User:ProteinBoxBot/PBB Log Wiki 11-8-2007 A-3

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Contents 1 Log file for Protein Box Bot 2 Protein Status Quick Log - Date: 19:28, 8 November 2007 (UTC) 2.1 Proteins without matches (17) 2.2 Proteins with a High Potential Match (8) 2.3 Created (10) 2.4 Manual Inspection (Page not found) (15) 3 Protein Status Grid - Date: 19:28, 8 November 2007 (UTC) 4 Vebose Log - Date: 19:28, 8 November 2007 (UTC) 4.1 CALCRL 4.2 CCL11 4.3 CTSS 4.4 DEFA1 4.5 DUSP1 4.6 ENPP1 4.7 FABP2 4.8 FES 4.9 FTH1 4.10 GCH1 4.11 HAMP 4.12 IL11 4.13 MICB 4.14 NOTCH3 4.15 PDGFA 4.16 PDX1 4.17 PTPRA 4.18 RANBP2 4.19 RANBP5 4.20 RUNX3 4.21 SDC4 4.22 TERC 4.23 TRADD 4.24 UTRN 4.25 WASL

[edit] Log file for Protein Box Bot

Log page index: User:ProteinBoxBot/PBB_Log_Index

[edit] Protein Status Quick Log - Date: 19:28, 8 November 2007 (UTC)

[edit] Proteins without matches (17)

DEFA1	NOTCH3	TERC	PDGFA	MICB
RANBP5	RUNX3	RANBP2	CALCRL	FES
PDX1	WASL	FABP2	ENPP1	SDC4
DUSP1	CTSS

[edit] Proteins with a High Potential Match (8)

GCH1	HAMP	FTH1	UTRN	IL11
PTPRA	TRADD	CCL11

[edit] Created (10)

PDGFA	MICB	RANBP5	RUNX3	RANBP2
CALCRL	PDX1	FABP2	SDC4	DUSP1

[edit] Manual Inspection (Page not found) (15)

DEFA1	GCH1	NOTCH3	TERC	HAMP
FTH1	UTRN	FES	WASL	IL11
ENPP1	PTPRA	TRADD	CTSS	CCL11

[edit] Protein Status Grid - Date: 19:28, 8 November 2007 (UTC)

HUGO Symbol	Action Summary	Target page(s)	WP Symbol Search
DEFA1	Manual Inspection (Page not found)	Other Pages: Defensin (Unknown Data); DEFA1 (No Data); DEF1 (No Data); Def1 (No Data); DEFA2 (No Data); Defa2 (No Data); HNP-1 (No Data); Hnp-1 (No Data); HP-1 (No Data); Hp-1 (No Data); MGC138393 (No Data); Mgc138393 (No Data); MRS (DisAmbig); Mrs (Redirect -> Mrs.); DEF3 (No Data); Def3 (No Data); HNP-3 (No Data); Hnp-3 (No Data); HNP3 (No Data); Hnp3 (No Data); HP-3 (No Data); Hp-3 (No Data); Mrs. (Unknown Data);	[1]
GCH1	Manual Inspection (Page not found)	Other Pages: GTP cyclohydrolase 1 (Redirect -> GTP cyclohydrolase I); GCH1 (No Data); DYT5 (No Data); Dyt5 (No Data); GCH (DisAmbig); Gch (No Data); GTP-CH-1 (No Data); Gtp-ch-1 (No Data); GTPCH1 (No Data); Gtpch1 (No Data); GTP cyclohydrolase I (Protein Template);	[2]
NOTCH3	Manual Inspection (Page not found)	Other Pages: Notch homolog 3 (No Data); NOTCH3 (No Data); CADASIL (Unknown Data); Cadasil (Redirect -> CADASIL); CASIL (No Data); Casil (No Data);	[3]
TERC	Manual Inspection (Page not found)	Other Pages: Telomerase RNA component (No Data); TERC (Redirect -> Investigations in Numbers, Data, and Space); TR (DisAmbig); Tr (Redirect -> TR); SCARNA19 (No Data); Scarna19 (No Data); TRC3 (No Data); Trc3 (No Data); HTR (Redirect -> Very high temperature reactor); Htr (No Data); Investigations in Numbers, Data, and Space (Unknown Data); Very high temperature reactor (Unknown Data);	[4]
HAMP	Manual Inspection (Page not found)	Other Pages: Hepcidin antimicrobial peptide (No Data); HAMP (Redirect -> Hepcidin); HEPC (No Data); Hepc (No Data); HFE2B (No Data); Hfe2b (No Data); LEAP-1 (Redirect -> Hepcidin); Leap-1 (No Data); LEAP1 (No Data); Leap1 (No Data); Hepcidin (Protein Template);	[5]
PDGFA	Created	Other Pages: Platelet-derived growth factor alpha polypeptide (No Data); PDGFA (No Data); PDGF-A (No Data); Pdgf-a (No Data); PDGF1 (No Data); Pdgf1 (No Data);	[6]
MICB	Created	Other Pages: MHC class I polypeptide-related sequence B (No Data); MICB (No Data); PERB11.2 (No Data); Perb11.2 (No Data);	[7]
RANBP5	Created	Other Pages: RAN binding protein 5 (No Data); RANBP5 (No Data); DKFZp686O1576 (No Data); Dkfzp686o1576 (No Data); FLJ43041 (No Data); Flj43041 (No Data); IMB3 (No Data); Imb3 (No Data); IPO5 (No Data); Ipo5 (No Data); KPNB3 (No Data); Kpnb3 (No Data); MGC2068 (No Data); Mgc2068 (No Data);	[8]
RUNX3	Created	Other Pages: Runt-related transcription factor 3 (No Data); RUNX3 (No Data); AML2 (No Data); Aml2 (No Data); CBFA3 (No Data); Cbfa3 (No Data); FLJ34510 (No Data); Flj34510 (No Data); MGC16070 (No Data); Mgc16070 (No Data); PEBP2aC (No Data); Pebp2ac (No Data);	[9]
RANBP2	Created	Other Pages: RAN binding protein 2 (No Data); RANBP2 (No Data); TRP1 (No Data); Trp1 (No Data); NUP358 (No Data); Nup358 (No Data); TRP2 (No Data); Trp2 (No Data);	[10]
CALCRL	Created	Other Pages: Calcitonin receptor-like (No Data); CALCRL (No Data); CGRPR (No Data); Cgrpr (No Data); CRLR (No Data); Crlr (No Data);	[11]
FTH1	Manual Inspection (Page not found)	Other Pages: Ferritin (Protein Template); FTH1 (No Data); FTH (No Data); Fth (No Data); FTHL6 (No Data); Fthl6 (No Data); MGC104426 (No Data); Mgc104426 (No Data); PIG15 (No Data); Pig15 (No Data); PLIF (DisAmbig); Plif (No Data);	[12]
UTRN	Manual Inspection (Page not found)	Other Pages: Utrophin (Protein Template); UTRN (No Data); DRP1 (No Data); Drp1 (No Data); DMDL (No Data); Dmdl (No Data); DRP (DisAmbig); Drp (No Data); FLJ23678 (No Data); Flj23678 (No Data);	[13]
FES	Manual Inspection (Page not found)	Other Pages: Feline sarcoma oncogene (No Data); FES (DisAmbig); FPS (DisAmbig); Fps (Redirect -> FPS);	[14]
PDX1	Created	Other Pages: Pancreatic and duodenal homeobox 1 (No Data); PDX1 (No Data); IDX-1 (No Data); Idx-1 (No Data); IPF1 (No Data); Ipf1 (No Data); IUF1 (No Data); Iuf1 (No Data); MODY4 (No Data); Mody4 (No Data); PDX-1 (No Data); Pdx-1 (No Data); STF-1 (No Data); Stf-1 (No Data);	[15]
WASL	Manual Inspection (Page not found)	Other Pages: Wiskott-Aldrich syndrome-like (No Data); WASL (DisAmbig); DKFZp779G0847 (No Data); Dkfzp779g0847 (No Data); MGC48327 (No Data); Mgc48327 (No Data); N-WASP (No Data); N-wasp (No Data);	[16]
FABP2	Created	Other Pages: Fatty acid binding protein 2 (No Data); FABP2 (No Data); FABPI (No Data); Fabpi (No Data); I-FABP (No Data); I-fabp (No Data); MGC133132 (No Data); Mgc133132 (No Data);	[17]
IL11	Manual Inspection (Page not found)	Other Pages: Interleukin 11 (Protein Template); IL11 (No Data); AGIF (Redirect -> American GI Forum); Agif (No Data); IL-11 (Redirect -> interleukin 11); Il-11 (No Data); American GI Forum (Unknown Data);	[18]
ENPP1	Manual Inspection (Page not found)	Other Pages: Ectonucleotide pyrophosphatase/phosphodiesterase 1 (No Data); ENPP1 (No Data); M6S1 (No Data); M6s1 (No Data); NPP1 (No Data); Npp1 (No Data); NPPS (No Data); Npps (No Data); PC-1 (Redirect -> PC-1 (cable system)); Pc-1 (No Data); PCA1 (No Data); Pca1 (No Data); PDNP1 (No Data); Pdnp1 (No Data); PC-1 (cable system) (Unknown Data);	[19]
PTPRA	Manual Inspection (Page not found)	Other Pages: Protein tyrosine phosphatase (Protein Template); PTPRA (No Data); LRP (DisAmbig); Lrp (No Data); PTPA (No Data); Ptpa (No Data); HEPTP (No Data); Heptp (No Data); HLPR (No Data); Hlpr (No Data); HPTPA (No Data); Hptpa (No Data); HPTPalpha (No Data); Hptpalpha (No Data); PTPRL2 (No Data); Ptprl2 (No Data); R-PTP-alpha (No Data); R-ptp-alpha (No Data); RPTPA (No Data); Rptpa (No Data);	[20]
SDC4	Created	Other Pages: Syndecan 4 (No Data); SDC4 (No Data); MGC22217 (No Data); Mgc22217 (No Data); SYND4 (No Data); Synd4 (No Data);	[21]
TRADD	Manual Inspection (Page not found)	Other Pages: TNFRSF1A-associated via death domain (No Data); TRADD (Protein Template); Hs.89862 (No Data); MGC11078 (No Data); Mgc11078 (No Data);	[22]
DUSP1	Created	Other Pages: Dual specificity phosphatase 1 (No Data); DUSP1 (No Data); CL100 (No Data); Cl100 (No Data); HVH1 (No Data); Hvh1 (No Data); MKP-1 (No Data); Mkp-1 (No Data); PTPN10 (No Data); Ptpn10 (No Data);	[23]
CTSS	Manual Inspection (Page not found)	Other Pages: Cathepsin S (Redirect -> Cathepsin); CTSS (Redirect -> Compatible Time-Sharing System); MGC3886 (No Data); Mgc3886 (No Data); Cathepsin (Unknown Data); Compatible Time-Sharing System (Unknown Data);	[24]
CCL11	Manual Inspection (Page not found)	Other Pages: Chemokine ligand 11 (No Data); CCL11 (Protein Template); MGC22554 (No Data); Mgc22554 (No Data); SCYA11 (No Data); Scya11 (No Data);	[25]

[edit] Vebose Log - Date: 19:28, 8 November 2007 (UTC)

[edit] CALCRL

• INFO: Beginning work on CALCRL... {November 8, 2007 11:18:43 AM PST}
• CREATE: Found no pages, creating new page. {November 8, 2007 11:19:38 AM PST}
• CREATED: Created new protein page: CALCRL {November 8, 2007 11:19:46 AM PST}

[edit] CCL11

• INFO: Beginning work on CCL11... {November 8, 2007 11:12:22 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:12:55 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:13:08 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_CCL11_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1eot.
 | PDB = {{PDB2|1eot}}, {{PDB2|2eot}}
 | Name = Chemokine (C-C motif) ligand 11
 | HGNCid = 10610
 | Symbol = CCL11
 | AltSymbols =; MGC22554; SCYA11
 | OMIM = 601156
 | ECnumber =  
 | Homologene = 7929
 | MGIid = 103576
 | GeneAtlas_image1 = PBB_GE_CCL11_210133_at_tn.png
 | Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} 
 | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0009314 |text = response to radiation}} {{GNF_GO|id=GO:0009615 |text = response to virus}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6356
    | Hs_Ensembl = ENSG00000172156
    | Hs_RefseqProtein = NP_002977
    | Hs_RefseqmRNA = NM_002986
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 29636800
    | Hs_GenLoc_end = 29639312
    | Hs_Uniprot = P51671
    | Mm_EntrezGene = 20292
    | Mm_Ensembl = ENSMUSG00000020676
    | Mm_RefseqmRNA = NM_011330
    | Mm_RefseqProtein = NP_035460
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 81874046
    | Mm_GenLoc_end = 81879144
    | Mm_Uniprot = Q5SVB5
  }}
}}
'''Chemokine (C-C motif) ligand 11''', also known as '''CCL11''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.<ref>{{cite web | title = Entrez Gene: CCL11 chemokine (C-C motif) ligand 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6356| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

[edit] CTSS

• INFO: Beginning work on CTSS... {November 8, 2007 10:54:53 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 10:55:46 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 10:55:58 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no 
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_CTSS_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1glo.
 | PDB = {{PDB2|1glo}}, {{PDB2|1ms6}}, {{PDB2|1npz}}, {{PDB2|1nqc}}, {{PDB2|2c0y}}, {{PDB2|2f1g}}, {{PDB2|2fq9}}, {{PDB2|2fra}}, {{PDB2|2frq}}, {{PDB2|2ft2}}, {{PDB2|2fud}}, {{PDB2|2fye}}, {{PDB2|2g6d}}, {{PDB2|2g7y}}, {{PDB2|2h7j}}, {{PDB2|2hh5}}, {{PDB2|2hhn}}, {{PDB2|2hxz}}, {{PDB2|2op3}}
 | Name = Cathepsin S
 | HGNCid = 2545
 | Symbol = CTSS
 | AltSymbols =; MGC3886
 | OMIM = 116845
 | ECnumber =  
 | Homologene = 20867
 | MGIid = 107341
 | GeneAtlas_image1 = PBB_GE_CTSS_202902_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_CTSS_202901_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0004218 |text = cathepsin S activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006955 |text = immune response}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1520
    | Hs_Ensembl = ENSG00000163131
    | Hs_RefseqProtein = NP_004070
    | Hs_RefseqmRNA = NM_004079
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 148969296
    | Hs_GenLoc_end = 149005057
    | Hs_Uniprot = P25774
    | Mm_EntrezGene = 13040
    | Mm_Ensembl = ENSMUSG00000038642
    | Mm_RefseqmRNA = NM_021281
    | Mm_RefseqProtein = NP_067256
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 95612190
    | Mm_GenLoc_end = 95641804
    | Mm_Uniprot = Q3U5K1
  }}
}}
'''Cathepsin S''', also known as '''CTSS''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Transcript variants utilizing alternative polyadenylation signals exist for this gene.<ref>{{cite web | title = Entrez Gene: CTSS cathepsin S| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1520| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

[edit] DEFA1

• INFO: Beginning work on DEFA1... {November 8, 2007 10:55:58 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 10:56:30 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 10:56:58 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_DEFA1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dfn.
 | PDB = {{PDB2|1dfn}}, {{PDB2|1zmh}}, {{PDB2|1zmi}}, {{PDB2|1zmk}}, {{PDB2|2pm1}}, {{PDB2|2pm4}}, {{PDB2|2pm5}}
 | Name = Defensin, alpha 1
 | HGNCid = 2761
 | Symbol = DEFA1
 | AltSymbols =; DEF1; DEFA2; HNP-1; HP-1; MGC138393; MRS; DEF3; HNP-3; HNP3; HP-3
 | OMIM = 125220
 | ECnumber =  
 | Homologene = 37877
 | MGIid =  
 | GeneAtlas_image1 = PBB_GE_DEFA1_205033_s_at_tn.png
 | Function = 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} 
 | Process = {{GNF_GO|id=GO:0006805 |text = xenobiotic metabolic process}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0050832 |text = defense response to fungus}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1667
    | Hs_Ensembl = ENSG00000185918
    | Hs_RefseqProtein = NP_004075
    | Hs_RefseqmRNA = NM_004084
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 6860801
    | Hs_GenLoc_end = 6863233
    | Hs_Uniprot = P59666
    | Mm_EntrezGene =  
    | Mm_Ensembl =  
    | Mm_RefseqmRNA =  
    | Mm_RefseqProtein =  
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Defensin, alpha 1''', also known as '''DEFA1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It differs from defensin, alpha 3 by only one amino acid.<ref>{{cite web | title = Entrez Gene: DEFA1 defensin, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1667| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Lehrer RI, Lichtenstein AK, Ganz T |title=Defensins: antimicrobial and cytotoxic peptides of mammalian cells. |journal=Annu. Rev. Immunol. |volume=11 |issue=  |pages= 105-28 |year= 1993 |pmid= 8476558 |doi= 10.1146/annurev.iy.11.040193.000541 }}
*{{cite journal  | author=Corda D, Di Girolamo M |title=Mono-ADP-ribosylation: a tool for modulating immune response and cell signaling. |journal=Sci. STKE |volume=2002 |issue= 163 |pages= PE53 |year= 2003 |pmid= 12488509 |doi= 10.1126/stke.2002.163.pe53 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] DUSP1

• INFO: Beginning work on DUSP1... {November 8, 2007 10:56:58 AM PST}
• CREATE: Found no pages, creating new page. {November 8, 2007 10:57:52 AM PST}
• CREATED: Created new protein page: DUSP1 {November 8, 2007 10:57:59 AM PST}

[edit] ENPP1

• INFO: Beginning work on ENPP1... {November 8, 2007 11:08:58 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:10:08 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Ectonucleotide pyrophosphatase/phosphodiesterase 1
 | HGNCid = 3356
 | Symbol = ENPP1
 | AltSymbols =; M6S1; NPP1; NPPS; PC-1; PCA1; PDNP1
 | OMIM = 173335
 | ECnumber =  
 | Homologene = 38151
 | MGIid = 97370
 | GeneAtlas_image1 = PBB_GE_ENPP1_205066_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_ENPP1_205065_at_tn.png
 | Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004528 |text = phosphodiesterase I activity}} {{GNF_GO|id=GO:0004551 |text = nucleotide diphosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} 
 | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006796 |text = phosphate metabolic process}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0009117 |text = nucleotide metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5167
    | Hs_Ensembl = ENSG00000197594
    | Hs_RefseqProtein = NP_006199
    | Hs_RefseqmRNA = NM_006208
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 132170849
    | Hs_GenLoc_end = 132257988
    | Hs_Uniprot = P22413
    | Mm_EntrezGene = 18605
    | Mm_Ensembl = ENSMUSG00000037370
    | Mm_RefseqmRNA = NM_008813
    | Mm_RefseqProtein = NP_032839
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 24330827
    | Mm_GenLoc_end = 24401518
    | Mm_Uniprot = Q3V3C8
  }}
}}
'''Ectonucleotide pyrophosphatase/phosphodiesterase 1''', also known as '''ENPP1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.<ref>{{cite web | title = Entrez Gene: ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5167| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Abate N, Chandalia M, Di Paola R, ''et al.'' |title=Mechanisms of disease: Ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptors. |journal=Nature clinical practice. Endocrinology & metabolism |volume=2 |issue= 12 |pages= 694-701 |year= 2007 |pmid= 17143316 |doi= 10.1038/ncpendmet0367 }}
*{{cite journal  | author=Bacci S, De Cosmo S, Prudente S, Trischitta V |title=ENPP1 gene, insulin resistance and related clinical outcomes. |journal=Current opinion in clinical nutrition and metabolic care |volume=10 |issue= 4 |pages= 403-9 |year= 2007 |pmid= 17563456 |doi= 10.1097/MCO.0b013e3281e386c9 }}
*{{cite journal  | author=Fadini GP, Pauletto P, Avogaro A, Rattazzi M |title=The good and the bad in the link between insulin resistance and vascular calcification. |journal=Atherosclerosis |volume=193 |issue= 2 |pages= 241-4 |year= 2007 |pmid= 17606264 |doi= 10.1016/j.atherosclerosis.2007.05.015 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] FABP2

• INFO: Beginning work on FABP2... {November 8, 2007 10:57:59 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 10:58:34 AM PST}
• CREATE: Found no pages, creating new page. {November 8, 2007 10:58:48 AM PST}
• CREATED: Created new protein page: FABP2 {November 8, 2007 10:58:55 AM PST}

[edit] FES

• INFO: Beginning work on FES... {November 8, 2007 10:58:55 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 10:59:40 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 10:59:50 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_FES_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wqu.
 | PDB = {{PDB2|1wqu}}, {{PDB2|2dcr}}
 | Name = Feline sarcoma oncogene
 | HGNCid = 3657
 | Symbol = FES
 | AltSymbols =; FPS
 | OMIM = 190030
 | ECnumber =  
 | Homologene = 37563
 | MGIid = 95514
 | GeneAtlas_image1 = PBB_GE_FES_205418_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2242
    | Hs_Ensembl = ENSG00000182511
    | Hs_RefseqProtein = NP_001996
    | Hs_RefseqmRNA = NM_002005
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 89228713
    | Hs_GenLoc_end = 89240010
    | Hs_Uniprot = P07332
    | Mm_EntrezGene = 14159
    | Mm_Ensembl = ENSMUSG00000053158
    | Mm_RefseqmRNA = XM_981464
    | Mm_RefseqProtein = XP_986558
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 80251268
    | Mm_GenLoc_end = 80261449
    | Mm_Uniprot = Q3TD20
  }}
}}
'''Feline sarcoma oncogene''', also known as '''FES''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.<ref>{{cite web | title = Entrez Gene: FES feline sarcoma oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2242| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Smithgall TE, Rogers JA, Peters KL, ''et al.'' |title=The c-Fes family of protein-tyrosine kinases. |journal=Critical reviews in oncogenesis |volume=9 |issue= 1 |pages= 43-62 |year= 1998 |pmid= 9754447 |doi=  }}
*{{cite journal  | author=Jiang H, Harris MB, Rothman P |title=IL-4/IL-13 signaling beyond JAK/STAT. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 6 Pt 1 |pages= 1063-70 |year= 2000 |pmid= 10856136 |doi=  }}
*{{cite journal  | author=Greer P |title=Closing in on the biological functions of Fps/Fes and Fer. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 4 |pages= 278-89 |year= 2002 |pmid= 11994747 |doi= 10.1038/nrm783 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] FTH1

• INFO: Beginning work on FTH1... {November 8, 2007 10:59:50 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:00:42 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:01:00 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_FTH1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fha.
 | PDB = {{PDB2|1fha}}, {{PDB2|2cei}}, {{PDB2|2chi}}, {{PDB2|2cih}}, {{PDB2|2clu}}, {{PDB2|2cn6}}, {{PDB2|2cn7}}, {{PDB2|2fha}}, {{PDB2|2iu2}}
 | Name = Ferritin, heavy polypeptide 1
 | HGNCid = 3976
 | Symbol = FTH1
 | AltSymbols =; FTH; FTHL6; MGC104426; PIG15; PLIF
 | OMIM = 134770
 | ECnumber =  
 | Homologene = 74295
 | MGIid = 95588
 | GeneAtlas_image1 = PBB_GE_FTH1_200748_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_FTH1_214211_at_tn.png
 | Function = {{GNF_GO|id=GO:0004322 |text = ferroxidase activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008199 |text = ferric iron binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0019900 |text = kinase binding}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0008043 |text = ferritin complex}} 
 | Process = {{GNF_GO|id=GO:0006826 |text = iron ion transport}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}} {{GNF_GO|id=GO:0006880 |text = intracellular sequestering of iron ion}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2495
    | Hs_Ensembl = ENSG00000167996
    | Hs_RefseqProtein = NP_002023
    | Hs_RefseqmRNA = NM_002032
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 61488335
    | Hs_GenLoc_end = 61491679
    | Hs_Uniprot = P02794
    | Mm_EntrezGene = 14319
    | Mm_Ensembl = ENSMUSG00000024661
    | Mm_RefseqmRNA = NM_010239
    | Mm_RefseqProtein = NP_034369
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 10049748
    | Mm_GenLoc_end = 10052137
    | Mm_Uniprot = P09528
  }}
}}
'''Ferritin, heavy polypeptide 1''', also known as '''FTH1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.<ref>{{cite web | title = Entrez Gene: FTH1 ferritin, heavy polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2495| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Percy ME, Wong S, Bauer S, ''et al.'' |title=Iron metabolism and human ferritin heavy chain cDNA from adult brain with an elongated untranslated region: new findings and insights. |journal=The Analyst |volume=123 |issue= 1 |pages= 41-50 |year= 1998 |pmid= 9581019 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

[edit] GCH1

• INFO: Beginning work on GCH1... {November 8, 2007 11:01:00 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:01:31 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:01:49 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_GCH1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fb1.
 | PDB = {{PDB2|1fb1}}, {{PDB2|1is7}}, {{PDB2|1is8}}, {{PDB2|1wpl}}
 | Name = GTP cyclohydrolase 1 (dopa-responsive dystonia)
 | HGNCid = 4193
 | Symbol = GCH1
 | AltSymbols =; DYT5; GCH; GTP-CH-1; GTPCH1
 | OMIM = 600225
 | ECnumber =  
 | Homologene = 132
 | MGIid = 95675
 | GeneAtlas_image1 = PBB_GE_GCH1_204224_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003934 |text = GTP cyclohydrolase I activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0006559 |text = L-phenylalanine catabolic process}} {{GNF_GO|id=GO:0006729 |text = tetrahydrobiopterin biosynthetic process}} {{GNF_GO|id=GO:0006809 |text = nitric oxide biosynthetic process}} {{GNF_GO|id=GO:0019438 |text = aromatic compound biosynthetic process}} {{GNF_GO|id=GO:0042133 |text = neurotransmitter metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2643
    | Hs_Ensembl = ENSG00000131979
    | Hs_RefseqProtein = NP_000152
    | Hs_RefseqmRNA = NM_000161
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 54378476
    | Hs_GenLoc_end = 54439292
    | Hs_Uniprot = P30793
    | Mm_EntrezGene = 14528
    | Mm_Ensembl = ENSMUSG00000037580
    | Mm_RefseqmRNA = NM_008102
    | Mm_RefseqProtein = NP_032128
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 46075772
    | Mm_GenLoc_end = 46111279
    | Mm_Uniprot = Q3U7P6
  }}
}}
'''GTP cyclohydrolase 1 (dopa-responsive dystonia)''', also known as '''GCH1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.<ref>{{cite web | title = Entrez Gene: GCH1 GTP cyclohydrolase 1 (dopa-responsive dystonia)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2643| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Thöny B, Blau N |title=Mutations in the GTP cyclohydrolase I and 6-pyruvoyl-tetrahydropterin synthase genes. |journal=Hum. Mutat. |volume=10 |issue= 1 |pages= 11-20 |year= 1997 |pmid= 9222755 |doi= 10.1002/(SICI)1098-1004(1997)10:1<11::AID-HUMU2>3.0.CO;2-P }}
*{{cite journal  | author=Müller U, Steinberger D, Topka H |title=Mutations of GCH1 in Dopa-responsive dystonia. |journal=Journal of neural transmission (Vienna, Austria : 1996) |volume=109 |issue= 3 |pages= 321-8 |year= 2002 |pmid= 11956954 |doi= 10.1007/s007020200026 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] HAMP

• INFO: Beginning work on HAMP... {November 8, 2007 11:19:46 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:20:55 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:21:13 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_HAMP_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1m4f.
 | PDB = {{PDB2|1m4f}}
 | Name = Hepcidin antimicrobial peptide
 | HGNCid = 15598
 | Symbol = HAMP
 | AltSymbols =; HEPC; HFE2B; LEAP-1; LEAP1
 | OMIM = 606464
 | ECnumber =  
 | Homologene = 81623
 | MGIid =  
 | GeneAtlas_image1 = PBB_GE_HAMP_220491_at_tn.png
 | Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} 
 | Process = {{GNF_GO|id=GO:0006805 |text = xenobiotic metabolic process}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0050832 |text = defense response to fungus}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57817
    | Hs_Ensembl = ENSG00000105697
    | Hs_RefseqProtein = NP_066998
    | Hs_RefseqmRNA = NM_021175
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 40465250
    | Hs_GenLoc_end = 40467886
    | Hs_Uniprot = P81172
    | Mm_EntrezGene =  
    | Mm_Ensembl =  
    | Mm_RefseqmRNA =  
    | Mm_RefseqProtein =  
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Hepcidin antimicrobial peptide''', also known as '''HAMP''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Ganz T |title=Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. |journal=Blood |volume=102 |issue= 3 |pages= 783-8 |year= 2003 |pmid= 12663437 |doi= 10.1182/blood-2003-03-0672 }}
*{{cite journal  | author=Roy CN, Andrews NC |title=Anemia of inflammation: the hepcidin link. |journal=Curr. Opin. Hematol. |volume=12 |issue= 2 |pages= 107-11 |year= 2005 |pmid= 15725899 |doi=  }}
*{{cite journal  | author=Fleming RE, Britton RS, Waheed A, ''et al.'' |title=Pathophysiology of hereditary hemochromatosis. |journal=Semin. Liver Dis. |volume=25 |issue= 4 |pages= 411-9 |year= 2006 |pmid= 16315135 |doi= 10.1055/s-2005-923313 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] IL11

• INFO: Beginning work on IL11... {November 8, 2007 11:01:49 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:02:44 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Interleukin 11
 | HGNCid = 5966
 | Symbol = IL11
 | AltSymbols =; AGIF; IL-11
 | OMIM = 147681
 | ECnumber =  
 | Homologene = 535
 | MGIid = 107613
 | GeneAtlas_image1 = PBB_GE_IL11_206926_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_IL11_206924_at_tn.png
 | Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005142 |text = interleukin-11 receptor binding}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} 
 | Process = {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}} {{GNF_GO|id=GO:0030219 |text = megakaryocyte differentiation}} {{GNF_GO|id=GO:0045444 |text = fat cell differentiation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3589
    | Hs_Ensembl = ENSG00000095752
    | Hs_RefseqProtein = NP_000632
    | Hs_RefseqmRNA = NM_000641
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 60567569
    | Hs_GenLoc_end = 60573626
    | Hs_Uniprot = P20809
    | Mm_EntrezGene = 16156
    | Mm_Ensembl = ENSMUSG00000004371
    | Mm_RefseqmRNA = NM_008350
    | Mm_RefseqProtein = NP_032376
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 4376654
    | Mm_GenLoc_end = 4379588
    | Mm_Uniprot = Q3V0U3
  }}
}}
'''Interleukin 11''', also known as '''IL11''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.<ref>{{cite web | title = Entrez Gene: IL11 interleukin 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3589| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Yang YC, Yin T |title=Interleukin-11 and its receptor. |journal=Biofactors |volume=4 |issue= 1 |pages= 15-21 |year= 1993 |pmid= 1292471 |doi=  }}
*{{cite journal  | author=Bhatia M, Davenport V, Cairo MS |title=The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors, lymphoma, acute myeloid leukemia and bone marrow failure syndromes. |journal=Leuk. Lymphoma |volume=48 |issue= 1 |pages= 9-15 |year= 2007 |pmid= 17325843 |doi= 10.1080/10428190600909115 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] MICB

• INFO: Beginning work on MICB... {November 8, 2007 11:05:55 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:06:45 AM PST}
• CREATE: Found no pages, creating new page. {November 8, 2007 11:06:58 AM PST}
• CREATED: Created new protein page: MICB {November 8, 2007 11:07:06 AM PST}

[edit] NOTCH3

• INFO: Beginning work on NOTCH3... {November 8, 2007 11:07:06 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:07:58 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Notch homolog 3 (Drosophila)
 | HGNCid = 7883
 | Symbol = NOTCH3
 | AltSymbols =; CADASIL; CASIL
 | OMIM = 600276
 | ECnumber =  
 | Homologene = 376
 | MGIid = 99460
 | GeneAtlas_image1 = PBB_GE_NOTCH3_203238_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_NOTCH3_203237_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} {{GNF_GO|id=GO:0045665 |text = negative regulation of neuron differentiation}} {{GNF_GO|id=GO:0048663 |text = neuron fate commitment}} {{GNF_GO|id=GO:0050793 |text = regulation of developmental process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4854
    | Hs_Ensembl = ENSG00000074181
    | Hs_RefseqProtein = NP_000426
    | Hs_RefseqmRNA = NM_000435
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 15131445
    | Hs_GenLoc_end = 15172792
    | Hs_Uniprot = Q9UM47
    | Mm_EntrezGene = 18131
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_008716
    | Mm_RefseqProtein = NP_032742
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Notch homolog 3 (Drosophila)''', also known as '''NOTCH3''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).<ref>{{cite web | title = Entrez Gene: NOTCH3 Notch homolog 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4854| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Lewis J |title=Neurogenic genes and vertebrate neurogenesis. |journal=Curr. Opin. Neurobiol. |volume=6 |issue= 1 |pages= 3-10 |year= 1996 |pmid= 8794055 |doi=  }}
*{{cite journal  | author=Joutel A, Tournier-Lasserve E |title=[Molecular basis and physiopathogenic mechanisms of CADASIL: a model of small vessel diseases of the brain] |journal=J. Soc. Biol. |volume=196 |issue= 1 |pages= 109-15 |year= 2002 |pmid= 12134625 |doi=  }}
*{{cite journal  | author=Guidetti D, Casali B, Mazzei RL, Dotti MT |title=Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. |journal=Clin. Exp. Hypertens. |volume=28 |issue= 3-4 |pages= 271-7 |year= 2006 |pmid= 16833034 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

[edit] PDGFA

• INFO: Beginning work on PDGFA... {November 8, 2007 11:07:58 AM PST}
• CREATE: Found no pages, creating new page. {November 8, 2007 11:08:49 AM PST}
• CREATED: Created new protein page: PDGFA {November 8, 2007 11:08:58 AM PST}

[edit] PDX1

• INFO: Beginning work on PDX1... {November 8, 2007 11:02:44 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:03:42 AM PST}
• CREATE: Found no pages, creating new page. {November 8, 2007 11:04:02 AM PST}
• CREATED: Created new protein page: PDX1 {November 8, 2007 11:04:09 AM PST}

[edit] PTPRA

• INFO: Beginning work on PTPRA... {November 8, 2007 11:10:08 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:10:22 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:10:48 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PTPRA_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p15.
 | PDB = {{PDB2|1p15}}, {{PDB2|1yfo}}
 | Name = Protein tyrosine phosphatase, receptor type, A
 | HGNCid = 9664
 | Symbol = PTPRA
 | AltSymbols =; LRP; PTPA; HEPTP; HLPR; HPTPA; HPTPalpha; PTPRL2; R-PTP-alpha; RPTPA
 | OMIM = 176884
 | ECnumber =  
 | Homologene = 20621
 | MGIid = 97808
 | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005001 |text = transmembrane receptor protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} 
 | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5786
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_002827
    | Hs_RefseqmRNA = NM_002836
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 19262
    | Mm_Ensembl = ENSMUSG00000027303
    | Mm_RefseqmRNA = NM_008980
    | Mm_RefseqProtein = NP_033006
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 130141723
    | Mm_GenLoc_end = 130245741
    | Mm_Uniprot = Q3TRY9
  }}
}}
'''Protein tyrosine phosphatase, receptor type, A''', also known as '''PTPRA''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.<ref>{{cite web | title = Entrez Gene: PTPRA protein tyrosine phosphatase, receptor type, A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5786| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Mustelin T, Hunter T |title=Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha. |journal=Sci. STKE |volume=2002 |issue= 115 |pages= PE3 |year= 2002 |pmid= 11796915 |doi= 10.1126/stke.2002.115.pe3 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] RANBP2

• INFO: Beginning work on RANBP2... {November 8, 2007 11:10:48 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:11:57 AM PST}
• CREATE: Found no pages, creating new page. {November 8, 2007 11:12:11 AM PST}
• CREATED: Created new protein page: RANBP2 {November 8, 2007 11:12:22 AM PST}

[edit] RANBP5

• INFO: Beginning work on RANBP5... {November 8, 2007 11:04:09 AM PST}
• CREATE: Found no pages, creating new page. {November 8, 2007 11:05:48 AM PST}
• CREATED: Created new protein page: RANBP5 {November 8, 2007 11:05:55 AM PST}

[edit] RUNX3

• INFO: Beginning work on RUNX3... {November 8, 2007 10:53:38 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 10:54:28 AM PST}
• CREATE: Found no pages, creating new page. {November 8, 2007 10:54:45 AM PST}
• CREATED: Created new protein page: RUNX3 {November 8, 2007 10:54:53 AM PST}

[edit] SDC4

• INFO: Beginning work on SDC4... {November 8, 2007 11:13:08 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:13:39 AM PST}
• CREATE: Found no pages, creating new page. {November 8, 2007 11:13:51 AM PST}
• CREATED: Created new protein page: SDC4 {November 8, 2007 11:13:59 AM PST}

[edit] TERC

• INFO: Beginning work on TERC... {November 8, 2007 11:13:59 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:15:38 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Telomerase RNA component
 | HGNCid = 11727
 | Symbol = TERC
 | AltSymbols =; TR; SCARNA19; TRC3; hTR
 | OMIM = 602322
 | ECnumber =  
 | Homologene =  
 | MGIid =  
 | Function = 
 | Component = 
 | Process = 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7012
    | Hs_Ensembl =  
    | Hs_RefseqProtein =  
    | Hs_RefseqmRNA =  
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene =  
    | Mm_Ensembl =  
    | Mm_RefseqmRNA =  
    | Mm_RefseqProtein =  
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Telomerase RNA component''', also known as '''TERC''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia.<ref>{{cite web | title = Entrez Gene: TERC telomerase RNA component| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7012| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=de Lange T, Jacks T |title=For better or worse? Telomerase inhibition and cancer. |journal=Cell |volume=98 |issue= 3 |pages= 273-5 |year= 1999 |pmid= 10458601 |doi=  }}
*{{cite journal  | author=Marrone A, Dokal I |title=Dyskeratosis congenita: molecular insights into telomerase function, ageing and cancer. |journal=Expert reviews in molecular medicine |volume=6 |issue= 26 |pages= 1-23 |year= 2007 |pmid= 15613268 |doi= 10.1017/S1462399404008671 }}
*{{cite journal  | author=Yamaguchi H |title=Mutations of telomerase complex genes linked to bone marrow failures. |journal=Journal of Nippon Medical School = Nihon Ika Daigaku zasshi |volume=74 |issue= 3 |pages= 202-9 |year= 2007 |pmid= 17625368 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

[edit] TRADD

• INFO: Beginning work on TRADD... {November 8, 2007 11:16:49 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:17:40 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:17:53 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_TRADD_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1f2h.
 | PDB = {{PDB2|1f2h}}, {{PDB2|1f3v}}
 | Name = TNFRSF1A-associated via death domain
 | HGNCid = 12030
 | Symbol = TRADD
 | AltSymbols =; Hs.89862; MGC11078
 | OMIM = 603500
 | ECnumber =  
 | Homologene = 2807
 | MGIid = 109200
 | GeneAtlas_image1 = PBB_GE_TRADD_1729_at_tn.png
 | GeneAtlas_image2 = PBB_GE_TRADD_205641_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8717
    | Hs_Ensembl = ENSG00000102871
    | Hs_RefseqProtein = NP_700474
    | Hs_RefseqmRNA = NM_153425
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 65745605
    | Hs_GenLoc_end = 65751306
    | Hs_Uniprot = Q15628
    | Mm_EntrezGene = 71609
    | Mm_Ensembl = ENSMUSG00000031887
    | Mm_RefseqmRNA = NM_001033161
    | Mm_RefseqProtein = NP_001028333
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 108147415
    | Mm_GenLoc_end = 108153738
    | Mm_Uniprot =  
  }}
}}
'''TNFRSF1A-associated via death domain''', also known as '''TRADD''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.<ref>{{cite web | title = Entrez Gene: TRADD TNFRSF1A-associated via death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8717| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Baker SJ, Reddy EP |title=Modulation of life and death by the TNF receptor superfamily. |journal=Oncogene |volume=17 |issue= 25 |pages= 3261-70 |year= 1999 |pmid= 9916988 |doi= 10.1038/sj.onc.1202568 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] UTRN

• INFO: Beginning work on UTRN... {November 8, 2007 11:15:38 AM PST}
• UPLOAD: Added new Image to wiki: {November 8, 2007 11:16:32 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:16:49 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_UTRN_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bhd.
 | PDB = {{PDB2|1bhd}}, {{PDB2|1qag}}
 | Name = Utrophin
 | HGNCid = 12635
 | Symbol = UTRN
 | AltSymbols =; DRP1; DMDL; DRP; FLJ23678
 | OMIM = 128240
 | ECnumber =  
 | Homologene = 21398
 | MGIid = 104631
 | GeneAtlas_image1 = PBB_GE_UTRN_213023_at_tn.png
 | GeneAtlas_image2 = PBB_GE_UTRN_213022_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0030054 |text = cell junction}} {{GNF_GO|id=GO:0045202 |text = synapse}} 
 | Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007517 |text = muscle development}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7402
    | Hs_Ensembl = ENSG00000152818
    | Hs_RefseqProtein = NP_009055
    | Hs_RefseqmRNA = NM_007124
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 144654658
    | Hs_GenLoc_end = 145215863
    | Hs_Uniprot = P46939
    | Mm_EntrezGene = 22288
    | Mm_Ensembl = ENSMUSG00000019820
    | Mm_RefseqmRNA = NM_011682
    | Mm_RefseqProtein = NP_035812
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 12075702
    | Mm_GenLoc_end = 12551836
    | Mm_Uniprot =  
  }}
}}
'''Utrophin''', also known as '''UTRN''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined.<ref>{{cite web | title = Entrez Gene: UTRN utrophin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7402| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Haenggi T, Fritschy JM |title=Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue. |journal=Cell. Mol. Life Sci. |volume=63 |issue= 14 |pages= 1614-31 |year= 2006 |pmid= 16710609 |doi= 10.1007/s00018-005-5461-0 }}
}}
{{refend}}

{{protein-stub}}
 

[edit] WASL

• INFO: Beginning work on WASL... {November 8, 2007 11:17:53 AM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:18:43 AM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Wiskott-Aldrich syndrome-like
 | HGNCid = 12735
 | Symbol = WASL
 | AltSymbols =; DKFZp779G0847; MGC48327; N-WASP
 | OMIM = 605056
 | ECnumber =  
 | Homologene = 74515
 | MGIid = 1920428
 | GeneAtlas_image1 = PBB_GE_WASL_205810_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005083 |text = small GTPase regulator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}} 
 | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0008154 |text = actin polymerization and/or depolymerization}} {{GNF_GO|id=GO:0009617 |text = response to bacterium}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8976
    | Hs_Ensembl = ENSG00000106299
    | Hs_RefseqProtein = NP_003932
    | Hs_RefseqmRNA = NM_003941
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 123109237
    | Hs_GenLoc_end = 123176352
    | Hs_Uniprot = O00401
    | Mm_EntrezGene = 73178
    | Mm_Ensembl = ENSMUSG00000029684
    | Mm_RefseqmRNA = NM_028459
    | Mm_RefseqProtein = NP_082735
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 24563813
    | Mm_GenLoc_end = 24614998
    | Mm_Uniprot = Q05CX6
  }}
}}
'''Wiskott-Aldrich syndrome-like''', also known as '''WASL''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.<ref>{{cite web | title = Entrez Gene: WASL Wiskott-Aldrich syndrome-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8976| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Ramesh N, Antón IM, Martínez-Quiles N, Geha RS |title=Waltzing with WASP. |journal=Trends Cell Biol. |volume=9 |issue= 1 |pages= 15-9 |year= 1999 |pmid= 10087612 |doi=  }}
*{{cite journal  | author=Carlier MF, Ducruix A, Pantaloni D |title=Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection. |journal=Chem. Biol. |volume=6 |issue= 9 |pages= R235-40 |year= 1999 |pmid= 10467124 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

end log.