 |doi= }}
*{{cite journal | author=Mitchell P, Petfalski E, Tollervey D |title=The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism. |journal=Genes Dev. |volume=10 |issue= 4 |pages= 502-13 |year= 1996 |pmid= 8600032 |doi= }}
*{{cite journal | author=Mitchell P, Petfalski E, Shevchenko A, ''et al.'' |title=The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. |journal=Cell |volume=91 |issue= 4 |pages= 457-66 |year= 1997 |pmid= 9390555 |doi= }}
*{{cite journal | author=Allmang C, Petfalski E, Podtelejnikov A, ''et al.'' |title=The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. |journal=Genes Dev. |volume=13 |issue= 16 |pages= 2148-58 |year= 1999 |pmid= 10465791 |doi= }}
*{{cite journal | author=Brouwer R, Allmang C, Raijmakers R, ''et al.'' |title=Three novel components of the human exosome. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6177-84 |year= 2001 |pmid= 11110791 |doi= 10.1074/jbc.M007603200 }}
*{{cite journal | author=Chen CY, Gherzi R, Ong SE, ''et al.'' |title=AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. |journal=Cell |volume=107 |issue= 4 |pages= 451-64 |year= 2002 |pmid= 11719186 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GABPA... {November 19, 2007 11:27:33 AM PST}
- SEARCH REDIRECT: Control Box Found: GABPA {November 19, 2007 11:28:08 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:28:09 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:28:09 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:28:09 AM PST}
- UPDATED: Updated protein page: GABPA {November 19, 2007 11:28:16 AM PST}
- INFO: Beginning work on GFRA1... {November 19, 2007 11:28:16 AM PST}
- SEARCH REDIRECT: Control Box Found: GFRA1 {November 19, 2007 11:29:03 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:29:04 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:29:04 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:29:04 AM PST}
- UPDATED: Updated protein page: GFRA1 {November 19, 2007 11:29:10 AM PST}
- INFO: Beginning work on GGA2... {November 19, 2007 11:41:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:42:04 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GGA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mhq.
| PDB = {{PDB2|1mhq}}
| Name = Golgi associated, gamma adaptin ear containing, ARF binding protein 2
| HGNCid = 16064
| Symbol = GGA2
| AltSymbols =; FLJ20966; KIAA1080; VEAR
| OMIM = 606005
| ECnumber =
| Homologene = 22860
| MGIid = 1921355
| GeneAtlas_image1 = PBB_GE_GGA2_208913_at_tn.png
| GeneAtlas_image2 = PBB_GE_GGA2_208914_at_tn.png
| GeneAtlas_image3 = PBB_GE_GGA2_208915_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030306 |text = ADP-ribosylation factor binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005802 |text = trans-Golgi network}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030130 |text = clathrin coat of trans-Golgi network vesicle}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23062
| Hs_Ensembl = ENSG00000103365
| Hs_RefseqProtein = NP_055859
| Hs_RefseqmRNA = NM_015044
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 23383145
| Hs_GenLoc_end = 23429309
| Hs_Uniprot = Q9UJY4
| Mm_EntrezGene = 74105
| Mm_Ensembl = ENSMUSG00000030872
| Mm_RefseqmRNA = NM_028758
| Mm_RefseqProtein = NP_083034
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 121777870
| Mm_GenLoc_end = 121812315
| Mm_Uniprot = Q3TVV9
}}
}}
'''Golgi associated, gamma adaptin ear containing, ARF binding protein 2''', also known as '''GGA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23062| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.<ref name="entrez">{{cite web | title = Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23062| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi= }}
*{{cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295-308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
*{{cite journal | author=Poussu A, Lohi O, Lehto VP |title=Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7176-83 |year= 2000 |pmid= 10702286 |doi= }}
*{{cite journal | author=Hirst J, Lui WW, Bright NA, ''et al.'' |title=A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 67-80 |year= 2000 |pmid= 10747088 |doi= }}
*{{cite journal | author=Dell'Angelica EC, Puertollano R, Mullins C, ''et al.'' |title=GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 81-94 |year= 2000 |pmid= 10747089 |doi= }}
*{{cite journal | author=Boman AL, Zhang C, Zhu X, Kahn RA |title=A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi. |journal=Mol. Biol. Cell |volume=11 |issue= 4 |pages= 1241-55 |year= 2000 |pmid= 10749927 |doi= }}
*{{cite journal | author=Takatsu H, Yoshino K, Nakayama K |title=Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 3 |pages= 719-25 |year= 2000 |pmid= 10814529 |doi= 10.1006/bbrc.2000.2700 }}
*{{cite journal | author=Puertollano R, Randazzo PA, Presley JF, ''et al.'' |title=The GGAs promote ARF-dependent recruitment of clathrin to the TGN. |journal=Cell |volume=105 |issue= 1 |pages= 93-102 |year= 2001 |pmid= 11301005 |doi= }}
*{{cite journal | author=Nielsen MS, Madsen P, Christensen EI, ''et al.'' |title=The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2180-90 |year= 2001 |pmid= 11331584 |doi= 10.1093/emboj/20.9.2180 }}
*{{cite journal | author=Puertollano R, Aguilar RC, Gorshkova I, ''et al.'' |title=Sorting of mannose 6-phosphate receptors mediated by the GGAs. |journal=Science |volume=292 |issue= 5522 |pages= 1712-6 |year= 2001 |pmid= 11387475 |doi= 10.1126/science.1060750 }}
*{{cite journal | author=Zhu Y, Doray B, Poussu A, ''et al.'' |title=Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor. |journal=Science |volume=292 |issue= 5522 |pages= 1716-8 |year= 2001 |pmid= 11387476 |doi= 10.1126/science.1060896 }}
*{{cite journal | author=Takatsu H, Katoh Y, Shiba Y, Nakayama K |title=Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28541-5 |year= 2001 |pmid= 11390366 |doi= 10.1074/jbc.C100218200 }}
*{{cite journal | author=Jacobsen L, Madsen P, Nielsen MS, ''et al.'' |title=The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. |journal=FEBS Lett. |volume=511 |issue= 1-3 |pages= 155-8 |year= 2002 |pmid= 11821067 |doi= }}
*{{cite journal | author=Doray B, Bruns K, Ghosh P, Kornfeld S |title=Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18477-82 |year= 2002 |pmid= 11886874 |doi= 10.1074/jbc.M201879200 }}
*{{cite journal | author=Takatsu H, Yoshino K, Toda K, Nakayama K |title=GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 369-78 |year= 2002 |pmid= 11950392 |doi= 10.1042/BJ20020428 }}
*{{cite journal | author=He X, Chang WP, Koelsch G, Tang J |title=Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. |journal=FEBS Lett. |volume=524 |issue= 1-3 |pages= 183-7 |year= 2002 |pmid= 12135764 |doi= }}
*{{cite journal | author=Wasiak S, Legendre-Guillemin V, Puertollano R, ''et al.'' |title=Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. |journal=J. Cell Biol. |volume=158 |issue= 5 |pages= 855-62 |year= 2002 |pmid= 12213833 |doi= 10.1083/jcb.200205078 }}
*{{cite journal | author=Kalthoff C, Groos S, Kohl R, ''et al.'' |title=Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4060-73 |year= 2003 |pmid= 12429846 |doi= 10.1091/mbc.E02-03-0171 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GM2A... {November 19, 2007 11:29:10 AM PST}
- SEARCH REDIRECT: Control Box Found: GM2A {November 19, 2007 11:29:43 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:29:45 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:29:45 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:29:45 AM PST}
- UPDATED: Updated protein page: GM2A {November 19, 2007 11:29:52 AM PST}
- INFO: Beginning work on GP9... {November 19, 2007 11:29:52 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:30:16 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glycoprotein IX (platelet)
| HGNCid = 4444
| Symbol = GP9
| AltSymbols =; CD42a; GPIX
| OMIM = 173515
| ECnumber =
| Homologene = 144
| MGIid = 1860137
| GeneAtlas_image1 = PBB_GE_GP9_206883_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2815
| Hs_Ensembl = ENSG00000169704
| Hs_RefseqProtein = NP_000165
| Hs_RefseqmRNA = NM_000174
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 130262300
| Hs_GenLoc_end = 130263941
| Hs_Uniprot = P14770
| Mm_EntrezGene = 54368
| Mm_Ensembl = ENSMUSG00000030054
| Mm_RefseqmRNA = NM_018762
| Mm_RefseqProtein = NP_061232
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 87743777
| Mm_GenLoc_end = 87745403
| Mm_Uniprot =
}}
}}
'''Glycoprotein IX (platelet)''', also known as '''GP9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GP9 glycoprotein IX (platelet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2815| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GP9 glycoprotein IX (platelet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2815| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kunishima S, Kamiya T, Saito H |title=Genetic abnormalities of Bernard-Soulier syndrome. |journal=Int. J. Hematol. |volume=76 |issue= 4 |pages= 319-27 |year= 2003 |pmid= 12463594 |doi= }}
*{{cite journal | author=Hickey MJ, Deaven LL, Roth GJ |title=Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3. |journal=FEBS Lett. |volume=274 |issue= 1-2 |pages= 189-92 |year= 1991 |pmid= 2253772 |doi= }}
*{{cite journal | author=Du X, Beutler L, Ruan C, ''et al.'' |title=Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane. |journal=Blood |volume=69 |issue= 5 |pages= 1524-7 |year= 1987 |pmid= 2436691 |doi= }}
*{{cite journal | author=Andrews RK, Booth WJ, Gorman JJ, ''et al.'' |title=Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex. |journal=Biochemistry |volume=28 |issue= 21 |pages= 8317-26 |year= 1990 |pmid= 2557900 |doi= }}
*{{cite journal | author=Hickey MJ, Williams SA, Roth GJ |title=Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 17 |pages= 6773-7 |year= 1989 |pmid= 2771955 |doi= }}
*{{cite journal | author=Roth GJ, Ozols J, Nugent DJ, Williams SA |title=Isolation and characterization of human platelet glycoprotein IX. |journal=Biochem. Biophys. Res. Commun. |volume=156 |issue= 2 |pages= 931-9 |year= 1988 |pmid= 3056407 |doi= }}
*{{cite journal | author=Meyer SC, Fox JE |title=Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14693-9 |year= 1995 |pmid= 7782333 |doi= }}
*{{cite journal | author=Clemetson JM, Kyrle PA, Brenner B, Clemetson KJ |title=Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX. |journal=Blood |volume=84 |issue= 4 |pages= 1124-31 |year= 1994 |pmid= 8049428 |doi= }}
*{{cite journal | author=Hickey MJ, Roth GJ |title=Characterization of the gene encoding human platelet glycoprotein IX. |journal=J. Biol. Chem. |volume=268 |issue= 5 |pages= 3438-43 |year= 1993 |pmid= 8429020 |doi= }}
*{{cite journal | author=Wright SD, Michaelides K, Johnson DJ, ''et al.'' |title=Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome. |journal=Blood |volume=81 |issue= 9 |pages= 2339-47 |year= 1993 |pmid= 8481514 |doi= }}
*{{cite journal | author=Berger G, Massé JM, Cramer EM |title=Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V. |journal=Blood |volume=87 |issue= 4 |pages= 1385-95 |year= 1996 |pmid= 8608228 |doi= }}
*{{cite journal | author=Hollmann C, Haag F, Schlott M, ''et al.'' |title=Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products. |journal=Mol. Immunol. |volume=33 |issue= 9 |pages= 807-17 |year= 1996 |pmid= 8811076 |doi= }}
*{{cite journal | author=Noris P, Simsek S, Stibbe J, von dem Borne AE |title=A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome. |journal=Br. J. Haematol. |volume=97 |issue= 2 |pages= 312-20 |year= 1997 |pmid= 9163595 |doi= }}
*{{cite journal | author=Hayashi T, Suzuki K, Yahagi A, ''et al.'' |title=Corrected DNA sequence of the platelet glycoprotein IX gene. |journal=Thromb. Haemost. |volume=77 |issue= 5 |pages= 1034-5 |year= 1997 |pmid= 9184424 |doi= }}
*{{cite journal | author=Bradford HN, Dela Cadena RA, Kunapuli SP, ''et al.'' |title=Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. |journal=Blood |volume=90 |issue= 4 |pages= 1508-15 |year= 1997 |pmid= 9269768 |doi= }}
*{{cite journal | author=Suzuki K, Hayashi T, Yahagi A, ''et al.'' |title=Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome. |journal=Br. J. Haematol. |volume=99 |issue= 4 |pages= 794-800 |year= 1998 |pmid= 9432024 |doi= }}
*{{cite journal | author=Noris P, Arbustini E, Spedini P, ''et al.'' |title=A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV. |journal=Br. J. Haematol. |volume=103 |issue= 4 |pages= 1004-13 |year= 1999 |pmid= 9886312 |doi= }}
*{{cite journal | author=Longhurst CM, White MM, Wilkinson DA, Jennings LK |title=A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. |journal=Eur. J. Biochem. |volume=263 |issue= 1 |pages= 104-11 |year= 1999 |pmid= 10429193 |doi= }}
*{{cite journal | author=Kunishima S, Tomiyama Y, Honda S, ''et al.'' |title=Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome. |journal=Br. J. Haematol. |volume=107 |issue= 3 |pages= 539-45 |year= 2000 |pmid= 10583255 |doi= }}
*{{cite journal | author=Rivera CE, Villagra J, Riordan M, ''et al.'' |title=Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome. |journal=Br. J. Haematol. |volume=112 |issue= 1 |pages= 105-8 |year= 2001 |pmid= 11167791 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRP... {November 19, 2007 11:30:16 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:30:53 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gastrin-releasing peptide
| HGNCid = 4605
| Symbol = GRP
| AltSymbols =; BN; GRP-10; preproGRP; proGRP
| OMIM = 137260
| ECnumber =
| Homologene = 1580
| MGIid = 95833
| GeneAtlas_image1 = PBB_GE_GRP_206326_at_tn.png
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2922
| Hs_Ensembl = ENSG00000134443
| Hs_RefseqProtein = NP_001012530
| Hs_RefseqmRNA = NM_001012512
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 55038380
| Hs_GenLoc_end = 55048980
| Hs_Uniprot = P07492
| Mm_EntrezGene = 225642
| Mm_Ensembl = ENSMUSG00000024517
| Mm_RefseqmRNA = NM_175012
| Mm_RefseqProtein = NP_778177
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 65998863
| Mm_GenLoc_end = 66011948
| Mm_Uniprot = Q8R1I2
}}
}}
'''Gastrin-releasing peptide''', also known as '''GRP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRP gastrin-releasing peptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2922| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: GRP gastrin-releasing peptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2922| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Merali Z, McIntosh J, Anisman H |title=Role of bombesin-related peptides in the control of food intake. |journal=Neuropeptides |volume=33 |issue= 5 |pages= 376-86 |year= 2000 |pmid= 10657515 |doi= 10.1054/npep.1999.0054 }}
*{{cite journal | author=Baraniuk JN, Lundgren JD, Shelhamer JH, Kaliner MA |title=Gastrin releasing peptide (GRP) binding sites in human bronchi. |journal=Neuropeptides |volume=21 |issue= 2 |pages= 81-4 |year= 1992 |pmid= 1557184 |doi= }}
*{{cite journal | author=Spindel ER, Zilberberg MD, Habener JF, Chin WW |title=Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 1 |pages= 19-23 |year= 1986 |pmid= 3001723 |doi= }}
*{{cite journal | author=Sausville EA, Lebacq-Verheyden AM, Spindel ER, ''et al.'' |title=Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs. |journal=J. Biol. Chem. |volume=261 |issue= 5 |pages= 2451-7 |year= 1986 |pmid= 3003116 |doi= }}
*{{cite journal | author=Lebacq-Verheyden AM, Bertness V, Kirsch I, ''et al.'' |title=Human gastrin-releasing peptide gene maps to chromosome band 18q21. |journal=Somat. Cell Mol. Genet. |volume=13 |issue= 1 |pages= 81-6 |year= 1987 |pmid= 3027901 |doi= }}
*{{cite journal | author=Naylor SL, Sakaguchi AY, Spindel E, Chin WW |title=Human gastrin-releasing peptide gene is located on chromosome 18. |journal=Somat. Cell Mol. Genet. |volume=13 |issue= 1 |pages= 87-91 |year= 1987 |pmid= 3027902 |doi= }}
*{{cite journal | author=Lebacq-Verheyden AM, Kasprzyk PG, Raum MG, ''et al.'' |title=Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor. |journal=Mol. Cell. Biol. |volume=8 |issue= 8 |pages= 3129-35 |year= 1989 |pmid= 3211139 |doi= }}
*{{cite journal | author=Spindel ER, Chin WW, Price J, ''et al.'' |title=Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 18 |pages= 5699-703 |year= 1984 |pmid= 6207529 |doi= }}
*{{cite journal | author=Benya RV, Kusui T, Pradhan TK, ''et al.'' |title=Expression and characterization of cloned human bombesin receptors. |journal=Mol. Pharmacol. |volume=47 |issue= 1 |pages= 10-20 |year= 1995 |pmid= 7838118 |doi= }}
*{{cite journal | author=Moody TW, Zia F, Venugopal R, ''et al.'' |title=Corticotropin-releasing factor stimulates cyclic AMP, arachidonic acid release, and growth of lung cancer cells. |journal=Peptides |volume=15 |issue= 2 |pages= 281-5 |year= 1994 |pmid= 8008632 |doi= }}
*{{cite journal | author=Frankel A, Tsao MS, Viallet J |title=Receptor subtype expression and responsiveness to bombesin in cultured human bronchial epithelial cells. |journal=Cancer Res. |volume=54 |issue= 7 |pages= 1613-6 |year= 1994 |pmid= 8137267 |doi= }}
*{{cite journal | author=Lü F, Jin T, Drucker DJ |title=Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line. |journal=Endocrinology |volume=137 |issue= 9 |pages= 3710-6 |year= 1996 |pmid= 8756537 |doi= }}
*{{cite journal | author=Bertenshaw GP, Turk BE, Hubbard SJ, ''et al.'' |title=Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13248-55 |year= 2001 |pmid= 11278902 |doi= 10.1074/jbc.M011414200 }}
*{{cite journal | author=Lambeir AM, Durinx C, Proost P, ''et al.'' |title=Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion. |journal=FEBS Lett. |volume=507 |issue= 3 |pages= 327-30 |year= 2001 |pmid= 11696365 |doi= }}
*{{cite journal | author=Mason S, Smart D, Marshall IC, ''et al.'' |title=Identification and characterisation of functional bombesin receptors in human astrocytes. |journal=Eur. J. Pharmacol. |volume=438 |issue= 1-2 |pages= 25-34 |year= 2002 |pmid= 11906707 |doi= }}
*{{cite journal | author=Carroll RE, Matkowskyj K, Saunthararajah Y, ''et al.'' |title=Contribution of gastrin-releasing peptide and its receptor to villus development in the murine and human gastrointestinal tract. |journal=Mech. Dev. |volume=113 |issue= 2 |pages= 121-30 |year= 2002 |pmid= 11960700 |doi= }}
*{{cite journal | author=Uchida K, Kojima A, Morokawa N, ''et al.'' |title=Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer. |journal=J. Cancer Res. Clin. Oncol. |volume=128 |issue= 12 |pages= 633-40 |year= 2003 |pmid= 12474049 |doi= 10.1007/s00432-002-0392-8 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Schneider J, Philipp M, Velcovsky HG, ''et al.'' |title=Pro-gastrin-releasing peptide (ProGRP), neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and cytokeratin 19-fragments (CYFRA 21-1) in patients with lung cancer in comparison to other lung diseases. |journal=Anticancer Res. |volume=23 |issue= 2A |pages= 885-93 |year= 2003 |pmid= 12820318 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HUS1... {November 19, 2007 11:30:53 AM PST}
- SEARCH REDIRECT: Control Box Found: HUS1 {November 19, 2007 11:31:19 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:31:22 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:31:22 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:31:22 AM PST}
- UPDATED: Updated protein page: HUS1 {November 19, 2007 11:31:28 AM PST}
- INFO: Beginning work on IL10RA... {November 19, 2007 11:31:28 AM PST}
- SEARCH REDIRECT: Control Box Found: IL10RA {November 19, 2007 11:32:19 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:32:20 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:32:20 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:32:20 AM PST}
- UPDATED: Updated protein page: IL10RA {November 19, 2007 11:32:26 AM PST}
- INFO: Beginning work on ITGB7... {November 19, 2007 11:33:18 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:34:22 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ITGB7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2brq.
| PDB = {{PDB2|2brq}}
| Name = Integrin, beta 7
| HGNCid = 6162
| Symbol = ITGB7
| AltSymbols =;
| OMIM = 147559
| ECnumber =
| Homologene = 20247
| MGIid = 96616
| GeneAtlas_image1 = PBB_GE_ITGB7_205718_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3695
| Hs_Ensembl = ENSG00000139626
| Hs_RefseqProtein = NP_000880
| Hs_RefseqmRNA = NM_000889
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 51871375
| Hs_GenLoc_end = 51887267
| Hs_Uniprot = P26010
| Mm_EntrezGene = 16421
| Mm_Ensembl = ENSMUSG00000001281
| Mm_RefseqmRNA = NM_013566
| Mm_RefseqProtein = NP_038594
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 102044030
| Mm_GenLoc_end = 102059969
| Mm_Uniprot = P26011
}}
}}
'''Integrin, beta 7''', also known as '''ITGB7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITGB7 integrin, beta 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3695| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rüegg C, Postigo AA, Sikorski EE, ''et al.'' |title=Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. |journal=J. Cell Biol. |volume=117 |issue= 1 |pages= 179-89 |year= 1992 |pmid= 1372909 |doi= }}
*{{cite journal | author=Chan BM, Elices MJ, Murphy E, Hemler ME |title=Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY. |journal=J. Biol. Chem. |volume=267 |issue= 12 |pages= 8366-70 |year= 1992 |pmid= 1373725 |doi= }}
*{{cite journal | author=Jiang WM, Jenkins D, Yuan Q, ''et al.'' |title=The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. |journal=Int. Immunol. |volume=4 |issue= 9 |pages= 1031-40 |year= 1992 |pmid= 1382574 |doi= }}
*{{cite journal | author=Baker E, Sutherland GR, Jiang WM, ''et al.'' |title=Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization. |journal=Mamm. Genome |volume=2 |issue= 4 |pages= 272-3 |year= 1992 |pmid= 1543919 |doi= }}
*{{cite journal | author=Yuan QA, Jiang WM, Krissansen GW, Watson JD |title=Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. |journal=Int. Immunol. |volume=3 |issue= 12 |pages= 1373-4 |year= 1992 |pmid= 1777426 |doi= }}
*{{cite journal | author=Erle DJ, Rüegg C, Sheppard D, Pytela R |title=Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11009-16 |year= 1991 |pmid= 2040616 |doi= }}
*{{cite journal | author=Yuan QA, Jiang WM, Krissansen GW, Watson JD |title=Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. |journal=Int. Immunol. |volume=2 |issue= 11 |pages= 1097-108 |year= 1991 |pmid= 2083230 |doi= }}
*{{cite journal | author=Erle DJ, Brown T, Christian D, Aris R |title=Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression. |journal=Am. J. Respir. Cell Mol. Biol. |volume=10 |issue= 3 |pages= 237-44 |year= 1994 |pmid= 7509610 |doi= }}
*{{cite journal | author=Postigo AA, Sánchez-Mateos P, Lazarovits AI, ''et al.'' |title=Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes. |journal=J. Immunol. |volume=151 |issue= 5 |pages= 2471-83 |year= 1993 |pmid= 7689608 |doi= }}
*{{cite journal | author=Shaw SK, Cepek KL, Murphy EA, ''et al.'' |title=Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution. |journal=J. Biol. Chem. |volume=269 |issue= 8 |pages= 6016-25 |year= 1994 |pmid= 8119947 |doi= }}
*{{cite journal | author=Tidswell M, Pachynski R, Wu SW, ''et al.'' |title=Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1. |journal=J. Immunol. |volume=159 |issue= 3 |pages= 1497-505 |year= 1997 |pmid= 9233649 |doi= }}
*{{cite journal | author=Tan K, Casasnovas JM, Liu JH, ''et al.'' |title=The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition. |journal=Structure |volume=6 |issue= 6 |pages= 793-801 |year= 1998 |pmid= 9655832 |doi= }}
*{{cite journal | author=Rietzler M, Bittner M, Kolanus W, ''et al.'' |title=The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27459-66 |year= 1998 |pmid= 9765275 |doi= }}
*{{cite journal | author=Taraszka KS, Higgins JM, Tan K, ''et al.'' |title=Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin. |journal=J. Exp. Med. |volume=191 |issue= 9 |pages= 1555-67 |year= 2000 |pmid= 10790430 |doi= }}
*{{cite journal | author=Higgins JM, Cernadas M, Tan K, ''et al.'' |title=The role of alpha and beta chains in ligand recognition by beta 7 integrins. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25652-64 |year= 2000 |pmid= 10837471 |doi= 10.1074/jbc.M001228200 }}
*{{cite journal | author=Puig-Kröger A, Sanz-Rodríguez F, Longo N, ''et al.'' |title=Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells. |journal=J. Immunol. |volume=165 |issue= 8 |pages= 4338-45 |year= 2000 |pmid= 11035069 |doi= }}
*{{cite journal | author=Guilliano MJ, Foxx-Orenstein AE, Lebman DA |title=The microenvironment of human Peyer's patches inhibits the increase in CD38 expression associated with the germinal center reaction. |journal=J. Immunol. |volume=166 |issue= 4 |pages= 2179-85 |year= 2001 |pmid= 11160270 |doi= }}
*{{cite journal | author=Calderwood DA, Huttenlocher A, Kiosses WB, ''et al.'' |title=Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. |journal=Nat. Cell Biol. |volume=3 |issue= 12 |pages= 1060-8 |year= 2002 |pmid= 11781567 |doi= 10.1038/ncb1201-1060 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Calderwood DA, Fujioka Y, de Pereda JM, ''et al.'' |title=Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2272-7 |year= 2003 |pmid= 12606711 |doi= 10.1073/pnas.262791999 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KCND2... {November 19, 2007 11:34:22 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:34:57 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_KCND2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nn7.
| PDB = {{PDB2|1nn7}}, {{PDB2|1s6c}}
| Name = Potassium voltage-gated channel, Shal-related subfamily, member 2
| HGNCid = 6238
| Symbol = KCND2
| AltSymbols =; KIAA1044; KV4.2; MGC119702; MGC119703; RK5
| OMIM = 605410
| ECnumber =
| Homologene = 40828
| MGIid = 102663
| Function = {{GNF_GO|id=GO:0005249 |text = voltage-gated potassium channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0043197 |text = dendritic spine}}
| Process = {{GNF_GO|id=GO:0001508 |text = regulation of action potential}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3751
| Hs_Ensembl = ENSG00000184408
| Hs_RefseqProtein = NP_036413
| Hs_RefseqmRNA = NM_012281
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 119701923
| Hs_GenLoc_end = 120175148
| Hs_Uniprot = Q9NZV8
| Mm_EntrezGene = 16508
| Mm_Ensembl = ENSMUSG00000060882
| Mm_RefseqmRNA = NM_019697
| Mm_RefseqProtein = NP_062671
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 21166300
| Mm_GenLoc_end = 21677343
| Mm_Uniprot = Q9Z0V2
}}
}}
'''Potassium voltage-gated channel, Shal-related subfamily, member 2''', also known as '''KCND2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3751| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.<ref name="entrez">{{cite web | title = Entrez Gene: KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3751| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gutman GA, Chandy KG, Grissmer S, ''et al.'' |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473-508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10 }}
*{{cite journal | author=Kong W, Po S, Yamagishi T, ''et al.'' |title=Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing. |journal=Am. J. Physiol. |volume=275 |issue= 6 Pt 2 |pages= H1963-70 |year= 1999 |pmid= 9843794 |doi= }}
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi= }}
*{{cite journal | author=Kurschner C, Yuzaki M |title=Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. |journal=J. Neurosci. |volume=19 |issue= 18 |pages= 7770-80 |year= 1999 |pmid= 10479680 |doi= }}
*{{cite journal | author=Zhu XR, Wulf A, Schwarz M, ''et al.'' |title=Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current. |journal=Recept. Channels |volume=6 |issue= 5 |pages= 387-400 |year= 1999 |pmid= 10551270 |doi= }}
*{{cite journal | author=An WF, Bowlby MR, Betty M, ''et al.'' |title=Modulation of A-type potassium channels by a family of calcium sensors. |journal=Nature |volume=403 |issue= 6769 |pages= 553-6 |year= 2000 |pmid= 10676964 |doi= 10.1038/35000592 }}
*{{cite journal | author=Isbrandt D, Leicher T, Waldschütz R, ''et al.'' |title=Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). |journal=Genomics |volume=64 |issue= 2 |pages= 144-54 |year= 2000 |pmid= 10729221 |doi= 10.1006/geno.2000.6117 }}
*{{cite journal | author=Postma AV, Bezzina CR, de Vries JF, ''et al.'' |title=Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3. |journal=Hum. Genet. |volume=106 |issue= 6 |pages= 614-9 |year= 2000 |pmid= 10942109 |doi= }}
*{{cite journal | author=Petrecca K, Miller DM, Shrier A |title=Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. |journal=J. Neurosci. |volume=20 |issue= 23 |pages= 8736-44 |year= 2001 |pmid= 11102480 |doi= }}
*{{cite journal | author=Bähring R, Dannenberg J, Peters HC, ''et al.'' |title=Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23888-94 |year= 2001 |pmid= 11287421 |doi= 10.1074/jbc.M101320200 }}
*{{cite journal | author=Nakamura TY, Pountney DJ, Ozaita A, ''et al.'' |title=A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 22 |pages= 12808-13 |year= 2001 |pmid= 11606724 |doi= 10.1073/pnas.221168498 }}
*{{cite journal | author=Morohashi Y, Hatano N, Ohya S, ''et al.'' |title=Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14965-75 |year= 2002 |pmid= 11847232 |doi= 10.1074/jbc.M200897200 }}
*{{cite journal | author=Eldstrom J, Doerksen KW, Steele DF, Fedida D |title=N-terminal PDZ-binding domain in Kv1 potassium channels. |journal=FEBS Lett. |volume=531 |issue= 3 |pages= 529-37 |year= 2002 |pmid= 12435606 |doi= }}
*{{cite journal | author=Schrader LA, Anderson AE, Mayne A, ''et al.'' |title=PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. |journal=J. Neurosci. |volume=22 |issue= 23 |pages= 10123-33 |year= 2002 |pmid= 12451113 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Shin BK, Wang H, Yim AM, ''et al.'' |title=Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7607-16 |year= 2003 |pmid= 12493773 |doi= 10.1074/jbc.M210455200 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Wong W, Schlichter LC |title=Differential recruitment of Kv1.4 and Kv4.2 to lipid rafts by PSD-95. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 444-52 |year= 2004 |pmid= 14559911 |doi= 10.1074/jbc.M304675200 }}
*{{cite journal | author=Kim LA, Furst J, Butler MH, ''et al.'' |title=Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5549-54 |year= 2004 |pmid= 14623880 |doi= 10.1074/jbc.M311332200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KRT7... {November 19, 2007 11:34:57 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:35:34 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Keratin 7
| HGNCid = 6445
| Symbol = KRT7
| AltSymbols =; CK7; K2C7; K7; MGC129731; MGC3625; SCL
| OMIM = 148059
| ECnumber =
| Homologene = 4058
| MGIid = 96704
| GeneAtlas_image1 = PBB_GE_KRT7_209016_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005882 |text = intermediate filament}}
| Process = {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3855
| Hs_Ensembl = ENSG00000135480
| Hs_RefseqProtein = NP_005547
| Hs_RefseqmRNA = NM_005556
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 50913348
| Hs_GenLoc_end = 50928969
| Hs_Uniprot = P08729
| Mm_EntrezGene = 110310
| Mm_Ensembl = ENSMUSG00000023039
| Mm_RefseqmRNA = NM_033073
| Mm_RefseqProtein = NP_149064
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 101240436
| Mm_GenLoc_end = 101255827
| Mm_Uniprot =
}}
}}
'''Keratin 7''', also known as '''KRT7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KRT7 keratin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3855| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.<ref name="entrez">{{cite web | title = Entrez Gene: KRT7 keratin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3855| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bouwens L |title=Cytokeratins and cell differentiation in the pancreas. |journal=J. Pathol. |volume=184 |issue= 3 |pages= 234-9 |year= 1998 |pmid= 9614373 |doi= 10.1002/(SICI)1096-9896(199803)184:3<234::AID-PATH28>3.0.CO;2-D }}
*{{cite journal | author=Rosenberg M, Fuchs E, Le Beau MM, ''et al.'' |title=Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12. |journal=Cytogenet. Cell Genet. |volume=57 |issue= 1 |pages= 33-8 |year= 1991 |pmid= 1713141 |doi= }}
*{{cite journal | author=Glass C, Kim KH, Fuchs E |title=Sequence and expression of a human type II mesothelial keratin. |journal=J. Cell Biol. |volume=101 |issue= 6 |pages= 2366-73 |year= 1986 |pmid= 2415537 |doi= }}
*{{cite journal | author=Ramaekers F, Huysmans A, Schaart G, ''et al.'' |title=Tissue distribution of keratin 7 as monitored by a monoclonal antibody. |journal=Exp. Cell Res. |volume=170 |issue= 1 |pages= 235-49 |year= 1987 |pmid= 2436934 |doi= }}
*{{cite journal | author=Glass C, Fuchs E |title=Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells. |journal=J. Cell Biol. |volume=107 |issue= 4 |pages= 1337-50 |year= 1988 |pmid= 2459129 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Gress TM, Müller-Pillasch F, Geng M, ''et al.'' |title=A pancreatic cancer-specific expression profile. |journal=Oncogene |volume=13 |issue= 8 |pages= 1819-30 |year= 1996 |pmid= 8895530 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Alvarez Alvarez C, Sánchez Merino JM, Busto Castañón L, ''et al.'' |title=[Mucinous adenocarcinoma of the urachus synchronic with colorectal adenocarcinoma. Value of immunohistochemistry in the differential diagnosis] |journal=Actas urologicas españolas |volume=22 |issue= 6 |pages= 515-8 |year= 1998 |pmid= 9734130 |doi= }}
*{{cite journal | author=Kaba A, Jiang PH, Chany-Fournier F, Chany C |title=Sarcolectin (SCL): structure and expression of the recombinant molecule. |journal=Biochimie |volume=81 |issue= 7 |pages= 709-15 |year= 1999 |pmid= 10492017 |doi= }}
*{{cite journal | author=Lin L, Holbro T, Alonso G, ''et al.'' |title=Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. |journal=J. Cell. Biochem. |volume=80 |issue= 4 |pages= 483-90 |year= 2001 |pmid= 11169732 |doi= }}
*{{cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
*{{cite journal | author=Harris RA, Yang A, Stein RC, ''et al.'' |title=Cluster analysis of an extensive human breast cancer cell line protein expression map database. |journal=Proteomics |volume=2 |issue= 2 |pages= 212-23 |year= 2002 |pmid= 11840567 |doi= }}
*{{cite journal | author=Bonvini P, Gastaldi T, Falini B, Rosolen A |title=Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin. |journal=Cancer Res. |volume=62 |issue= 5 |pages= 1559-66 |year= 2002 |pmid= 11888936 |doi= }}
*{{cite journal | author=Jovanovic I, Tzardi M, Mouzas IA, ''et al.'' |title=Changing pattern of cytokeratin 7 and 20 expression from normal epithelium to intestinal metaplasia of the gastric mucosa and gastroesophageal junction. |journal=Histol. Histopathol. |volume=17 |issue= 2 |pages= 445-54 |year= 2002 |pmid= 11962749 |doi= }}
*{{cite journal | author=Kanduc D |title=Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7. |journal=J. Virol. |volume=76 |issue= 14 |pages= 7040-8 |year= 2002 |pmid= 12072504 |doi= }}
*{{cite journal | author=Smith FJ, Porter RM, Corden LD, ''et al.'' |title=Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 4 |pages= 818-27 |year= 2002 |pmid= 12359226 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Blagoev B, Kratchmarova I, Ong SE, ''et al.'' |title=A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. |journal=Nat. Biotechnol. |volume=21 |issue= 3 |pages= 315-8 |year= 2003 |pmid= 12577067 |doi= 10.1038/nbt790 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LALBA... {November 19, 2007 11:35:34 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:35:59 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LALBA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a4v.
| PDB = {{PDB2|1a4v}}, {{PDB2|1alc}}, {{PDB2|1b9o}}, {{PDB2|1hml}}
| Name = Lactalbumin, alpha-
| HGNCid = 6480
| Symbol = LALBA
| AltSymbols =; MGC138521; MGC138523
| OMIM = 149750
| ECnumber =
| Homologene = 1720
| MGIid = 96742
| GeneAtlas_image1 = PBB_GE_LALBA_207816_at_tn.png
| Function = {{GNF_GO|id=GO:0004461 |text = lactose synthase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0005989 |text = lactose biosynthetic process}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3906
| Hs_Ensembl = ENSG00000167531
| Hs_RefseqProtein = NP_002280
| Hs_RefseqmRNA = NM_002289
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 47247735
| Hs_GenLoc_end = 47250096
| Hs_Uniprot = P00709
| Mm_EntrezGene = 16770
| Mm_Ensembl = ENSMUSG00000022991
| Mm_RefseqmRNA = XM_993980
| Mm_RefseqProtein = XP_999074
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 98308434
| Mm_GenLoc_end = 98310717
| Mm_Uniprot = P29752
}}
}}
'''Lactalbumin, alpha-''', also known as '''LALBA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LALBA lactalbumin, alpha-| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3906| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells.<ref name="entrez">{{cite web | title = Entrez Gene: LALBA lactalbumin, alpha-| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3906| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Heine WE, Klein PD, Reeds PJ |title=The importance of alpha-lactalbumin in infant nutrition. |journal=J. Nutr. |volume=121 |issue= 3 |pages= 277-83 |year= 1991 |pmid= 2002399 |doi= }}
*{{cite journal | author=Permyakov EA, Berliner LJ |title=alpha-Lactalbumin: structure and function. |journal=FEBS Lett. |volume=473 |issue= 3 |pages= 269-74 |year= 2000 |pmid= 10818224 |doi= }}
*{{cite journal | author=Hall L, Emery DC, Davies MS, ''et al.'' |title=Organization and sequence of the human alpha-lactalbumin gene. |journal=Biochem. J. |volume=242 |issue= 3 |pages= 735-42 |year= 1987 |pmid= 2954544 |doi= }}
*{{cite journal | author=Davies MS, West LF, Davis MB, ''et al.'' |title=The gene for human alpha-lactalbumin is assigned to chromosome 12q13. |journal=Ann. Hum. Genet. |volume=51 |issue= Pt 3 |pages= 183-8 |year= 1987 |pmid= 3479943 |doi= }}
*{{cite journal | author=Findlay JB, Brew K |title=The complete amino-acid sequence of human -lactalbumin. |journal=Eur. J. Biochem. |volume=27 |issue= 1 |pages= 65-86 |year= 1972 |pmid= 5049057 |doi= }}
*{{cite journal | author=Hall L, Craig RK, Edbrooke MR, Campbell PN |title=Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene. |journal=Nucleic Acids Res. |volume=10 |issue= 11 |pages= 3503-15 |year= 1982 |pmid= 6285305 |doi= }}
*{{cite journal | author=Håkansson A, Zhivotovsky B, Orrenius S, ''et al.'' |title=Apoptosis induced by a human milk protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 8064-8 |year= 1995 |pmid= 7644538 |doi= }}
*{{cite journal | author=Stacey A, Schnieke A, Kerr M, ''et al.'' |title=Lactation is disrupted by alpha-lactalbumin deficiency and can be restored by human alpha-lactalbumin gene replacement in mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 7 |pages= 2835-9 |year= 1995 |pmid= 7708733 |doi= }}
*{{cite journal | author=Fujiwara Y, Miwa M, Takahashi R, ''et al.'' |title=Position-independent and high-level expression of human alpha-lactalbumin in the milk of transgenic rats carrying a 210-kb YAC DNA. |journal=Mol. Reprod. Dev. |volume=47 |issue= 2 |pages= 157-63 |year= 1997 |pmid= 9136116 |doi= 10.1002/(SICI)1098-2795(199706)47:2<157::AID-MRD5>3.0.CO;2-L }}
*{{cite journal | author=Lindner RA, Kapur A, Carver JA |title=The interaction of the molecular chaperone, alpha-crystallin, with molten globule states of bovine alpha-lactalbumin. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27722-9 |year= 1997 |pmid= 9346914 |doi= }}
*{{cite journal | author=Giuffrida MG, Cavaletto M, Giunta C, ''et al.'' |title=The unusual amino acid triplet Asn-Ile-Cys is a glycosylation consensus site in human alpha-lactalbumin. |journal=J. Protein Chem. |volume=16 |issue= 8 |pages= 747-53 |year= 1998 |pmid= 9365923 |doi= }}
*{{cite journal | author=Chandra N, Brew K, Acharya KR |title=Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin. |journal=Biochemistry |volume=37 |issue= 14 |pages= 4767-72 |year= 1998 |pmid= 9537992 |doi= 10.1021/bi973000t }}
*{{cite journal | author=Håkansson A, Andréasson J, Zhivotovsky B, ''et al.'' |title=Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei. |journal=Exp. Cell Res. |volume=246 |issue= 2 |pages= 451-60 |year= 1999 |pmid= 9925761 |doi= 10.1006/excr.1998.4265 }}
*{{cite journal | author=Svensson M, Sabharwal H, Håkansson A, ''et al.'' |title=Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells. |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6388-96 |year= 1999 |pmid= 10037730 |doi= }}
*{{cite journal | author=Harata K, Abe Y, Muraki M |title=Crystallographic evaluation of internal motion of human alpha-lactalbumin refined by full-matrix least-squares method. |journal=J. Mol. Biol. |volume=287 |issue= 2 |pages= 347-58 |year= 1999 |pmid= 10080897 |doi= 10.1006/jmbi.1999.2598 }}
*{{cite journal | author=Last AM, Schulman BA, Robinson CV, Redfield C |title=Probing subtle differences in the hydrogen exchange behavior of variants of the human alpha-lactalbumin molten globule using mass spectrometry. |journal=J. Mol. Biol. |volume=311 |issue= 4 |pages= 909-19 |year= 2001 |pmid= 11518539 |doi= 10.1006/jmbi.2001.4911 }}
*{{cite journal | author=Bai P, Peng Z |title=Cooperative folding of the isolated alpha-helical domain of hen egg-white lysozyme. |journal=J. Mol. Biol. |volume=314 |issue= 2 |pages= 321-9 |year= 2001 |pmid= 11718563 |doi= 10.1006/jmbi.2001.5122 }}
*{{cite journal | author=Andrews P |title=Purification of lactose synthetase a protein from human milk and demonstration of its interaction with alpha-lactalbumin. |journal= |volume=9 |issue= 5 |pages= 297-300 |year= |pmid= 11947697 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LBR... {November 19, 2007 11:35:59 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:36:31 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LBR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dig.
| PDB = {{PDB2|2dig}}
| Name = Lamin B receptor
| HGNCid = 6518
| Symbol = LBR
| AltSymbols =; DHCR14B; LMN2R; MGC9041; PHA
| OMIM = 600024
| ECnumber =
| Homologene = 2455
| MGIid = 2138281
| GeneAtlas_image1 = PBB_GE_LBR_201795_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005521 |text = lamin binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005639 |text = integral to nuclear inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3930
| Hs_Ensembl = ENSG00000143815
| Hs_RefseqProtein = NP_002287
| Hs_RefseqmRNA = NM_002296
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 223655827
| Hs_GenLoc_end = 223683142
| Hs_Uniprot = Q14739
| Mm_EntrezGene = 98386
| Mm_Ensembl = ENSMUSG00000004880
| Mm_RefseqmRNA = NM_133815
| Mm_RefseqProtein = NP_598576
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 183651991
| Mm_GenLoc_end = 183679029
| Mm_Uniprot = Q811V7
}}
}}
'''Lamin B receptor''', also known as '''LBR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LBR lamin B receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3930| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: LBR lamin B receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3930| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Worman HJ, Yuan J, Blobel G, Georgatos SD |title=A lamin B receptor in the nuclear envelope. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 22 |pages= 8531-4 |year= 1988 |pmid= 2847165 |doi= }}
*{{cite journal | author=Soullam B, Worman HJ |title=The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal. |journal=J. Cell Biol. |volume=120 |issue= 5 |pages= 1093-100 |year= 1993 |pmid= 7679672 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Ye Q, Worman HJ |title=Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11306-11 |year= 1994 |pmid= 8157662 |doi= }}
*{{cite journal | author=Schuler E, Lin F, Worman HJ |title=Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane. |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11312-7 |year= 1994 |pmid= 8157663 |doi= }}
*{{cite journal | author=Ye Q, Worman HJ |title=Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 14653-6 |year= 1996 |pmid= 8663349 |doi= }}
*{{cite journal | author=Wydner KL, McNeil JA, Lin F, ''et al.'' |title=Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization. |journal=Genomics |volume=32 |issue= 3 |pages= 474-8 |year= 1997 |pmid= 8838815 |doi= 10.1006/geno.1996.0146 }}
*{{cite journal | author=Pyrpasopoulou A, Meier J, Maison C, ''et al.'' |title=The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope. |journal=EMBO J. |volume=15 |issue= 24 |pages= 7108-19 |year= 1997 |pmid= 9003786 |doi= }}
*{{cite journal | author=Ye Q, Callebaut I, Pezhman A, ''et al.'' |title=Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14983-9 |year= 1997 |pmid= 9169472 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Holmer L, Pezhman A, Worman HJ |title=The human lamin B receptor/sterol reductase multigene family. |journal=Genomics |volume=54 |issue= 3 |pages= 469-76 |year= 1999 |pmid= 9878250 |doi= 10.1006/geno.1998.5615 }}
*{{cite journal | author=Papoutsopoulou S, Nikolakaki E, Giannakouros T |title=SRPK1 and LBR protein kinases show identical substrate specificities. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 3 |pages= 602-7 |year= 1999 |pmid= 10049757 |doi= 10.1006/bbrc.1999.0249 }}
*{{cite journal | author=Papoutsopoulou S, Nikolakaki E, Chalepakis G, ''et al.'' |title=SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1. |journal=Nucleic Acids Res. |volume=27 |issue= 14 |pages= 2972-80 |year= 1999 |pmid= 10390541 |doi= }}
*{{cite journal | author=Bedford MT, Sarbassova D, Xu J, ''et al.'' |title=A novel pro-Arg motif recognized by WW domains. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10359-69 |year= 2000 |pmid= 10744724 |doi= }}
*{{cite journal | author=Duband-Goulet I, Courvalin JC |title=Inner nuclear membrane protein LBR preferentially interacts with DNA secondary structures and nucleosomal linker. |journal=Biochemistry |volume=39 |issue= 21 |pages= 6483-8 |year= 2000 |pmid= 10828963 |doi= }}
*{{cite journal | author=Martins SB, Eide T, Steen RL, ''et al.'' |title=HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics. |journal=J. Cell. Sci. |volume=113 Pt 21 |issue= |pages= 3703-13 |year= 2001 |pmid= 11034899 |doi= }}
*{{cite journal | author=Takano M, Takeuchi M, Ito H, ''et al.'' |title=The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region. |journal=Eur. J. Biochem. |volume=269 |issue= 3 |pages= 943-53 |year= 2002 |pmid= 11846796 |doi= }}
*{{cite journal | author=Hoffmann K, Dreger CK, Olins AL, ''et al.'' |title=Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly). |journal=Nat. Genet. |volume=31 |issue= 4 |pages= 410-4 |year= 2002 |pmid= 12118250 |doi= 10.1038/ng925 }}
*{{cite journal | author=Wells L, Vosseller K, Cole RN, ''et al.'' |title=Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications. |journal=Mol. Cell Proteomics |volume=1 |issue= 10 |pages= 791-804 |year= 2003 |pmid= 12438562 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LIG1... {November 19, 2007 11:36:31 AM PST}
- SEARCH REDIRECT: Control Box Found: LIG1 {November 19, 2007 11:36:59 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:37:00 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:37:00 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:37:00 AM PST}
- UPDATED: Updated protein page: LIG1 {November 19, 2007 11:37:06 AM PST}
- INFO: Beginning work on MAGEA1... {November 19, 2007 11:37:06 AM PST}
- SEARCH REDIRECT: Control Box Found: MAGEA1 {November 19, 2007 11:37:37 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:37:42 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:37:42 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:37:42 AM PST}
- UPDATED: Updated protein page: MAGEA1 {November 19, 2007 11:37:49 AM PST}
- INFO: Beginning work on MATK... {November 19, 2007 11:37:49 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:38:35 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MATK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jwo.
| PDB = {{PDB2|1jwo}}, {{PDB2|1x6g}}
| Name = Megakaryocyte-associated tyrosine kinase
| HGNCid = 6906
| Symbol = MATK
| AltSymbols =; CHK; CTK; DKFZp434N1212; HHYLTK; HYL; HYLTK; Lsk; MGC1708; MGC2101
| OMIM = 600038
| ECnumber =
| Homologene = 48104
| MGIid = 99259
| GeneAtlas_image1 = PBB_GE_MATK_206267_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007498 |text = mesoderm development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4145
| Hs_Ensembl = ENSG00000007264
| Hs_RefseqProtein = NP_002369
| Hs_RefseqmRNA = NM_002378
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 3728968
| Hs_GenLoc_end = 3740345
| Hs_Uniprot = P42679
| Mm_EntrezGene = 17179
| Mm_Ensembl = ENSMUSG00000004933
| Mm_RefseqmRNA = NM_010768
| Mm_RefseqProtein = NP_034898
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 80660674
| Mm_GenLoc_end = 80666110
| Mm_Uniprot = P70223
}}
}}
'''Megakaryocyte-associated tyrosine kinase''', also known as '''MATK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MATK megakaryocyte-associated tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4145| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MATK megakaryocyte-associated tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4145| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Okada M, Nada S, Yamanashi Y, ''et al.'' |title=CSK: a protein-tyrosine kinase involved in regulation of src family kinases. |journal=J. Biol. Chem. |volume=266 |issue= 36 |pages= 24249-52 |year= 1992 |pmid= 1722201 |doi= }}
*{{cite journal | author=McVicar DW, Lal BK, Lloyd A, ''et al.'' |title=Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes. |journal=Oncogene |volume=9 |issue= 7 |pages= 2037-44 |year= 1994 |pmid= 7516063 |doi= }}
*{{cite journal | author=Avraham S, Jiang S, Ota S, ''et al.'' |title=Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. |journal=J. Biol. Chem. |volume=270 |issue= 4 |pages= 1833-42 |year= 1995 |pmid= 7530249 |doi= }}
*{{cite journal | author=Jhun BH, Rivnay B, Price D, Avraham H |title=The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit. |journal=J. Biol. Chem. |volume=270 |issue= 16 |pages= 9661-6 |year= 1995 |pmid= 7536744 |doi= }}
*{{cite journal | author=Hamaguchi I, Iwama A, Yamaguchi N, ''et al.'' |title=Characterization of mouse non-receptor tyrosine kinase gene, HYL. |journal=Oncogene |volume=9 |issue= 11 |pages= 3371-4 |year= 1994 |pmid= 7936664 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Sakano S, Iwama A, Inazawa J, ''et al.'' |title=Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase). |journal=Oncogene |volume=9 |issue= 4 |pages= 1155-61 |year= 1994 |pmid= 8134117 |doi= }}
*{{cite journal | author=Bennett BD, Cowley S, Jiang S, ''et al.'' |title=Identification and characterization of a novel tyrosine kinase from megakaryocytes. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1068-74 |year= 1994 |pmid= 8288563 |doi= }}
*{{cite journal | author=Zrihan-Licht S, Lim J, Keydar I, ''et al.'' |title=Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1856-63 |year= 1997 |pmid= 8999872 |doi= }}
*{{cite journal | author=Price DJ, Rivnay B, Fu Y, ''et al.'' |title=Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5915-20 |year= 1997 |pmid= 9038210 |doi= }}
*{{cite journal | author=Hirao A, Hamaguchi I, Suda T, Yamaguchi N |title=Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. |journal=EMBO J. |volume=16 |issue= 9 |pages= 2342-51 |year= 1997 |pmid= 9171348 |doi= 10.1093/emboj/16.9.2342 }}
*{{cite journal | author=Grgurevich S, Linnekin D, Musso T, ''et al.'' |title=The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e. |journal=Growth Factors |volume=14 |issue= 2-3 |pages= 103-15 |year= 1997 |pmid= 9255603 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Grgurevich S, Mikhael A, McVicar DW |title=The Csk homologous kinase, Chk, binds tyrosine phosphorylated paxillin in human blastic T cells. |journal=Biochem. Biophys. Res. Commun. |volume=256 |issue= 3 |pages= 668-75 |year= 1999 |pmid= 10080957 |doi= 10.1006/bbrc.1999.0398 }}
*{{cite journal | author=Yamashita H, Avraham S, Jiang S, ''et al.'' |title=The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 15059-65 |year= 1999 |pmid= 10329710 |doi= }}
*{{cite journal | author=McShan GD, Zagozdzon R, Park SY, ''et al.'' |title=Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration. |journal=Int. J. Oncol. |volume=21 |issue= 1 |pages= 197-205 |year= 2002 |pmid= 12063569 |doi= }}
*{{cite journal | author=Kim S, Zagozdzon R, Meisler A, ''et al.'' |title=Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36465-70 |year= 2002 |pmid= 12122014 |doi= 10.1074/jbc.M206018200 }}
*{{cite journal | author=Zagozdzon R, Bougeret C, Fu Y, Avraham HK |title=Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells. |journal=Int. J. Oncol. |volume=21 |issue= 6 |pages= 1347-52 |year= 2003 |pmid= 12429987 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Mikkola ET, Bergman M |title=Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK. |journal=FEBS Lett. |volume=544 |issue= 1-3 |pages= 11-4 |year= 2003 |pmid= 12782282 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MB... {November 19, 2007 11:38:35 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:38:57 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1m6c.
| PDB = {{PDB2|1m6c}}, {{PDB2|1m6m}}, {{PDB2|1mdn}}, {{PDB2|1mnh}}, {{PDB2|1mni}}, {{PDB2|1mnj}}, {{PDB2|1mnk}}, {{PDB2|1mno}}, {{PDB2|1mwc}}, {{PDB2|1mwd}}, {{PDB2|1myg}}, {{PDB2|1myh}}, {{PDB2|1myi}}, {{PDB2|1myj}}, {{PDB2|1pmb}}, {{PDB2|1yca}}, {{PDB2|1ycb}}, {{PDB2|2mm1}}
| Name = Myoglobin
| HGNCid = 6915
| Symbol = MB
| AltSymbols =; MGC13548; PVALB
| OMIM = 160000
| ECnumber =
| Homologene = 3916
| MGIid = 96922
| GeneAtlas_image1 = PBB_GE_MB_204179_at_tn.png
| Function = {{GNF_GO|id=GO:0005344 |text = oxygen transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0015671 |text = oxygen transport}} {{GNF_GO|id=GO:0043353 |text = enucleate erythrocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4151
| Hs_Ensembl = ENSG00000198125
| Hs_RefseqProtein = NP_005359
| Hs_RefseqmRNA = NM_005368
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 34332757
| Hs_GenLoc_end = 34349347
| Hs_Uniprot = P02144
| Mm_EntrezGene = 17189
| Mm_Ensembl = ENSMUSG00000018893
| Mm_RefseqmRNA = NM_013593
| Mm_RefseqProtein = NP_038621
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 76842742
| Mm_GenLoc_end = 76877925
| Mm_Uniprot = Q3UVB1
}}
}}
'''Myoglobin''', also known as '''MB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MB myoglobin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4151| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: MB myoglobin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4151| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Suzuki T, Imai K |title=Evolution of myoglobin. |journal=Cell. Mol. Life Sci. |volume=54 |issue= 9 |pages= 979-1004 |year= 1998 |pmid= 9791540 |doi= }}
*{{cite journal | author=Lundholm K, Scherstén T |title=Protein synthesis in isolated human skeletal muscle tissue: evaluation of an experimental model. |journal=Clin. Sci. |volume=57 |issue= 2 |pages= 221-3 |year= 1979 |pmid= 477257 |doi= }}
*{{cite journal | author=Hubbard SR, Hendrickson WA, Lambright DG, Boxer SG |title=X-ray crystal structure of a recombinant human myoglobin mutant at 2.8 A resolution. |journal=J. Mol. Biol. |volume=213 |issue= 2 |pages= 215-8 |year= 1990 |pmid= 2342104 |doi= }}
*{{cite journal | author=Akaboshi E |title=Cloning of the human myoglobin gene. |journal=Gene |volume=33 |issue= 3 |pages= 241-9 |year= 1985 |pmid= 2989088 |doi= }}
*{{cite journal | author=Romero Herrera AE, Lehmann H |title=The myoglobin of primates. II. Pan Troglodytes (chimpanzee). |journal=Biochim. Biophys. Acta |volume=278 |issue= 1 |pages= 62-7 |year= 1972 |pmid= 4627044 |doi= }}
*{{cite journal | author=Herrera AE, Lehmann H |title=Primary structure of human myoglobin. |journal=Nature New Biol. |volume=232 |issue= 31 |pages= 149-52 |year= 1971 |pmid= 5285572 |doi= }}
*{{cite journal | author=Boulton FE, Huntsman RG, Yawson GI, ''et al.'' |title=The second variant of human myoglobin; 138(H16) arginine leads to glutamine. |journal=Br. J. Haematol. |volume=20 |issue= 1 |pages= 69-74 |year= 1971 |pmid= 5540041 |doi= }}
*{{cite journal | author=Boulton FE, Huntsman RG, Romero Herrera A, ''et al.'' |title=The third variant of human myoglobin showing an unusual amino acid substitution: 138(H16)arginine--tryptophan. |journal=Biochim. Biophys. Acta |volume=229 |issue= 3 |pages= 716-9 |year= 1971 |pmid= 5555219 |doi= }}
*{{cite journal | author=Boulton FE, Huntsman RG, Romero Herrera AE, ''et al.'' |title=A human myoglobin variant 133 (H-10)lysine--asparagine. |journal=Biochim. Biophys. Acta |volume=229 |issue= 3 |pages= 871-6 |year= 1971 |pmid= 5555226 |doi= }}
*{{cite journal | author=Boulton FE, Huntsman RG, Lorkin PA, Lehmann H |title=Abnormal human myoglobin: 53 (D4) glutamic acid--lysine. |journal=Nature |volume=223 |issue= 5208 |pages= 832-3 |year= 1969 |pmid= 5805522 |doi= }}
*{{cite journal | author=Jeffreys AJ, Wilson V, Blanchetot A, ''et al.'' |title=The human myoglobin gene: a third dispersed globin locus in the human genome. |journal=Nucleic Acids Res. |volume=12 |issue= 7 |pages= 3235-43 |year= 1984 |pmid= 6326055 |doi= }}
*{{cite journal | author=Weller P, Jeffreys AJ, Wilson V, Blanchetot A |title=Organization of the human myoglobin gene. |journal=EMBO J. |volume=3 |issue= 2 |pages= 439-46 |year= 1984 |pmid= 6571704 |doi= }}
*{{cite journal | author=Corbett JM, Wheeler CH, Baker CS, ''et al.'' |title=The human myocardial two-dimensional gel protein database: update 1994. |journal=Electrophoresis |volume=15 |issue= 11 |pages= 1459-65 |year= 1995 |pmid= 7895732 |doi= }}
*{{cite journal | author=Bassel-Duby R, Hernandez MD, Yang Q, ''et al.'' |title=Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. |journal=Mol. Cell. Biol. |volume=14 |issue= 7 |pages= 4596-605 |year= 1994 |pmid= 8007964 |doi= }}
*{{cite journal | author=Qiu Y, Sutton L, Riggs AF |title=Identification of myoglobin in human smooth muscle. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23426-32 |year= 1998 |pmid= 9722578 |doi= }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Witting PK, Douglas DJ, Mauk AG |title=Reaction of human myoglobin and H2O2. Involvement of a thiyl radical produced at cysteine 110. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20391-8 |year= 2000 |pmid= 10779502 |doi= 10.1074/jbc.M000373200 }}
*{{cite journal | author=Romero Herrera AE, Lehmann H |title=The myoglobin of primates. I. Hylobates agilis (gibbon). |journal=Biochim. Biophys. Acta |volume=251 |issue= 3 |pages= 482-8 |year= 2001 |pmid= 11452891 |doi= }}
*{{cite journal | author=Moore LG, Zamudio S, Zhuang J, ''et al.'' |title=Analysis of the myoglobin gene in Tibetans living at high altitude. |journal=High Alt. Med. Biol. |volume=3 |issue= 1 |pages= 39-47 |year= 2002 |pmid= 12006163 |doi= 10.1089/152702902753639531 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MCM4... {November 19, 2007 11:38:57 AM PST}
- SEARCH REDIRECT: Control Box Found: MCM4 {November 19, 2007 11:39:50 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:39:53 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:39:53 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:39:53 AM PST}
- UPDATED: Updated protein page: MCM4 {November 19, 2007 11:39:59 AM PST}
- INFO: Beginning work on MT1A... {November 19, 2007 11:39:59 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:40:26 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MT1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mhu.
| PDB = {{PDB2|1mhu}}, {{PDB2|1mrb}}, {{PDB2|2mhu}}
| Name = Metallothionein 1A
| HGNCid = 7393
| Symbol = MT1A
| AltSymbols =; MGC32848; MT1; MT1S; MTC
| OMIM = 156350
| ECnumber =
| Homologene = 88733
| MGIid =
| Function = {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046870 |text = cadmium ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4489
| Hs_Ensembl = ENSG00000205362
| Hs_RefseqProtein = NP_005937
| Hs_RefseqmRNA = NM_005946
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 55230152
| Hs_GenLoc_end = 55231363
| Hs_Uniprot = P04731
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Metallothionein 1A''', also known as '''MT1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MT1A metallothionein 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4489| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, ''et al.'' |title=Metallothionein: an overview. |journal=World J. Gastroenterol. |volume=13 |issue= 7 |pages= 993-6 |year= 2007 |pmid= 17373731 |doi= }}
*{{cite journal | author=Sutherland GR, Baker E, Callen DF, ''et al.'' |title=The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia. |journal=Genomics |volume=6 |issue= 1 |pages= 144-8 |year= 1990 |pmid= 2303255 |doi= }}
*{{cite journal | author=Grider A, Bailey LB, Cousins RJ |title=Erythrocyte metallothionein as an index of zinc status in humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 4 |pages= 1259-62 |year= 1990 |pmid= 2304897 |doi= }}
*{{cite journal | author=Le Beau MM, Diaz MO, Karin M, Rowley JD |title=Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia. |journal=Nature |volume=313 |issue= 6004 |pages= 709-11 |year= 1985 |pmid= 3856101 |doi= }}
*{{cite journal | author=Hunziker PE, Kägi JH |title=Isolation and characterization of six human hepatic isometallothioneins. |journal=Biochem. J. |volume=231 |issue= 2 |pages= 375-82 |year= 1985 |pmid= 4062903 |doi= }}
*{{cite journal | author=Karin M, Eddy RL, Henry WM, ''et al.'' |title=Human metallothionein genes are clustered on chromosome 16. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 17 |pages= 5494-8 |year= 1984 |pmid= 6089206 |doi= }}
*{{cite journal | author=Richards RI, Heguy A, Karin M |title=Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. |journal=Cell |volume=37 |issue= 1 |pages= 263-72 |year= 1984 |pmid= 6327055 |doi= }}
*{{cite journal | author=Armitage IM, Otvos JD, Briggs RW, Boulanger Y |title=Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR. |journal=Fed. Proc. |volume=41 |issue= 13 |pages= 2974-80 |year= 1983 |pmid= 7140998 |doi= }}
*{{cite journal | author=Akintola DF, Sampson B, Fleck A |title=Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine. |journal=J. Lab. Clin. Med. |volume=126 |issue= 2 |pages= 119-27 |year= 1995 |pmid= 7543551 |doi= }}
*{{cite journal | author=Davis SR, McMahon RJ, Cousins RJ |title=Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. |journal=J. Nutr. |volume=128 |issue= 5 |pages= 825-31 |year= 1998 |pmid= 9566988 |doi= }}
*{{cite journal | author=Simpkins C, Lloyd T, Li S, Balderman S |title=Metallothionein-induced increase in mitochondrial inner membrane permeability. |journal=J. Surg. Res. |volume=75 |issue= 1 |pages= 30-4 |year= 1998 |pmid= 9614853 |doi= 10.1006/jsre.1997.5241 }}
*{{cite journal | author=Lau JC, Cherian MG |title=Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice. |journal=Biochem. Cell Biol. |volume=76 |issue= 4 |pages= 615-23 |year= 1999 |pmid= 10099782 |doi= }}
*{{cite journal | author=Levadoux M, Mahon C, Beattie JH, ''et al.'' |title=Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34961-6 |year= 2000 |pmid= 10574972 |doi= }}
*{{cite journal | author=Garrett SH, Sens MA, Shukla D, ''et al.'' |title=Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. |journal=Prostate |volume=43 |issue= 2 |pages= 125-35 |year= 2000 |pmid= 10754528 |doi= }}
*{{cite journal | author=Vandeghinste N, Proost P, De Ley M |title=Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 2 |pages= 419-33 |year= 2000 |pmid= 10774930 |doi= }}
*{{cite journal | author=Campagne MV, Thibodeaux H, van Bruggen N, ''et al.'' |title=Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. |journal=J. Neurosci. |volume=20 |issue= 14 |pages= 5200-7 |year= 2000 |pmid= 10884303 |doi= }}
*{{cite journal | author=Rahman MT, De Ley M |title=Metallothionein isogene transcription in red blood cell precursors from human cord blood. |journal=Eur. J. Biochem. |volume=268 |issue= 3 |pages= 849-56 |year= 2001 |pmid= 11168427 |doi= }}
*{{cite journal | author=Levadoux-Martin M, Hesketh JE, Beattie JH, Wallace HM |title=Influence of metallothionein-1 localization on its function. |journal=Biochem. J. |volume=355 |issue= Pt 2 |pages= 473-9 |year= 2001 |pmid= 11284736 |doi= }}
*{{cite journal | author=Richarz AN, Brätter P |title=Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins. |journal=Analytical and bioanalytical chemistry |volume=372 |issue= 3 |pages= 412-7 |year= 2002 |pmid= 11939525 |doi= 10.1007/s00216-001-1187-5 }}
*{{cite journal | author=Minami T, Kubo K, Ichida S |title=Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH. |journal=J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |volume=779 |issue= 2 |pages= 211-9 |year= 2003 |pmid= 12361735 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MYOG... {November 19, 2007 11:41:01 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:41:24 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myogenin (myogenic factor 4)
| HGNCid = 7612
| Symbol = MYOG
| AltSymbols =; MYF4; MYOGENIN
| OMIM = 159980
| ECnumber =
| Homologene = 1854
| MGIid = 97276
| GeneAtlas_image1 = PBB_GE_MYOG_207282_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007519 |text = striated muscle development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4656
| Hs_Ensembl = ENSG00000122180
| Hs_RefseqProtein = NP_002470
| Hs_RefseqmRNA = NM_002479
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 201318883
| Hs_GenLoc_end = 201321789
| Hs_Uniprot = P15173
| Mm_EntrezGene = 17928
| Mm_Ensembl = ENSMUSG00000026459
| Mm_RefseqmRNA = NM_031189
| Mm_RefseqProtein = NP_112466
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 136106400
| Mm_GenLoc_end = 136108958
| Mm_Uniprot = P12979
}}
}}
'''Myogenin (myogenic factor 4)''', also known as '''MYOG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYOG myogenin (myogenic factor 4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4656| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle.<ref name="entrez">{{cite web | title = Entrez Gene: MYOG myogenin (myogenic factor 4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4656| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Weintraub H, Davis R, Tapscott S, ''et al.'' |title=The myoD gene family: nodal point during specification of the muscle cell lineage. |journal=Science |volume=251 |issue= 4995 |pages= 761-6 |year= 1991 |pmid= 1846704 |doi= }}
*{{cite journal | author=Chakraborty T, Martin JF, Olson EN |title=Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system. |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 17498-501 |year= 1992 |pmid= 1325437 |doi= }}
*{{cite journal | author=Funk WD, Wright WE |title=Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 20 |pages= 9484-8 |year= 1992 |pmid= 1329097 |doi= }}
*{{cite journal | author=Lassar AB, Davis RL, Wright WE, ''et al.'' |title=Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. |journal=Cell |volume=66 |issue= 2 |pages= 305-15 |year= 1991 |pmid= 1649701 |doi= }}
*{{cite journal | author=Salminen A, Braun T, Buchberger A, ''et al.'' |title=Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins. |journal=J. Cell Biol. |volume=115 |issue= 4 |pages= 905-17 |year= 1991 |pmid= 1659574 |doi= }}
*{{cite journal | author=Pearson-White SH |title=Human MyoD: cDNA and deduced amino acid sequence. |journal=Nucleic Acids Res. |volume=19 |issue= 5 |pages= 1148 |year= 1991 |pmid= 1850513 |doi= }}
*{{cite journal | author=Olson E, Edmondson D, Wright WE, ''et al.'' |title=Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes. |journal=Genomics |volume=8 |issue= 3 |pages= 427-34 |year= 1991 |pmid= 1962752 |doi= }}
*{{cite journal | author=Brennan TJ, Olson EN |title=Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization. |journal=Genes Dev. |volume=4 |issue= 4 |pages= 582-95 |year= 1990 |pmid= 2163343 |doi= }}
*{{cite journal | author=Braun T, Bober E, Buschhausen-Denker G, ''et al.'' |title=Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3617-25 |year= 1990 |pmid= 2583111 |doi= }}
*{{cite journal | author=Groisman R, Masutani H, Leibovitch MP, ''et al.'' |title=Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5258-64 |year= 1996 |pmid= 8617811 |doi= }}
*{{cite journal | author=Chen CM, Kraut N, Groudine M, Weintraub H |title=I-mf, a novel myogenic repressor, interacts with members of the MyoD family. |journal=Cell |volume=86 |issue= 5 |pages= 731-41 |year= 1996 |pmid= 8797820 |doi= }}
*{{cite journal | author=Kong Y, Flick MJ, Kudla AJ, Konieczny SF |title=Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. |journal=Mol. Cell. Biol. |volume=17 |issue= 8 |pages= 4750-60 |year= 1997 |pmid= 9234731 |doi= }}
*{{cite journal | author=Langlands K, Yin X, Anand G, Prochownik EV |title=Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19785-93 |year= 1997 |pmid= 9242638 |doi= }}
*{{cite journal | author=Biesiada E, Hamamori Y, Kedes L, Sartorelli V |title=Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 2577-84 |year= 1999 |pmid= 10082523 |doi= }}
*{{cite journal | author=Tseng BS, Cavin ST, Hoffman EP, ''et al.'' |title=Human bHLH transcription factor gene myogenin (MYOG): genomic sequence and negative mutation analysis in patients with severe congenital myopathies. |journal=Genomics |volume=57 |issue= 3 |pages= 419-23 |year= 1999 |pmid= 10329008 |doi= 10.1006/geno.1998.5719 }}
*{{cite journal | author=Knoepfler PS, Bergstrom DA, Uetsuki T, ''et al.'' |title=A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. |journal=Nucleic Acids Res. |volume=27 |issue= 18 |pages= 3752-61 |year= 1999 |pmid= 10471746 |doi= }}
*{{cite journal | author=Onions J, Hermann S, Grundström T |title=A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors. |journal=Biochemistry |volume=39 |issue= 15 |pages= 4366-74 |year= 2000 |pmid= 10757985 |doi= }}
*{{cite journal | author=Corbi N, Di Padova M, De Angelis R, ''et al.'' |title=The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin. |journal=FASEB J. |volume=16 |issue= 12 |pages= 1639-41 |year= 2002 |pmid= 12207009 |doi= 10.1096/fj.02-0123fje }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
end log.
