User:ProteinBoxBot/PBB Log Wiki 11-7-2007 A-8

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Contents

[edit] Log file for Protein Box Bot

Log page index: User:ProteinBoxBot/PBB_Log_Index

[edit] Protein Status Quick Log - Date: 00:55, 8 November 2007 (UTC)

[edit] Proteins without matches (23)

CDKN1C FGR ATRX ALOX15 HGS
SLC5A5 EPHX1 CYR61 AKR1B1 ND4L
GRN SULT1A1 EFNB2 PTBP1 MAPKAPK2
SCN1A SDC2 BIN1 APOA4 SSB
SSTR2 HTR2C MAP3K1

[edit] Proteins with a High Potential Match (2)

BGN AGTR2

[edit] Created (10)

ALOX15 CYR61 ND4L EFNB2 MAPKAPK2
SDC2 BIN1 APOA4 SSTR2 HTR2C

[edit] Manual Inspection (Page not found) (15)

BGN CDKN1C FGR ATRX HGS
SLC5A5 EPHX1 AKR1B1 GRN SULT1A1
PTBP1 SCN1A SSB AGTR2 MAP3K1


[edit] Protein Status Grid - Date: 00:55, 8 November 2007 (UTC)

HUGO Symbol Action Summary Target page(s) WP Symbol Search
BGN Manual Inspection (Page not found) Other Pages: Biglycan (Protein Template); BGN (DisAmbig); DSPG1 (No Data); Dspg1 (No Data); PG-S1 (No Data); Pg-s1 (No Data); PGI (DisAmbig); Pgi (No Data); SLRR1A (No Data); Slrr1a (No Data); [1]
CDKN1C Manual Inspection (Page not found) Other Pages: Cyclin-dependent kinase inhibitor 1C (No Data); CDKN1C (Redirect -> Cyclin-dependent kinase inhibitor protein); BWCR (No Data); Bwcr (No Data); BWS (Unknown Data); Bws (No Data); KIP2 (No Data); Kip2 (No Data); WBS (DisAmbig); Wbs (No Data); P57 (DisAmbig); Cyclin-dependent kinase inhibitor protein (Unknown Data); [2]
FGR Manual Inspection (Page not found) Other Pages: Gardner-Rasheed feline sarcoma viral oncogene homolog (No Data); FGR (DisAmbig); FLJ43153 (No Data); Flj43153 (No Data); MGC75096 (No Data); Mgc75096 (No Data); SRC2 (No Data); Src2 (No Data); C-fgr (No Data); C-src2 (No Data); P55c-fgr (No Data); P58c-fgr (No Data); [3]
ATRX Manual Inspection (Page not found) Other Pages: Alpha thalassemia/mental retardation syndrome X-linked (No Data); ATRX (No Data); ATR2 (No Data); Atr2 (No Data); MGC2094 (No Data); Mgc2094 (No Data); MRXS3 (No Data); Mrxs3 (No Data); RAD54 (No Data); Rad54 (No Data); RAD54L (No Data); Rad54l (No Data); SHS (DisAmbig); Shs (No Data); XH2 (No Data); Xh2 (No Data); XNP (No Data); Xnp (No Data); ZNF-HX (No Data); Znf-hx (No Data); [4]
ALOX15 Created Other Pages: Arachidonate 15-lipoxygenase (No Data); ALOX15 (No Data); 15-LOX2 (No Data); 15-lox2 (No Data); [5]
HGS Manual Inspection (Page not found) Other Pages: Hepatocyte growth factor-regulated tyrosine kinase substrate (No Data); HGS (DisAmbig); HRS (DisAmbig); Hrs (Redirect -> hour); ZFYVE8 (No Data); Zfyve8 (No Data); Hour (Unknown Data); [6]
SLC5A5 Manual Inspection (Page not found) Other Pages: Solute carrier family 5 (No Data); SLC5A5 (No Data); NIS (DisAmbig); Nis (Redirect -> Niš); Niš (Unknown Data); [7]
EPHX1 Manual Inspection (Page not found) Other Pages: Epoxide hydrolase 1 (No Data); EPHX1 (No Data); EPHX (No Data); Ephx (No Data); EPOX (No Data); Epox (Redirect -> EPoX); MEH (No Data); Meh (No Data); EPoX (Unknown Data); [8]
CYR61 Created Other Pages: Cysteine-rich (No Data); CYR61 (No Data); CCN1 (No Data); Ccn1 (No Data); GIG1 (No Data); Gig1 (No Data); IGFBP10 (No Data); Igfbp10 (No Data); [9]
AKR1B1 Manual Inspection (Page not found) Other Pages: Aldo-keto reductase family 1 (No Data); AKR1B1 (No Data); ADR (DisAmbig); Adr (Redirect -> ADR); ALDR1 (No Data); Aldr1 (No Data); AR (DisAmbig); Ar (Redirect -> AR); MGC1804 (No Data); Mgc1804 (No Data); [10]
ND4L Created Other Pages: NADH dehydrogenase subunit 4L (No Data); ND4L (No Data); MTND4L (No Data); Mtnd4l (No Data); [11]
GRN Manual Inspection (Page not found) Other Pages: Granulin (No Data); GRN (Redirect -> Government Radio Network (Australia)); GEP (DisAmbig); Gep (Redirect -> Gäp); GP88 (No Data); Gp88 (No Data); PCDGF (No Data); Pcdgf (No Data); PEPI (No Data); Pepi (Human Name DisAmbig - not counted); PGRN (No Data); Pgrn (No Data); Government Radio Network (Australia) (Unknown Data); Gäp (Unknown Data); [12]
SULT1A1 Manual Inspection (Page not found) Other Pages: Sulfotransferase family (No Data); SULT1A1 (No Data); P-PST (No Data); P-pst (No Data); MGC131921 (No Data); Mgc131921 (No Data); MGC5163 (No Data); Mgc5163 (No Data); PST (DisAmbig); Pst (Redirect -> PST); ST1A3 (No Data); St1a3 (No Data); STP (DisAmbig); Stp (Redirect -> STP); STP1 (No Data); Stp1 (No Data); TSPST1 (No Data); Tspst1 (No Data); [13]
EFNB2 Created Other Pages: Ephrin-B2 (No Data); EFNB2 (No Data); EPLG5 (No Data); Eplg5 (No Data); HTKL (No Data); Htkl (No Data); Htk-L (No Data); Htk-l (No Data); LERK5 (No Data); Lerk5 (No Data); MGC126226 (No Data); Mgc126226 (No Data); MGC126227 (No Data); Mgc126227 (No Data); MGC126228 (No Data); Mgc126228 (No Data); [14]
PTBP1 Manual Inspection (Page not found) Other Pages: Polypyrimidine tract binding protein 1 (No Data); PTBP1 (No Data); HNRNPI (No Data); Hnrnpi (No Data); HNRPI (No Data); Hnrpi (No Data); MGC10830 (No Data); Mgc10830 (No Data); MGC8461 (No Data); Mgc8461 (No Data); PTB (DisAmbig); Ptb (Redirect -> PTB); PTB-1 (No Data); Ptb-1 (No Data); PTB-T (No Data); Ptb-t (No Data); PTB2 (No Data); Ptb2 (No Data); PTB3 (No Data); Ptb3 (No Data); PTB4 (No Data); Ptb4 (No Data); PPTB (No Data); Pptb (No Data); [15]
MAPKAPK2 Created Other Pages: Mitogen-activated protein kinase-activated protein kinase 2 (No Data); MAPKAPK2 (No Data); [16]
SCN1A Manual Inspection (Page not found) Other Pages: Sodium channel (Unknown Data); SCN1A (No Data); FEB3 (No Data); Feb3 (No Data); GEFSP2 (No Data); Gefsp2 (No Data); HBSCI (No Data); Hbsci (No Data); NAC1 (No Data); Nac1 (No Data); Nav1.1 (No Data); SCN1 (No Data); Scn1 (No Data); SMEI (DisAmbig); Smei (No Data); [17]
SDC2 Created Other Pages: Syndecan 2 (No Data); SDC2 (No Data); HSPG (No Data); Hspg (No Data); HSPG1 (No Data); Hspg1 (No Data); SYND2 (No Data); Synd2 (No Data); [18]
BIN1 Created Other Pages: Bridging integrator 1 (No Data); BIN1 (No Data); AMPH2 (No Data); Amph2 (No Data); AMPHL (No Data); Amphl (No Data); DKFZp547F068 (No Data); Dkfzp547f068 (No Data); MGC10367 (No Data); Mgc10367 (No Data); SH3P9 (No Data); Sh3p9 (No Data); [19]
APOA4 Created Other Pages: Apolipoprotein A-IV (No Data); APOA4 (No Data); MGC142154 (No Data); Mgc142154 (No Data); MGC142156 (No Data); Mgc142156 (No Data); [20]
SSB Manual Inspection (Page not found) Other Pages: Sjogren syndrome antigen B (No Data); SSB (DisAmbig); LARP3 (No Data); Larp3 (No Data); La (DisAmbig); [21]
SSTR2 Created Other Pages: Somatostatin receptor 2 (No Data); SSTR2 (No Data); [22]
HTR2C Created Other Pages: 5-hydroxytryptamine receptor 2C (No Data); HTR2C (No Data); 5-HT2C (No Data); 5-ht2c (No Data); HTR1C (No Data); Htr1c (No Data); [23]
AGTR2 Manual Inspection (Page not found) Other Pages: Angiotensin II receptor (Redirect -> Angiotensin receptor); AGTR2 (No Data); AT2 (No Data); At2 (No Data); ATGR2 (No Data); Atgr2 (No Data); MRX88 (No Data); Mrx88 (No Data); Angiotensin receptor (Protein Template); [24]
MAP3K1 Manual Inspection (Page not found) Other Pages: Mitogen-activated protein kinase kinase kinase 1 (No Data); MAP3K1 (No Data); MAPKKK1 (No Data); Mapkkk1 (No Data); MEKK (No Data); Mekk (No Data); MEKK1 (Redirect -> MAP kinase kinase kinase); Mekk1 (No Data); MAP kinase kinase kinase (Unknown Data); [25]

[edit] Vebose Log - Date: 00:55, 8 November 2007 (UTC)

[edit] AGTR2

  • INFO: Beginning work on AGTR2... {November 7, 2007 3:55:29 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:56:41 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Angiotensin II receptor, type 2
 | HGNCid = 338
 | Symbol = AGTR2
 | AltSymbols =; AT2; ATGR2; MRX88
 | OMIM = 300034
 | ECnumber =  
 | Homologene = 20172
 | MGIid = 87966
 | GeneAtlas_image1 = PBB_GE_AGTR2_207294_at_tn.png
 | GeneAtlas_image2 = PBB_GE_AGTR2_207293_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_AGTR2_222321_at_tn.png
 | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004860 |text = protein kinase inhibitor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004945 |text = angiotensin type II receptor activity}} {{GNF_GO|id=GO:0004947 |text = bradykinin receptor activity}} 
 | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0002033 |text = angiotensin mediated vasodilation during regulation of blood pressure}} {{GNF_GO|id=GO:0002035 |text = brain renin-angiotensin system}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007610 |text = behavior}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 186
    | Hs_Ensembl = ENSG00000180772
    | Hs_RefseqProtein = NP_000677
    | Hs_RefseqmRNA = NM_000686
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 115216003
    | Hs_GenLoc_end = 115220253
    | Hs_Uniprot = P50052
    | Mm_EntrezGene = 11609
    | Mm_Ensembl = ENSMUSG00000068122
    | Mm_RefseqmRNA = NM_007429
    | Mm_RefseqProtein = NP_031455
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 20641585
    | Mm_GenLoc_end = 20646123
    | Mm_Uniprot = Q3US12
  }}
}}
'''Angiotensin II receptor, type 2''', also known as '''AGTR2''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G-protein coupled receptors. It is an intergral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame.<ref>{{cite web | title = Entrez Gene: AGTR2 angiotensin II receptor, type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=186| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Regitz-Zagrosek V, Neuss M, Warnecke C, ''et al.'' |title=Subtype 2 and atypical angiotensin receptors in the human heart. |journal=Basic Res. Cardiol. |volume=91 Suppl 2 |issue=  |pages= 73-7 |year= 1997 |pmid= 8957548 |doi=  }}
*{{cite journal  | author=Berry C, Touyz R, Dominiczak AF, ''et al.'' |title=Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=281 |issue= 6 |pages= H2337-65 |year= 2002 |pmid= 11709400 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] AKR1B1

  • INFO: Beginning work on AKR1B1... {November 7, 2007 3:56:41 PM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_AKR1B1_image.jpg {November 7, 2007 3:57:13 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:57:29 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_AKR1B1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1abn.
 | PDB = {{PDB2|1abn}}, {{PDB2|1ads}}, {{PDB2|1az1}}, {{PDB2|1az2}}, {{PDB2|1ef3}}, {{PDB2|1el3}}, {{PDB2|1iei}}, {{PDB2|1mar}}, {{PDB2|1pwl}}, {{PDB2|1pwm}}, {{PDB2|1t40}}, {{PDB2|1t41}}, {{PDB2|1us0}}, {{PDB2|1x96}}, {{PDB2|1x97}}, {{PDB2|1x98}}, {{PDB2|1xgd}}, {{PDB2|1z3n}}, {{PDB2|1z89}}, {{PDB2|1z8a}}, {{PDB2|2acq}}, {{PDB2|2acr}}, {{PDB2|2acs}}, {{PDB2|2acu}}, {{PDB2|2agt}}, {{PDB2|2dux}}, {{PDB2|2duz}}, {{PDB2|2dv0}}, {{PDB2|2f2k}}, {{PDB2|2fz8}}, {{PDB2|2fz9}}, {{PDB2|2fzb}}, {{PDB2|2fzd}}, {{PDB2|2hv5}}, {{PDB2|2hvn}}, {{PDB2|2hvo}}, {{PDB2|2i16}}, {{PDB2|2i17}}, {{PDB2|2ikg}}, {{PDB2|2ikh}}, {{PDB2|2iki}}, {{PDB2|2ikj}}, {{PDB2|2ine}}, {{PDB2|2inz}}, {{PDB2|2ipw}}, {{PDB2|2iq0}}, {{PDB2|2iqd}}, {{PDB2|2is7}}, {{PDB2|2isf}}, {{PDB2|2j8t}}, {{PDB2|2nvc}}, {{PDB2|2nvd}}, {{PDB2|2pev}}, {{PDB2|2pf8}}, {{PDB2|2pfh}}
 | Name = Aldo-keto reductase family 1, member B1 (aldose reductase)
 | HGNCid = 381
 | Symbol = AKR1B1
 | AltSymbols =; ADR; ALDR1; AR; MGC1804
 | OMIM = 103880
 | ECnumber =  
 | Homologene = 68193
 | MGIid = 1353494
 | GeneAtlas_image1 = PBB_GE_AKR1B1_201272_at_tn.png
 | Function = {{GNF_GO|id=GO:0004032 |text = aldehyde reductase activity}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} 
 | Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} 
 | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006950 |text = response to stress}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 231
    | Hs_Ensembl = ENSG00000085662
    | Hs_RefseqProtein = NP_001619
    | Hs_RefseqmRNA = NM_001628
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 133777649
    | Hs_GenLoc_end = 133794428
    | Hs_Uniprot = P15121
    | Mm_EntrezGene = 11677
    | Mm_Ensembl = ENSMUSG00000001642
    | Mm_RefseqmRNA = NM_009658
    | Mm_RefseqProtein = NP_033788
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 34234092
    | Mm_GenLoc_end = 34247655
    | Mm_Uniprot = Q3TCL2
  }}
}}
'''Aldo-keto reductase family 1, member B1 (aldose reductase)''', also known as '''AKR1B1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. There are a few putative pseudogenes for this gene, and one of them has been confirmed and mapped to chromosome 3.<ref>{{cite web | title = Entrez Gene: AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=231| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

[edit] ALOX15

  • INFO: Beginning work on ALOX15... {November 7, 2007 3:57:29 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 3:57:59 PM PST}
  • CREATED: Created new protein page: ALOX15 {November 7, 2007 3:58:06 PM PST}

[edit] APOA4

  • INFO: Beginning work on APOA4... {November 7, 2007 4:00:29 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 4:01:07 PM PST}
  • CREATED: Created new protein page: APOA4 {November 7, 2007 4:01:14 PM PST}

[edit] ATRX

  • INFO: Beginning work on ATRX... {November 7, 2007 4:01:14 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:01:52 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
 | HGNCid = 886
 | Symbol = ATRX
 | AltSymbols =; ATR2; MGC2094; MRXS3; RAD54; RAD54L; SHS; XH2; XNP; ZNF-HX
 | OMIM = 300032
 | ECnumber =  
 | Homologene = 416
 | MGIid = 103067
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003678 |text = DNA helicase activity}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} 
 | Component = {{GNF_GO|id=GO:0000228 |text = nuclear chromosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005720 |text = nuclear heterochromatin}} 
 | Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006306 |text = DNA methylation}} {{GNF_GO|id=GO:0006310 |text = DNA recombination}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 546
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_000480
    | Hs_RefseqmRNA = NM_000489
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 22589
    | Mm_Ensembl = ENSMUSG00000031229
    | Mm_RefseqmRNA = NM_009530
    | Mm_RefseqProtein = NP_033556
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 102002894
    | Mm_GenLoc_end = 102131271
    | Mm_Uniprot = Q3TP53
  }}
}}
'''Alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)''', also known as '''ATRX''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: ATRX alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=546| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Mulley JC, Kerr B, Stevenson R, Lubs H |title=Nomenclature guidelines for X-linked mental retardation. |journal=Am. J. Med. Genet. |volume=43 |issue= 1-2 |pages= 383-91 |year= 1992 |pmid= 1605216 |doi=  }}
*{{cite journal  | author=Tang P, Park DJ, Marshall Graves JA, Harley VR |title=ATRX and sex differentiation. |journal=Trends Endocrinol. Metab. |volume=15 |issue= 7 |pages= 339-44 |year= 2005 |pmid= 15350606 |doi= 10.1016/j.tem.2004.07.006 }}
*{{cite journal  | author=Forget BG |title=De novo and acquired forms of alpha thalassemia. |journal=Curr. Hematol. Rep. |volume=5 |issue= 1 |pages= 11-4 |year= 2006 |pmid= 16537041 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] BGN

  • INFO: Beginning work on BGN... {November 7, 2007 4:01:52 PM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_BGN_image.jpg {November 7, 2007 4:03:17 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:03:32 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_BGN_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ft3.
 | PDB = {{PDB2|2ft3}}
 | Name = Biglycan
 | HGNCid = 1044
 | Symbol = BGN
 | AltSymbols =; DSPG1; PG-S1; PGI; SLRR1A
 | OMIM = 301870
 | ECnumber =  
 | Homologene = 1293
 | MGIid = 88158
 | GeneAtlas_image1 = PBB_GE_BGN_201262_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_BGN_201261_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_BGN_213905_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0030133 |text = transport vesicle}} 
 | Process = {{GNF_GO|id=GO:0008150 |text = biological_process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 633
    | Hs_Ensembl = ENSG00000182492
    | Hs_RefseqProtein = NP_001702
    | Hs_RefseqmRNA = NM_001711
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 152413591
    | Hs_GenLoc_end = 152428206
    | Hs_Uniprot = P21810
    | Mm_EntrezGene = 12111
    | Mm_Ensembl = ENSMUSG00000031375
    | Mm_RefseqmRNA = NM_007542
    | Mm_RefseqProtein = NP_031568
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 69736364
    | Mm_GenLoc_end = 69748653
    | Mm_Uniprot = Q3TAF9
  }}
}}
'''Biglycan''', also known as '''BGN''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival. This gene is a candidate gene for the Happle syndrome.<ref>{{cite web | title = Entrez Gene: BGN biglycan| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=633| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Iozzo RV |title=The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 18843-6 |year= 1999 |pmid= 10383378 |doi=  }}
*{{cite journal  | author=Klezovitch O, Scanu AM |title=Domains of apolipoprotein E involved in the binding to the protein core of biglycan of the vascular extracellular matrix: potential relationship between retention and anti-atherogenic properties of this apolipoprotein. |journal=Trends Cardiovasc. Med. |volume=11 |issue= 7 |pages= 263-8 |year= 2001 |pmid= 11709279 |doi=  }}
*{{cite journal  | author=Fujisawa R |title=[Recent advances in research on bone matrix proteins] |journal=Nippon Rinsho |volume=60 Suppl 3 |issue=  |pages= 72-8 |year= 2002 |pmid= 11979972 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] BIN1

  • INFO: Beginning work on BIN1... {November 7, 2007 3:58:06 PM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_BIN1_image.jpg {November 7, 2007 4:00:04 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 4:00:21 PM PST}
  • CREATED: Created new protein page: BIN1 {November 7, 2007 4:00:29 PM PST}

[edit] CDKN1C

  • INFO: Beginning work on CDKN1C... {November 7, 2007 4:03:32 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:05:08 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Cyclin-dependent kinase inhibitor 1C (p57, Kip2)
 | HGNCid = 1786
 | Symbol = CDKN1C
 | AltSymbols =; BWCR; BWS; KIP2; WBS; p57
 | OMIM = 600856
 | ECnumber =  
 | Homologene = 58
 | MGIid = 104564
 | GeneAtlas_image1 = PBB_GE_CDKN1C_213348_at_tn.png
 | GeneAtlas_image2 = PBB_GE_CDKN1C_213182_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_CDKN1C_216894_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0004861 |text = cyclin-dependent protein kinase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0000080 |text = G1 phase of mitotic cell cycle}} {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0042551 |text = neuron maturation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1028
    | Hs_Ensembl = ENSG00000129757
    | Hs_RefseqProtein = NP_000067
    | Hs_RefseqmRNA = NM_000076
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 2861019
    | Hs_GenLoc_end = 2863577
    | Hs_Uniprot = P49918
    | Mm_EntrezGene = 12577
    | Mm_Ensembl = ENSMUSG00000037664
    | Mm_RefseqmRNA = NM_009876
    | Mm_RefseqProtein = NP_034006
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 143267730
    | Mm_GenLoc_end = 143270386
    | Mm_Uniprot = Q791X1
  }}
}}
'''Cyclin-dependent kinase inhibitor 1C (p57, Kip2)''', also known as '''CDKN1C''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation.  Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndorome suggesting that it is a tumor suppressor candidate.<ref>{{cite web | title = Entrez Gene: CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1028| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Seizinger BR |title=Genes associated with tumor suppression and growth control in the human nervous system. |journal=Cancer Metastasis Rev. |volume=10 |issue= 4 |pages= 281-7 |year= 1992 |pmid= 1786629 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] CYR61

  • INFO: Beginning work on CYR61... {November 7, 2007 4:10:24 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 4:11:19 PM PST}
  • CREATED: Created new protein page: CYR61 {November 7, 2007 4:11:26 PM PST}

[edit] EFNB2

  • INFO: Beginning work on EFNB2... {November 7, 2007 4:05:08 PM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_EFNB2_image.jpg {November 7, 2007 4:06:00 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 4:06:23 PM PST}
  • CREATED: Created new protein page: EFNB2 {November 7, 2007 4:06:31 PM PST}

[edit] EPHX1

  • INFO: Beginning work on EPHX1... {November 7, 2007 4:06:31 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:07:10 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Epoxide hydrolase 1, microsomal (xenobiotic)
 | HGNCid = 3401
 | Symbol = EPHX1
 | AltSymbols =; EPHX; EPOX; MEH
 | OMIM = 132810
 | ECnumber =  
 | Homologene = 94
 | MGIid = 95405
 | GeneAtlas_image1 = PBB_GE_EPHX1_202017_at_tn.png
 | Function = {{GNF_GO|id=GO:0004301 |text = epoxide hydrolase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} 
 | Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006805 |text = xenobiotic metabolic process}} {{GNF_GO|id=GO:0009636 |text = response to toxin}} {{GNF_GO|id=GO:0019439 |text = aromatic compound catabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2052
    | Hs_Ensembl = ENSG00000143819
    | Hs_RefseqProtein = NP_000111
    | Hs_RefseqmRNA = NM_000120
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 224064459
    | Hs_GenLoc_end = 224099883
    | Hs_Uniprot = P07099
    | Mm_EntrezGene = 13849
    | Mm_Ensembl = ENSMUSG00000038776
    | Mm_RefseqmRNA = NM_010145
    | Mm_RefseqProtein = NP_034275
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 182826233
    | Mm_GenLoc_end = 182854196
    | Mm_Uniprot = P97869
  }}
}}
'''Epoxide hydrolase 1, microsomal (xenobiotic)''', also known as '''EPHX1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Epoxide hydrolase plays an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons.<ref>{{cite web | title = Entrez Gene: EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2052| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Seidegård J, Ekström G |title=The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics. |journal=Environ. Health Perspect. |volume=105 Suppl 4 |issue=  |pages= 791-9 |year= 1997 |pmid= 9255563 |doi=  }}
*{{cite journal  | author=Wormhoudt LW, Commandeur JN, Vermeulen NP |title=Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity. |journal=Crit. Rev. Toxicol. |volume=29 |issue= 1 |pages= 59-124 |year= 1999 |pmid= 10066160 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] FGR

  • INFO: Beginning work on FGR... {November 7, 2007 4:07:10 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:07:52 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
 | HGNCid = 3697
 | Symbol = FGR
 | AltSymbols =; FLJ43153; MGC75096; SRC2; c-fgr; c-src2; p55c-fgr; p58c-fgr
 | OMIM = 164940
 | ECnumber =  
 | Homologene = 3842
 | MGIid = 95527
 | GeneAtlas_image1 = PBB_GE_FGR_208438_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0009615 |text = response to virus}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2268
    | Hs_Ensembl = ENSG00000000938
    | Hs_RefseqProtein = NP_001036194
    | Hs_RefseqmRNA = NM_001042729
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 27811162
    | Hs_GenLoc_end = 27834375
    | Hs_Uniprot = P09769
    | Mm_EntrezGene = 14191
    | Mm_Ensembl = ENSMUSG00000028874
    | Mm_RefseqmRNA = NM_010208
    | Mm_RefseqProtein = NP_034338
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 132246266
    | Mm_GenLoc_end = 132273953
    | Mm_Uniprot = Q6GTF2
  }}
}}
'''Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog''', also known as '''FGR''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.<ref>{{cite web | title = Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2268| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Patel M, Faulkner L, Katz DR, Brickell PM |title=The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages. |journal=Pathobiology |volume=59 |issue= 4 |pages= 289-92 |year= 1991 |pmid= 1652975 |doi=  }}
*{{cite journal  | author=Resh MD |title=Myristylation and palmitylation of Src family members: the fats of the matter. |journal=Cell |volume=76 |issue= 3 |pages= 411-3 |year= 1994 |pmid= 8313462 |doi=  }}
*{{cite journal  | author=Lowell CA, Berton G |title=Integrin signal transduction in myeloid leukocytes. |journal=J. Leukoc. Biol. |volume=65 |issue= 3 |pages= 313-20 |year= 1999 |pmid= 10080533 |doi=  }}
*{{cite journal  | author=Snapper SB, Rosen FS |title=The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization. |journal=Annu. Rev. Immunol. |volume=17 |issue=  |pages= 905-29 |year= 1999 |pmid= 10358777 |doi= 10.1146/annurev.immunol.17.1.905 }}
*{{cite journal  | author=Tatosyan AG, Mizenina OA |title=Kinases of the Src family: structure and functions. |journal=Biochemistry Mosc. |volume=65 |issue= 1 |pages= 49-58 |year= 2000 |pmid= 10702640 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] GRN

  • INFO: Beginning work on GRN... {November 7, 2007 4:07:52 PM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_GRN_image.jpg {November 7, 2007 4:09:01 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:09:23 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_GRN_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1g26.
 | PDB = {{PDB2|1g26}}
 | Name = Granulin
 | HGNCid = 4601
 | Symbol = GRN
 | AltSymbols =; GEP; GP88; PCDGF; PEPI; PGRN
 | OMIM = 138945
 | ECnumber =  
 | Homologene = 1577
 | MGIid = 95832
 | GeneAtlas_image1 = PBB_GE_GRN_211284_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_GRN_200678_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_GRN_216041_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} 
 | Process = {{GNF_GO|id=GO:0001835 |text = blastocyst hatching}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0050679 |text = positive regulation of epithelial cell proliferation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2896
    | Hs_Ensembl = ENSG00000030582
    | Hs_RefseqProtein = NP_001012497
    | Hs_RefseqmRNA = NM_001012479
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 39778017
    | Hs_GenLoc_end = 39785996
    | Hs_Uniprot = P28799
    | Mm_EntrezGene = 14824
    | Mm_Ensembl = ENSMUSG00000034708
    | Mm_RefseqmRNA = XM_984981
    | Mm_RefseqProtein = XP_990075
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 102246571
    | Mm_GenLoc_end = 102252895
    | Mm_Uniprot = Q3TVQ3
  }}
}}
'''Granulin''', also known as '''GRN''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.<ref>{{cite web | title = Entrez Gene: GRN granulin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2896| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Serrero G |title=Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 3 |pages= 409-13 |year= 2003 |pmid= 12914763 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] HGS

  • INFO: Beginning work on HGS... {November 7, 2007 4:23:34 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:24:06 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Hepatocyte growth factor-regulated tyrosine kinase substrate
 | HGNCid = 4897
 | Symbol = HGS
 | AltSymbols =; HRS; ZFYVE8
 | OMIM = 604375
 | ECnumber =  
 | Homologene = 37954
 | MGIid = 104681
 | GeneAtlas_image1 = PBB_GE_HGS_210428_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016197 |text = endosome transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9146
    | Hs_Ensembl = ENSG00000185359
    | Hs_RefseqProtein = NP_004703
    | Hs_RefseqmRNA = NM_004712
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 77261425
    | Hs_GenLoc_end = 77279548
    | Hs_Uniprot = O14964
    | Mm_EntrezGene = 15239
    | Mm_Ensembl = ENSMUSG00000025793
    | Mm_RefseqmRNA = NM_008244
    | Mm_RefseqProtein = NP_032270
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 120283765
    | Mm_GenLoc_end = 120300065
    | Mm_Uniprot = Q3TLL4
  }}
}}
'''Hepatocyte growth factor-regulated tyrosine kinase substrate''', also known as '''HGS''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Comoglio PM |title=Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. |journal=EXS |volume=65 |issue=  |pages= 131-65 |year= 1993 |pmid= 8380735 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] HTR2C

  • INFO: Beginning work on HTR2C... {November 7, 2007 4:09:23 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 4:10:17 PM PST}
  • CREATED: Created new protein page: HTR2C {November 7, 2007 4:10:24 PM PST}

[edit] MAP3K1

  • INFO: Beginning work on MAP3K1... {November 7, 2007 4:11:26 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:12:06 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
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| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Mitogen-activated protein kinase kinase kinase 1
 | HGNCid = 6848
 | Symbol = MAP3K1
 | AltSymbols =; MAPKKK1; MEKK; MEKK1
 | OMIM = 600982
 | ECnumber =  
 | Homologene = 8056
 | MGIid = 1346872
 | GeneAtlas_image1 = PBB_GE_MAP3K1_214786_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004709 |text = MAP kinase kinase kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} 
 | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0008637 |text = apoptotic mitochondrial changes}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0030838 |text = positive regulation of actin filament polymerization}} {{GNF_GO|id=GO:0042060 |text = wound healing}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4214
    | Hs_Ensembl = ENSG00000095015
    | Hs_RefseqProtein = XP_001128827
    | Hs_RefseqmRNA = XM_001128827
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 56147216
    | Hs_GenLoc_end = 56225472
    | Hs_Uniprot = Q13233
    | Mm_EntrezGene = 26401
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_011945
    | Mm_RefseqProtein = NP_036075
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Mitogen-activated protein kinase kinase kinase 1''', also known as '''MAP3K1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4214| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

[edit] MAPKAPK2

  • INFO: Beginning work on MAPKAPK2... {November 7, 2007 4:24:06 PM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_MAPKAPK2_image.jpg {November 7, 2007 4:46:53 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 4:47:01 PM PST}
  • CREATED: Created new protein page: MAPKAPK2 {November 7, 2007 4:47:09 PM PST}

[edit] ND4L

  • INFO: Beginning work on ND4L... {November 7, 2007 4:12:06 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 4:12:26 PM PST}
  • CREATED: Created new protein page: ND4L {November 7, 2007 4:12:33 PM PST}

[edit] PTBP1

  • INFO: Beginning work on PTBP1... {November 7, 2007 4:12:33 PM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_PTBP1_image.jpg {November 7, 2007 4:14:39 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:15:11 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PTBP1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qm9.
 | PDB = {{PDB2|1qm9}}, {{PDB2|1sjq}}, {{PDB2|1sjr}}, {{PDB2|2ad9}}, {{PDB2|2adb}}, {{PDB2|2adc}}, {{PDB2|2evz}}
 | Name = Polypyrimidine tract binding protein 1
 | HGNCid = 9583
 | Symbol = PTBP1
 | AltSymbols =; HNRNPI; HNRPI; MGC10830; MGC8461; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; pPTB
 | OMIM = 600693
 | ECnumber =  
 | Homologene = 49188
 | MGIid = 97791
 | GeneAtlas_image1 = PBB_GE_PTBP1_212016_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_PTBP1_202189_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_PTBP1_211270_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008187 |text = poly-pyrimidine tract binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0030530 |text = heterogeneous nuclear ribonucleoprotein complex}} 
 | Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5725
    | Hs_Ensembl = ENSG00000011304
    | Hs_RefseqProtein = NP_002810
    | Hs_RefseqmRNA = NM_002819
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 748411
    | Hs_GenLoc_end = 763327
    | Hs_Uniprot = P26599
    | Mm_EntrezGene = 19205
    | Mm_Ensembl = ENSMUSG00000006498
    | Mm_RefseqmRNA = NM_001077363
    | Mm_RefseqProtein = NP_001070831
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 79257797
    | Mm_GenLoc_end = 79267561
    | Mm_Uniprot = Q8C2R5
  }}
}}
'''Polypyrimidine tract binding protein 1''', also known as '''PTBP1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.<ref>{{cite web | title = Entrez Gene: PTBP1 polypyrimidine tract binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5725| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

[edit] SCN1A

  • INFO: Beginning work on SCN1A... {November 7, 2007 4:15:11 PM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_SCN1A_image.jpg {November 7, 2007 4:15:44 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:16:28 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_SCN1A_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1byy.
 | PDB = {{PDB2|1byy}}
 | Name = Sodium channel, voltage-gated, type I, alpha subunit
 | HGNCid = 10585
 | Symbol = SCN1A
 | AltSymbols =; FEB3; GEFSP2; HBSCI; NAC1; Nav1.1; SCN1; SMEI
 | OMIM = 182389
 | ECnumber =  
 | Homologene = 21375
 | MGIid = 98246
 | GeneAtlas_image1 = PBB_GE_SCN1A_210383_at_tn.png
 | Function = {{GNF_GO|id=GO:0005248 |text = voltage-gated sodium channel activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}} 
 | Component = {{GNF_GO|id=GO:0001518 |text = voltage-gated sodium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6323
    | Hs_Ensembl = ENSG00000144285
    | Hs_RefseqProtein = NP_008851
    | Hs_RefseqmRNA = NM_006920
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 166553919
    | Hs_GenLoc_end = 166638395
    | Hs_Uniprot = P35498
    | Mm_EntrezGene = 20265
    | Mm_Ensembl = ENSMUSG00000064329
    | Mm_RefseqmRNA = XM_001001733
    | Mm_RefseqProtein = XP_001001733
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 66073727
    | Mm_GenLoc_end = 66119125
    | Mm_Uniprot =  
  }}
}}
'''Sodium channel, voltage-gated, type I, alpha subunit''', also known as '''SCN1A''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, chiefly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit and 2 smaller auxiliary beta subunits. Functional studies have indicated that the transmembrane alpha subunit of the brain sodium channels is sufficient for expression of functional sodium channels (Goldin et al., 1986; Isom, 2002). Brain sodium channel alpha subunits form a gene subfamily with several structurally distinct isoforms clustering on chromosome 2, types I, II (SCN2A1, MIM 182390; SCN2A2, MIM 601219); and III (SCN3A, MIM 182391). There are also several distinct sodium channel alpha subunit isoforms in skeletal and cardiac muscle (SCN4A, MIM 603967; SCN5A, MIM 600163; SCN7A, MIM 182392).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SCN1A sodium channel, voltage-gated, type I, alpha subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6323| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Lerche H, Jurkat-Rott K, Lehmann-Horn F |title=Ion channels and epilepsy. |journal=Am. J. Med. Genet. |volume=106 |issue= 2 |pages= 146-59 |year= 2001 |pmid= 11579435 |doi= 10.1002/ajmg.1582 }}
*{{cite journal  | author=Isom LL |title=The role of sodium channels in cell adhesion. |journal=Front. Biosci. |volume=7 |issue=  |pages= 12-23 |year= 2002 |pmid= 11779698 |doi=  }}
*{{cite journal  | author=Kanai K, Hirose S, Oguni H, ''et al.'' |title=Effect of localization of missense mutations in SCN1A on epilepsy phenotype severity. |journal=Neurology |volume=63 |issue= 2 |pages= 329-34 |year= 2005 |pmid= 15277629 |doi=  }}
*{{cite journal  | author=Oguni H, Hayashi K, Osawa M, ''et al.'' |title=Severe myoclonic epilepsy in infancy: clinical analysis and relation to SCN1A mutations in a Japanese cohort. |journal=Advances in neurology |volume=95 |issue=  |pages= 103-17 |year= 2004 |pmid= 15508916 |doi=  }}
*{{cite journal  | author=Mulley JC, Scheffer IE, Petrou S, ''et al.'' |title=SCN1A mutations and epilepsy. |journal=Hum. Mutat. |volume=25 |issue= 6 |pages= 535-42 |year= 2006 |pmid= 15880351 |doi= 10.1002/humu.20178 }}
*{{cite journal  | author=Catterall WA, Goldin AL, Waxman SG |title=International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 397-409 |year= 2006 |pmid= 16382098 |doi= 10.1124/pr.57.4.4 }}
}}
{{refend}}

{{protein-stub}}

[edit] SDC2

  • INFO: Beginning work on SDC2... {November 7, 2007 4:16:28 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 4:17:55 PM PST}
  • CREATED: Created new protein page: SDC2 {November 7, 2007 4:18:02 PM PST}

[edit] SLC5A5

  • INFO: Beginning work on SLC5A5... {November 7, 2007 4:18:02 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:18:36 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Solute carrier family 5 (sodium iodide symporter), member 5
 | HGNCid = 11040
 | Symbol = SLC5A5
 | AltSymbols =; NIS
 | OMIM = 601843
 | ECnumber =  
 | Homologene = 37311
 | MGIid = 2149330
 | GeneAtlas_image1 = PBB_GE_SLC5A5_211123_at_tn.png
 | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0008507 |text = sodium:iodide symporter activity}} {{GNF_GO|id=GO:0015111 |text = iodide transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}} 
 | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6528
    | Hs_Ensembl = ENSG00000105641
    | Hs_RefseqProtein = NP_000444
    | Hs_RefseqmRNA = NM_000453
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 17843782
    | Hs_GenLoc_end = 17865897
    | Hs_Uniprot = Q92911
    | Mm_EntrezGene = 114479
    | Mm_Ensembl = ENSMUSG00000000792
    | Mm_RefseqmRNA = NM_053248
    | Mm_RefseqProtein = NP_444478
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 73811881
    | Mm_GenLoc_end = 73821746
    | Mm_Uniprot = Q99PN0
  }}
}}
'''Solute carrier family 5 (sodium iodide symporter), member 5''', also known as '''SLC5A5''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The sodium-iodide symporter (NIS), a member of the sodium/solute symporter family, actively transports iodide across the basolateral plasma membrane of the thyroid follicular cells.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SLC5A5 solute carrier family 5 (sodium iodide symporter), member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6528| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Fukushima K, Kaneko CR, Fuchs AF |title=The neuronal substrate of integration in the oculomotor system. |journal=Prog. Neurobiol. |volume=39 |issue= 6 |pages= 609-39 |year= 1992 |pmid= 1410443 |doi=  }}
*{{cite journal  | author=De La Vieja A, Dohan O, Levy O, Carrasco N |title=Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. |journal=Physiol. Rev. |volume=80 |issue= 3 |pages= 1083-105 |year= 2000 |pmid= 10893432 |doi=  }}
*{{cite journal  | author=Dohán O, De la Vieja A, Paroder V, ''et al.'' |title=The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. |journal=Endocr. Rev. |volume=24 |issue= 1 |pages= 48-77 |year= 2003 |pmid= 12588808 |doi=  }}
*{{cite journal  | author=Kogai T, Taki K, Brent GA |title=Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. |journal=Endocr. Relat. Cancer |volume=13 |issue= 3 |pages= 797-826 |year= 2007 |pmid= 16954431 |doi= 10.1677/erc.1.01143 }}
*{{cite journal  | author=Riesco-Eizaguirre G, Santisteban P |title=A perspective view of sodium iodide symporter research and its clinical implications. |journal=Eur. J. Endocrinol. |volume=155 |issue= 4 |pages= 495-512 |year= 2006 |pmid= 16990649 |doi= 10.1530/eje.1.02257 }}
}}
{{refend}}

{{protein-stub}}

[edit] SSB

  • INFO: Beginning work on SSB... {November 7, 2007 4:18:36 PM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_SSB_image.jpg {November 7, 2007 4:19:25 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:19:36 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_SSB_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1owx.
 | PDB = {{PDB2|1owx}}, {{PDB2|1s79}}, {{PDB2|1s7a}}, {{PDB2|1yty}}, {{PDB2|1zh5}}
 | Name = Sjogren syndrome antigen B (autoantigen La)
 | HGNCid = 11316
 | Symbol = SSB
 | AltSymbols =; LARP3; La
 | OMIM = 109090
 | ECnumber =  
 | Homologene = 2366
 | MGIid = 98423
 | GeneAtlas_image1 = PBB_GE_SSB_201138_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_SSB_201139_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0000049 |text = tRNA binding}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003729 |text = mRNA binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}} 
 | Process = {{GNF_GO|id=GO:0006383 |text = transcription from RNA polymerase III promoter}} {{GNF_GO|id=GO:0006396 |text = RNA processing}} {{GNF_GO|id=GO:0006400 |text = tRNA modification}} {{GNF_GO|id=GO:0008334 |text = histone mRNA metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6741
    | Hs_Ensembl = ENSG00000138385
    | Hs_RefseqProtein = NP_003133
    | Hs_RefseqmRNA = NM_003142
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 170363605
    | Hs_GenLoc_end = 170376797
    | Hs_Uniprot = P05455
    | Mm_EntrezGene = 20823
    | Mm_Ensembl = ENSMUSG00000068882
    | Mm_RefseqmRNA = NM_009278
    | Mm_RefseqProtein = NP_033304
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 69662419
    | Mm_GenLoc_end = 69672625
    | Mm_Uniprot = Q3TG93
  }}
}}
'''Sjogren syndrome antigen B (autoantigen La)''', also known as '''SSB''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SSB Sjogren syndrome antigen B (autoantigen La)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6741| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

[edit] SSTR2

  • INFO: Beginning work on SSTR2... {November 7, 2007 4:19:36 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 4:20:26 PM PST}
  • CREATED: Created new protein page: SSTR2 {November 7, 2007 4:20:33 PM PST}

[edit] SULT1A1

  • INFO: Beginning work on SULT1A1... {November 7, 2007 4:20:33 PM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_SULT1A1_image.jpg {November 7, 2007 4:23:10 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:23:34 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_SULT1A1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cjm.
 | PDB = {{PDB2|1cjm}}, {{PDB2|1ls6}}, {{PDB2|1z28}}, {{PDB2|1z29}}, {{PDB2|2a3r}}, {{PDB2|2d06}}
 | Name = Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
 | HGNCid = 11453
 | Symbol = SULT1A1
 | AltSymbols =; P-PST; HAST1/HAST2; MGC131921; MGC5163; PST; ST1A3; STP; STP1; TSPST1
 | OMIM = 171150
 | ECnumber =  
 | Homologene = 68152
 | MGIid = 102896
 | GeneAtlas_image1 = PBB_GE_SULT1A1_203615_x_at_tn.png
 | GeneAtlas_image2 = PBB_GE_SULT1A1_207122_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_SULT1A1_209607_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0004062 |text = aryl sulfotransferase activity}} {{GNF_GO|id=GO:0008146 |text = sulfotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006584 |text = catecholamine metabolic process}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0009308 |text = amine metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6817
    | Hs_Ensembl = ENSG00000196502
    | Hs_RefseqProtein = NP_001046
    | Hs_RefseqmRNA = NM_001055
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 28524450
    | Hs_GenLoc_end = 28542447
    | Hs_Uniprot = P50225
    | Mm_EntrezGene = 20887
    | Mm_Ensembl = ENSMUSG00000030711
    | Mm_RefseqmRNA = NM_133670
    | Mm_RefseqProtein = NP_598431
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 126464291
    | Mm_GenLoc_end = 126467505
    | Mm_Uniprot = Q91W19
  }}
}}
'''Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1''', also known as '''SULT1A1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity.  Multiple alternatively spliced variants that encode two isoforms have been identified for this gene.<ref>{{cite web | title = Entrez Gene: SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6817| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Weinshilboum RM, Otterness DM, Aksoy IA, ''et al.'' |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3-14 |year= 1997 |pmid= 9034160 |doi=  }}
*{{cite journal  | author=Windmill KF, Christiansen A, Teusner JT, ''et al.'' |title=Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry. |journal=Chem. Biol. Interact. |volume=109 |issue= 1-3 |pages= 341-6 |year= 1998 |pmid= 9566757 |doi=  }}
*{{cite journal  | author=Glatt H, Engelke CE, Pabel U, ''et al.'' |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue=  |pages= 341-8 |year= 2000 |pmid= 10720750 |doi=  }}
*{{cite journal  | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1-2 |pages= 141-70 |year= 2001 |pmid= 11154739 |doi=  }}
*{{cite journal  | author=Glatt H, Boeing H, Engelke CE, ''et al.'' |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1-2 |pages= 27-40 |year= 2001 |pmid= 11535246 |doi=  }}
}}
{{refend}}

{{protein-stub}}

end log.