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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 03:07, 8 November 2007 (UTC)
[edit] Proteins without matches (17)
[edit] Proteins with a High Potential Match (7)
[edit] Redirected Proteins (1)
[edit] Created (10)
[edit] Manual Inspection (Page not found) (14)
[edit] Updated (1)
[edit] Protein Status Grid - Date: 03:07, 8 November 2007 (UTC)
[edit] Vebose Log - Date: 03:07, 8 November 2007 (UTC)
- INFO: Beginning work on AHSG... {November 7, 2007 6:37:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:38:23 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Alpha-2-HS-glycoprotein
| HGNCid = 349
| Symbol = AHSG
| AltSymbols =; A2HS; AHS; FETUA; HSGA
| OMIM = 138680
| ECnumber =
| Homologene = 1225
| MGIid = 107189
| GeneAtlas_image1 = PBB_GE_AHSG_204551_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_AHSG_210929_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004869 |text = cysteine protease inhibitor activity}} {{GNF_GO|id=GO:0019210 |text = kinase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0006907 |text = pinocytosis}} {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0030502 |text = negative regulation of bone mineralization}} {{GNF_GO|id=GO:0046627 |text = negative regulation of insulin receptor signaling pathway}} {{GNF_GO|id=GO:0050727 |text = regulation of inflammatory response}} {{GNF_GO|id=GO:0050766 |text = positive regulation of phagocytosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 197
| Hs_Ensembl = ENSG00000145192
| Hs_RefseqProtein = NP_001613
| Hs_RefseqmRNA = NM_001622
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 187813549
| Hs_GenLoc_end = 187821786
| Hs_Uniprot = P02765
| Mm_EntrezGene = 11625
| Mm_Ensembl = ENSMUSG00000022868
| Mm_RefseqmRNA = NM_013465
| Mm_RefseqProtein = NP_038493
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 22807376
| Mm_GenLoc_end = 22814772
| Mm_Uniprot = O35399
}}
}}
'''Alpha-2-HS-glycoprotein''', also known as '''AHSG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure.<ref>{{cite web | title = Entrez Gene: AHSG alpha-2-HS-glycoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=197| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ketteler M, Vermeer C, Wanner C, ''et al.'' |title=Novel insights into uremic vascular calcification: role of matrix Gla protein and alpha-2-Heremans Schmid glycoprotein/fetuin. |journal=Blood Purif. |volume=20 |issue= 5 |pages= 473-6 |year= 2003 |pmid= 12207096 |doi= }}
*{{cite journal | author=Ketteler M |title=Fetuin-A and extraosseous calcification in uremia. |journal=Curr. Opin. Nephrol. Hypertens. |volume=14 |issue= 4 |pages= 337-42 |year= 2005 |pmid= 15931001 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on APOC2... {November 7, 2007 6:38:23 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:38:37 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:38:49 PM PST}
- CREATED: Created new protein page: APOC2 {November 7, 2007 6:38:57 PM PST}
- INFO: Beginning work on BMI1... {November 7, 2007 6:38:57 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:39:33 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:39:46 PM PST}
- CREATED: Created new protein page: BMI1 {November 7, 2007 6:39:54 PM PST}
- INFO: Beginning work on CD79A... {November 7, 2007 6:39:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:40:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD79a molecule, immunoglobulin-associated alpha
| HGNCid = 1698
| Symbol = CD79A
| AltSymbols =; IGA; MB-1
| OMIM = 112205
| ECnumber =
| Homologene = 31053
| MGIid = 101774
| GeneAtlas_image1 = PBB_GE_CD79A_205049_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005771 |text = multivesicular body}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019815 |text = B cell receptor complex}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0050853 |text = B cell receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 973
| Hs_Ensembl = ENSG00000105369
| Hs_RefseqProtein = NP_001774
| Hs_RefseqmRNA = NM_001783
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 47073030
| Hs_GenLoc_end = 47077275
| Hs_Uniprot = P11912
| Mm_EntrezGene = 12518
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_989437
| Mm_RefseqProtein = XP_994531
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''CD79a molecule, immunoglobulin-associated alpha''', also known as '''CD79A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.<ref>{{cite web | title = Entrez Gene: CD79A CD79a molecule, immunoglobulin-associated alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=973| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reth M |title=Antigen receptors on B lymphocytes. |journal=Annu. Rev. Immunol. |volume=10 |issue= |pages= 97-121 |year= 1992 |pmid= 1591006 |doi= 10.1146/annurev.iy.10.040192.000525 }}
*{{cite journal | author=Herren B, Burrows PD |title=B cell-restricted human mb-1 gene: expression, function, and lineage infidelity. |journal=Immunol. Res. |volume=26 |issue= 1-3 |pages= 35-43 |year= 2003 |pmid= 12403343 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CLN3... {November 7, 2007 6:40:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:41:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
| HGNCid = 2074
| Symbol = CLN3
| AltSymbols =; BTS; MGC102840
| OMIM = 607042
| ECnumber =
| Homologene = 37259
| MGIid = 107537
| GeneAtlas_image1 = PBB_GE_CLN3_209275_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CLN3_210859_x_at_tn.png
| Function = {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005769 |text = early endosome}} {{GNF_GO|id=GO:0005770 |text = late endosome}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005795 |text = Golgi stack}} {{GNF_GO|id=GO:0005802 |text = trans-Golgi network}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005901 |text = caveola}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030176 |text = integral to endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0043005 |text = neuron projection}} {{GNF_GO|id=GO:0045121 |text = lipid raft}}
| Process = {{GNF_GO|id=GO:0001508 |text = regulation of action potential}} {{GNF_GO|id=GO:0001575 |text = globoside metabolic process}} {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006520 |text = amino acid metabolic process}} {{GNF_GO|id=GO:0006678 |text = glucosylceramide metabolic process}} {{GNF_GO|id=GO:0006681 |text = galactosylceramide metabolic process}} {{GNF_GO|id=GO:0006684 |text = sphingomyelin metabolic process}} {{GNF_GO|id=GO:0006865 |text = amino acid transport}} {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}} {{GNF_GO|id=GO:0007042 |text = lysosomal lumen acidification}} {{GNF_GO|id=GO:0008306 |text = associative learning}} {{GNF_GO|id=GO:0015809 |text = arginine transport}} {{GNF_GO|id=GO:0016044 |text = membrane organization and biogenesis}} {{GNF_GO|id=GO:0016236 |text = macroautophagy}} {{GNF_GO|id=GO:0016485 |text = protein processing}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}} {{GNF_GO|id=GO:0035235 |text = ionotropic glutamate receptor signaling pathway}} {{GNF_GO|id=GO:0042133 |text = neurotransmitter metabolic process}} {{GNF_GO|id=GO:0042987 |text = amyloid precursor protein catabolic process}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}} {{GNF_GO|id=GO:0045861 |text = negative regulation of proteolysis}} {{GNF_GO|id=GO:0050885 |text = regulation of balance}} {{GNF_GO|id=GO:0051453 |text = regulation of cellular pH}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1201
| Hs_Ensembl = ENSG00000188603
| Hs_RefseqProtein = NP_000077
| Hs_RefseqmRNA = NM_000086
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 28396102
| Hs_GenLoc_end = 28413398
| Hs_Uniprot = Q13286
| Mm_EntrezGene = 12752
| Mm_Ensembl = ENSMUSG00000030720
| Mm_RefseqmRNA = XM_993441
| Mm_RefseqProtein = XP_998535
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 126362548
| Mm_GenLoc_end = 126374526
| Mm_Uniprot = O35934
}}
}}
'''Ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)''', also known as '''CLN3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene.<ref>{{cite web | title = Entrez Gene: CLN3 ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1201| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dawson G, Cho S |title=Batten's disease: clues to neuronal protein catabolism in lysosomes. |journal=J. Neurosci. Res. |volume=60 |issue= 2 |pages= 133-40 |year= 2000 |pmid= 10740217 |doi= }}
*{{cite journal | author=Vesa J, Peltonen L |title=Mutated genes in juvenile and variant late infantile neuronal ceroid lipofuscinoses encode lysosomal proteins. |journal=Curr. Mol. Med. |volume=2 |issue= 5 |pages= 439-44 |year= 2003 |pmid= 12125809 |doi= }}
*{{cite journal | author=Phillips SN, Benedict JW, Weimer JM, Pearce DA |title=CLN3, the protein associated with batten disease: structure, function and localization. |journal=J. Neurosci. Res. |volume=79 |issue= 5 |pages= 573-83 |year= 2005 |pmid= 15657902 |doi= 10.1002/jnr.20367 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CREM... {November 7, 2007 6:41:30 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:43:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:43:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CREM_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dh3.
| PDB = {{PDB2|1dh3}}
| Name = CAMP responsive element modulator
| HGNCid = 2352
| Symbol = CREM
| AltSymbols =; ICER; MGC111110; MGC17881; MGC41893; hCREM-2
| OMIM = 123812
| ECnumber =
| Homologene = 84591
| MGIid =
| GeneAtlas_image1 = PBB_GE_CREM_207630_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CREM_209967_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CREM_210171_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008140 |text = cAMP response element binding protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1390
| Hs_Ensembl = ENSG00000095794
| Hs_RefseqProtein = NP_001872
| Hs_RefseqmRNA = NM_001881
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 35455807
| Hs_GenLoc_end = 35541892
| Hs_Uniprot = Q03060
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''CAMP responsive element modulator''', also known as '''CREM''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.<ref>{{cite web | title = Entrez Gene: CREM cAMP responsive element modulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1390| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Don J, Stelzer G |title=The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis. |journal=Mol. Cell. Endocrinol. |volume=187 |issue= 1-2 |pages= 115-24 |year= 2003 |pmid= 11988318 |doi= }}
*{{cite journal | author=Yan C, Miller CL, Abe J |title=Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart. |journal=Circ. Res. |volume=100 |issue= 4 |pages= 489-501 |year= 2007 |pmid= 17332439 |doi= 10.1161/01.RES.0000258451.44949.d7 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EPS15... {November 7, 2007 6:43:31 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:44:30 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:44:43 PM PST}
- CREATED: Created new protein page: EPS15 {November 7, 2007 6:44:51 PM PST}
- INFO: Beginning work on F12... {November 7, 2007 6:44:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:45:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Coagulation factor XII (Hageman factor)
| HGNCid = 3530
| Symbol = F12
| AltSymbols =; HAF
| OMIM = 234000
| ECnumber =
| Homologene = 425
| MGIid = 1891012
| GeneAtlas_image1 = PBB_GE_F12_205774_at_tn.png
| Function = {{GNF_GO|id=GO:0003805 |text = coagulation factor XIa activity}} {{GNF_GO|id=GO:0003806 |text = coagulation factor XIIa activity}} {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0042730 |text = fibrinolysis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2161
| Hs_Ensembl = ENSG00000131187
| Hs_RefseqProtein = NP_000496
| Hs_RefseqmRNA = NM_000505
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 176761747
| Hs_GenLoc_end = 176769183
| Hs_Uniprot = P00748
| Mm_EntrezGene = 58992
| Mm_Ensembl = ENSMUSG00000021492
| Mm_RefseqmRNA = NM_021489
| Mm_RefseqProtein = NP_067464
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 55427588
| Mm_GenLoc_end = 55436415
| Mm_Uniprot =
}}
}}
'''Coagulation factor XII (Hageman factor)''', also known as '''F12''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.<ref>{{cite web | title = Entrez Gene: F12 coagulation factor XII (Hageman factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2161| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Girolami A, Randi ML, Gavasso S, ''et al.'' |title=The occasional venous thromboses seen in patients with severe (homozygous) FXII deficiency are probably due to associated risk factors: a study of prevalence in 21 patients and review of the literature. |journal=J. Thromb. Thrombolysis |volume=17 |issue= 2 |pages= 139-43 |year= 2005 |pmid= 15306750 |doi= 10.1023/B:THRO.0000037670.42776.cd }}
*{{cite journal | author=Renné T, Gailani D |title=Role of Factor XII in hemostasis and thrombosis: clinical implications. |journal=Expert review of cardiovascular therapy |volume=5 |issue= 4 |pages= 733-41 |year= 2007 |pmid= 17605651 |doi= 10.1586/14779072.5.4.733 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FPR1... {November 7, 2007 6:45:22 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:46:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Formyl peptide receptor 1
| HGNCid = 3826
| Symbol = FPR1
| AltSymbols =; FMLP; FPR
| OMIM = 136537
| ECnumber =
| Homologene = 20466
| MGIid = 107443
| GeneAtlas_image1 = PBB_GE_FPR1_205119_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FPR1_205118_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004982 |text = N-formyl peptide receptor activity}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007263 |text = nitric oxide mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2357
| Hs_Ensembl = ENSG00000171051
| Hs_RefseqProtein = NP_002020
| Hs_RefseqmRNA = NM_002029
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 56940237
| Hs_GenLoc_end = 56946912
| Hs_Uniprot = P21462
| Mm_EntrezGene = 14293
| Mm_Ensembl = ENSMUSG00000045551
| Mm_RefseqmRNA = NM_013521
| Mm_RefseqProtein = NP_038549
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 17581087
| Mm_GenLoc_end = 17588557
| Mm_Uniprot = Q3UV01
}}
}}
'''Formyl peptide receptor 1''', also known as '''FPR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HLA-F... {November 7, 2007 6:46:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:47:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Major histocompatibility complex, class I, F
| HGNCid = 4963
| Symbol = HLA-F
| AltSymbols =; HLA-5.4; HLA-CDA12; HLAF
| OMIM = 143110
| ECnumber =
| Homologene = 85957
| MGIid = 95931
| GeneAtlas_image1 = PBB_GE_HLA-F_204806_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_HLA-F_221875_x_at_tn.png
| Function = {{GNF_GO|id=GO:0032393 |text = MHC class I receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042612 |text = MHC class I protein complex}}
| Process = {{GNF_GO|id=GO:0002474 |text = antigen processing and presentation of peptide antigen via MHC class I}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3134
| Hs_Ensembl = ENSG00000137403
| Hs_RefseqProtein = NP_061823
| Hs_RefseqmRNA = NM_018950
| Hs_GenLoc_db =
| Hs_GenLoc_chr = c6_COX
| Hs_GenLoc_start = 29832424
| Hs_GenLoc_end = 29836307
| Hs_Uniprot = P30511
| Mm_EntrezGene = 15013
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_010392
| Mm_RefseqProtein = NP_034522
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Major histocompatibility complex, class I, F''', also known as '''HLA-F''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = HLA-F belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-F binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 42 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. The HLA-F gene exhibits few polymorphisms.<ref>{{cite web | title = Entrez Gene: HLA-F major histocompatibility complex, class I, F| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3134| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580-5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141 }}
*{{cite journal | author=Greenway AL, Holloway G, McPhee DA, ''et al.'' |title=HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. |journal=J. Biosci. |volume=28 |issue= 3 |pages= 323-35 |year= 2004 |pmid= 12734410 |doi= }}
*{{cite journal | author=Bénichou S, Benmerah A |title=[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100-6 |year= 2003 |pmid= 12836198 |doi= }}
*{{cite journal | author=Leavitt SA, SchOn A, Klein JC, ''et al.'' |title=Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm. |journal=Curr. Protein Pept. Sci. |volume=5 |issue= 1 |pages= 1-8 |year= 2004 |pmid= 14965316 |doi= }}
*{{cite journal | author=Tolstrup M, Ostergaard L, Laursen AL, ''et al.'' |title=HIV/SIV escape from immune surveillance: focus on Nef. |journal=Curr. HIV Res. |volume=2 |issue= 2 |pages= 141-51 |year= 2004 |pmid= 15078178 |doi= }}
*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87-94 |year= 2005 |pmid= 15638726 |doi= }}
*{{cite journal | author=Anderson JL, Hope TJ |title=HIV accessory proteins and surviving the host cell. |journal=Current HIV/AIDS reports |volume=1 |issue= 1 |pages= 47-53 |year= 2005 |pmid= 16091223 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSPA1A... {November 7, 2007 6:47:20 PM PST}
- SEARCH REDIRECT: Control Box Found: HSPA1A {November 7, 2007 6:47:42 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 7, 2007 6:47:43 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 7, 2007 6:47:43 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 7, 2007 6:47:43 PM PST}
- UPDATED: Updated protein page: HSPA1A {November 7, 2007 6:47:51 PM PST}
- INFO: Beginning work on IL3... {November 7, 2007 6:47:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:48:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Interleukin 3 (colony-stimulating factor, multiple)
| HGNCid = 6011
| Symbol = IL3
| AltSymbols =; IL-3; MCGF; MGC79398; MGC79399; MULTI-CSF
| OMIM = 147740
| ECnumber =
| Homologene = 47938
| MGIid =
| GeneAtlas_image1 = PBB_GE_IL3_207906_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005135 |text = interleukin-3 receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0045885 |text = positive regulation of survival gene product activity}} {{GNF_GO|id=GO:0050731 |text = positive regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3562
| Hs_Ensembl = ENSG00000164399
| Hs_RefseqProtein = NP_000579
| Hs_RefseqmRNA = NM_000588
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 131424121
| Hs_GenLoc_end = 131426796
| Hs_Uniprot = P08700
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Interleukin 3 (colony-stimulating factor, multiple)''', also known as '''IL3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.<ref>{{cite web | title = Entrez Gene: IL3 interleukin 3 (colony-stimulating factor, multiple)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3562| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wagemaker G, Burger H, van Gils FC, ''et al.'' |title=Interleukin-3. |journal=Biotherapy (Dordrecht, Netherlands) |volume=2 |issue= 4 |pages= 337-45 |year= 1991 |pmid= 2268499 |doi= }}
*{{cite journal | author=Martinez-Moczygemba M, Huston DP |title=Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF. |journal=J. Allergy Clin. Immunol. |volume=112 |issue= 4 |pages= 653-65; quiz 666 |year= 2003 |pmid= 14564341 |doi= 10.1016/S0091 }}
*{{cite journal | author=Mroczko B, Szmitkowski M |title=Hematopoietic cytokines as tumor markers. |journal=Clin. Chem. Lab. Med. |volume=42 |issue= 12 |pages= 1347-54 |year= 2005 |pmid= 15576295 |doi= 10.1515/CCLM.2004.253 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KCNE1... {November 7, 2007 6:48:29 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:49:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium voltage-gated channel, Isk-related family, member 1
| HGNCid = 6240
| Symbol = KCNE1
| AltSymbols =; ISK; JLNS; JLNS2; LQT5; MGC33114; MinK
| OMIM = 176261
| ECnumber =
| Homologene = 185
| MGIid = 96673
| GeneAtlas_image1 = PBB_GE_KCNE1_208514_at_tn.png
| Function = {{GNF_GO|id=GO:0005251 |text = delayed rectifier potassium channel activity}} {{GNF_GO|id=GO:0015459 |text = potassium channel regulator activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}}
| Process = {{GNF_GO|id=GO:0002070 |text = epithelial cell maturation}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3753
| Hs_Ensembl = ENSG00000180509
| Hs_RefseqProtein = NP_000210
| Hs_RefseqmRNA = NM_000219
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 34740858
| Hs_GenLoc_end = 34806443
| Hs_Uniprot = P15382
| Mm_EntrezGene = 16509
| Mm_Ensembl = ENSMUSG00000039639
| Mm_RefseqmRNA = XM_983408
| Mm_RefseqProtein = XP_988502
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 92234860
| Mm_GenLoc_end = 92248327
| Mm_Uniprot = Q545H6
}}
}}
'''Potassium voltage-gated channel, Isk-related family, member 1''', also known as '''KCNE1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = KCNE1 together with KCNQ1 encode the two subunits of the K+ channel responsible for the delayed-rectifier K+ current in cardiac myocytes (referred to as IsK).<ref>{{cite web | title = Entrez Gene: KCNE1 potassium voltage-gated channel, Isk-related family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3753| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KPNA4... {November 7, 2007 6:49:17 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:50:01 PM PST}
- CREATED: Created new protein page: KPNA4 {November 7, 2007 6:50:09 PM PST}
- INFO: Beginning work on LAMA5... {November 7, 2007 6:50:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:50:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Laminin, alpha 5
| HGNCid = 6485
| Symbol = LAMA5
| AltSymbols =; KIAA1907
| OMIM = 601033
| ECnumber =
| Homologene = 4060
| MGIid = 105382
| GeneAtlas_image1 = PBB_GE_LAMA5_210150_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005605 |text = basal lamina}} {{GNF_GO|id=GO:0005606 |text = laminin-1 complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0045995 |text = regulation of embryonic development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3911
| Hs_Ensembl = ENSG00000130702
| Hs_RefseqProtein = NP_005551
| Hs_RefseqmRNA = NM_005560
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 60317510
| Hs_GenLoc_end = 60375763
| Hs_Uniprot = O15230
| Mm_EntrezGene = 16776
| Mm_Ensembl = ENSMUSG00000015647
| Mm_RefseqmRNA = XM_203796
| Mm_RefseqProtein = XP_203796
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 180105782
| Mm_GenLoc_end = 180155210
| Mm_Uniprot = Q3TZ05
}}
}}
'''Laminin, alpha 5''', also known as '''LAMA5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.<ref>{{cite web | title = Entrez Gene: LAMA5 laminin, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3911| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LYZ... {November 7, 2007 6:50:45 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:51:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:51:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LYZ_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 133l.
| PDB = {{PDB2|133l}}, {{PDB2|134l}}, {{PDB2|1b5u}}, {{PDB2|1b5v}}, {{PDB2|1b5w}}, {{PDB2|1b5x}}, {{PDB2|1b5y}}, {{PDB2|1b5z}}, {{PDB2|1b7l}}, {{PDB2|1b7m}}, {{PDB2|1b7n}}, {{PDB2|1b7o}}, {{PDB2|1b7p}}, {{PDB2|1b7q}}, {{PDB2|1b7r}}, {{PDB2|1b7s}}, {{PDB2|1bb3}}, {{PDB2|1bb4}}, {{PDB2|1bb5}}, {{PDB2|1c43}}, {{PDB2|1c45}}, {{PDB2|1c46}}, {{PDB2|1c7p}}, {{PDB2|1cj6}}, {{PDB2|1cj7}}, {{PDB2|1cj8}}, {{PDB2|1cj9}}, {{PDB2|1ckc}}, {{PDB2|1ckd}}, {{PDB2|1ckf}}, {{PDB2|1ckg}}, {{PDB2|1ckh}}, {{PDB2|1d6p}}, {{PDB2|1d6q}}, {{PDB2|1di3}}, {{PDB2|1di4}}, {{PDB2|1di5}}, {{PDB2|1eq4}}, {{PDB2|1eq5}}, {{PDB2|1eqe}}, {{PDB2|1gay}}, {{PDB2|1gaz}}, {{PDB2|1gb0}}, {{PDB2|1gb2}}, {{PDB2|1gb3}}, {{PDB2|1gb5}}, {{PDB2|1gb6}}, {{PDB2|1gb7}}, {{PDB2|1gb8}}, {{PDB2|1gb9}}, {{PDB2|1gbo}}, {{PDB2|1gbw}}, {{PDB2|1gbx}}, {{PDB2|1gby}}, {{PDB2|1gbz}}, {{PDB2|1gdw}}, {{PDB2|1gdx}}, {{PDB2|1ge0}}, {{PDB2|1ge1}}, {{PDB2|1ge2}}, {{PDB2|1ge3}}, {{PDB2|1ge4}}, {{PDB2|1gev}}, {{PDB2|1gez}}, {{PDB2|1gf0}}, {{PDB2|1gf3}}, {{PDB2|1gf4}}, {{PDB2|1gf5}}, {{PDB2|1gf6}}, {{PDB2|1gf7}}, {{PDB2|1gf8}}, {{PDB2|1gf9}}, {{PDB2|1gfa}}, {{PDB2|1gfe}}, {{PDB2|1gfg}}, {{PDB2|1gfh}}, {{PDB2|1gfj}}, {{PDB2|1gfk}}, {{PDB2|1gfr}}, {{PDB2|1gft}}, {{PDB2|1gfu}}, {{PDB2|1gfv}}, {{PDB2|1hnl}}, {{PDB2|1i1z}}, {{PDB2|1i20}}, {{PDB2|1i22}}, {{PDB2|1inu}}, {{PDB2|1ioc}}, {{PDB2|1ip1}}, {{PDB2|1ip2}}, {{PDB2|1ip3}}, {{PDB2|1ip4}}, {{PDB2|1ip5}}, {{PDB2|1ip6}}, {{PDB2|1ip7}}, {{PDB2|1iwt}}, {{PDB2|1iwu}}, {{PDB2|1iwv}}, {{PDB2|1iww}}, {{PDB2|1iwx}}, {{PDB2|1iwy}}, {{PDB2|1iwz}}, {{PDB2|1ix0}}, {{PDB2|1iy3}}, {{PDB2|1iy4}}, {{PDB2|1jka}}, {{PDB2|1jkb}}, {{PDB2|1jkc}}, {{PDB2|1jkd}}, {{PDB2|1jsf}}, {{PDB2|1jwr}}, {{PDB2|1laa}}, {{PDB2|1lhh}}, {{PDB2|1lhi}}, {{PDB2|1lhj}}, {{PDB2|1lhk}}, {{PDB2|1lhl}}, {{PDB2|1lhm}}, {{PDB2|1lmt}}, {{PDB2|1loz}}, {{PDB2|1lyy}}, {{PDB2|1lz1}}, {{PDB2|1lz4}}, {{PDB2|1lz5}}, {{PDB2|1lz6}}, {{PDB2|1lzr}}, {{PDB2|1lzs}}, {{PDB2|1op9}}, {{PDB2|1oua}}, {{PDB2|1oub}}, {{PDB2|1ouc}}, {{PDB2|1oud}}, {{PDB2|1oue}}, {{PDB2|1ouf}}, {{PDB2|1oug}}, {{PDB2|1ouh}}, {{PDB2|1oui}}, {{PDB2|1ouj}}, {{PDB2|1qsw}}, {{PDB2|1re2}}, {{PDB2|1rem}}, {{PDB2|1rex}}, {{PDB2|1rey}}, {{PDB2|1rez}}, {{PDB2|1tay}}, {{PDB2|1tby}}, {{PDB2|1tcy}}, {{PDB2|1tdy}}, {{PDB2|1ubz}}, {{PDB2|1w08}}, {{PDB2|1wqm}}, {{PDB2|1wqn}}, {{PDB2|1wqo}}, {{PDB2|1wqp}}, {{PDB2|1wqq}}, {{PDB2|1wqr}}, {{PDB2|1yam}}, {{PDB2|1yan}}, {{PDB2|1yao}}, {{PDB2|1yap}}, {{PDB2|1yaq}}, {{PDB2|207l}}, {{PDB2|208l}}, {{PDB2|2bqa}}, {{PDB2|2bqb}}, {{PDB2|2bqc}}, {{PDB2|2bqd}}, {{PDB2|2bqe}}, {{PDB2|2bqf}}, {{PDB2|2bqg}}, {{PDB2|2bqh}}, {{PDB2|2bqi}}, {{PDB2|2bqj}}, {{PDB2|2bqk}}, {{PDB2|2bql}}, {{PDB2|2bqm}}, {{PDB2|2bqn}}, {{PDB2|2bqo}}, {{PDB2|2hea}}, {{PDB2|2heb}}, {{PDB2|2hec}}, {{PDB2|2hed}}, {{PDB2|2hee}}, {{PDB2|2hef}}, {{PDB2|2lhm}}, {{PDB2|2mea}}, {{PDB2|2meb}}, {{PDB2|2mec}}, {{PDB2|2med}}, {{PDB2|2mee}}, {{PDB2|2mef}}, {{PDB2|2meg}}, {{PDB2|2meh}}, {{PDB2|2mei}}, {{PDB2|2nwd}}, {{PDB2|3lhm}}
| Name = Lysozyme (renal amyloidosis)
| HGNCid = 6740
| Symbol = LYZ
| AltSymbols =;
| OMIM = 153450
| ECnumber =
| Homologene = 37278
| MGIid = 96897
| GeneAtlas_image1 = PBB_GE_LYZ_213975_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003796 |text = lysozyme activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0016998 |text = cell wall catabolic process}} {{GNF_GO|id=GO:0019835 |text = cytolysis}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4069
| Hs_Ensembl = ENSG00000090382
| Hs_RefseqProtein = NP_000230
| Hs_RefseqmRNA = NM_000239
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 68028401
| Hs_GenLoc_end = 68034280
| Hs_Uniprot = P61626
| Mm_EntrezGene = 17105
| Mm_Ensembl = ENSMUSG00000069516
| Mm_RefseqmRNA = NM_017372
| Mm_RefseqProtein = NP_059068
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 116681441
| Mm_GenLoc_end = 116686397
| Mm_Uniprot = Q3TXG2
}}
}}
'''Lysozyme (renal amyloidosis)''', also known as '''LYZ''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = LYZ encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the anti-microbial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, aliva, and tears. Missense mutations in LYZ have been identified in heritable renal anyloidosis.<ref>{{cite web | title = Entrez Gene: LYZ lysozyme (renal amyloidosis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4069| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reitamo S, Klockars M, Adinolfi M, Osserman EF |title=Human lysozyme (origin and distribution in health and disease). |journal=La Ricerca in clinica e in laboratorio |volume=8 |issue= 4 |pages= 211-31 |year= 1979 |pmid= 366724 |doi= }}
*{{cite journal | author=McKenzie HA |title=alpha-Lactalbumins and lysozymes. |journal=EXS |volume=75 |issue= |pages= 365-409 |year= 1996 |pmid= 8765309 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MAPK7... {November 7, 2007 6:52:02 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:52:56 PM PST}
- CREATED: Created new protein page: MAPK7 {November 7, 2007 6:53:04 PM PST}
- INFO: Beginning work on MYD88... {November 7, 2007 6:51:27 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:51:55 PM PST}
- CREATED: Created new protein page: MYD88 {November 7, 2007 6:52:02 PM PST}
- INFO: Beginning work on PSMA3... {November 7, 2007 6:53:04 PM PST}
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- INFO: Beginning work on RNASEL... {November 7, 2007 6:54:01 PM PST}
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- CREATE: Found no pages, creating new page. {November 7, 2007 6:54:55 PM PST}
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- INFO: Beginning work on SIAH1... {November 7, 2007 6:55:03 PM PST}
- UPLOAD: Added new Image to wiki:
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- CREATE: Found no pages, creating new page. {November 7, 2007 6:56:10 PM PST}
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- INFO: Beginning work on SPHK1... {November 7, 2007 6:58:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:59:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Sphingosine kinase 1
| HGNCid = 11240
| Symbol = SPHK1
| AltSymbols =; SPHK
| OMIM = 603730
| ECnumber =
| Homologene = 40294
| MGIid = 1316649
| GeneAtlas_image1 = PBB_GE_SPHK1_219257_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004143 |text = diacylglycerol kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008481 |text = sphinganine kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0017050 |text = D-erythro-sphingosine kinase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0001568 |text = blood vessel development}} {{GNF_GO|id=GO:0006670 |text = sphingosine metabolic process}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007205 |text = protein kinase C activation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0019722 |text = calcium-mediated signaling}} {{GNF_GO|id=GO:0030307 |text = positive regulation of cell growth}} {{GNF_GO|id=GO:0030335 |text = positive regulation of cell migration}} {{GNF_GO|id=GO:0045766 |text = positive regulation of angiogenesis}} {{GNF_GO|id=GO:0045931 |text = positive regulation of progression through mitotic cell cycle}} {{GNF_GO|id=GO:0045987 |text = positive regulation of smooth muscle contraction}} {{GNF_GO|id=GO:0046521 |text = sphingoid catabolic process}} {{GNF_GO|id=GO:0048146 |text = positive regulation of fibroblast proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8877
| Hs_Ensembl = ENSG00000176170
| Hs_RefseqProtein = NP_068807
| Hs_RefseqmRNA = NM_021972
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 71892326
| Hs_GenLoc_end = 71895530
| Hs_Uniprot = Q9NYA1
| Mm_EntrezGene = 20698
| Mm_Ensembl = ENSMUSG00000061878
| Mm_RefseqmRNA = NM_011451
| Mm_RefseqProtein = NP_035581
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 116348001
| Mm_GenLoc_end = 116352758
| Mm_Uniprot =
}}
}}
'''Sphingosine kinase 1''', also known as '''SPHK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SPHK1 sphingosine kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8877| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tsukahara T, Mizuno H, Igarashi Y |title=[Molecular diversity of sphingosine kinase] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 4 Suppl |pages= 509-13 |year= 2002 |pmid= 11915350 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SRD5A2... {November 7, 2007 6:56:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:56:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
| HGNCid = 11285
| Symbol = SRD5A2
| AltSymbols =; MGC138457
| OMIM = 607306
| ECnumber =
| Homologene = 37292
| MGIid = 2150380
| GeneAtlas_image1 = PBB_GE_SRD5A2_206938_at_tn.png
| Function = {{GNF_GO|id=GO:0003865 |text = 3-oxo-5-alpha-steroid 4-dehydrogenase activity}} {{GNF_GO|id=GO:0009917 |text = sterol 5-alpha reductase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006702 |text = androgen biosynthetic process}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007530 |text = sex determination}} {{GNF_GO|id=GO:0007548 |text = sex differentiation}} {{GNF_GO|id=GO:0008584 |text = male gonad development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030539 |text = male genitalia development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6716
| Hs_Ensembl = ENSG00000049319
| Hs_RefseqProtein = NP_000339
| Hs_RefseqmRNA = NM_000348
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 31603160
| Hs_GenLoc_end = 31659473
| Hs_Uniprot = P31213
| Mm_EntrezGene = 94224
| Mm_Ensembl = ENSMUSG00000038541
| Mm_RefseqmRNA = NM_053188
| Mm_RefseqProtein = NP_444418
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 73922606
| Mm_GenLoc_end = 73952814
| Mm_Uniprot = Q3UTZ9
}}
}}
'''Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)''', also known as '''SRD5A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).<ref>{{cite web | title = Entrez Gene: SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6716| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TERF2... {November 7, 2007 6:56:51 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:57:25 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:57:38 PM PST}
- CREATED: Created new protein page: TERF2 {November 7, 2007 6:57:45 PM PST}
- INFO: Beginning work on UCHL1... {November 7, 2007 6:57:45 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:58:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:58:33 PM PST}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_UCHL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2etl.
| PDB = {{PDB2|2etl}}
| Name = Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
| HGNCid = 12513
| Symbol = UCHL1
| AltSymbols =; PARK5; PGP9.5; Uch-L1
| OMIM = 191342
| ECnumber =
| Homologene = 37894
| MGIid = 103149
| GeneAtlas_image1 = PBB_GE_UCHL1_201387_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004197 |text = cysteine-type endopeptidase activity}} {{GNF_GO|id=GO:0004221 |text = ubiquitin thiolesterase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008242 |text = omega peptidase activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0043130 |text = ubiquitin binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0043025 |text = cell soma}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007412 |text = axon target recognition}} {{GNF_GO|id=GO:0007628 |text = adult walking behavior}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0016579 |text = protein deubiquitination}} {{GNF_GO|id=GO:0019896 |text = axon transport of mitochondrion}} {{GNF_GO|id=GO:0042755 |text = eating behavior}} {{GNF_GO|id=GO:0050905 |text = neuromuscular process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7345
| Hs_Ensembl = ENSG00000154277
| Hs_RefseqProtein = NP_004172
| Hs_RefseqmRNA = NM_004181
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 40953607
| Hs_GenLoc_end = 40965203
| Hs_Uniprot = P09936
| Mm_EntrezGene = 22223
| Mm_Ensembl = ENSMUSG00000029223
| Mm_RefseqmRNA = NM_011670
| Mm_RefseqProtein = NP_035800
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 66955376
| Mm_GenLoc_end = 66966364
| Mm_Uniprot = Q3TCH2
}}
}}
'''Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)''', also known as '''UCHL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (Doran et al., 1983).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7345| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Healy DG, Abou-Sleiman PM, Wood NW |title=Genetic causes of Parkinson's disease: UCHL-1. |journal=Cell Tissue Res. |volume=318 |issue= 1 |pages= 189-94 |year= 2005 |pmid= 15221445 |doi= 10.1007/s00441-004-0917-3 }}
}}
{{refend}}
{{protein-stub}}
end log.
