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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 20:48, 7 November 2007 (UTC)
[edit] Proteins without matches (20)
[edit] Proteins with a High Potential Match (5)
[edit] Created (4)
[edit] Manual Inspection (Page not found) (21)
[edit] Protein Status Grid - Date: 20:48, 7 November 2007 (UTC)
[edit] Vebose Log - Date: 20:48, 7 November 2007 (UTC)
- INFO: Beginning work on ARRB1... {November 7, 2007 12:12:10 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:12:49 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:13:01 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ARRB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1g4m.
| PDB = {{PDB2|1g4m}}, {{PDB2|1g4r}}, {{PDB2|1jsy}}, {{PDB2|1zsh}}
| Name = Arrestin, beta 1
| HGNCid = 711
| Symbol = ARRB1
| AltSymbols =; ARB1; ARR1
| OMIM = 107940
| ECnumber =
| Homologene = 2981
| MGIid = 99473
| GeneAtlas_image1 = PBB_GE_ARRB1_218832_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004857 |text = enzyme inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007600 |text = sensory perception}} {{GNF_GO|id=GO:0008277 |text = regulation of G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 408
| Hs_Ensembl = ENSG00000137486
| Hs_RefseqProtein = NP_004032
| Hs_RefseqmRNA = NM_004041
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 74654130
| Hs_GenLoc_end = 74740521
| Hs_Uniprot = P49407
| Mm_EntrezGene = 109689
| Mm_Ensembl = ENSMUSG00000018909
| Mm_RefseqmRNA = NM_177231
| Mm_RefseqProtein = NP_796205
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 99409569
| Mm_GenLoc_end = 99480854
| Mm_Uniprot = Q8BWG8
}}
}}
'''Arrestin, beta 1''', also known as '''ARRB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.<ref>{{cite web | title = Entrez Gene: ARRB1 arrestin, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=408| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lefkowitz RJ |title=G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. |journal=J. Biol. Chem. |volume=273 |issue= 30 |pages= 18677-80 |year= 1998 |pmid= 9668034 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ATXN3... {November 7, 2007 12:26:07 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:27:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:27:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ATXN3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yzb.
| PDB = {{PDB2|1yzb}}, {{PDB2|2aga}}, {{PDB2|2dos}}
| Name = Ataxin 3
| HGNCid = 7106
| Symbol = ATXN3
| AltSymbols =; AT3; ATX3; JOS; MJD; MJD1; SCA3
| OMIM = 607047
| ECnumber =
| Homologene = 3658
| MGIid = 1099442
| GeneAtlas_image1 = PBB_GE_ATXN3_205415_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATXN3_205416_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008219 |text = cell death}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4287
| Hs_Ensembl = ENSG00000066427
| Hs_RefseqProtein = NP_001019802
| Hs_RefseqmRNA = NM_001024631
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 91598887
| Hs_GenLoc_end = 91642707
| Hs_Uniprot =
| Mm_EntrezGene = 110616
| Mm_Ensembl = ENSMUSG00000021189
| Mm_RefseqmRNA = NM_029705
| Mm_RefseqProtein = NP_083981
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 102320604
| Mm_GenLoc_end = 102359232
| Mm_Uniprot = Q546X9
}}
}}
'''Ataxin 3''', also known as '''ATXN3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: ATXN3 ataxin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4287| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goto J, Watanabe M, Ichikawa Y, ''et al.'' |title=Machado-Joseph disease gene products carrying different carboxyl termini. |journal=Neurosci. Res. |volume=28 |issue= 4 |pages= 373-7 |year= 1997 |pmid= 9274833 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BIRC3... {November 7, 2007 12:10:30 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:11:20 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:11:48 PM PST}
- CREATED: Created new protein page: BIRC3 {November 7, 2007 12:12:10 PM PST}
- INFO: Beginning work on CD1D... {November 7, 2007 12:13:01 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:13:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:13:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD1D_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1zt4.
| PDB = {{PDB2|1zt4}}
| Name = CD1d molecule
| HGNCid = 1637
| Symbol = CD1D
| AltSymbols =; CD1A; MGC34622; R3
| OMIM = 188410
| ECnumber =
| Homologene = 1337
| MGIid = 107674
| GeneAtlas_image1 = PBB_GE_CD1D_205789_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0030881 |text = beta-2-microglobulin binding}} {{GNF_GO|id=GO:0030884 |text = exogenous lipid antigen binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0016045 |text = detection of bacterium}} {{GNF_GO|id=GO:0045058 |text = T cell selection}} {{GNF_GO|id=GO:0045089 |text = positive regulation of innate immune response}} {{GNF_GO|id=GO:0048006 |text = antigen processing and presentation, endogenous lipid antigen via MHC class Ib}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 912
| Hs_Ensembl = ENSG00000158473
| Hs_RefseqProtein = NP_001757
| Hs_RefseqmRNA = NM_001766
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 156416361
| Hs_GenLoc_end = 156421310
| Hs_Uniprot = P15813
| Mm_EntrezGene = 12479
| Mm_Ensembl = ENSMUSG00000028076
| Mm_RefseqmRNA = NM_007639
| Mm_RefseqProtein = NP_031665
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 87081765
| Mm_GenLoc_end = 87085264
| Mm_Uniprot = Q91XK9
}}
}}
'''CD1d molecule''', also known as '''CD1D''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail.<ref>{{cite web | title = Entrez Gene: CD1D CD1d molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=912| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Melián A, Beckman EM, Porcelli SA, Brenner MB |title=Antigen presentation by CD1 and MHC-encoded class I-like molecules. |journal=Curr. Opin. Immunol. |volume=8 |issue= 1 |pages= 82-8 |year= 1996 |pmid= 8729450 |doi= }}
*{{cite journal | author=Joyce S |title=CD1d and natural T cells: how their properties jump-start the immune system. |journal=Cell. Mol. Life Sci. |volume=58 |issue= 3 |pages= 442-69 |year= 2001 |pmid= 11315191 |doi= }}
*{{cite journal | author=Sköld M, Behar SM |title=Role of CD1d-restricted NKT cells in microbial immunity. |journal=Infect. Immun. |volume=71 |issue= 10 |pages= 5447-55 |year= 2003 |pmid= 14500461 |doi= }}
*{{cite journal | author=Brigl M, Brenner MB |title=CD1: antigen presentation and T cell function. |journal=Annu. Rev. Immunol. |volume=22 |issue= |pages= 817-90 |year= 2004 |pmid= 15032598 |doi= 10.1146/annurev.immunol.22.012703.104608 }}
*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57-64 |year= 2006 |pmid= 16454711 |doi= }}
*{{cite journal | author=Brutkiewicz RR |title=CD1d ligands: the good, the bad, and the ugly. |journal=J. Immunol. |volume=177 |issue= 2 |pages= 769-75 |year= 2006 |pmid= 16818729 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD3E... {November 7, 2007 12:13:51 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:14:21 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:14:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD3E_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xiw.
| PDB = {{PDB2|1xiw}}
| Name = CD3e molecule, epsilon (CD3-TCR complex)
| HGNCid = 1674
| Symbol = CD3E
| AltSymbols =; T3E; TCRE
| OMIM = 186830
| ECnumber =
| Homologene = 586
| MGIid = 88332
| GeneAtlas_image1 = PBB_GE_CD3E_205456_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017124 |text = SH3 domain binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0030159 |text = receptor signaling complex scaffold activity}} {{GNF_GO|id=GO:0042608 |text = T cell receptor binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0042105 |text = alpha-beta T cell receptor complex}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007172 |text = signal complex assembly}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0042110 |text = T cell activation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0045060 |text = negative thymic T cell selection}} {{GNF_GO|id=GO:0050731 |text = positive regulation of peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0050850 |text = positive regulation of calcium-mediated signaling}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 916
| Hs_Ensembl = ENSG00000198851
| Hs_RefseqProtein = NP_000724
| Hs_RefseqmRNA = NM_000733
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 117680662
| Hs_GenLoc_end = 117692096
| Hs_Uniprot = P07766
| Mm_EntrezGene = 12501
| Mm_Ensembl = ENSMUSG00000032093
| Mm_RefseqmRNA = NM_007648
| Mm_RefseqProtein = NP_031674
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 44749738
| Mm_GenLoc_end = 44760585
| Mm_Uniprot = P22646
}}
}}
'''CD3e molecule, epsilon (CD3-TCR complex)''', also known as '''CD3E''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL4A1... {November 7, 2007 12:14:35 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:17:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:17:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_COL4A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1li1.
| PDB = {{PDB2|1li1}}, {{PDB2|1m3d}}, {{PDB2|1t60}}, {{PDB2|1t61}}
| Name = Collagen, type IV, alpha 1
| HGNCid = 2202
| Symbol = COL4A1
| AltSymbols =; arresten
| OMIM = 120130
| ECnumber =
| Homologene = 20437
| MGIid = 88454
| GeneAtlas_image1 = PBB_GE_COL4A1_211980_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL4A1_211981_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1282
| Hs_Ensembl = ENSG00000187498
| Hs_RefseqProtein = NP_001836
| Hs_RefseqmRNA = NM_001845
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 109599311
| Hs_GenLoc_end = 109757505
| Hs_Uniprot = P02462
| Mm_EntrezGene = 12826
| Mm_Ensembl = ENSMUSG00000031502
| Mm_RefseqmRNA = NM_009931
| Mm_RefseqProtein = NP_034061
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 11198403
| Mm_GenLoc_end = 11312702
| Mm_Uniprot = Q3UHJ4
}}
}}
'''Collagen, type IV, alpha 1''', also known as '''COL4A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.<ref>{{cite web | title = Entrez Gene: COL4A1 collagen, type IV, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1282| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tryggvason K, Soininen R, Hostikka SL, ''et al.'' |title=Structure of the human type IV collagen genes. |journal=Ann. N. Y. Acad. Sci. |volume=580 |issue= |pages= 97-111 |year= 1990 |pmid= 2186699 |doi= }}
*{{cite journal | author=Hinek A |title=Nature and the multiple functions of the 67-kD elastin-/laminin binding protein. |journal=Cell Adhes. Commun. |volume=2 |issue= 3 |pages= 185-93 |year= 1995 |pmid= 7827955 |doi= }}
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL4A3... {November 7, 2007 12:17:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:19:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type IV, alpha 3 (Goodpasture antigen)
| HGNCid = 2204
| Symbol = COL4A3
| AltSymbols =;
| OMIM = 120070
| ECnumber =
| Homologene = 68033
| MGIid = 104688
| GeneAtlas_image1 = PBB_GE_COL4A3_214641_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL4A3_216893_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_COL4A3_222073_at_tn.png
| Function = {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008191 |text = metalloendopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016525 |text = negative regulation of angiogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1285
| Hs_Ensembl = ENSG00000169031
| Hs_RefseqProtein = NP_000082
| Hs_RefseqmRNA = NM_000091
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 227810928
| Hs_GenLoc_end = 227884953
| Hs_Uniprot = Q01955
| Mm_EntrezGene = 12828
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_007734
| Mm_RefseqProtein = NP_031760
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Collagen, type IV, alpha 3 (Goodpasture antigen)''', also known as '''COL4A3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. There are multiple alternate transcripts that appear to be unique to this human alpha 3 gene and alternate splicing is restricted to the six exons that encode this C-terminal domain. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Some exons of this gene are interspersed with exons of an uncharacterized gene which is on the opposite strand.<ref>{{cite web | title = Entrez Gene: COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1285| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hinek A |title=Nature and the multiple functions of the 67-kD elastin-/laminin binding protein. |journal=Cell Adhes. Commun. |volume=2 |issue= 3 |pages= 185-93 |year= 1995 |pmid= 7827955 |doi= }}
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
*{{cite journal | author=Pescucci C, Longo I, Bruttini M, ''et al.'' |title=Type-IV collagen related diseases. |journal=J. Nephrol. |volume=16 |issue= 2 |pages= 314-6 |year= 2003 |pmid= 12768082 |doi= }}
*{{cite journal | author=Torra R, Tazón-Vega B, Ars E, Ballarín J |title=Collagen type IV (alpha3-alpha4) nephropathy: from isolated haematuria to renal failure. |journal=Nephrol. Dial. Transplant. |volume=19 |issue= 10 |pages= 2429-32 |year= 2005 |pmid= 15280517 |doi= 10.1093/ndt/gfh435 }}
*{{cite journal | author=Rana K, Wang YY, Buzza M, ''et al.'' |title=The genetics of thin basement membrane nephropathy. |journal=Semin. Nephrol. |volume=25 |issue= 3 |pages= 163-70 |year= 2005 |pmid= 15880327 |doi= }}
*{{cite journal | author=Maziers N, Dahan K, Pirson Y |title=[From Alport syndrome to benign familial hematuria: clinical and genetic aspect] |journal=Nephrol. Ther. |volume=1 |issue= 2 |pages= 90-100 |year= 2006 |pmid= 16895672 |doi= 10.1016/j.nephro.2005.03.005 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COX2... {November 7, 2007 12:29:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:29:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome c oxidase subunit II
| HGNCid = 7421
| Symbol = COX2
| AltSymbols =; MTCO2
| OMIM =
| ECnumber =
| Homologene = 5017
| MGIid = 102503
| Function = {{GNF_GO|id=GO:0004129 |text = cytochrome-c oxidase activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005746 |text = mitochondrial respiratory chain}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006123 |text = mitochondrial electron transport, cytochrome c to oxygen}} {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4513
| Hs_Ensembl = ENSG00000198712
| Hs_RefseqProtein = NP_536846
| Hs_RefseqmRNA =
| Hs_GenLoc_db =
| Hs_GenLoc_chr = MT
| Hs_GenLoc_start = 7587
| Hs_GenLoc_end = 8270
| Hs_Uniprot = P00403
| Mm_EntrezGene = 17709
| Mm_Ensembl = ENSMUSG00000064354
| Mm_RefseqmRNA =
| Mm_RefseqProtein = NP_904331
| Mm_GenLoc_db =
| Mm_GenLoc_chr = MT
| Mm_GenLoc_start = 7013
| Mm_GenLoc_end = 7696
| Mm_Uniprot = Q7JCZ1
}}
}}
'''Cytochrome c oxidase subunit II''', also known as '''COX2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Torroni A, Achilli A, Macaulay V, ''et al.'' |title=Harvesting the fruit of the human mtDNA tree. |journal=Trends Genet. |volume=22 |issue= 6 |pages= 339-45 |year= 2006 |pmid= 16678300 |doi= 10.1016/j.tig.2006.04.001 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP1A2... {November 7, 2007 12:19:08 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:20:25 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:20:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CYP1A2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hi4.
| PDB = {{PDB2|2hi4}}
| Name = Cytochrome P450, family 1, subfamily A, polypeptide 2
| HGNCid = 2596
| Symbol = CYP1A2
| AltSymbols =; CP12; P3-450; P450(PA)
| OMIM = 124060
| ECnumber =
| Homologene = 68082
| MGIid = 88589
| GeneAtlas_image1 = PBB_GE_CYP1A2_207609_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CYP1A2_207608_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1544
| Hs_Ensembl = ENSG00000140505
| Hs_RefseqProtein = NP_000752
| Hs_RefseqmRNA = NM_000761
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 72828237
| Hs_GenLoc_end = 72835994
| Hs_Uniprot = P05177
| Mm_EntrezGene = 13077
| Mm_Ensembl = ENSMUSG00000032310
| Mm_RefseqmRNA = NM_009993
| Mm_RefseqProtein = NP_034123
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 57475074
| Mm_GenLoc_end = 57481792
| Mm_Uniprot = P00186
}}
}}
'''Cytochrome P450, family 1, subfamily A, polypeptide 2''', also known as '''CYP1A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.<ref>{{cite web | title = Entrez Gene: CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1544| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Landi MT, Sinha R, Lang NP, Kadlubar FF |title=Human cytochrome P4501A2. |journal=IARC Sci. Publ. |volume= |issue= 148 |pages= 173-95 |year= 1999 |pmid= 10493258 |doi= }}
*{{cite journal | author=Nelson DR, Zeldin DC, Hoffman SM, ''et al.'' |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1-18 |year= 2004 |pmid= 15128046 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP2C19... {November 7, 2007 12:20:39 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:21:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:21:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CYP2C19_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1r9o.
| PDB = {{PDB2|1r9o}}
| Name = Cytochrome P450, family 2, subfamily C, polypeptide 19
| HGNCid = 2621
| Symbol = CYP2C19
| AltSymbols =; CPCJ; CYP 2C; CYP2C; P450C2C; P450IIC19
| OMIM = 124020
| ECnumber =
| Homologene = 86659
| MGIid = 1306818
| GeneAtlas_image1 = PBB_GE_CYP2C19_216058_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016712 |text = oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen}} {{GNF_GO|id=GO:0018675 |text = (S)-limonene 6-monooxygenase activity}} {{GNF_GO|id=GO:0018676 |text = (S)-limonene 7-monooxygenase activity}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1557
| Hs_Ensembl = ENSG00000165841
| Hs_RefseqProtein = NP_000760
| Hs_RefseqmRNA = NM_000769
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 96512371
| Hs_GenLoc_end = 96603007
| Hs_Uniprot = P33261
| Mm_EntrezGene = 13098
| Mm_Ensembl = ENSMUSG00000025003
| Mm_RefseqmRNA = NM_010003
| Mm_RefseqProtein = NP_034133
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 39564182
| Mm_GenLoc_end = 39621840
| Mm_Uniprot = Q6PER7
}}
}}
'''Cytochrome P450, family 2, subfamily C, polypeptide 19''', also known as '''CYP2C19''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.<ref>{{cite web | title = Entrez Gene: CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1557| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goldstein JA, de Morais SM |title=Biochemistry and molecular biology of the human CYP2C subfamily. |journal=Pharmacogenetics |volume=4 |issue= 6 |pages= 285-99 |year= 1995 |pmid= 7704034 |doi= }}
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Ding X, Kaminsky LS |title=Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=43 |issue= |pages= 149-73 |year= 2003 |pmid= 12171978 |doi= 10.1146/annurev.pharmtox.43.100901.140251 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DIABLO... {November 7, 2007 12:38:54 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:39:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:39:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DIABLO_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1few.
| PDB = {{PDB2|1few}}, {{PDB2|1g73}}
| Name = Diablo homolog (Drosophila)
| HGNCid = 21528
| Symbol = DIABLO
| AltSymbols =; DIABLO-S; FLJ10537; FLJ25049; SMAC; SMAC3
| OMIM = 605219
| ECnumber =
| Homologene = 10532
| MGIid = 1913843
| GeneAtlas_image1 = PBB_GE_DIABLO_219350_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}} {{GNF_GO|id=GO:0008631 |text = induction of apoptosis by oxidative stress}} {{GNF_GO|id=GO:0008635 |text = caspase activation via cytochrome c}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 56616
| Hs_Ensembl = ENSG00000184047
| Hs_RefseqProtein = NP_063940
| Hs_RefseqmRNA = NM_019887
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 121258163
| Hs_GenLoc_end = 121277973
| Hs_Uniprot = Q9NR28
| Mm_EntrezGene = 66593
| Mm_Ensembl = ENSMUSG00000029433
| Mm_RefseqmRNA = NM_023232
| Mm_RefseqProtein = NP_075721
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 123773129
| Mm_GenLoc_end = 123784782
| Mm_Uniprot = Q542V8
}}
}}
'''Diablo homolog (Drosophila)''', also known as '''DIABLO''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively.<ref>{{cite web | title = Entrez Gene: DIABLO diablo homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56616| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Shi Y |title=A structural view of mitochondria-mediated apoptosis. |journal=Nat. Struct. Biol. |volume=8 |issue= 5 |pages= 394-401 |year= 2001 |pmid= 11323712 |doi= 10.1038/87548 }}
*{{cite journal | author=Anguiano-Hernandez YM, Chartier A, Huerta S |title=Smac/DIABLO and colon cancer. |journal=Anti-cancer agents in medicinal chemistry |volume=7 |issue= 4 |pages= 467-73 |year= 2007 |pmid= 17630921 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DMPK... {November 7, 2007 12:21:48 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:23:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:23:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DMPK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wt6.
| PDB = {{PDB2|1wt6}}
| Name = Dystrophia myotonica-protein kinase
| HGNCid = 2933
| Symbol = DMPK
| AltSymbols =; DM; DM1; DM1PK; DMK; MDPK; MT-PK
| OMIM = 605377
| ECnumber =
| Homologene = 3247
| MGIid = 94906
| GeneAtlas_image1 = PBB_GE_DMPK_37996_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DMPK_217066_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_DMPK_217661_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}} {{GNF_GO|id=GO:0051056 |text = regulation of small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1760
| Hs_Ensembl = ENSG00000104936
| Hs_RefseqProtein = NP_001075029
| Hs_RefseqmRNA = NM_001081560
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 50965579
| Hs_GenLoc_end = 50977469
| Hs_Uniprot = Q09013
| Mm_EntrezGene = 13400
| Mm_Ensembl = ENSMUSG00000030409
| Mm_RefseqmRNA = XM_986224
| Mm_RefseqProtein = XP_991318
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 18242463
| Mm_GenLoc_end = 18252340
| Mm_Uniprot = Q05CL1
}}
}}
'''Dystrophia myotonica-protein kinase''', also known as '''DMPK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref>{{cite web | title = Entrez Gene: DMPK dystrophia myotonica-protein kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1760| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Groenen P, Wieringa B |title=Expanding complexity in myotonic dystrophy. |journal=Bioessays |volume=20 |issue= 11 |pages= 901-12 |year= 1999 |pmid= 9872056 |doi= 10.1002/(SICI)1521-1878(199811)20:11<901::AID-BIES5>3.0.CO;2-0 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EPHA2... {November 7, 2007 12:23:29 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:24:05 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:24:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EPHA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mqb.
| PDB = {{PDB2|1mqb}}
| Name = EPH receptor A2
| HGNCid = 3386
| Symbol = EPHA2
| AltSymbols =; ECK
| OMIM = 176946
| ECnumber =
| Homologene = 20929
| MGIid = 95278
| GeneAtlas_image1 = PBB_GE_EPHA2_203499_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005003 |text = ephrin receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030182 |text = neuron differentiation}} {{GNF_GO|id=GO:0048013 |text = ephrin receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1969
| Hs_Ensembl = ENSG00000142627
| Hs_RefseqProtein = NP_004422
| Hs_RefseqmRNA = NM_004431
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 16323419
| Hs_GenLoc_end = 16355169
| Hs_Uniprot = P29317
| Mm_EntrezGene = 13836
| Mm_Ensembl = ENSMUSG00000006445
| Mm_RefseqmRNA = XM_982454
| Mm_RefseqProtein = XP_987548
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 140573316
| Mm_GenLoc_end = 140601454
| Mm_Uniprot = Q3UNI2
}}
}}
'''EPH receptor A2''', also known as '''EPHA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.<ref>{{cite web | title = Entrez Gene: EPHA2 EPH receptor A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1969| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309-45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
*{{cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151-81 |year= 1998 |pmid= 9576626 |doi= }}
*{{cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033-44 |year= 1999 |pmid= 10207129 |doi= }}
*{{cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177-244 |year= 2000 |pmid= 10730216 |doi= }}
*{{cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993-1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 }}
*{{cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155-64 |year= 2001 |pmid= 11256076 |doi= }}
*{{cite journal | author=Kinch MS, Carles-Kinch K |title=Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer. |journal=Clin. Exp. Metastasis |volume=20 |issue= 1 |pages= 59-68 |year= 2003 |pmid= 12650608 |doi= }}
*{{cite journal | author=Walker-Daniels J, Hess AR, Hendrix MJ, Kinch MS |title=Differential regulation of EphA2 in normal and malignant cells. |journal=Am. J. Pathol. |volume=162 |issue= 4 |pages= 1037-42 |year= 2003 |pmid= 12651595 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HLA-DRB5... {November 7, 2007 12:25:42 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:25:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:26:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HLA-DRB5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aqd.
| PDB = {{PDB2|1aqd}}, {{PDB2|1d5m}}, {{PDB2|1dlh}}, {{PDB2|1fv1}}, {{PDB2|1fyt}}, {{PDB2|1h15}}, {{PDB2|1hqr}}, {{PDB2|1hxy}}, {{PDB2|1j8h}}, {{PDB2|1jwm}}, {{PDB2|1jws}}, {{PDB2|1jwu}}, {{PDB2|1kg0}}, {{PDB2|1klg}}, {{PDB2|1klu}}, {{PDB2|1lo5}}, {{PDB2|1pyw}}, {{PDB2|1r5i}}, {{PDB2|1seb}}, {{PDB2|1sje}}, {{PDB2|1sjh}}, {{PDB2|1t5w}}, {{PDB2|1t5x}}, {{PDB2|1zgl}}, {{PDB2|2g9h}}, {{PDB2|2iam}}, {{PDB2|2ian}}, {{PDB2|2icw}}, {{PDB2|2ipk}}, {{PDB2|2oje}}
| Name = Major histocompatibility complex, class II, DR beta 5
| HGNCid = 4953
| Symbol = HLA-DRB5
| AltSymbols =;
| OMIM = 604776
| ECnumber =
| Homologene = 88657
| MGIid =
| Function = {{GNF_GO|id=GO:0032395 |text = MHC class II receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042613 |text = MHC class II protein complex}}
| Process = {{GNF_GO|id=GO:0002504 |text = antigen processing and presentation of peptide or polysaccharide antigen via MHC class II}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3127
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002116
| Hs_RefseqmRNA = NM_002125
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Major histocompatibility complex, class II, DR beta 5''', also known as '''HLA-DRB5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.<ref>{{cite web | title = Entrez Gene: HLA-DRB5 major histocompatibility complex, class II, DR beta 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3127| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lau M, Terasaki PI, Park MS |title=International Cell Exchange, 1994. |journal=Clinical transplants |volume= |issue= |pages= 467-88 |year= 1995 |pmid= 7547576 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MMP13... {November 7, 2007 12:27:30 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:28:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:28:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MMP13_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cxv.
| PDB = {{PDB2|1cxv}}, {{PDB2|1eub}}, {{PDB2|1fls}}, {{PDB2|1fm1}}, {{PDB2|1pex}}, {{PDB2|1xuc}}, {{PDB2|1xud}}, {{PDB2|1xur}}, {{PDB2|1you}}, {{PDB2|1ztq}}, {{PDB2|2d1n}}, {{PDB2|2e2d}}, {{PDB2|2ow9}}, {{PDB2|456c}}, {{PDB2|830c}}
| Name = Matrix metallopeptidase 13 (collagenase 3)
| HGNCid = 7159
| Symbol = MMP13
| AltSymbols =; CLG3
| OMIM = 600108
| ECnumber =
| Homologene = 20548
| MGIid = 1340026
| GeneAtlas_image1 = PBB_GE_MMP13_205959_at_tn.png
| Function = {{GNF_GO|id=GO:0004222 |text = metalloendopeptidase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008133 |text = collagenase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0000270 |text = peptidoglycan metabolic process}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0030574 |text = collagen catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4322
| Hs_Ensembl = ENSG00000137745
| Hs_RefseqProtein = NP_002418
| Hs_RefseqmRNA = NM_002427
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 102318937
| Hs_GenLoc_end = 102331672
| Hs_Uniprot = P45452
| Mm_EntrezGene = 17386
| Mm_Ensembl = ENSMUSG00000050578
| Mm_RefseqmRNA = NM_008607
| Mm_RefseqProtein = NP_032633
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 7272545
| Mm_GenLoc_end = 7283333
| Mm_Uniprot = Q3U2N6
}}
}}
'''Matrix metallopeptidase 13 (collagenase 3)''', also known as '''MMP13''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.<ref>{{cite web | title = Entrez Gene: MMP13 matrix metallopeptidase 13 (collagenase 3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4322| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nagase H, Woessner JF |title=Matrix metalloproteinases. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21491-4 |year= 1999 |pmid= 10419448 |doi= }}
*{{cite journal | author=Leeman MF, Curran S, Murray GI |title=The structure, regulation, and function of human matrix metalloproteinase-13. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=37 |issue= 3 |pages= 149-66 |year= 2003 |pmid= 12139441 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MRE11A... {November 7, 2007 12:28:17 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:29:05 PM PST}
- CREATED: Created new protein page: MRE11A {November 7, 2007 12:29:12 PM PST}
- INFO: Beginning work on POLR2D... {November 7, 2007 12:29:32 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:30:26 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:30:40 PM PST}
- CREATED: Created new protein page: POLR2D {November 7, 2007 12:30:47 PM PST}
- INFO: Beginning work on POU1F1... {November 7, 2007 12:30:47 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:31:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:31:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_POU1F1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1au7.
| PDB = {{PDB2|1au7}}
| Name = POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
| HGNCid = 9210
| Symbol = POU1F1
| AltSymbols =; GHF-1; PIT1; Pit-1; Pit-1 beta
| OMIM = 173110
| ECnumber =
| Homologene = 259
| MGIid = 97588
| GeneAtlas_image1 = PBB_GE_POU1F1_207846_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5449
| Hs_Ensembl = ENSG00000064835
| Hs_RefseqProtein = NP_000297
| Hs_RefseqmRNA = NM_000306
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 87391473
| Hs_GenLoc_end = 87408427
| Hs_Uniprot = P28069
| Mm_EntrezGene = 18736
| Mm_Ensembl = ENSMUSG00000004842
| Mm_RefseqmRNA = NM_008849
| Mm_RefseqProtein = NP_032875
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 65438862
| Mm_GenLoc_end = 65453881
| Mm_Uniprot = Q62089
}}
}}
'''POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)''', also known as '''POU1F1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: POU1F1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5449| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Parks JS, Brown MR |title=Transcription factors regulating pituitary development. |journal=Growth Horm. IGF Res. |volume=9 Suppl B |issue= |pages= 2-8; discussion 8-11 |year= 1999 |pmid= 10549299 |doi= }}
*{{cite journal | author=Rodriguez R, Andersen B |title=Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency. |journal=Minerva Endocrinol. |volume=28 |issue= 2 |pages= 123-33 |year= 2003 |pmid= 12717343 |doi= }}
*{{cite journal | author=Quentien MH, Barlier A, Franc JL, ''et al.'' |title=Pituitary transcription factors: from congenital deficiencies to gene therapy. |journal=J. Neuroendocrinol. |volume=18 |issue= 9 |pages= 633-42 |year= 2006 |pmid= 16879162 |doi= 10.1111/j.1365-2826.2006.01461.x }}
*{{cite journal | author=Cattini PA, Yang X, Jin Y, Detillieux KA |title=Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression. |journal=Neuroendocrinology |volume=83 |issue= 3-4 |pages= 145-53 |year= 2006 |pmid= 17047377 |doi= 10.1159/000095522 }}
*{{cite journal | author=Li X, Giachelli CM |title=Sodium-dependent phosphate cotransporters and vascular calcification. |journal=Curr. Opin. Nephrol. Hypertens. |volume=16 |issue= 4 |pages= 325-8 |year= 2007 |pmid= 17565274 |doi= 10.1097/MNH.0b013e3281c55ef1 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPP1CA... {November 7, 2007 12:31:51 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:32:26 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:32:43 PM PST}
- CREATED: Created new protein page: PPP1CA {November 7, 2007 12:32:50 PM PST}
- INFO: Beginning work on RBL1... {November 7, 2007 12:32:50 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:33:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Retinoblastoma-like 1 (p107)
| HGNCid = 9893
| Symbol = RBL1
| AltSymbols =; PRB1; CP107; MGC40006; p107
| OMIM = 116957
| ECnumber =
| Homologene = 2172
| MGIid = 103300
| GeneAtlas_image1 = PBB_GE_RBL1_205296_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0043550 |text = regulation of lipid kinase activity}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5933
| Hs_Ensembl = ENSG00000080839
| Hs_RefseqProtein = NP_002886
| Hs_RefseqmRNA = NM_002895
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 35058166
| Hs_GenLoc_end = 35157824
| Hs_Uniprot = P28749
| Mm_EntrezGene = 19650
| Mm_Ensembl = ENSMUSG00000027641
| Mm_RefseqmRNA = NM_011249
| Mm_RefseqProtein = NP_035379
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 156837339
| Mm_GenLoc_end = 156895960
| Mm_Uniprot = Q3U1D4
}}
}}
'''Retinoblastoma-like 1 (p107)''', also known as '''RBL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: RBL1 retinoblastoma-like 1 (p107)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5933| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RPGR... {November 7, 2007 12:33:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:35:01 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Retinitis pigmentosa GTPase regulator
| HGNCid = 10295
| Symbol = RPGR
| AltSymbols =; CRD; COD1; CORDX1; PCDX; RP15; RP3; XLRP3; orf15
| OMIM = 312610
| ECnumber =
| Homologene = 55455
| MGIid = 1344037
| GeneAtlas_image1 = PBB_GE_RPGR_207624_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6103
| Hs_Ensembl = ENSG00000156313
| Hs_RefseqProtein = NP_000319
| Hs_RefseqmRNA = NM_000328
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 38013368
| Hs_GenLoc_end = 38071732
| Hs_Uniprot = Q92834
| Mm_EntrezGene = 19893
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011285
| Mm_RefseqProtein = NP_035415
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Retinitis pigmentosa GTPase regulator''', also known as '''RPGR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.<ref>{{cite web | title = Entrez Gene: RPGR retinitis pigmentosa GTPase regulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6103| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jin ZB, Hayakawa M, Murakami A, Nao-i N |title=RCC1-like domain and ORF15: essentials in RPGR gene. |journal=Adv. Exp. Med. Biol. |volume=572 |issue= |pages= 29-33 |year= 2007 |pmid= 17249551 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on S100A8... {November 7, 2007 12:35:01 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:35:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:36:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_S100A8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mr8.
| PDB = {{PDB2|1mr8}}, {{PDB2|1xk4}}
| Name = S100 calcium binding protein A8
| HGNCid = 10498
| Symbol = S100A8
| AltSymbols =; MIF; 60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MRP8; NIF; P8
| OMIM = 123885
| ECnumber =
| Homologene = 2225
| MGIid = 88244
| GeneAtlas_image1 = PBB_GE_S100A8_202917_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6279
| Hs_Ensembl = ENSG00000143546
| Hs_RefseqProtein = NP_002955
| Hs_RefseqmRNA = NM_002964
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 151629132
| Hs_GenLoc_end = 151630288
| Hs_Uniprot = P05109
| Mm_EntrezGene = 20201
| Mm_Ensembl = ENSMUSG00000056054
| Mm_RefseqmRNA = NM_013650
| Mm_RefseqProtein = NP_038678
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 90755012
| Mm_GenLoc_end = 90755961
| Mm_Uniprot = Q53X15
}}
}}
'''S100 calcium binding protein A8''', also known as '''S100A8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.<ref>{{cite web | title = Entrez Gene: S100A8 S100 calcium binding protein A8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6279| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi= }}
*{{cite journal | author=Kerkhoff C, Klempt M, Sorg C |title=Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 200-11 |year= 1999 |pmid= 9920411 |doi= }}
*{{cite journal | author=Nacken W, Roth J, Sorg C, Kerkhoff C |title=S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity. |journal=Microsc. Res. Tech. |volume=60 |issue= 6 |pages= 569-80 |year= 2003 |pmid= 12645005 |doi= 10.1002/jemt.10299 }}
*{{cite journal | author=Roth J, Vogl T, Sorg C, Sunderkötter C |title=Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. |journal=Trends Immunol. |volume=24 |issue= 4 |pages= 155-8 |year= 2004 |pmid= 12697438 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SFN... {November 7, 2007 12:24:15 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:25:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:25:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SFN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ywt.
| PDB = {{PDB2|1ywt}}, {{PDB2|1yz5}}
| Name = Stratifin
| HGNCid = 10773
| Symbol = SFN
| AltSymbols =; YWHAS
| OMIM = 601290
| ECnumber =
| Homologene = 4475
| MGIid = 1891831
| GeneAtlas_image1 = PBB_GE_SFN_33322_i_at_tn.png
| GeneAtlas_image2 = PBB_GE_SFN_33323_r_at_tn.png
| GeneAtlas_image3 = PBB_GE_SFN_209260_at_tn.png
| Function = {{GNF_GO|id=GO:0008426 |text = protein kinase C inhibitor activity}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0006469 |text = negative regulation of protein kinase activity}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}} {{GNF_GO|id=GO:0043588 |text = skin development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2810
| Hs_Ensembl = ENSG00000175793
| Hs_RefseqProtein = NP_006133
| Hs_RefseqmRNA = NM_006142
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 27062216
| Hs_GenLoc_end = 27063535
| Hs_Uniprot = P31947
| Mm_EntrezGene = 55948
| Mm_Ensembl = ENSMUSG00000047281
| Mm_RefseqmRNA = NM_018754
| Mm_RefseqProtein = NP_061224
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 132873099
| Mm_GenLoc_end = 132873845
| Mm_Uniprot = Q3TEZ1
}}
}}
'''Stratifin''', also known as '''SFN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hermeking H |title=Extracellular 14-3-3sigma protein: a potential mediator of epithelial-mesenchymal interactions. |journal=J. Invest. Dermatol. |volume=124 |issue= 1 |pages= ix-x |year= 2005 |pmid= 15654940 |doi= 10.1111/j.0022-202X.2004.23534.x }}
*{{cite journal | author=Mhawech P |title=14-3-3 proteins--an update. |journal=Cell Res. |volume=15 |issue= 4 |pages= 228-36 |year= 2005 |pmid= 15857577 |doi= 10.1038/sj.cr.7290291 }}
*{{cite journal | author=Lodygin D, Hermeking H |title=The role of epigenetic inactivation of 14-3-3sigma in human cancer. |journal=Cell Res. |volume=15 |issue= 4 |pages= 237-46 |year= 2005 |pmid= 15857578 |doi= 10.1038/sj.cr.7290292 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TGFB2... {November 7, 2007 12:36:09 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:37:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:37:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TGFB2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tfg.
| PDB = {{PDB2|1tfg}}, {{PDB2|2tgi}}
| Name = Transforming growth factor, beta 2
| HGNCid = 11768
| Symbol = TGFB2
| AltSymbols =; MGC116892; TGF-beta2
| OMIM = 190220
| ECnumber =
| Homologene = 2432
| MGIid = 98726
| GeneAtlas_image1 = PBB_GE_TGFB2_209908_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TGFB2_209909_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TGFB2_220407_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001540 |text = beta-amyloid binding}} {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005160 |text = transforming growth factor beta receptor binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0043025 |text = cell soma}}
| Process = {{GNF_GO|id=GO:0000902 |text = cell morphogenesis}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001654 |text = eye development}} {{GNF_GO|id=GO:0001707 |text = mesoderm formation}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0010002 |text = cardioblast differentiation}} {{GNF_GO|id=GO:0016049 |text = cell growth}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030307 |text = positive regulation of cell growth}} {{GNF_GO|id=GO:0030593 |text = neutrophil chemotaxis}} {{GNF_GO|id=GO:0031069 |text = hair follicle morphogenesis}} {{GNF_GO|id=GO:0042060 |text = wound healing}} {{GNF_GO|id=GO:0042416 |text = dopamine biosynthetic process}} {{GNF_GO|id=GO:0042637 |text = catagen}} {{GNF_GO|id=GO:0043525 |text = positive regulation of neuron apoptosis}} {{GNF_GO|id=GO:0045617 |text = negative regulation of keratinocyte differentiation}} {{GNF_GO|id=GO:0045787 |text = positive regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045823 |text = positive regulation of heart contraction}} {{GNF_GO|id=GO:0048103 |text = somatic stem cell division}} {{GNF_GO|id=GO:0048666 |text = neuron development}} {{GNF_GO|id=GO:0048699 |text = generation of neurons}} {{GNF_GO|id=GO:0050777 |text = negative regulation of immune response}} {{GNF_GO|id=GO:0050778 |text = positive regulation of immune response}} {{GNF_GO|id=GO:0051795 |text = positive regulation of catagen}} {{GNF_GO|id=GO:0051891 |text = positive regulation of cardioblast differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7042
| Hs_Ensembl = ENSG00000092969
| Hs_RefseqProtein = NP_003229
| Hs_RefseqmRNA = NM_003238
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 216586200
| Hs_GenLoc_end = 216684584
| Hs_Uniprot = P61812
| Mm_EntrezGene = 21808
| Mm_Ensembl = ENSMUSG00000039239
| Mm_RefseqmRNA = NM_009367
| Mm_RefseqProtein = NP_033393
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 188324430
| Mm_GenLoc_end = 188406777
| Mm_Uniprot = Q3TWH5
}}
}}
'''Transforming growth factor, beta 2''', also known as '''TGFB2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Clark DA, Coker R |title=Transforming growth factor-beta (TGF-beta). |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 3 |pages= 293-8 |year= 1998 |pmid= 9611771 |doi= }}
*{{cite journal | author=Wick W, Platten M, Weller M |title=Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta. |journal=J. Neurooncol. |volume=53 |issue= 2 |pages= 177-85 |year= 2002 |pmid= 11716069 |doi= }}
*{{cite journal | author=Bissell DM |title=Chronic liver injury, TGF-beta, and cancer. |journal=Exp. Mol. Med. |volume=33 |issue= 4 |pages= 179-90 |year= 2002 |pmid= 11795478 |doi= }}
*{{cite journal | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776-84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on VCP... {November 7, 2007 12:37:40 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:38:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:38:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_VCP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e32.
| PDB = {{PDB2|1e32}}, {{PDB2|1oz4}}, {{PDB2|1r7r}}, {{PDB2|1s3s}}, {{PDB2|1ypw}}, {{PDB2|1yq0}}, {{PDB2|1yqi}}, {{PDB2|2pjh}}
| Name = Valosin-containing protein
| HGNCid = 12666
| Symbol = VCP
| AltSymbols =; p97; IBMPFD; MGC131997; MGC148092; MGC8560; TERA
| OMIM = 601023
| ECnumber =
| Homologene = 5168
| MGIid = 99919
| GeneAtlas_image1 = PBB_GE_VCP_208649_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_VCP_208648_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006302 |text = double-strand break repair}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0030433 |text = ER-associated protein catabolic process}} {{GNF_GO|id=GO:0030968 |text = unfolded protein response}} {{GNF_GO|id=GO:0030970 |text = retrograde protein transport, ER to cytosol}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0045184 |text = establishment of protein localization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7415
| Hs_Ensembl = ENSG00000165280
| Hs_RefseqProtein = NP_009057
| Hs_RefseqmRNA = NM_007126
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 35046061
| Hs_GenLoc_end = 35063246
| Hs_Uniprot = P55072
| Mm_EntrezGene = 269523
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009503
| Mm_RefseqProtein = NP_033529
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Valosin-containing protein''', also known as '''VCP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.<ref>{{cite web | title = Entrez Gene: VCP valosin-containing protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7415| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
end log.
