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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 06:23, 7 November 2007 (UTC)
[edit] Proteins without matches (14)
[edit] Proteins with a High Potential Match (11)
[edit] Created (3)
[edit] Manual Inspection (Page not found) (22)
[edit] Protein Status Grid - Date: 06:23, 7 November 2007 (UTC)
[edit] Vebose Log - Date: 06:23, 7 November 2007 (UTC)
- INFO: Beginning work on ALOX5... {November 6, 2007 9:56:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 9:57:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Arachidonate 5-lipoxygenase
| HGNCid = 435
| Symbol = ALOX5
| AltSymbols =; 5-LO; 5LPG; LOG5; MGC163204
| OMIM = 152390
| ECnumber =
| Homologene = 561
| MGIid = 87999
| GeneAtlas_image1 = PBB_GE_ALOX5_204446_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ALOX5_204445_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ALOX5_214366_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004051 |text = arachidonate 5-lipoxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016165 |text = lipoxygenase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006691 |text = leukotriene metabolic process}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0019370 |text = leukotriene biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 240
| Hs_Ensembl = ENSG00000012779
| Hs_RefseqProtein = XP_001127464
| Hs_RefseqmRNA = XM_001127464
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 45189635
| Hs_GenLoc_end = 45261567
| Hs_Uniprot = P09917
| Mm_EntrezGene = 11689
| Mm_Ensembl = ENSMUSG00000025701
| Mm_RefseqmRNA = NM_009662
| Mm_RefseqProtein = NP_033792
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 116375696
| Mm_GenLoc_end = 116426797
| Mm_Uniprot = Q3TB75
}}
}}
'''Arachidonate 5-lipoxygenase''', also known as '''ALOX5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.<ref>{{cite web | title = Entrez Gene: ALOX5 arachidonate 5-lipoxygenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=240| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rådmark OP |title=The molecular biology and regulation of 5-lipoxygenase. |journal=Am. J. Respir. Crit. Care Med. |volume=161 |issue= 2 Pt 2 |pages= S11-5 |year= 2000 |pmid= 10673219 |doi= }}
*{{cite journal | author=Hammarberg T, Reddy KV, Persson B, Rådmark O |title=Calcium binding to 5-lipoxygenase. |journal=Adv. Exp. Med. Biol. |volume=507 |issue= |pages= 117-21 |year= 2003 |pmid= 12664574 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ARF1... {November 6, 2007 9:57:44 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 9:58:19 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 9:58:27 PM PST}
- CREATED: Created new protein page: ARF1 {November 6, 2007 9:58:34 PM PST}
- INFO: Beginning work on CD59... {November 6, 2007 9:59:02 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:00:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:01:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD59_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cdq.
| PDB = {{PDB2|1cdq}}, {{PDB2|1cdr}}, {{PDB2|1cds}}, {{PDB2|1erg}}, {{PDB2|1erh}}, {{PDB2|2ofs}}
| Name = CD59 molecule, complement regulatory protein
| HGNCid = 1689
| Symbol = CD59
| AltSymbols =; 16.3A5; EJ16; EJ30; EL32; G344; MGC2354; MIC11; MIN1; MIN2; MIN3; MSK21; PROTECTIN; p18-20
| OMIM = 107271
| ECnumber =
| Homologene = 56386
| MGIid = 1888996
| GeneAtlas_image1 = PBB_GE_CD59_200984_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CD59_200983_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CD59_200985_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 966
| Hs_Ensembl = ENSG00000085063
| Hs_RefseqProtein = NP_000602
| Hs_RefseqmRNA = NM_000611
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 33681134
| Hs_GenLoc_end = 33714600
| Hs_Uniprot = P13987
| Mm_EntrezGene = 333883
| Mm_Ensembl = ENSMUSG00000068686
| Mm_RefseqmRNA = NM_181858
| Mm_RefseqProtein = NP_862906
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 103871849
| Mm_GenLoc_end = 103885796
| Mm_Uniprot = Q6PBG1
}}
}}
'''CD59 molecule, complement regulatory protein''', also known as '''CD59''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD80... {November 6, 2007 9:58:34 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 9:58:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 9:59:02 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD80_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dr9.
| PDB = {{PDB2|1dr9}}, {{PDB2|1i8l}}
| Name = CD80 molecule
| HGNCid = 1700
| Symbol = CD80
| AltSymbols =; CD28LG; CD28LG1; LAB7
| OMIM = 112203
| ECnumber =
| Homologene = 3804
| MGIid = 101775
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0015026 |text = coreceptor activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0009967 |text = positive regulation of signal transduction}} {{GNF_GO|id=GO:0042110 |text = T cell activation}} {{GNF_GO|id=GO:0045086 |text = positive regulation of interleukin-2 biosynthetic process}} {{GNF_GO|id=GO:0045425 |text = positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process}} {{GNF_GO|id=GO:0045627 |text = positive regulation of T-helper 1 cell differentiation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0050731 |text = positive regulation of peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0050798 |text = activated T cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 941
| Hs_Ensembl = ENSG00000121594
| Hs_RefseqProtein = NP_005182
| Hs_RefseqmRNA = NM_005191
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 120725835
| Hs_GenLoc_end = 120761139
| Hs_Uniprot = P33681
| Mm_EntrezGene = 12519
| Mm_Ensembl = ENSMUSG00000075122
| Mm_RefseqmRNA = NM_009855
| Mm_RefseqProtein = NP_033985
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 38378357
| Mm_GenLoc_end = 38405776
| Mm_Uniprot = Q3U4B5
}}
}}
'''CD80 molecule''', also known as '''CD80''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The B-lymphocyte activation antigen B7-1 (formerly referred to as B7) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 (MIM 186760) and CTLA4 (MIM 123890) ligands of T cells.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CD80 CD80 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=941| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Knolle PA, Gerken G |title=Local control of the immune response in the liver. |journal=Immunol. Rev. |volume=174 |issue= |pages= 21-34 |year= 2000 |pmid= 10807504 |doi= }}
*{{cite journal | author=Henz BM, Maurer M, Lippert U, ''et al.'' |title=Mast cells as initiators of immunity and host defense. |journal=Exp. Dermatol. |volume=10 |issue= 1 |pages= 1-10 |year= 2001 |pmid= 11168574 |doi= }}
*{{cite journal | author=Chang TT, Kuchroo VK, Sharpe AH |title=Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. |journal=Curr. Dir. Autoimmun. |volume=5 |issue= |pages= 113-30 |year= 2002 |pmid= 11826754 |doi= }}
*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57-64 |year= 2006 |pmid= 16454711 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DCN... {November 6, 2007 10:01:04 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:02:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:02:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DCN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xcd.
| PDB = {{PDB2|1xcd}}, {{PDB2|1xec}}, {{PDB2|1xku}}
| Name = Decorin
| HGNCid = 2705
| Symbol = DCN
| AltSymbols =; CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B
| OMIM = 125255
| ECnumber =
| Homologene = 22430
| MGIid = 94872
| GeneAtlas_image1 = PBB_GE_DCN_201893_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_DCN_209335_at_tn.png
| GeneAtlas_image3 = PBB_GE_DCN_211813_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}
| Process = {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1634
| Hs_Ensembl = ENSG00000011465
| Hs_RefseqProtein = NP_001911
| Hs_RefseqmRNA = NM_001920
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 90063167
| Hs_GenLoc_end = 90100937
| Hs_Uniprot = P07585
| Mm_EntrezGene = 13179
| Mm_Ensembl = ENSMUSG00000019929
| Mm_RefseqmRNA = NM_007833
| Mm_RefseqProtein = NP_031859
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 96912055
| Mm_GenLoc_end = 96947839
| Mm_Uniprot = Q3TSV1
}}
}}
'''Decorin''', also known as '''DCN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome.<ref>{{cite web | title = Entrez Gene: DCN decorin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1634| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Fujisawa R |title=[Recent advances in research on bone matrix proteins] |journal=Nippon Rinsho |volume=60 Suppl 3 |issue= |pages= 72-8 |year= 2002 |pmid= 11979972 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ERBB4... {November 6, 2007 10:02:52 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:03:26 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 10:03:40 PM PST}
- CREATED: Created new protein page: ERBB4 {November 6, 2007 10:03:47 PM PST}
- INFO: Beginning work on FSHR... {November 6, 2007 10:03:47 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:04:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:04:43 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FSHR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xwd.
| PDB = {{PDB2|1xwd}}
| Name = Follicle stimulating hormone receptor
| HGNCid = 3969
| Symbol = FSHR
| AltSymbols =; FSHRO; LGR1; MGC141667; MGC141668; ODG1
| OMIM = 136435
| ECnumber =
| Homologene = 117
| MGIid = 95583
| GeneAtlas_image1 = PBB_GE_FSHR_211201_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004963 |text = follicle-stimulating hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007292 |text = female gamete generation}} {{GNF_GO|id=GO:0008585 |text = female gonad development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2492
| Hs_Ensembl = ENSG00000170820
| Hs_RefseqProtein = NP_000136
| Hs_RefseqmRNA = NM_000145
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 49043156
| Hs_GenLoc_end = 49235134
| Hs_Uniprot = P23945
| Mm_EntrezGene = 14309
| Mm_Ensembl = ENSMUSG00000032937
| Mm_RefseqmRNA = NM_013523
| Mm_RefseqProtein = NP_038551
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 88893278
| Mm_GenLoc_end = 89109001
| Mm_Uniprot = P35378
}}
}}
'''Follicle stimulating hormone receptor''', also known as '''FSHR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.<ref>{{cite web | title = Entrez Gene: FSHR follicle stimulating hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2492| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=de la Chapelle A |title=Disease gene mapping in isolated human populations: the example of Finland. |journal=J. Med. Genet. |volume=30 |issue= 10 |pages= 857-65 |year= 1993 |pmid= 8230163 |doi= }}
*{{cite journal | author=Simoni M, Gromoll J, Nieschlag E |title=The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. |journal=Endocr. Rev. |volume=18 |issue= 6 |pages= 739-73 |year= 1998 |pmid= 9408742 |doi= }}
*{{cite journal | author=Amsterdam A, Hanoch T, Dantes A, ''et al.'' |title=Mechanisms of gonadotropin desensitization. |journal=Mol. Cell. Endocrinol. |volume=187 |issue= 1-2 |pages= 69-74 |year= 2003 |pmid= 11988313 |doi= }}
*{{cite journal | author=Simoni M, Nieschlag E, Gromoll J |title=Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction. |journal=Hum. Reprod. Update |volume=8 |issue= 5 |pages= 413-21 |year= 2003 |pmid= 12398222 |doi= }}
*{{cite journal | author=Delbaere A, Smits G, Olatunbosun O, ''et al.'' |title=New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome? |journal=Hum. Reprod. |volume=19 |issue= 3 |pages= 486-9 |year= 2004 |pmid= 14998941 |doi= 10.1093/humrep/deh124 }}
*{{cite journal | author=Bose CK |title=Role of nerve growth factor and FSH receptor in epithelial ovarian cancer. |journal=Reprod. Biomed. Online |volume=11 |issue= 2 |pages= 194-7 |year= 2005 |pmid= 16168216 |doi= }}
*{{cite journal | author=Wunsch A, Sonntag B, Simoni M |title=Polymorphism of the FSH receptor and ovarian response to FSH. |journal=Ann. Endocrinol. (Paris) |volume=68 |issue= 2-3 |pages= 160-6 |year= 2007 |pmid= 17544358 |doi= 10.1016/j.ando.2007.04.006 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GTF2B... {November 6, 2007 10:04:43 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:05:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:05:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GTF2B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c9b.
| PDB = {{PDB2|1c9b}}, {{PDB2|1dl6}}, {{PDB2|1rly}}, {{PDB2|1ro4}}, {{PDB2|1tfb}}, {{PDB2|1vol}}, {{PDB2|2phg}}
| Name = General transcription factor IIB
| HGNCid = 4648
| Symbol = GTF2B
| AltSymbols =; TF2B; TFIIB
| OMIM = 189963
| ECnumber =
| Homologene = 1158
| MGIid = 2385191
| GeneAtlas_image1 = PBB_GE_GTF2B_208066_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016251 |text = general RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0006352 |text = transcription initiation}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2959
| Hs_Ensembl = ENSG00000137947
| Hs_RefseqProtein = NP_001505
| Hs_RefseqmRNA = NM_001514
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 89091203
| Hs_GenLoc_end = 89129889
| Hs_Uniprot = Q00403
| Mm_EntrezGene = 229906
| Mm_Ensembl = ENSMUSG00000028271
| Mm_RefseqmRNA = NM_145546
| Mm_RefseqProtein = NP_663521
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 142702633
| Mm_GenLoc_end = 142720992
| Mm_Uniprot = Q3ULN2
}}
}}
'''General transcription factor IIB''', also known as '''GTF2B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.<ref>{{cite web | title = Entrez Gene: GTF2B general transcription factor IIB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2959| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Roeder RG |title=The role of general initiation factors in transcription by RNA polymerase II. |journal=Trends Biochem. Sci. |volume=21 |issue= 9 |pages= 327-35 |year= 1996 |pmid= 8870495 |doi= }}
*{{cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193-205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153-67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 }}
*{{cite journal | author=Seelamgari A, Maddukuri A, Berro R, ''et al.'' |title=Role of viral regulatory and accessory proteins in HIV-1 replication. |journal=Front. Biosci. |volume=9 |issue= |pages= 2388-413 |year= 2006 |pmid= 15353294 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HPRT1... {November 6, 2007 10:05:29 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:06:06 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:06:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HPRT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bzy.
| PDB = {{PDB2|1bzy}}, {{PDB2|1d6n}}, {{PDB2|1hmp}}, {{PDB2|1z7g}}
| Name = Hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)
| HGNCid = 5157
| Symbol = HPRT1
| AltSymbols =; HGPRT; HPRT
| OMIM = 308000
| ECnumber =
| Homologene = 56590
| MGIid = 96217
| GeneAtlas_image1 = PBB_GE_HPRT1_202854_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004422 |text = hypoxanthine phosphoribosyltransferase activity}} {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001975 |text = response to amphetamine}} {{GNF_GO|id=GO:0006164 |text = purine nucleotide biosynthetic process}} {{GNF_GO|id=GO:0006166 |text = purine ribonucleoside salvage}} {{GNF_GO|id=GO:0006168 |text = adenine salvage}} {{GNF_GO|id=GO:0006178 |text = guanine salvage}} {{GNF_GO|id=GO:0007625 |text = grooming behavior}} {{GNF_GO|id=GO:0009116 |text = nucleoside metabolic process}} {{GNF_GO|id=GO:0019835 |text = cytolysis}} {{GNF_GO|id=GO:0021756 |text = striatum development}} {{GNF_GO|id=GO:0021895 |text = cerebral cortex neuron differentiation}} {{GNF_GO|id=GO:0021954 |text = central nervous system neuron development}} {{GNF_GO|id=GO:0042417 |text = dopamine metabolic process}} {{GNF_GO|id=GO:0045964 |text = positive regulation of dopamine metabolic process}} {{GNF_GO|id=GO:0046100 |text = hypoxanthine metabolic process}} {{GNF_GO|id=GO:0046651 |text = lymphocyte proliferation}} {{GNF_GO|id=GO:0048813 |text = dendrite morphogenesis}} {{GNF_GO|id=GO:0051289 |text = protein homotetramerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3251
| Hs_Ensembl = ENSG00000165704
| Hs_RefseqProtein = NP_000185
| Hs_RefseqmRNA = NM_000194
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 133421849
| Hs_GenLoc_end = 133462364
| Hs_Uniprot = P00492
| Mm_EntrezGene = 15452
| Mm_Ensembl = ENSMUSG00000025630
| Mm_RefseqmRNA = NM_013556
| Mm_RefseqProtein = NP_038584
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 49232760
| Mm_GenLoc_end = 49266287
| Mm_Uniprot = Q6TDG6
}}
}}
'''Hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)''', also known as '''HPRT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sculley DG, Dawson PA, Emmerson BT, Gordon RB |title=A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. |journal=Hum. Genet. |volume=90 |issue= 3 |pages= 195-207 |year= 1993 |pmid= 1487231 |doi= }}
*{{cite journal | author=Davidson BL, Tarlé SA, Van Antwerp M, ''et al.'' |title=Identification of 17 independent mutations responsible for human hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. |journal=Am. J. Hum. Genet. |volume=48 |issue= 5 |pages= 951-8 |year= 1991 |pmid= 2018042 |doi= }}
*{{cite journal | author=Stout JT, Caskey CT |title=HPRT: gene structure, expression, and mutation. |journal=Annu. Rev. Genet. |volume=19 |issue= |pages= 127-48 |year= 1986 |pmid= 3909940 |doi= 10.1146/annurev.ge.19.120185.001015 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KRT18... {November 6, 2007 10:06:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:06:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Keratin 18
| HGNCid = 6430
| Symbol = KRT18
| AltSymbols =; CYK18; K18
| OMIM = 148070
| ECnumber =
| Homologene = 55448
| MGIid = 96692
| GeneAtlas_image1 = PBB_GE_KRT18_201596_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005882 |text = intermediate filament}}
| Process = {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3875
| Hs_Ensembl = ENSG00000111057
| Hs_RefseqProtein = NP_000215
| Hs_RefseqmRNA = NM_000224
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 51629225
| Hs_GenLoc_end = 51632951
| Hs_Uniprot = P05783
| Mm_EntrezGene = 16668
| Mm_Ensembl = ENSMUSG00000023043
| Mm_RefseqmRNA = NM_010664
| Mm_RefseqProtein = NP_034794
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 101856259
| Mm_GenLoc_end = 101860055
| Mm_Uniprot = Q3TIX1
}}
}}
'''Keratin 18''', also known as '''KRT18''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: KRT18 keratin 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3875| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MAP3K5... {November 6, 2007 10:06:51 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:07:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:07:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MAP3K5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2clq.
| PDB = {{PDB2|2clq}}
| Name = Mitogen-activated protein kinase kinase kinase 5
| HGNCid = 6857
| Symbol = MAP3K5
| AltSymbols =; ASK1; MAPKKK5; MEKK5
| OMIM = 602448
| ECnumber =
| Homologene = 38114
| MGIid = 1346876
| GeneAtlas_image1 = PBB_GE_MAP3K5_203837_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAP3K5_203836_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004709 |text = MAP kinase kinase kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008656 |text = caspase activator activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0000165 |text = MAPKKK cascade}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007257 |text = activation of JNK activity}} {{GNF_GO|id=GO:0008624 |text = induction of apoptosis by extracellular signals}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4217
| Hs_Ensembl = ENSG00000197442
| Hs_RefseqProtein = NP_005914
| Hs_RefseqmRNA = NM_005923
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 136919878
| Hs_GenLoc_end = 137155349
| Hs_Uniprot = Q99683
| Mm_EntrezGene = 26408
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001006040
| Mm_RefseqProtein = XP_001006040
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Mitogen-activated protein kinase kinase kinase 5''', also known as '''MAP3K5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.<ref>{{cite web | title = Entrez Gene: MAP3K5 mitogen-activated protein kinase kinase kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4217| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nagai H, Noguchi T, Takeda K, Ichijo H |title=Pathophysiological roles of ASK1-MAP kinase signaling pathways. |journal=J. Biochem. Mol. Biol. |volume=40 |issue= 1 |pages= 1-6 |year= 2007 |pmid= 17244475 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MYOD1... {November 6, 2007 10:07:53 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:08:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:08:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MYOD1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mdy.
| PDB = {{PDB2|1mdy}}
| Name = Myogenic differentiation 1
| HGNCid = 7611
| Symbol = MYOD1
| AltSymbols =; PUM; MYF3; MYOD
| OMIM = 159970
| ECnumber =
| Homologene = 7857
| MGIid = 97275
| GeneAtlas_image1 = PBB_GE_MYOD1_206657_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007518 |text = myoblast cell fate determination}} {{GNF_GO|id=GO:0007519 |text = striated muscle development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045445 |text = myoblast differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4654
| Hs_Ensembl = ENSG00000129152
| Hs_RefseqProtein = NP_002469
| Hs_RefseqmRNA = NM_002478
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 17697686
| Hs_GenLoc_end = 17700251
| Hs_Uniprot = P15172
| Mm_EntrezGene = 17927
| Mm_Ensembl = ENSMUSG00000009471
| Mm_RefseqmRNA = NM_010866
| Mm_RefseqProtein = NP_034996
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 46244516
| Mm_GenLoc_end = 46247134
| Mm_Uniprot = Q8C6B1
}}
}}
'''Myogenic differentiation 1''', also known as '''MYOD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis.<ref>{{cite web | title = Entrez Gene: MYOD1 myogenic differentiation 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4654| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Weintraub H, Davis R, Tapscott S, ''et al.'' |title=The myoD gene family: nodal point during specification of the muscle cell lineage. |journal=Science |volume=251 |issue= 4995 |pages= 761-6 |year= 1991 |pmid= 1846704 |doi= }}
*{{cite journal | author=Tapscott SJ, Weintraub H |title=MyoD and the regulation of myogenesis by helix-loop-helix proteins. |journal=J. Clin. Invest. |volume=87 |issue= 4 |pages= 1133-8 |year= 1991 |pmid= 1849142 |doi= }}
*{{cite journal | author=Olson EN |title=MyoD family: a paradigm for development? |journal=Genes Dev. |volume=4 |issue= 9 |pages= 1454-61 |year= 1991 |pmid= 2253873 |doi= }}
*{{cite journal | author=Goldman PS, Tran VK, Goodman RH |title=The multifunctional role of the co-activator CBP in transcriptional regulation. |journal=Recent Prog. Horm. Res. |volume=52 |issue= |pages= 103-19; discussion 119-20 |year= 1997 |pmid= 9238849 |doi= }}
*{{cite journal | author=Puri PL, Sartorelli V |title=Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications. |journal=J. Cell. Physiol. |volume=185 |issue= 2 |pages= 155-73 |year= 2000 |pmid= 11025438 |doi= 10.1002/1097-4652(200011)185:2<155::AID-JCP1>3.0.CO;2-Z }}
*{{cite journal | author=McKinsey TA, Zhang CL, Olson EN |title=Control of muscle development by dueling HATs and HDACs. |journal=Curr. Opin. Genet. Dev. |volume=11 |issue= 5 |pages= 497-504 |year= 2001 |pmid= 11532390 |doi= }}
*{{cite journal | author=Berkes CA, Tapscott SJ |title=MyoD and the transcriptional control of myogenesis. |journal=Semin. Cell Dev. Biol. |volume=16 |issue= 4-5 |pages= 585-95 |year= 2006 |pmid= 16099183 |doi= 10.1016/j.semcdb.2005.07.006 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NPY... {November 6, 2007 10:08:40 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:09:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:09:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NPY_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1f8p.
| PDB = {{PDB2|1f8p}}, {{PDB2|1fvn}}, {{PDB2|1icy}}, {{PDB2|1ron}}
| Name = Neuropeptide Y
| HGNCid = 7955
| Symbol = NPY
| AltSymbols =; PYY4
| OMIM = 162640
| ECnumber =
| Homologene = 697
| MGIid = 97374
| GeneAtlas_image1 = PBB_GE_NPY_206001_at_tn.png
| Function = {{GNF_GO|id=GO:0001664 |text = G-protein-coupled receptor binding}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}} {{GNF_GO|id=GO:0005246 |text = calcium channel regulator activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005623 |text = cell}}
| Process = {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008343 |text = adult feeding behavior}} {{GNF_GO|id=GO:0032100 |text = positive regulation of appetite}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4852
| Hs_Ensembl = ENSG00000122585
| Hs_RefseqProtein = NP_000896
| Hs_RefseqmRNA = NM_000905
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 24290332
| Hs_GenLoc_end = 24298002
| Hs_Uniprot = P01303
| Mm_EntrezGene = 109648
| Mm_Ensembl = ENSMUSG00000029819
| Mm_RefseqmRNA = NM_023456
| Mm_RefseqProtein = NP_075945
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 49753184
| Mm_GenLoc_end = 49758913
| Mm_Uniprot = P57774
}}
}}
'''Neuropeptide Y''', also known as '''NPY''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wan CP, Lau BH |title=Neuropeptide Y receptor subtypes. |journal=Life Sci. |volume=56 |issue= 13 |pages= 1055-64 |year= 1997 |pmid= 9001438 |doi= }}
*{{cite journal | author=Parker E, Van Heek M, Stamford A |title=Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status. |journal=Eur. J. Pharmacol. |volume=440 |issue= 2-3 |pages= 173-87 |year= 2002 |pmid= 12007534 |doi= }}
*{{cite journal | author=Kask A, Harro J, von Hörsten S, ''et al.'' |title=The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. |journal=Neuroscience and biobehavioral reviews |volume=26 |issue= 3 |pages= 259-83 |year= 2002 |pmid= 12034130 |doi= }}
*{{cite journal | author=Bettio A, Beck-Sickinger AG |title=Biophysical methods to study ligand-receptor interactions of neuropeptide Y. |journal=Biopolymers |volume=60 |issue= 6 |pages= 420-37 |year= 2002 |pmid= 12209475 |doi= 10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W }}
*{{cite journal | author=Donoso MV, Delpiano AM, Huidobro-Toro JP |title=Modulator role of neuropeptide Y in human vascular sympathetic neuroeffector junctions. |journal=EXS |volume= |issue= 95 |pages= 65-76 |year= 2006 |pmid= 16382997 |doi= }}
*{{cite journal | author=Westfall TC |title=Neuropeptide Y and sympathetic control of vascular tone in hypertension. |journal=EXS |volume= |issue= 95 |pages= 89-103 |year= 2006 |pmid= 16382999 |doi= }}
*{{cite journal | author=Edvinsson L |title=Neuropeptide Y and the cerebral circulation. |journal=EXS |volume= |issue= 95 |pages= 105-12 |year= 2006 |pmid= 16383000 |doi= }}
*{{cite journal | author=Feuerstein GZ, Lee EW |title=Neuropeptide Y and the heart: implication for myocardial infarction and heart failure. |journal=EXS |volume= |issue= 95 |pages= 113-22 |year= 2006 |pmid= 16383001 |doi= }}
*{{cite journal | author=Dutton MA, Lee EW, Zukowska Z |title=NPY and extreme stress: lessons learned from posttraumatic stress disorder. |journal=EXS |volume= |issue= 95 |pages= 213-22 |year= 2006 |pmid= 16383009 |doi= }}
*{{cite journal | author=Colton CA, Vitek MP |title=NPY and chronic neurodegenerative disease. |journal=EXS |volume= |issue= 95 |pages= 223-44 |year= 2006 |pmid= 16383010 |doi= }}
*{{cite journal | author=Ruscica M, Dozio E, Motta M, Magni P |title=Modulatory actions of neuropeptide Y on prostate cancer growth: role of MAP kinase/ERK 1/2 activation. |journal=Adv. Exp. Med. Biol. |volume=604 |issue= |pages= 96-100 |year= 2007 |pmid= 17695723 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OPRM1... {November 6, 2007 10:09:25 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:09:59 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Opioid receptor, mu 1
| HGNCid = 8156
| Symbol = OPRM1
| AltSymbols =; MOR1; KIAA0403; OPRM
| OMIM = 600018
| ECnumber =
| Homologene = 37368
| MGIid = 97441
| GeneAtlas_image1 = PBB_GE_OPRM1_211359_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004988 |text = mu-opioid receptor activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007600 |text = sensory perception}} {{GNF_GO|id=GO:0007610 |text = behavior}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4988
| Hs_Ensembl = ENSG00000112038
| Hs_RefseqProtein = NP_000905
| Hs_RefseqmRNA = NM_000914
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 154402136
| Hs_GenLoc_end = 154609693
| Hs_Uniprot = P35372
| Mm_EntrezGene = 18390
| Mm_Ensembl = ENSMUSG00000000766
| Mm_RefseqmRNA = XM_001052051
| Mm_RefseqProtein = XP_001052051
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 3332431
| Mm_GenLoc_end = 3588035
| Mm_Uniprot = Q8CH75
}}
}}
'''Opioid receptor, mu 1''', also known as '''OPRM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Uhl GR, Sora I, Wang Z |title=The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 14 |pages= 7752-5 |year= 1999 |pmid= 10393893 |doi= }}
*{{cite journal | author=Christie MJ, Connor M, Vaughan CW, ''et al.'' |title=Cellular actions of opioids and other analgesics: implications for synergism in pain relief. |journal=Clin. Exp. Pharmacol. Physiol. |volume=27 |issue= 7 |pages= 520-3 |year= 2000 |pmid= 10874510 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PAX3... {November 6, 2007 10:09:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:11:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Paired box gene 3 (Waardenburg syndrome 1)
| HGNCid = 8617
| Symbol = PAX3
| AltSymbols =; CDHS; HUP2; MGC120381; MGC120382; MGC120383; MGC120384; MGC134778; WS1
| OMIM = 606597
| ECnumber =
| Homologene = 22494
| MGIid = 97487
| GeneAtlas_image1 = PBB_GE_PAX3_207680_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_PAX3_216059_at_tn.png
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0016566 |text = specific transcriptional repressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0001755 |text = neural crest cell migration}} {{GNF_GO|id=GO:0001843 |text = neural tube closure}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007367 |text = segment polarity determination}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048066 |text = pigmentation during development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5077
| Hs_Ensembl = ENSG00000135903
| Hs_RefseqProtein = NP_000429
| Hs_RefseqmRNA = NM_000438
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 222772851
| Hs_GenLoc_end = 222871944
| Hs_Uniprot = P23760
| Mm_EntrezGene = 18505
| Mm_Ensembl = ENSMUSG00000004872
| Mm_RefseqmRNA = XM_986648
| Mm_RefseqProtein = XP_991742
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 77985839
| Mm_GenLoc_end = 78080283
| Mm_Uniprot = Q3UGH9
}}
}}
'''Paired box gene 3 (Waardenburg syndrome 1)''', also known as '''PAX3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.<ref>{{cite web | title = Entrez Gene: PAX3 paired box gene 3 (Waardenburg syndrome 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5077| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Moase CE, Trasler DG |title=Splotch locus mouse mutants: models for neural tube defects and Waardenburg syndrome type I in humans. |journal=J. Med. Genet. |volume=29 |issue= 3 |pages= 145-51 |year= 1992 |pmid= 1552554 |doi= }}
*{{cite journal | author=Baldwin CT, Hoth CF, Macina RA, Milunsky A |title=Mutations in PAX3 that cause Waardenburg syndrome type I: ten new mutations and review of the literature. |journal=Am. J. Med. Genet. |volume=58 |issue= 2 |pages= 115-22 |year= 1996 |pmid= 8533800 |doi= 10.1002/ajmg.1320580205 }}
*{{cite journal | author=Blake J, Ziman MR |title=Aberrant PAX3 and PAX7 expression. A link to the metastatic potential of embryonal rhabdomyosarcoma and cutaneous malignant melanoma? |journal=Histol. Histopathol. |volume=18 |issue= 2 |pages= 529-39 |year= 2003 |pmid= 12647804 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PDPK1... {November 6, 2007 10:11:09 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:12:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:12:21 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PDPK1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h1w.
| PDB = {{PDB2|1h1w}}, {{PDB2|1oky}}, {{PDB2|1okz}}, {{PDB2|1uu3}}, {{PDB2|1uu7}}, {{PDB2|1uu8}}, {{PDB2|1uu9}}, {{PDB2|1uvr}}, {{PDB2|1w1d}}, {{PDB2|1w1g}}, {{PDB2|1w1h}}, {{PDB2|1z5m}}, {{PDB2|2biy}}
| Name = 3-phosphoinositide dependent protein kinase-1
| HGNCid = 8816
| Symbol = PDPK1
| AltSymbols =; PDK1; MGC20087; MGC35290; PRO0461; PkB-like; PkB-like 1
| OMIM = 605213
| ECnumber =
| Homologene = 37643
| MGIid = 1338068
| GeneAtlas_image1 = PBB_GE_PDPK1_32029_at_tn.png
| GeneAtlas_image2 = PBB_GE_PDPK1_204524_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004676 |text = 3-phosphoinositide-dependent protein kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016023 |text = cytoplasmic membrane-bound vesicle}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006972 |text = hyperosmotic response}} {{GNF_GO|id=GO:0008286 |text = insulin receptor signaling pathway}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5170
| Hs_Ensembl = ENSG00000140992
| Hs_RefseqProtein = XP_001130789
| Hs_RefseqmRNA = XM_001130789
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 2527971
| Hs_GenLoc_end = 2593189
| Hs_Uniprot = O15530
| Mm_EntrezGene = 18607
| Mm_Ensembl = ENSMUSG00000024122
| Mm_RefseqmRNA = NM_001080773
| Mm_RefseqProtein = NP_001074242
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 23803292
| Mm_GenLoc_end = 23869207
| Mm_Uniprot = Q810Z4
}}
}}
'''3-phosphoinositide dependent protein kinase-1''', also known as '''PDPK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vanhaesebroeck B, Alessi DR |title=The PI3K-PDK1 connection: more than just a road to PKB. |journal=Biochem. J. |volume=346 Pt 3 |issue= |pages= 561-76 |year= 2000 |pmid= 10698680 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPP2CA... {November 6, 2007 10:12:21 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:12:57 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 10:13:11 PM PST}
- CREATED: Created new protein page: PPP2CA {November 6, 2007 10:13:21 PM PST}
- INFO: Beginning work on PRKAR1A... {November 6, 2007 10:13:21 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:14:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:15:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRKAR1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ne4.
| PDB = {{PDB2|1ne4}}, {{PDB2|1ne6}}, {{PDB2|1rgs}}, {{PDB2|1rl3}}, {{PDB2|1u7e}}, {{PDB2|2ezw}}
| Name = Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
| HGNCid = 9388
| Symbol = PRKAR1A
| AltSymbols =; CAR; CNC; CNC1; DKFZp779L0468; MGC17251; PKR1; PRKAR1; TSE1
| OMIM = 188830
| ECnumber =
| Homologene = 37664
| MGIid = 104878
| GeneAtlas_image1 = PBB_GE_PRKAR1A_200603_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRKAR1A_200604_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PRKAR1A_200605_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008603 |text = cAMP-dependent protein kinase regulator activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0030552 |text = cAMP binding}}
| Component = {{GNF_GO|id=GO:0005952 |text = cAMP-dependent protein kinase complex}} {{GNF_GO|id=GO:0031594 |text = neuromuscular junction}}
| Process = {{GNF_GO|id=GO:0001707 |text = mesoderm formation}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5573
| Hs_Ensembl = ENSG00000108946
| Hs_RefseqProtein = NP_002725
| Hs_RefseqmRNA = NM_002734
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 64019705
| Hs_GenLoc_end = 64040503
| Hs_Uniprot = P10644
| Mm_EntrezGene = 19084
| Mm_Ensembl = ENSMUSG00000020612
| Mm_RefseqmRNA = NM_021880
| Mm_RefseqProtein = NP_068680
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 109466334
| Mm_GenLoc_end = 109485746
| Mm_Uniprot = Q3UBA7
}}
}}
'''Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)''', also known as '''PRKAR1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Functional null mutations in this gene cause Carney complex (CNC), an autosomal dominant multiple neoplasia syndrome. This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. Three alternatively spliced transcript variants encoding the same protein have been observed.<ref>{{cite web | title = Entrez Gene: PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5573| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Stratakis CA |title=Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit (PRKAR1A) in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas" (Carney complex). |journal=Ann. N. Y. Acad. Sci. |volume=968 |issue= |pages= 3-21 |year= 2002 |pmid= 12119264 |doi= }}
*{{cite journal | author=Bourdeau I, Stratakis CA |title=Cyclic AMP-dependent signaling aberrations in macronodular adrenal disease. |journal=Ann. N. Y. Acad. Sci. |volume=968 |issue= |pages= 240-55 |year= 2002 |pmid= 12119280 |doi= }}
*{{cite journal | author=Alto N, Carlisle Michel JJ, Dodge KL, ''et al.'' |title=Intracellular targeting of protein kinases and phosphatases. |journal=Diabetes |volume=51 Suppl 3 |issue= |pages= S385-8 |year= 2003 |pmid= 12475780 |doi= }}
*{{cite journal | author=Stergiopoulos SG, Stratakis CA |title=Human tumors associated with Carney complex and germline PRKAR1A mutations: a protein kinase A disease! |journal=FEBS Lett. |volume=546 |issue= 1 |pages= 59-64 |year= 2003 |pmid= 12829237 |doi= }}
*{{cite journal | author=Bossis I, Stratakis CA |title=Minireview: PRKAR1A: normal and abnormal functions. |journal=Endocrinology |volume=145 |issue= 12 |pages= 5452-8 |year= 2004 |pmid= 15331577 |doi= 10.1210/en.2004-0900 }}
*{{cite journal | author=Cho-Chung YS, Nesterova MV |title=Tumor reversion: protein kinase A isozyme switching. |journal=Ann. N. Y. Acad. Sci. |volume=1058 |issue= |pages= 76-86 |year= 2006 |pmid= 16394127 |doi= 10.1196/annals.1359.014 }}
*{{cite journal | author=Lytras A, Tolis G |title=Growth hormone-secreting tumors: genetic aspects and data from animal models. |journal=Neuroendocrinology |volume=83 |issue= 3-4 |pages= 166-78 |year= 2006 |pmid= 17047380 |doi= 10.1159/000095525 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTHLH... {November 6, 2007 10:15:00 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:15:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:16:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PTHLH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bzg.
| PDB = {{PDB2|1bzg}}, {{PDB2|1m5n}}
| Name = Parathyroid hormone-like hormone
| HGNCid = 9607
| Symbol = PTHLH
| AltSymbols =; PLP; HHM; MGC14611; PTHR; PTHRP
| OMIM = 168470
| ECnumber =
| Homologene = 2113
| MGIid = 97800
| GeneAtlas_image1 = PBB_GE_PTHLH_206300_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTHLH_211756_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0002076 |text = osteoblast development}} {{GNF_GO|id=GO:0007189 |text = G-protein signaling, adenylate cyclase activating pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007595 |text = lactation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}} {{GNF_GO|id=GO:0043129 |text = surfactant homeostasis}} {{GNF_GO|id=GO:0046058 |text = cAMP metabolic process}} {{GNF_GO|id=GO:0048286 |text = alveolus development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5744
| Hs_Ensembl = ENSG00000087494
| Hs_RefseqProtein = NP_002811
| Hs_RefseqmRNA = NM_002820
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 28006092
| Hs_GenLoc_end = 28015124
| Hs_Uniprot = P12272
| Mm_EntrezGene = 19227
| Mm_Ensembl = ENSMUSG00000048776
| Mm_RefseqmRNA = NM_008970
| Mm_RefseqProtein = NP_032996
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 147214106
| Mm_GenLoc_end = 147220540
| Mm_Uniprot = Q540C1
}}
}}
'''Parathyroid hormone-like hormone''', also known as '''PTHLH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.<ref>{{cite web | title = Entrez Gene: PTHLH parathyroid hormone-like hormone| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5744| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Casey ML, MacDonald PC |title=The endothelin-parathyroid hormone-related protein vasoactive peptide system in human endometrium: modulation by transforming growth factor-beta. |journal=Hum. Reprod. |volume=11 Suppl 2 |issue= |pages= 62-82 |year= 1997 |pmid= 8982748 |doi= }}
*{{cite journal | author=Lam MH, Thomas RJ, Martin TJ, ''et al.'' |title=Nuclear and nucleolar localization of parathyroid hormone-related protein. |journal=Immunol. Cell Biol. |volume=78 |issue= 4 |pages= 395-402 |year= 2000 |pmid= 10947864 |doi= }}
*{{cite journal | author=Fiaschi-Taesch NM, Stewart AF |title=Minireview: parathyroid hormone-related protein as an intracrine factor--trafficking mechanisms and functional consequences. |journal=Endocrinology |volume=144 |issue= 2 |pages= 407-11 |year= 2003 |pmid= 12538599 |doi= }}
*{{cite journal | author=Jans DA, Thomas RJ, Gillespie MT |title=Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles. |journal=Vitam. Horm. |volume=66 |issue= |pages= 345-84 |year= 2003 |pmid= 12852260 |doi= }}
*{{cite journal | author=Maioli E, Fortino V, Pacini A |title=Parathyroid hormone-related protein in preeclampsia: a linkage between maternal and fetal failures. |journal=Biol. Reprod. |volume=71 |issue= 6 |pages= 1779-84 |year= 2005 |pmid= 15286039 |doi= 10.1095/biolreprod.104.030932 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on S100B... {November 6, 2007 10:16:09 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:16:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:16:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_S100B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b4c.
| PDB = {{PDB2|1b4c}}, {{PDB2|1cfp}}, {{PDB2|1dt7}}, {{PDB2|1mho}}, {{PDB2|1mq1}}, {{PDB2|1mwn}}, {{PDB2|1psb}}, {{PDB2|1qlk}}, {{PDB2|1sym}}, {{PDB2|1uwo}}, {{PDB2|1xyd}}, {{PDB2|2h61}}
| Name = S100 calcium binding protein B
| HGNCid = 10500
| Symbol = S100B
| AltSymbols =; S100; NEF; S100beta
| OMIM = 176990
| ECnumber =
| Homologene = 4567
| MGIid = 98217
| GeneAtlas_image1 = PBB_GE_S100B_209686_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0019210 |text = kinase inhibitor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0048154 |text = S100 beta binding}} {{GNF_GO|id=GO:0048156 |text = tau protein binding}} {{GNF_GO|id=GO:0048306 |text = calcium-dependent protein binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0043025 |text = cell soma}}
| Process = {{GNF_GO|id=GO:0006112 |text = energy reserve metabolic process}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007613 |text = memory}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0042035 |text = regulation of cytokine biosynthetic process}} {{GNF_GO|id=GO:0045917 |text = positive regulation of complement activation}} {{GNF_GO|id=GO:0048143 |text = astrocyte activation}} {{GNF_GO|id=GO:0048151 |text = hyperphosphorylation}} {{GNF_GO|id=GO:0048169 |text = regulation of long-term neuronal synaptic plasticity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6285
| Hs_Ensembl = ENSG00000160307
| Hs_RefseqProtein = NP_006263
| Hs_RefseqmRNA = NM_006272
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 46842968
| Hs_GenLoc_end = 46849424
| Hs_Uniprot = P04271
| Mm_EntrezGene = 20203
| Mm_Ensembl = ENSMUSG00000033208
| Mm_RefseqmRNA = NM_009115
| Mm_RefseqProtein = NP_033141
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 75697569
| Mm_GenLoc_end = 75703788
| Mm_Uniprot = Q3UY00
}}
}}
'''S100 calcium binding protein B''', also known as '''S100B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.<ref>{{cite web | title = Entrez Gene: S100B S100 calcium binding protein B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6285| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi= }}
*{{cite journal | author=Garbuglia M, Verzini M, Sorci G, ''et al.'' |title=The calcium-modulated proteins, S100A1 and S100B, as potential regulators of the dynamics of type III intermediate filaments. |journal=Braz. J. Med. Biol. Res. |volume=32 |issue= 10 |pages= 1177-85 |year= 2000 |pmid= 10510252 |doi= }}
*{{cite journal | author=Rothermundt M, Peters M, Prehn JH, Arolt V |title=S100B in brain damage and neurodegeneration. |journal=Microsc. Res. Tech. |volume=60 |issue= 6 |pages= 614-32 |year= 2003 |pmid= 12645009 |doi= 10.1002/jemt.10303 }}
*{{cite journal | author=Michetti F, Gazzolo D |title=S100B testing in pregnancy. |journal=Clin. Chim. Acta |volume=335 |issue= 1-2 |pages= 1-7 |year= 2004 |pmid= 12927678 |doi= }}
*{{cite journal | author=Raabe A, Kopetsch O, Woszczyk A, ''et al.'' |title=Serum S-100B protein as a molecular marker in severe traumatic brain injury. |journal=Restor. Neurol. Neurosci. |volume=21 |issue= 3-4 |pages= 159-69 |year= 2004 |pmid= 14530578 |doi= }}
*{{cite journal | author=Sen J, Belli A |title=S100B in neuropathologic states: the CRP of the brain? |journal=J. Neurosci. Res. |volume=85 |issue= 7 |pages= 1373-80 |year= 2007 |pmid= 17348038 |doi= 10.1002/jnr.21211 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SOCS1... {November 6, 2007 10:18:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:19:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Suppressor of cytokine signaling 1
| HGNCid = 19383
| Symbol = SOCS1
| AltSymbols =; CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3
| OMIM = 603597
| ECnumber =
| Homologene = 2776
| MGIid = 1354910
| GeneAtlas_image1 = PBB_GE_SOCS1_210001_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOCS1_209999_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004860 |text = protein kinase inhibitor activity}} {{GNF_GO|id=GO:0005159 |text = insulin-like growth factor receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0001932 |text = regulation of protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0042518 |text = negative regulation of tyrosine phosphorylation of Stat3 protein}} {{GNF_GO|id=GO:0045444 |text = fat cell differentiation}} {{GNF_GO|id=GO:0046426 |text = negative regulation of JAK-STAT cascade}} {{GNF_GO|id=GO:0046627 |text = negative regulation of insulin receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8651
| Hs_Ensembl = ENSG00000185338
| Hs_RefseqProtein = NP_003736
| Hs_RefseqmRNA = NM_003745
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 11255775
| Hs_GenLoc_end = 11257540
| Hs_Uniprot = O15524
| Mm_EntrezGene = 12703
| Mm_Ensembl = ENSMUSG00000038037
| Mm_RefseqmRNA = NM_009896
| Mm_RefseqProtein = NP_034026
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 10695821
| Mm_GenLoc_end = 10699114
| Mm_Uniprot = O35716
}}
}}
'''Suppressor of cytokine signaling 1''', also known as '''SOCS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.<ref>{{cite web | title = Entrez Gene: SOCS1 suppressor of cytokine signaling 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8651| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Krebs DL, Hilton DJ |title=SOCS proteins: negative regulators of cytokine signaling. |journal=Stem Cells |volume=19 |issue= 5 |pages= 378-87 |year= 2001 |pmid= 11553846 |doi= }}
*{{cite journal | author=Wang J, Campbell IL |title=Cytokine signaling in the brain: putting a SOCS in it? |journal=J. Neurosci. Res. |volume=67 |issue= 4 |pages= 423-7 |year= 2002 |pmid= 11835308 |doi= }}
*{{cite journal | author=Kile BT, Schulman BA, Alexander WS, ''et al.'' |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235-41 |year= 2002 |pmid= 12076535 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on STK11... {November 6, 2007 10:16:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:17:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Serine/threonine kinase 11
| HGNCid = 11389
| Symbol = STK11
| AltSymbols =; LKB1; PJS
| OMIM = 602216
| ECnumber =
| Homologene = 393
| MGIid = 1341870
| GeneAtlas_image1 = PBB_GE_STK11_41657_at_tn.png
| GeneAtlas_image2 = PBB_GE_STK11_204292_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6794
| Hs_Ensembl = ENSG00000118046
| Hs_RefseqProtein = NP_000446
| Hs_RefseqmRNA = NM_000455
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 1156798
| Hs_GenLoc_end = 1179434
| Hs_Uniprot = Q15831
| Mm_EntrezGene = 20869
| Mm_Ensembl = ENSMUSG00000003068
| Mm_RefseqmRNA = NM_011492
| Mm_RefseqProtein = NP_035622
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 79519331
| Mm_GenLoc_end = 79533808
| Mm_Uniprot = Q3V4A1
}}
}}
'''Serine/threonine kinase 11''', also known as '''STK11''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref>{{cite web | title = Entrez Gene: STK11 serine/threonine kinase 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6794| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yoo LI, Chung DC, Yuan J |title=LKB1--a master tumour suppressor of the small intestine and beyond. |journal=Nat. Rev. Cancer |volume=2 |issue= 7 |pages= 529-35 |year= 2002 |pmid= 12094239 |doi= 10.1038/nrc843 }}
*{{cite journal | author=Baas AF, Smit L, Clevers H |title=LKB1 tumor suppressor protein: PARtaker in cell polarity. |journal=Trends Cell Biol. |volume=14 |issue= 6 |pages= 312-9 |year= 2004 |pmid= 15183188 |doi= 10.1016/j.tcb.2004.04.001 }}
*{{cite journal | author=Katajisto P, Vallenius T, Vaahtomeri K, ''et al.'' |title=The LKB1 tumor suppressor kinase in human disease. |journal=Biochim. Biophys. Acta |volume=1775 |issue= 1 |pages= 63-75 |year= 2007 |pmid= 17010524 |doi= 10.1016/j.bbcan.2006.08.003 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TAF1... {November 6, 2007 10:17:46 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:18:22 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:18:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TAF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1eqf.
| PDB = {{PDB2|1eqf}}
| Name = TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
| HGNCid = 11535
| Symbol = TAF1
| AltSymbols =; NSCL2; OF; BA2R; CCG1; CCGS; P250; TAF2A; TAFII250
| OMIM = 313650
| ECnumber =
| Homologene = 37942
| MGIid = 1336878
| GeneAtlas_image1 = PBB_GE_TAF1_216711_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005669 |text = transcription factor TFIID complex}}
| Process = {{GNF_GO|id=GO:0000080 |text = G1 phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006352 |text = transcription initiation}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6872
| Hs_Ensembl = ENSG00000147133
| Hs_RefseqProtein = NP_004597
| Hs_RefseqmRNA = NM_004606
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 70502839
| Hs_GenLoc_end = 70667100
| Hs_Uniprot = P21675
| Mm_EntrezGene = 270627
| Mm_Ensembl = ENSMUSG00000031314
| Mm_RefseqmRNA = XM_001000569
| Mm_RefseqProtein = XP_001000569
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 97735541
| Mm_GenLoc_end = 97802241
| Mm_Uniprot =
}}
}}
'''TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa''', also known as '''TAF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Two transcripts encoding different isoforms have been identified for this gene.<ref>{{cite web | title = Entrez Gene: TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6872| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wassarman DA, Sauer F |title=TAF(II)250: a transcription toolbox. |journal=J. Cell. Sci. |volume=114 |issue= Pt 16 |pages= 2895-902 |year= 2002 |pmid= 11686293 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNFRSF10B... {November 6, 2007 10:19:58 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:21:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:21:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNFRSF10B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d0g.
| PDB = {{PDB2|1d0g}}, {{PDB2|1d4v}}, {{PDB2|1du3}}, {{PDB2|1za3}}, {{PDB2|2h9g}}
| Name = Tumor necrosis factor receptor superfamily, member 10b
| HGNCid = 11905
| Symbol = TNFRSF10B
| AltSymbols =; CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9
| OMIM = 603612
| ECnumber =
| Homologene = 88698
| MGIid =
| GeneAtlas_image1 = PBB_GE_TNFRSF10B_209295_at_tn.png
| GeneAtlas_image2 = PBB_GE_TNFRSF10B_209294_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TNFRSF10B_210405_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008656 |text = caspase activator activity}} {{GNF_GO|id=GO:0045569 |text = TRAIL binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007250 |text = activation of NF-kappaB-inducing kinase}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8795
| Hs_Ensembl = ENSG00000120889
| Hs_RefseqProtein = NP_003833
| Hs_RefseqmRNA = NM_003842
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 22933598
| Hs_GenLoc_end = 22982637
| Hs_Uniprot = O14763
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Tumor necrosis factor receptor superfamily, member 10b''', also known as '''TNFRSF10B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracelluar death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.<ref>{{cite web | title = Entrez Gene: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8795| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Abe K, Kurakin A, Mohseni-Maybodi M, ''et al.'' |title=The complexity of TNF-related apoptosis-inducing ligand. |journal=Ann. N. Y. Acad. Sci. |volume=926 |issue= |pages= 52-63 |year= 2001 |pmid= 11193041 |doi= }}
*{{cite journal | author=Cha SS, Song YL, Oh BH |title=Specificity of molecular recognition learned from the crystal structures of TRAIL and the TRAIL:sDR5 complex. |journal=Vitam. Horm. |volume=67 |issue= |pages= 1-17 |year= 2004 |pmid= 15110168 |doi= 10.1016/S0083-6729(04)67001-4 }}
*{{cite journal | author=Kimberley FC, Screaton GR |title=Following a TRAIL: update on a ligand and its five receptors. |journal=Cell Res. |volume=14 |issue= 5 |pages= 359-72 |year= 2005 |pmid= 15538968 |doi= 10.1038/sj.cr.7290236 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNFSF13B... {November 6, 2007 10:21:34 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:21:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:22:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNFSF13B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jh5.
| PDB = {{PDB2|1jh5}}, {{PDB2|1kd7}}, {{PDB2|1kxg}}, {{PDB2|1oqd}}, {{PDB2|1oqe}}, {{PDB2|1osg}}, {{PDB2|1otz}}
| Name = Tumor necrosis factor (ligand) superfamily, member 13b
| HGNCid = 11929
| Symbol = TNFSF13B
| AltSymbols =; BAFF; BLYS; CD257; TALL-1; TALL1; THANK; TNFSF20; ZTNF4; delta BAFF
| OMIM = 603969
| ECnumber =
| Homologene = 48443
| MGIid = 1344376
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005164 |text = tumor necrosis factor receptor binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001782 |text = B cell homeostasis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030890 |text = positive regulation of B cell proliferation}} {{GNF_GO|id=GO:0031295 |text = T cell costimulation}} {{GNF_GO|id=GO:0031296 |text = B cell costimulation}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0045885 |text = positive regulation of survival gene product activity}} {{GNF_GO|id=GO:0048305 |text = immunoglobulin secretion}} {{GNF_GO|id=GO:0050776 |text = regulation of immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10673
| Hs_Ensembl = ENSG00000102524
| Hs_RefseqProtein = NP_006564
| Hs_RefseqmRNA = NM_006573
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 107720067
| Hs_GenLoc_end = 107758826
| Hs_Uniprot = Q9Y275
| Mm_EntrezGene = 24099
| Mm_Ensembl = ENSMUSG00000031497
| Mm_RefseqmRNA = NM_033622
| Mm_RefseqProtein = NP_296371
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 10006815
| Mm_GenLoc_end = 10035413
| Mm_Uniprot = Q3KP92
}}
}}
'''Tumor necrosis factor (ligand) superfamily, member 13b''', also known as '''TNFSF13B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells.<ref>{{cite web | title = Entrez Gene: TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10673| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nardelli B, Moore PA, Li Y, Hilbert DM |title=B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases. |journal=Leuk. Lymphoma |volume=43 |issue= 7 |pages= 1367-73 |year= 2003 |pmid= 12389615 |doi= }}
*{{cite journal | author=Zhou T, Zhang J, Carter R, Kimberly R |title=BLyS and B cell autoimmunity. |journal=Curr. Dir. Autoimmun. |volume=6 |issue= |pages= 21-37 |year= 2003 |pmid= 12408045 |doi= }}
*{{cite journal | author=Stohl W |title=A therapeutic role for BLyS antagonists. |journal=Lupus |volume=13 |issue= 5 |pages= 317-22 |year= 2005 |pmid= 15230285 |doi= }}
*{{cite journal | author=Quartuccio L, Fabris M, Ferraccioli G |title=[B lymphocyte stimulator (BLyS) and monocytes: possible role in autoimmune diseases with a particular reference to rheumatoid arthritis] |journal=Reumatismo |volume=56 |issue= 3 |pages= 143-6 |year= 2004 |pmid= 15470519 |doi= }}
*{{cite journal | author=Sutherland AP, Mackay F, Mackay CR |title=Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas. |journal=Pharmacol. Ther. |volume=112 |issue= 3 |pages= 774-86 |year= 2007 |pmid= 16863659 |doi= 10.1016/j.pharmthera.2006.06.002 }}
*{{cite journal | author=Bossen C, Schneider P |title=BAFF, APRIL and their receptors: structure, function and signaling. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 263-75 |year= 2007 |pmid= 16914324 |doi= 10.1016/j.smim.2006.04.006 }}
*{{cite journal | author=Brink R |title=Regulation of B cell self-tolerance by BAFF. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 276-83 |year= 2007 |pmid= 16916609 |doi= 10.1016/j.smim.2006.04.003 }}
*{{cite journal | author=Tangye SG, Bryant VL, Cuss AK, Good KL |title=BAFF, APRIL and human B cell disorders. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 305-17 |year= 2007 |pmid= 16916610 |doi= 10.1016/j.smim.2006.04.004 }}
*{{cite journal | author=Treml LS, Crowley JE, Cancro MP |title=BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 297-304 |year= 2007 |pmid= 16919470 |doi= 10.1016/j.smim.2006.07.001 }}
*{{cite journal | author=Woodland RT, Schmidt MR, Thompson CB |title=BLyS and B cell homeostasis. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 318-26 |year= 2007 |pmid= 16931037 |doi= 10.1016/j.smim.2006.06.001 }}
*{{cite journal | author=Kalled SL |title=Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 290-6 |year= 2007 |pmid= 16931038 |doi= 10.1016/j.smim.2006.06.002 }}
*{{cite journal | author=Mackay F, Leung H |title=The role of the BAFF/APRIL system on T cell function. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 284-9 |year= 2007 |pmid= 16931039 |doi= 10.1016/j.smim.2006.04.005 }}
*{{cite journal | author=Bosello S, Pers JO, Rochas C, ''et al.'' |title=BAFF and rheumatic autoimmune disorders: implications for disease management and therapy. |journal=International journal of immunopathology and pharmacology |volume=20 |issue= 1 |pages= 1-8 |year= 2007 |pmid= 17346422 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
