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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 21:42, 7 November 2007 (UTC)
[edit] Proteins without matches (11)
[edit] Proteins with a High Potential Match (14)
[edit] Created (7)
[edit] Manual Inspection (Page not found) (18)
[edit] Protein Status Grid - Date: 21:42, 7 November 2007 (UTC)
[edit] Vebose Log - Date: 21:42, 7 November 2007 (UTC)
- INFO: Beginning work on AFP... {November 7, 2007 1:10:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:11:10 PM PST}
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Alpha-fetoprotein
| HGNCid = 317
| Symbol = AFP
| AltSymbols =; FETA; HPAFP
| OMIM = 104150
| ECnumber =
| Homologene = 36278
| MGIid = 87951
| GeneAtlas_image1 = PBB_GE_AFP_204694_at_tn.png
| Function = {{GNF_GO|id=GO:0005386 |text = transmembrane transporter activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0016151 |text = nickel ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001542 |text = ovulation (sensu Mammalia)}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0019953 |text = sexual reproduction}} {{GNF_GO|id=GO:0042448 |text = progesterone metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 174
| Hs_Ensembl = ENSG00000081051
| Hs_RefseqProtein = NP_001125
| Hs_RefseqmRNA = NM_001134
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 74520797
| Hs_GenLoc_end = 74540356
| Hs_Uniprot = P02771
| Mm_EntrezGene = 11576
| Mm_Ensembl = ENSMUSG00000054932
| Mm_RefseqmRNA = NM_007423
| Mm_RefseqProtein = NP_031449
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 91565937
| Mm_GenLoc_end = 91584107
| Mm_Uniprot = Q3TGA3
}}
}}
'''Alpha-fetoprotein''', also known as '''AFP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.<ref>{{cite web | title = Entrez Gene: AFP alpha-fetoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=174| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nahon JL |title=The regulation of albumin and alpha-fetoprotein gene expression in mammals. |journal=Biochimie |volume=69 |issue= 5 |pages= 445-59 |year= 1987 |pmid= 2445387 |doi= }}
*{{cite journal | author=Tilghman SM |title=The structure and regulation of the alpha-fetoprotein and albumin genes. |journal=Oxf. Surv. Eukaryot. Genes |volume=2 |issue= |pages= 160-206 |year= 1989 |pmid= 2474300 |doi= }}
*{{cite journal | author=Mizejewski GJ |title=Biological role of alpha-fetoprotein in cancer: prospects for anticancer therapy. |journal=Expert Rev Anticancer Ther |volume=2 |issue= 6 |pages= 709-35 |year= 2003 |pmid= 12503217 |doi= 10.1586/14737140.2.6.709 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BDKRB2... {November 7, 2007 1:11:10 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:11:52 PM PST}
- CREATED: Created new protein page: BDKRB2 {November 7, 2007 1:11:59 PM PST}
- INFO: Beginning work on CD63... {November 7, 2007 1:11:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:12:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD63 molecule
| HGNCid = 1692
| Symbol = CD63
| AltSymbols =; LAMP-3; ME491; MLA1; OMA81H; TSPAN30
| OMIM = 155740
| ECnumber =
| Homologene = 37526
| MGIid =
| GeneAtlas_image1 = PBB_GE_CD63_200663_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005765 |text = lysosomal membrane}} {{GNF_GO|id=GO:0005770 |text = late endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0010008 |text = endosome membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 967
| Hs_Ensembl = ENSG00000135404
| Hs_RefseqProtein = NP_001035123
| Hs_RefseqmRNA = NM_001040034
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 54405533
| Hs_GenLoc_end = 54409711
| Hs_Uniprot = P08962
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''CD63 molecule''', also known as '''CD63''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins.<ref>{{cite web | title = Entrez Gene: CD63 CD63 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=967| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Horejsí V, Vlcek C |title=Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. |journal=FEBS Lett. |volume=288 |issue= 1-2 |pages= 1-4 |year= 1991 |pmid= 1879540 |doi= }}
*{{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CDC25A... {November 7, 2007 1:12:40 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:13:39 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:13:50 PM PST}
- CREATED: Created new protein page: CDC25A {November 7, 2007 1:13:57 PM PST}
- INFO: Beginning work on COX1... {November 7, 2007 1:21:09 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:21:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:21:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_COX1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1occ.
| PDB = {{PDB2|1occ}}, {{PDB2|1oco}}, {{PDB2|1ocr}}, {{PDB2|1ocz}}, {{PDB2|1v54}}, {{PDB2|1v55}}, {{PDB2|2dyr}}, {{PDB2|2dys}}, {{PDB2|2eij}}, {{PDB2|2eik}}, {{PDB2|2eil}}, {{PDB2|2eim}}, {{PDB2|2ein}}, {{PDB2|2occ}}
| Name = Cytochrome c oxidase subunit I
| HGNCid = 7419
| Symbol = COX1
| AltSymbols =; MTCO1
| OMIM =
| ECnumber =
| Homologene = 5016
| MGIid = 102504
| Function = {{GNF_GO|id=GO:0004129 |text = cytochrome-c oxidase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005746 |text = mitochondrial respiratory chain}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006123 |text = mitochondrial electron transport, cytochrome c to oxygen}} {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4512
| Hs_Ensembl = ENSG00000198804
| Hs_RefseqProtein = NP_536845
| Hs_RefseqmRNA =
| Hs_GenLoc_db =
| Hs_GenLoc_chr = MT
| Hs_GenLoc_start = 5905
| Hs_GenLoc_end = 7446
| Hs_Uniprot = P00395
| Mm_EntrezGene = 17708
| Mm_Ensembl = ENSMUSG00000064351
| Mm_RefseqmRNA =
| Mm_RefseqProtein = NP_904330
| Mm_GenLoc_db =
| Mm_GenLoc_chr = MT
| Mm_GenLoc_start = 5328
| Mm_GenLoc_end = 6872
| Mm_Uniprot = Q35042
}}
}}
'''Cytochrome c oxidase subunit I''', also known as '''COX1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Torroni A, Achilli A, Macaulay V, ''et al.'' |title=Harvesting the fruit of the human mtDNA tree. |journal=Trends Genet. |volume=22 |issue= 6 |pages= 339-45 |year= 2006 |pmid= 16678300 |doi= 10.1016/j.tig.2006.04.001 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CR2... {November 7, 2007 1:13:57 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:14:31 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:15:02 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CR2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ghq.
| PDB = {{PDB2|1ghq}}, {{PDB2|1ly2}}, {{PDB2|1w2r}}, {{PDB2|1w2s}}, {{PDB2|2gsx}}
| Name = Complement component (3d/Epstein Barr virus) receptor 2
| HGNCid = 2336
| Symbol = CR2
| AltSymbols =; C3DR; CD21
| OMIM = 120650
| ECnumber =
| Homologene = 55611
| MGIid = 88489
| GeneAtlas_image1 = PBB_GE_CR2_205544_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004875 |text = complement receptor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1380
| Hs_Ensembl = ENSG00000117322
| Hs_RefseqProtein = NP_001006659
| Hs_RefseqmRNA = NM_001006658
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 205694198
| Hs_GenLoc_end = 205729863
| Hs_Uniprot = P20023
| Mm_EntrezGene = 12902
| Mm_Ensembl = ENSMUSG00000026616
| Mm_RefseqmRNA = NM_007758
| Mm_RefseqProtein = NP_031784
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 196841897
| Mm_GenLoc_end = 196877439
| Mm_Uniprot = Q6LAP4
}}
}}
'''Complement component (3d/Epstein Barr virus) receptor 2''', also known as '''CR2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Complement component receptor-2 (CR2) is the membrane protein on B lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells. See also MIM 120620. Yefenof et al. (1976) found complete overlapping of EBV receptors and C3 (MIM 120700) receptors on human B lymphocytes.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CR2 complement component (3d/Epstein Barr virus) receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1380| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cooper NR, Bradt BM, Rhim JS, Nemerow GR |title=CR2 complement receptor. |journal=J. Invest. Dermatol. |volume=94 |issue= 6 Suppl |pages= 112S-117S |year= 1990 |pmid= 2161885 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CRH... {November 7, 2007 1:15:02 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:15:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:16:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CRH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1go9.
| PDB = {{PDB2|1go9}}, {{PDB2|1goe}}
| Name = Corticotropin releasing hormone
| HGNCid = 2355
| Symbol = CRH
| AltSymbols =; CRF
| OMIM = 122560
| ECnumber =
| Homologene = 599
| MGIid = 88496
| GeneAtlas_image1 = PBB_GE_CRH_205630_at_tn.png
| GeneAtlas_image2 = PBB_GE_CRH_205629_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007567 |text = parturition}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1392
| Hs_Ensembl = ENSG00000147571
| Hs_RefseqProtein = NP_000747
| Hs_RefseqmRNA = NM_000756
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 67251166
| Hs_GenLoc_end = 67253380
| Hs_Uniprot = P06850
| Mm_EntrezGene = 12918
| Mm_Ensembl = ENSMUSG00000049796
| Mm_RefseqmRNA = NM_205769
| Mm_RefseqProtein = NP_991338
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 19885565
| Mm_GenLoc_end = 19887480
| Mm_Uniprot = Q14AA2
}}
}}
'''Corticotropin releasing hormone''', also known as '''CRH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition.<ref>{{cite web | title = Entrez Gene: CRH corticotropin releasing hormone| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1392| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Florio P, Severi FM, Ciarmela P, ''et al.'' |title=Placental stress factors and maternal-fetal adaptive response: the corticotropin-releasing factor family. |journal=Endocrine |volume=19 |issue= 1 |pages= 91-102 |year= 2003 |pmid= 12583606 |doi= }}
*{{cite journal | author=Florio P, Rossi M, Sigurdardottir M, ''et al.'' |title=Paracrine regulation of endometrial function: interaction between progesterone and corticotropin-releasing factor (CRF) and activin A. |journal=Steroids |volume=68 |issue= 10-13 |pages= 801-7 |year= 2004 |pmid= 14667971 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYCS... {November 7, 2007 1:34:00 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:34:41 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:34:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CYCS_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1j3s.
| PDB = {{PDB2|1j3s}}, {{PDB2|2b4z}}
| Name = Cytochrome c, somatic
| HGNCid = 19986
| Symbol = CYCS
| AltSymbols =; HCS; CYC
| OMIM = 123970
| ECnumber =
| Homologene = 68675
| MGIid = 88578
| GeneAtlas_image1 = PBB_GE_CYCS_208905_at_tn.png
| Function = {{GNF_GO|id=GO:0000158 |text = protein phosphatase type 2A activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0045155 |text = electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000159 |text = protein phosphatase type 2A complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005746 |text = mitochondrial respiratory chain}} {{GNF_GO|id=GO:0005758 |text = mitochondrial intermembrane space}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0008635 |text = caspase activation via cytochrome c}} {{GNF_GO|id=GO:0045333 |text = cellular respiration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 54205
| Hs_Ensembl = ENSG00000172115
| Hs_RefseqProtein = NP_061820
| Hs_RefseqmRNA = NM_018947
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 25124802
| Hs_GenLoc_end = 25131480
| Hs_Uniprot = P99999
| Mm_EntrezGene = 13063
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_975140
| Mm_RefseqProtein = XP_980234
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cytochrome c, somatic''', also known as '''CYCS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes cytochrome c, a component of the electron transport chain in mitochondria. The heme group of cytochrome c accepts electrons from the b-c1 complex and transfers electrons to the cytochrome oxidase complex. Cytochrome c is also involved in initiation of apoptosis. Upon release of cytochrome c to the cytoplasm, the protein binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Many cytochrome c pseudogenes exist, scattered throughout the human genome.<ref>{{cite web | title = Entrez Gene: CYCS cytochrome c, somatic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54205| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Skulachev VP |title=Cytochrome c in the apoptotic and antioxidant cascades. |journal=FEBS Lett. |volume=423 |issue= 3 |pages= 275-80 |year= 1998 |pmid= 9515723 |doi= }}
*{{cite journal | author=Mannella CA |title=Conformational changes in the mitochondrial channel protein, VDAC, and their functional implications. |journal=J. Struct. Biol. |volume=121 |issue= 2 |pages= 207-18 |year= 1998 |pmid= 9615439 |doi= 10.1006/jsbi.1997.3954 }}
*{{cite journal | author=Britton RS, Leicester KL, Bacon BR |title=Iron toxicity and chelation therapy. |journal=Int. J. Hematol. |volume=76 |issue= 3 |pages= 219-28 |year= 2002 |pmid= 12416732 |doi= }}
*{{cite journal | author=Haider N, Narula N, Narula J |title=Apoptosis in heart failure represents programmed cell survival, not death, of cardiomyocytes and likelihood of reverse remodeling. |journal=J. Card. Fail. |volume=8 |issue= 6 Suppl |pages= S512-7 |year= 2003 |pmid= 12555167 |doi= 10.1054/jcaf.2002.130034 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EPAS1... {November 7, 2007 1:16:11 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:17:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:17:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EPAS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p97.
| PDB = {{PDB2|1p97}}, {{PDB2|2a24}}
| Name = Endothelial PAS domain protein 1
| HGNCid = 3374
| Symbol = EPAS1
| AltSymbols =; HIF2A; HLF; MOP2; PASD2
| OMIM = 603349
| ECnumber =
| Homologene = 1095
| MGIid = 109169
| GeneAtlas_image1 = PBB_GE_EPAS1_200878_at_tn.png
| GeneAtlas_image2 = PBB_GE_EPAS1_200879_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0035035 |text = histone acetyltransferase binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2034
| Hs_Ensembl = ENSG00000116016
| Hs_RefseqProtein = NP_001421
| Hs_RefseqmRNA = NM_001430
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 46378045
| Hs_GenLoc_end = 46467340
| Hs_Uniprot = Q99814
| Mm_EntrezGene = 13819
| Mm_Ensembl = ENSMUSG00000024140
| Mm_RefseqmRNA = XM_986887
| Mm_RefseqProtein = XP_991981
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 86662228
| Mm_GenLoc_end = 86739907
| Mm_Uniprot = Q6PEU2
}}
}}
'''Endothelial PAS domain protein 1''', also known as '''EPAS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Brahimi-Horn MC, Pouysségur J |title=The hypoxia-inducible factor and tumor progression along the angiogenic pathway. |journal=Int. Rev. Cytol. |volume=242 |issue= |pages= 157-213 |year= 2005 |pmid= 15598469 |doi= 10.1016/S0074-7696(04)42004-X }}
*{{cite journal | author=Haase VH |title=Hypoxia-inducible factors in the kidney. |journal=Am. J. Physiol. Renal Physiol. |volume=291 |issue= 2 |pages= F271-81 |year= 2006 |pmid= 16554418 |doi= 10.1152/ajprenal.00071.2006 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FEN1... {November 7, 2007 1:17:17 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:18:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:18:24 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FEN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ul1.
| PDB = {{PDB2|1ul1}}
| Name = Flap structure-specific endonuclease 1
| HGNCid = 3650
| Symbol = FEN1
| AltSymbols =; FEN-1; MF1; RAD2
| OMIM = 600393
| ECnumber =
| Homologene = 3034
| MGIid = 102779
| GeneAtlas_image1 = PBB_GE_FEN1_204767_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FEN1_204768_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004523 |text = ribonuclease H activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008309 |text = double-stranded DNA specific exodeoxyribonuclease activity}} {{GNF_GO|id=GO:0008409 |text = 5'-3' exonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017108 |text = 5'-flap endonuclease activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006302 |text = double-strand break repair}} {{GNF_GO|id=GO:0009650 |text = UV protection}} {{GNF_GO|id=GO:0048015 |text = phosphoinositide-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2237
| Hs_Ensembl = ENSG00000168496
| Hs_RefseqProtein = NP_004102
| Hs_RefseqmRNA = NM_004111
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 61316726
| Hs_GenLoc_end = 61321284
| Hs_Uniprot = P39748
| Mm_EntrezGene = 14156
| Mm_Ensembl = ENSMUSG00000024742
| Mm_RefseqmRNA = NM_007999
| Mm_RefseqProtein = NP_032025
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 10266184
| Mm_GenLoc_end = 10270988
| Mm_Uniprot = Q3TGH6
}}
}}
'''Flap structure-specific endonuclease 1''', also known as '''FEN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.<ref>{{cite web | title = Entrez Gene: FEN1 flap structure-specific endonuclease 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2237| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FTL... {November 7, 2007 1:18:24 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:19:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:19:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FTL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ffx.
| PDB = {{PDB2|2ffx}}, {{PDB2|2fg4}}, {{PDB2|2fg8}}
| Name = Ferritin, light polypeptide
| HGNCid = 3999
| Symbol = FTL
| AltSymbols =; MGC71996
| OMIM = 134790
| ECnumber =
| Homologene = 79330
| MGIid = 95590
| GeneAtlas_image1 = PBB_GE_FTL_212788_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_FTL_213187_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0008199 |text = ferric iron binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0008043 |text = ferritin complex}}
| Process = {{GNF_GO|id=GO:0006826 |text = iron ion transport}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2512
| Hs_Ensembl = ENSG00000087086
| Hs_RefseqProtein = NP_000137
| Hs_RefseqmRNA = NM_000146
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 54160378
| Hs_GenLoc_end = 54161850
| Hs_Uniprot = P02792
| Mm_EntrezGene = 14337
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_008049
| Mm_RefseqProtein = NP_032075
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Ferritin, light polypeptide''', also known as '''FTL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.<ref>{{cite web | title = Entrez Gene: FTL ferritin, light polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2512| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Munro HN, Aziz N, Leibold EA, ''et al.'' |title=The ferritin genes: structure, expression, and regulation. |journal=Ann. N. Y. Acad. Sci. |volume=526 |issue= |pages= 113-23 |year= 1988 |pmid= 3291676 |doi= }}
*{{cite journal | author=Cazzola M, Skoda RC |title=Translational pathophysiology: a novel molecular mechanism of human disease. |journal=Blood |volume=95 |issue= 11 |pages= 3280-8 |year= 2000 |pmid= 10828006 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSD11B2... {November 7, 2007 1:19:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:20:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Hydroxysteroid (11-beta) dehydrogenase 2
| HGNCid = 5209
| Symbol = HSD11B2
| AltSymbols =; AME; AME1; HSD11K; HSD2
| OMIM = 218030
| ECnumber =
| Homologene = 20088
| MGIid = 104720
| GeneAtlas_image1 = PBB_GE_HSD11B2_204130_at_tn.png
| Function = {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}}
| Process = {{GNF_GO|id=GO:0006704 |text = glucocorticoid biosynthetic process}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3291
| Hs_Ensembl = ENSG00000176387
| Hs_RefseqProtein = NP_000187
| Hs_RefseqmRNA = NM_000196
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 66022518
| Hs_GenLoc_end = 66028953
| Hs_Uniprot = P80365
| Mm_EntrezGene = 15484
| Mm_Ensembl = ENSMUSG00000031891
| Mm_RefseqmRNA = NM_008289
| Mm_RefseqProtein = NP_032315
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 108407884
| Mm_GenLoc_end = 108413115
| Mm_Uniprot = Q3U2R0
}}
}}
'''Hydroxysteroid (11-beta) dehydrogenase 2''', also known as '''HSD11B2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=White PC, Mune T, Agarwal AK |title=11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. |journal=Endocr. Rev. |volume=18 |issue= 1 |pages= 135-56 |year= 1997 |pmid= 9034789 |doi= }}
*{{cite journal | author=Wilson RC, Dave-Sharma S, Wei JQ, ''et al.'' |title=A genetic defect resulting in mild low-renin hypertension. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10200-5 |year= 1998 |pmid= 9707624 |doi= }}
*{{cite journal | author=Quinkler M, Stewart PM |title=Hypertension and the cortisol-cortisone shuttle. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2384-92 |year= 2003 |pmid= 12788832 |doi= }}
*{{cite journal | author=Tomlinson JW, Walker EA, Bujalska IJ, ''et al.'' |title=11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. |journal=Endocr. Rev. |volume=25 |issue= 5 |pages= 831-66 |year= 2005 |pmid= 15466942 |doi= 10.1210/er.2003-0031 }}
*{{cite journal | author=Persu A |title=11beta-Hydroxysteroid deshydrogenase: a multi-faceted enzyme. |journal=J. Hypertens. |volume=23 |issue= 1 |pages= 29-31 |year= 2005 |pmid= 15643119 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LCP2... {November 7, 2007 1:20:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:21:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
| HGNCid = 6529
| Symbol = LCP2
| AltSymbols =; SLP-76; SLP76
| OMIM = 601603
| ECnumber =
| Homologene = 4065
| MGIid = 1321402
| GeneAtlas_image1 = PBB_GE_LCP2_205269_at_tn.png
| GeneAtlas_image2 = PBB_GE_LCP2_205270_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0045576 |text = mast cell activation}} {{GNF_GO|id=GO:0050663 |text = cytokine secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3937
| Hs_Ensembl = ENSG00000043462
| Hs_RefseqProtein = NP_005556
| Hs_RefseqmRNA = NM_005565
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 169607667
| Hs_GenLoc_end = 169657400
| Hs_Uniprot = Q13094
| Mm_EntrezGene = 16822
| Mm_Ensembl = ENSMUSG00000002699
| Mm_RefseqmRNA = NM_010696
| Mm_RefseqProtein = NP_034826
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 33947144
| Mm_GenLoc_end = 33992281
| Mm_Uniprot = Q3U5Y3
}}
}}
'''Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)''', also known as '''LCP2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.<ref>{{cite web | title = Entrez Gene: LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3937| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LEF1... {November 7, 2007 1:32:31 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:33:41 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:33:53 PM PST}
- CREATED: Created new protein page: LEF1 {November 7, 2007 1:34:00 PM PST}
- INFO: Beginning work on NFATC1... {November 7, 2007 1:21:45 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:22:20 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:22:35 PM PST}
- CREATED: Created new protein page: NFATC1 {November 7, 2007 1:22:43 PM PST}
- INFO: Beginning work on NRAS... {November 7, 2007 1:22:43 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:22:58 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:23:10 PM PST}
- CREATED: Created new protein page: NRAS {November 7, 2007 1:23:17 PM PST}
- INFO: Beginning work on NRP1... {November 7, 2007 1:29:14 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:30:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:30:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NRP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kex.
| PDB = {{PDB2|1kex}}, {{PDB2|2orx}}, {{PDB2|2orz}}
| Name = Neuropilin 1
| HGNCid = 8004
| Symbol = NRP1
| AltSymbols =; NRP; CD304; DKFZp686A03134; DKFZp781F1414; VEGF165R
| OMIM = 602069
| ECnumber =
| Homologene = 2876
| MGIid = 106206
| GeneAtlas_image1 = PBB_GE_NRP1_212298_at_tn.png
| GeneAtlas_image2 = PBB_GE_NRP1_210510_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_NRP1_210615_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005021 |text = vascular endothelial growth factor receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017154 |text = semaphorin receptor activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016358 |text = dendrite development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030517 |text = negative regulation of axon extension}} {{GNF_GO|id=GO:0048010 |text = vascular endothelial growth factor receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8829
| Hs_Ensembl = ENSG00000099250
| Hs_RefseqProtein = NP_001019799
| Hs_RefseqmRNA = NM_001024628
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 33506426
| Hs_GenLoc_end = 33665196
| Hs_Uniprot = O14786
| Mm_EntrezGene = 18186
| Mm_Ensembl = ENSMUSG00000025810
| Mm_RefseqmRNA = NM_008737
| Mm_RefseqProtein = NP_032763
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 131245328
| Mm_GenLoc_end = 131389437
| Mm_Uniprot = Q3UFP7
}}
}}
'''Neuropilin 1''', also known as '''NRP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: NRP1 neuropilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8829| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Zachary I, Gliki G |title=Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. |journal=Cardiovasc. Res. |volume=49 |issue= 3 |pages= 568-81 |year= 2001 |pmid= 11166270 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTPN22... {November 7, 2007 1:30:58 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:32:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:32:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PTPN22_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2p6x.
| PDB = {{PDB2|2p6x}}
| Name = Protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
| HGNCid = 9652
| Symbol = PTPN22
| AltSymbols =; LYP; PEP; Lyp1; Lyp2; PTPN8
| OMIM = 600716
| ECnumber =
| Homologene = 7498
| MGIid = 107170
| GeneAtlas_image1 = PBB_GE_PTPN22_206060_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTPN22_208010_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PTPN22_208011_at_tn.png
| Function = {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030217 |text = T cell differentiation}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 26191
| Hs_Ensembl = ENSG00000134242
| Hs_RefseqProtein = NP_036543
| Hs_RefseqmRNA = NM_012411
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 114092981
| Hs_GenLoc_end = 114215904
| Hs_Uniprot = Q9Y2R2
| Mm_EntrezGene = 19260
| Mm_Ensembl = ENSMUSG00000027843
| Mm_RefseqmRNA = NM_008979
| Mm_RefseqProtein = NP_033005
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 103989353
| Mm_GenLoc_end = 104041308
| Mm_Uniprot = Q3TEL9
}}
}}
'''Protein tyrosine phosphatase, non-receptor type 22 (lymphoid)''', also known as '''PTPN22''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein tyrosine phosphatase which is expressed primarily in lymphoid tissues. This enzyme associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.<ref>{{cite web | title = Entrez Gene: PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26191| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gregersen PK |title=Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond. |journal=Immunol. Rev. |volume=204 |issue= |pages= 74-86 |year= 2005 |pmid= 15790351 |doi= 10.1111/j.0105-2896.2005.00243.x }}
*{{cite journal | author=Brand O, Gough S, Heward J |title=HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity? |journal=Expert reviews in molecular medicine |volume=7 |issue= 23 |pages= 1-15 |year= 2007 |pmid= 16229750 |doi= 10.1017/S1462399405009981 }}
*{{cite journal | author=Bottini N, Vang T, Cucca F, Mustelin T |title=Role of PTPN22 in type 1 diabetes and other autoimmune diseases. |journal=Semin. Immunol. |volume=18 |issue= 4 |pages= 207-13 |year= 2007 |pmid= 16697661 |doi= 10.1016/j.smim.2006.03.008 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAP1A... {November 7, 2007 1:23:17 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:23:31 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:23:47 PM PST}
- CREATED: Created new protein page: RAP1A {November 7, 2007 1:23:55 PM PST}
- INFO: Beginning work on SFTPD... {November 7, 2007 1:23:55 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:24:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:24:43 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SFTPD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b08.
| PDB = {{PDB2|1b08}}, {{PDB2|1m7l}}, {{PDB2|1pw9}}, {{PDB2|1pwb}}, {{PDB2|2ggu}}, {{PDB2|2ggx}}, {{PDB2|2orj}}, {{PDB2|2ork}}, {{PDB2|2os9}}
| Name = Surfactant, pulmonary-associated protein D
| HGNCid = 10803
| Symbol = SFTPD
| AltSymbols =; COLEC7; PSP-D; SFTP4; SP-D
| OMIM = 178635
| ECnumber =
| Homologene = 2272
| MGIid = 109515
| GeneAtlas_image1 = PBB_GE_SFTPD_214199_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0008367 |text = bacterial binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0030139 |text = endocytic vesicle}}
| Process = {{GNF_GO|id=GO:0001817 |text = regulation of cytokine production}} {{GNF_GO|id=GO:0006800 |text = oxygen and reactive oxygen species metabolic process}} {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0042130 |text = negative regulation of T cell proliferation}} {{GNF_GO|id=GO:0043129 |text = surfactant homeostasis}} {{GNF_GO|id=GO:0045085 |text = negative regulation of interleukin-2 biosynthetic process}} {{GNF_GO|id=GO:0045087 |text = innate immune response}} {{GNF_GO|id=GO:0048246 |text = macrophage chemotaxis}} {{GNF_GO|id=GO:0048286 |text = alveolus development}} {{GNF_GO|id=GO:0050766 |text = positive regulation of phagocytosis}} {{GNF_GO|id=GO:0050828 |text = regulation of liquid surface tension}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6441
| Hs_Ensembl = ENSG00000133661
| Hs_RefseqProtein = NP_003010
| Hs_RefseqmRNA = NM_003019
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 81687476
| Hs_GenLoc_end = 81698839
| Hs_Uniprot = P35247
| Mm_EntrezGene = 20390
| Mm_Ensembl = ENSMUSG00000021795
| Mm_RefseqmRNA = NM_009160
| Mm_RefseqProtein = NP_033186
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 40080927
| Mm_GenLoc_end = 40093876
| Mm_Uniprot = P50404
}}
}}
'''Surfactant, pulmonary-associated protein D''', also known as '''SFTPD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hansen S, Holmskov U |title=Structural aspects of collectins and receptors for collectins. |journal=Immunobiology |volume=199 |issue= 2 |pages= 165-89 |year= 1999 |pmid= 9777404 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TH... {November 7, 2007 1:24:43 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:25:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:25:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1toh.
| PDB = {{PDB2|1toh}}, {{PDB2|2toh}}
| Name = Tyrosine hydroxylase
| HGNCid = 11782
| Symbol = TH
| AltSymbols =; TYH
| OMIM = 191290
| ECnumber =
| Homologene = 307
| MGIid = 98735
| GeneAtlas_image1 = PBB_GE_TH_208291_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0004511 |text = tyrosine 3-monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001963 |text = synaptic transmission, dopaminergic}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007612 |text = learning}} {{GNF_GO|id=GO:0007613 |text = memory}} {{GNF_GO|id=GO:0007617 |text = mating behavior}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}} {{GNF_GO|id=GO:0009072 |text = aromatic amino acid family metabolic process}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0042136 |text = neurotransmitter biosynthetic process}} {{GNF_GO|id=GO:0042423 |text = catecholamine biosynthetic process}} {{GNF_GO|id=GO:0042755 |text = eating behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7054
| Hs_Ensembl = ENSG00000180176
| Hs_RefseqProtein = NP_000351
| Hs_RefseqmRNA = NM_000360
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 2141735
| Hs_GenLoc_end = 2149612
| Hs_Uniprot = P07101
| Mm_EntrezGene = 21823
| Mm_Ensembl = ENSMUSG00000000214
| Mm_RefseqmRNA = NM_009377
| Mm_RefseqProtein = NP_033403
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 142702166
| Mm_GenLoc_end = 142709356
| Mm_Uniprot = Q3UTB3
}}
}}
'''Tyrosine hydroxylase''', also known as '''TH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.<ref>{{cite web | title = Entrez Gene: TH tyrosine hydroxylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7054| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Masserano JM, Weiner N |title=Tyrosine hydroxylase regulation in the central nervous system. |journal=Mol. Cell. Biochem. |volume=53-54 |issue= 1-2 |pages= 129-52 |year= 1983 |pmid= 6137760 |doi= }}
*{{cite journal | author=Meloni R, Biguet NF, Mallet J |title=Post-genomic era and gene discovery for psychiatric diseases: there is a new art of the trade? The example of the HUMTH01 microsatellite in the Tyrosine Hydroxylase gene. |journal=Mol. Neurobiol. |volume=26 |issue= 2-3 |pages= 389-403 |year= 2002 |pmid= 12428766 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on THPO... {November 7, 2007 1:25:25 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:26:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:26:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_THPO_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1v7m.
| PDB = {{PDB2|1v7m}}, {{PDB2|1v7n}}
| Name = Thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)
| HGNCid = 11795
| Symbol = THPO
| AltSymbols =; MGC163194; MGDF; MKCSF; ML; MPLLG; TPO
| OMIM = 600044
| ECnumber =
| Homologene = 398
| MGIid = 101875
| GeneAtlas_image1 = PBB_GE_THPO_211155_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_THPO_211154_at_tn.png
| GeneAtlas_image3 = PBB_GE_THPO_211831_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005179 |text = hormone activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030099 |text = myeloid cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7066
| Hs_Ensembl = ENSG00000090534
| Hs_RefseqProtein = NP_954698
| Hs_RefseqmRNA = NM_199228
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 185572995
| Hs_GenLoc_end = 185578626
| Hs_Uniprot = P40225
| Mm_EntrezGene = 21832
| Mm_Ensembl = ENSMUSG00000022847
| Mm_RefseqmRNA = NM_009379
| Mm_RefseqProtein = NP_033405
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 20638951
| Mm_GenLoc_end = 20642402
| Mm_Uniprot = Q543R9
}}
}}
'''Thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)''', also known as '''THPO''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.<ref>{{cite web | title = Entrez Gene: THPO thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7066| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kato T, Matsumoto A, Ogami K, ''et al.'' |title=Native thrombopoietin: structure and function. |journal=Stem Cells |volume=16 |issue= 5 |pages= 322-8 |year= 1999 |pmid= 9766811 |doi= }}
*{{cite journal | author=Kato T |title=Protein characteristics of thrombopoietin. |journal=Stem Cells |volume=14 Suppl 1 |issue= |pages= 139-47 |year= 2000 |pmid= 11012214 |doi= }}
*{{cite journal | author=Geddis AE, Linden HM, Kaushansky K |title=Thrombopoietin: a pan-hematopoietic cytokine. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 1 |pages= 61-73 |year= 2002 |pmid= 11750880 |doi= }}
*{{cite journal | author=von dem Borne A, Folman C, van den Oudenrijn S, ''et al.'' |title=The potential role of thrombopoietin in idiopathic thrombocytopenic purpura. |journal=Blood Rev. |volume=16 |issue= 1 |pages= 57-9 |year= 2002 |pmid= 11913997 |doi= 10.1054/blre.2001.0184 }}
*{{cite journal | author=Kaushansky K |title=Thrombopoietin: from theory to reality. |journal=Int. J. Hematol. |volume=76 Suppl 1 |issue= |pages= 343-5 |year= 2003 |pmid= 12430879 |doi= }}
*{{cite journal | author=Kralovics R, Skoda RC |title=Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders. |journal=Blood Rev. |volume=19 |issue= 1 |pages= 1-13 |year= 2005 |pmid= 15572213 |doi= 10.1016/j.blre.2004.02.002 }}
*{{cite journal | author=Migliaccio AR, Rana RA, Vannucchi AM, Manzoli FA |title=Role of thrombopoietin in mast cell differentiation. |journal=Ann. N. Y. Acad. Sci. |volume=1106 |issue= |pages= 152-74 |year= 2007 |pmid= 17468237 |doi= 10.1196/annals.1392.024 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNFRSF10A... {November 7, 2007 1:28:37 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 1:29:07 PM PST}
- CREATED: Created new protein page: TNFRSF10A {November 7, 2007 1:29:14 PM PST}
- INFO: Beginning work on TSC1... {November 7, 2007 1:26:57 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:27:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tuberous sclerosis 1
| HGNCid = 12362
| Symbol = TSC1
| AltSymbols =; TSC; KIAA0243; LAM; MGC86987
| OMIM = 605284
| ECnumber =
| Homologene = 314
| MGIid = 1929183
| GeneAtlas_image1 = PBB_GE_TSC1_209390_at_tn.png
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7248
| Hs_Ensembl = ENSG00000165699
| Hs_RefseqProtein = NP_000359
| Hs_RefseqmRNA = NM_000368
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 134756557
| Hs_GenLoc_end = 134809841
| Hs_Uniprot = Q92574
| Mm_EntrezGene = 64930
| Mm_Ensembl = ENSMUSG00000026812
| Mm_RefseqmRNA = NM_022887
| Mm_RefseqProtein = NP_075025
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 28463246
| Mm_GenLoc_end = 28513176
| Mm_Uniprot =
}}
}}
'''Tuberous sclerosis 1''', also known as '''TSC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hengstschläger M |title=Tuberous sclerosis complex genes: from flies to human genetics. |journal=Arch. Dermatol. Res. |volume=293 |issue= 8 |pages= 383-6 |year= 2002 |pmid= 11686512 |doi= }}
*{{cite journal | author=Ramesh V |title=Aspects of tuberous sclerosis complex (TSC) protein function in the brain. |journal=Biochem. Soc. Trans. |volume=31 |issue= Pt 3 |pages= 579-83 |year= 2004 |pmid= 12773159 |doi= 10.1042/ }}
*{{cite journal | author=Knowles MA, Hornigold N, Pitt E |title=Tuberous sclerosis complex (TSC) gene involvement in sporadic tumours. |journal=Biochem. Soc. Trans. |volume=31 |issue= Pt 3 |pages= 597-602 |year= 2004 |pmid= 12773163 |doi= 10.1042/ }}
*{{cite journal | author=Ellisen LW |title=Growth control under stress: mTOR regulation through the REDD1-TSC pathway. |journal=Cell Cycle |volume=4 |issue= 11 |pages= 1500-02 |year= 2007 |pmid= 16258273 |doi= }}
*{{cite journal | author=Jozwiak J, Jozwiak S |title=Giant cells: contradiction to two-hit model of tuber formation? |journal=Cell. Mol. Neurobiol. |volume=27 |issue= 2 |pages= 251-61 |year= 2007 |pmid= 16897363 |doi= 10.1007/s10571-006-9106-0 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on VCL... {November 7, 2007 1:27:39 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 1:28:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:28:37 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_VCL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qkr.
| PDB = {{PDB2|1qkr}}, {{PDB2|1rkc}}, {{PDB2|1rke}}, {{PDB2|1st6}}, {{PDB2|1syq}}, {{PDB2|1t01}}, {{PDB2|1tr2}}, {{PDB2|1u6h}}, {{PDB2|1xwj}}, {{PDB2|1ydi}}, {{PDB2|1zvz}}, {{PDB2|1zw2}}, {{PDB2|1zw3}}, {{PDB2|2gdc}}, {{PDB2|2gww}}, {{PDB2|2hsq}}
| Name = Vinculin
| HGNCid = 12665
| Symbol = VCL
| AltSymbols =; MVCL
| OMIM = 193065
| ECnumber =
| Homologene = 7594
| MGIid = 98927
| GeneAtlas_image1 = PBB_GE_VCL_200931_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_VCL_200930_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0045294 |text = alpha-catenin binding}}
| Component = {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0005912 |text = adherens junction}} {{GNF_GO|id=GO:0005925 |text = focal adhesion}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0030055 |text = cell-matrix junction}} {{GNF_GO|id=GO:0043034 |text = costamere}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030032 |text = lamellipodium biogenesis}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}} {{GNF_GO|id=GO:0043297 |text = apical junction assembly}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7414
| Hs_Ensembl = ENSG00000035403
| Hs_RefseqProtein = NP_003364
| Hs_RefseqmRNA = NM_003373
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 75427878
| Hs_GenLoc_end = 75549924
| Hs_Uniprot = P18206
| Mm_EntrezGene = 22330
| Mm_Ensembl = ENSMUSG00000021823
| Mm_RefseqmRNA = NM_009502
| Mm_RefseqProtein = NP_033528
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 19717950
| Mm_GenLoc_end = 19822228
| Mm_Uniprot = Q64727
}}
}}
'''Vinculin''', also known as '''VCL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Human vinculin protein exhibits a greater than 95% sequence identity to the chicken vinculin protein.<ref>{{cite web | title = Entrez Gene: VCL vinculin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7414| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Critchley DR |title=Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 5 |pages= 831-6 |year= 2005 |pmid= 15494027 |doi= 10.1042/BST0320831 }}
}}
{{refend}}
{{protein-stub}}
end log.
