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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 20:25, 1 November 2007 (UTC)
[edit] Proteins without matches (12)
[edit] Proteins with a High Potential Match (12)
[edit] Redirected Proteins (1)
[edit] Created (3)
[edit] Manual Inspection (Page not found) (21)
[edit] Updated (1)
[edit] Protein Status Grid - Date: 20:25, 1 November 2007 (UTC)
[edit] Vebose Log - Date: 20:25, 1 November 2007 (UTC)
- INFO: Beginning work on ACTA1... {November 1, 2007 12:48:32 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 12:49:13 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 12:50:59 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACTA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1atn.
| PDB = {{PDB2|1atn}}, {{PDB2|1c0g}}, {{PDB2|1d4x}}, {{PDB2|1eqy}}, {{PDB2|1esv}}, {{PDB2|1h1v}}, {{PDB2|1hlu}}, {{PDB2|1ijj}}, {{PDB2|1j6z}}, {{PDB2|1kxp}}, {{PDB2|1lcu}}, {{PDB2|1lot}}, {{PDB2|1m8q}}, {{PDB2|1ma9}}, {{PDB2|1mdu}}, {{PDB2|1mvw}}, {{PDB2|1nlv}}, {{PDB2|1nm1}}, {{PDB2|1nmd}}, {{PDB2|1nwk}}, {{PDB2|1o18}}, {{PDB2|1o19}}, {{PDB2|1o1a}}, {{PDB2|1o1b}}, {{PDB2|1o1c}}, {{PDB2|1o1d}}, {{PDB2|1o1e}}, {{PDB2|1o1f}}, {{PDB2|1o1g}}, {{PDB2|1p8z}}, {{PDB2|1qz5}}, {{PDB2|1qz6}}, {{PDB2|1rdw}}, {{PDB2|1rfq}}, {{PDB2|1rgi}}, {{PDB2|1s22}}, {{PDB2|1sqk}}, {{PDB2|1t44}}, {{PDB2|1wua}}, {{PDB2|1y64}}, {{PDB2|1yxq}}, {{PDB2|2a3z}}, {{PDB2|2a40}}, {{PDB2|2a41}}, {{PDB2|2a42}}, {{PDB2|2a5x}}, {{PDB2|2asm}}, {{PDB2|2aso}}, {{PDB2|2asp}}, {{PDB2|2btf}}, {{PDB2|2d1k}}, {{PDB2|2ff3}}, {{PDB2|2ff6}}, {{PDB2|2fxu}}, {{PDB2|2gwj}}, {{PDB2|2gwk}}, {{PDB2|2hf3}}, {{PDB2|2hf4}}, {{PDB2|2hmp}}, {{PDB2|2oan}}, {{PDB2|2q1n}}, {{PDB2|2q31}}, {{PDB2|2q36}}
| Name = Actin, alpha 1, skeletal muscle
| HGNCid = 129
| Symbol = ACTA1
| AltSymbols =; ACTA; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3
| OMIM = 102610
| ECnumber =
| Homologene = 88645
| MGIid = 87902
| GeneAtlas_image1 = PBB_GE_ACTA1_203872_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0017022 |text = myosin binding}} {{GNF_GO|id=GO:0043531 |text = ADP binding}}
| Component = {{GNF_GO|id=GO:0001725 |text = stress fiber}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005865 |text = striated muscle thin filament}} {{GNF_GO|id=GO:0005884 |text = actin filament}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0030240 |text = muscle thin filament assembly}} {{GNF_GO|id=GO:0048741 |text = skeletal muscle fiber development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 58
| Hs_Ensembl = ENSG00000143632
| Hs_RefseqProtein = NP_001091
| Hs_RefseqmRNA = NM_001100
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 227633615
| Hs_GenLoc_end = 227636468
| Hs_Uniprot = P68133
| Mm_EntrezGene = 11459
| Mm_Ensembl = ENSMUSG00000031972
| Mm_RefseqmRNA = NM_009606
| Mm_RefseqProtein = NP_033736
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 126777859
| Mm_GenLoc_end = 126780841
| Mm_Uniprot = Q61264
}}
}}
'''Actin, alpha 1, skeletal muscle''', also known as '''ACTA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.<ref>{{cite web | title = Entrez Gene: ACTA1 actin, alpha 1, skeletal muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=58| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227-30 |year= 1997 |pmid= 8997639 |doi= }}
*{{cite journal | author=Di Fiore PP, Scita G |title=Eps8 in the midst of GTPases. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 10 |pages= 1178-83 |year= 2002 |pmid= 12127568 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ADM... {November 1, 2007 12:50:59 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 12:51:39 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adrenomedullin
| HGNCid = 259
| Symbol = ADM
| AltSymbols =; AM
| OMIM = 103275
| ECnumber =
| Homologene = 873
| MGIid = 108058
| GeneAtlas_image1 = PBB_GE_ADM_202912_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006171 |text = cAMP biosynthetic process}} {{GNF_GO|id=GO:0006701 |text = progesterone biosynthetic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007588 |text = excretion}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0009611 |text = response to wounding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 133
| Hs_Ensembl = ENSG00000148926
| Hs_RefseqProtein = NP_001115
| Hs_RefseqmRNA = NM_001124
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 10283172
| Hs_GenLoc_end = 10285491
| Hs_Uniprot = P35318
| Mm_EntrezGene = 11535
| Mm_Ensembl = ENSMUSG00000030790
| Mm_RefseqmRNA = NM_009627
| Mm_RefseqProtein = NP_033757
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 110418838
| Mm_GenLoc_end = 110420996
| Mm_Uniprot = Q6GTK2
}}
}}
'''Adrenomedullin''', also known as '''ADM''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.<ref>{{cite web | title = Entrez Gene: ADM adrenomedullin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=133| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Richards AM, Nicholls MG, Lewis L, Lainchbury JG |title=Adrenomedullin. |journal=Clin. Sci. |volume=91 |issue= 1 |pages= 3-16 |year= 1996 |pmid= 8774254 |doi= }}
*{{cite journal | author=Samson WK |title=Proadrenomedullin-derived peptides. |journal=Frontiers in neuroendocrinology |volume=19 |issue= 2 |pages= 100-27 |year= 1998 |pmid= 9578982 |doi= 10.1006/frne.1998.0164 }}
*{{cite journal | author=Champion HC, Nussdorfer GG, Kadowitz PJ |title=Structure-activity relationships of adrenomedullin in the circulation and adrenal gland. |journal=Regul. Pept. |volume=85 |issue= 1 |pages= 1-8 |year= 2000 |pmid= 10588445 |doi= }}
*{{cite journal | author=Cuttitta F, Pío R, Garayoa M, ''et al.'' |title=Adrenomedullin functions as an important tumor survival factor in human carcinogenesis. |journal=Microsc. Res. Tech. |volume=57 |issue= 2 |pages= 110-9 |year= 2002 |pmid= 11921362 |doi= 10.1002/jemt.10059 }}
*{{cite journal | author=Elsasser TH, Kahl S |title=Adrenomedullin has multiple roles in disease stress: development and remission of the inflammatory response. |journal=Microsc. Res. Tech. |volume=57 |issue= 2 |pages= 120-9 |year= 2002 |pmid= 11921363 |doi= 10.1002/jemt.10058 }}
*{{cite journal | author=Fowler DE, Wang P |title=The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review). |journal=Int. J. Mol. Med. |volume=9 |issue= 5 |pages= 443-9 |year= 2002 |pmid= 11956648 |doi= }}
*{{cite journal | author=Ishimitsu T, Tsukada K, Minami J, ''et al.'' |title=Variations of human adrenomedullin gene and its relation to cardiovascular diseases. |journal=Hypertens. Res. |volume=26 Suppl |issue= |pages= S129-34 |year= 2003 |pmid= 12630823 |doi= }}
*{{cite journal | author=Nicholls MG, Charles CJ, Lainchbury JG, ''et al.'' |title=Adrenomedullin in heart failure. |journal=Hypertens. Res. |volume=26 Suppl |issue= |pages= S135-40 |year= 2003 |pmid= 12630824 |doi= }}
*{{cite journal | author=Fowler DE, Yang S, Zhou M, ''et al.'' |title=Adrenomedullin and adrenomedullin binding protein-1: their role in the septic response. |journal=J. Surg. Res. |volume=109 |issue= 2 |pages= 175-81 |year= 2003 |pmid= 12643861 |doi= }}
*{{cite journal | author=Udono-Fujimori R, Udono T, Totsune K, ''et al.'' |title=Adrenomedullin in the eye. |journal=Regul. Pept. |volume=112 |issue= 1-3 |pages= 95-101 |year= 2004 |pmid= 12667630 |doi= }}
*{{cite journal | author=Nishikimi T, Matsuoka H |title=Cardiac adrenomedullin: its role in cardiac hypertrophy and heart failure. |journal=Curr Med Chem Cardiovasc Hematol Agents |volume=3 |issue= 3 |pages= 231-42 |year= 2005 |pmid= 15974887 |doi= }}
*{{cite journal | author=Gibbons C, Dackor R, Dunworth W, ''et al.'' |title=Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling. |journal=Mol. Endocrinol. |volume=21 |issue= 4 |pages= 783-96 |year= 2007 |pmid= 17053041 |doi= 10.1210/me.2006-0156 }}
*{{cite journal | author=Nishikimi T |title=Adrenomedullin in the kidney-renal physiological and pathophysiological roles. |journal=Curr. Med. Chem. |volume=14 |issue= 15 |pages= 1689-99 |year= 2007 |pmid= 17584073 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CALM1... {November 1, 2007 12:51:39 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 12:52:04 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 12:53:07 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CALM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a29.
| PDB = {{PDB2|1a29}}, {{PDB2|1ahr}}, {{PDB2|1ak8}}, {{PDB2|1cdl}}, {{PDB2|1cdm}}, {{PDB2|1cfc}}, {{PDB2|1cfd}}, {{PDB2|1cff}}, {{PDB2|1ckk}}, {{PDB2|1cll}}, {{PDB2|1cm1}}, {{PDB2|1cm4}}, {{PDB2|1cmf}}, {{PDB2|1cmg}}, {{PDB2|1ctr}}, {{PDB2|1deg}}, {{PDB2|1dmo}}, {{PDB2|1f70}}, {{PDB2|1f71}}, {{PDB2|1fw4}}, {{PDB2|1g4y}}, {{PDB2|1iq5}}, {{PDB2|1iwq}}, {{PDB2|1j7o}}, {{PDB2|1j7p}}, {{PDB2|1k90}}, {{PDB2|1k93}}, {{PDB2|1l7z}}, {{PDB2|1lin}}, {{PDB2|1lvc}}, {{PDB2|1mux}}, {{PDB2|1mxe}}, {{PDB2|1niw}}, {{PDB2|1nwd}}, {{PDB2|1ooj}}, {{PDB2|1pk0}}, {{PDB2|1prw}}, {{PDB2|1qiv}}, {{PDB2|1qiw}}, {{PDB2|1qs7}}, {{PDB2|1qtx}}, {{PDB2|1qx5}}, {{PDB2|1qx7}}, {{PDB2|1s26}}, {{PDB2|1sk6}}, {{PDB2|1sw8}}, {{PDB2|1sy9}}, {{PDB2|1up5}}, {{PDB2|1vrk}}, {{PDB2|1wrz}}, {{PDB2|1x02}}, {{PDB2|1xa5}}, {{PDB2|1xfu}}, {{PDB2|1xfv}}, {{PDB2|1xfw}}, {{PDB2|1xfx}}, {{PDB2|1xfy}}, {{PDB2|1xfz}}, {{PDB2|1y0v}}, {{PDB2|1y6w}}, {{PDB2|1yr5}}, {{PDB2|1yrt}}, {{PDB2|1yru}}, {{PDB2|1zot}}, {{PDB2|1zuz}}, {{PDB2|2bbm}}, {{PDB2|2bbn}}, {{PDB2|2bcx}}, {{PDB2|2be6}}, {{PDB2|2bkh}}, {{PDB2|2bki}}, {{PDB2|2col}}, {{PDB2|2dfs}}, {{PDB2|2f2o}}, {{PDB2|2f2p}}, {{PDB2|2f3y}}, {{PDB2|2f3z}}, {{PDB2|2fot}}, {{PDB2|2hf5}}, {{PDB2|2ix7}}, {{PDB2|3cln}}, {{PDB2|4cln}}
| Name = Calmodulin 1 (phosphorylase kinase, delta)
| HGNCid = 1442
| Symbol = CALM1
| AltSymbols =; CALML2; CAMI; DD132; PHKD
| OMIM = 114180
| ECnumber =
| Homologene = 55999
| MGIid = 88251
| Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 801
| Hs_Ensembl =
| Hs_RefseqProtein = NP_008819
| Hs_RefseqmRNA = NM_006888
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 12313
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009790
| Mm_RefseqProtein = NP_033920
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Calmodulin 1 (phosphorylase kinase, delta)''', also known as '''CALM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CALM1 calmodulin 1 (phosphorylase kinase, delta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=801| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Zhang M, Yuan T |title=Molecular mechanisms of calmodulin's functional versatility. |journal=Biochem. Cell Biol. |volume=76 |issue= 2-3 |pages= 313-23 |year= 1999 |pmid= 9923700 |doi= }}
*{{cite journal | author=Gusev NB |title=Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation. |journal=Biochemistry Mosc. |volume=66 |issue= 10 |pages= 1112-21 |year= 2002 |pmid= 11736632 |doi= }}
*{{cite journal | author=Benaim G, Villalobo A |title=Phosphorylation of calmodulin. Functional implications. |journal=Eur. J. Biochem. |volume=269 |issue= 15 |pages= 3619-31 |year= 2002 |pmid= 12153558 |doi= }}
*{{cite journal | author=Trudeau MC, Zagotta WN |title=Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 18705-8 |year= 2003 |pmid= 12626507 |doi= 10.1074/jbc.R300001200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD14... {November 1, 2007 12:53:08 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 12:54:26 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD14 molecule
| HGNCid = 1628
| Symbol = CD14
| AltSymbols =;
| OMIM = 158120
| ECnumber =
| Homologene = 493
| MGIid = 88318
| GeneAtlas_image1 = PBB_GE_CD14_201743_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016019 |text = peptidoglycan receptor activity}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0019898 |text = extrinsic to membrane}}
| Process = {{GNF_GO|id=GO:0006909 |text = phagocytosis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 929
| Hs_Ensembl = ENSG00000170458
| Hs_RefseqProtein = NP_000582
| Hs_RefseqmRNA = NM_000591
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 139991522
| Hs_GenLoc_end = 139993157
| Hs_Uniprot = P08571
| Mm_EntrezGene = 12475
| Mm_Ensembl = ENSMUSG00000051439
| Mm_RefseqmRNA = NM_009841
| Mm_RefseqProtein = NP_033971
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 36851038
| Mm_GenLoc_end = 36852628
| Mm_Uniprot = Q3TE16
}}
}}
'''CD14 molecule''', also known as '''CD14''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. Alternative splicing results in multiple transcript variants encoding the same isoform.<ref>{{cite web | title = Entrez Gene: CD14 CD14 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=929| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Todd RF, Petty HR |title=Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors. |journal=J. Lab. Clin. Med. |volume=129 |issue= 5 |pages= 492-8 |year= 1997 |pmid= 9142045 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CEBPB... {November 1, 2007 12:54:26 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 12:55:11 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 12:56:08 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CEBPB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ci6.
| PDB = {{PDB2|1ci6}}, {{PDB2|1gtw}}, {{PDB2|1gu4}}, {{PDB2|1gu5}}, {{PDB2|1h88}}, {{PDB2|1h89}}, {{PDB2|1h8a}}, {{PDB2|1hjb}}, {{PDB2|1io4}}
| Name = CCAAT/enhancer binding protein (C/EBP), beta
| HGNCid = 1834
| Symbol = CEBPB
| AltSymbols =; C/EBP-beta; CRP2; IL6DBP; LAP; MGC32080; NF-IL6; TCF5
| OMIM = 189965
| ECnumber =
| Homologene = 3807
| MGIid = 88373
| GeneAtlas_image1 = PBB_GE_CEBPB_212501_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001892 |text = embryonic placenta development}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0030182 |text = neuron differentiation}} {{GNF_GO|id=GO:0045408 |text = regulation of interleukin-6 biosynthetic process}} {{GNF_GO|id=GO:0045444 |text = fat cell differentiation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1051
| Hs_Ensembl = ENSG00000172216
| Hs_RefseqProtein = NP_005185
| Hs_RefseqmRNA = NM_005194
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 48240678
| Hs_GenLoc_end = 48242633
| Hs_Uniprot = P17676
| Mm_EntrezGene = 12608
| Mm_Ensembl = ENSMUSG00000056501
| Mm_RefseqmRNA = NM_009883
| Mm_RefseqProtein = NP_034013
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 167380120
| Mm_GenLoc_end = 167381623
| Mm_Uniprot = Q3UPN9
}}
}}
'''CCAAT/enhancer binding protein (C/EBP), beta''', also known as '''CEBPB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.<ref>{{cite web | title = Entrez Gene: CEBPB CCAAT/enhancer binding protein (C/EBP), beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1051| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sladek FM, Darnell JE |title=Mechanisms of liver-specific gene expression. |journal=Curr. Opin. Genet. Dev. |volume=2 |issue= 2 |pages= 256-9 |year= 1992 |pmid= 1638120 |doi= }}
*{{cite journal | author=Maytin EV, Habener JF |title=Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo. |journal=J. Invest. Dermatol. |volume=110 |issue= 3 |pages= 238-46 |year= 1998 |pmid= 9506442 |doi= 10.1046/j.1523-1747.1998.00123.x }}
*{{cite journal | author=Cornwall GA, Hsia N |title=[Cres (cystatin-related epididymal spermatogenic) gene regulation and function] |journal=Zhonghua Nan Ke Xue |volume=8 |issue= 5 |pages= 313-8 |year= 2003 |pmid= 12479114 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DRD2... {November 1, 2007 12:56:08 PM PDT}
- CREATE: Found no pages, creating new page. {November 1, 2007 12:58:39 PM PDT}
- CREATED: Created new protein page: DRD2 {November 1, 2007 12:58:48 PM PDT}
- INFO: Beginning work on EGF... {November 1, 2007 12:58:48 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 12:59:26 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 12:59:36 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EGF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ivo.
| PDB = {{PDB2|1ivo}}, {{PDB2|1jl9}}, {{PDB2|1nql}}, {{PDB2|1p9j}}
| Name = Epidermal growth factor (beta-urogastrone)
| HGNCid = 3229
| Symbol = EGF
| AltSymbols =; URG
| OMIM = 131530
| ECnumber =
| Homologene = 1483
| MGIid = 95290
| GeneAtlas_image1 = PBB_GE_EGF_206254_at_tn.png
| Function = {{GNF_GO|id=GO:0005155 |text = epidermal growth factor receptor activating ligand activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0000186 |text = activation of MAPKK activity}} {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0048754 |text = branching morphogenesis of a tube}} {{GNF_GO|id=GO:0050730 |text = regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1950
| Hs_Ensembl = ENSG00000138798
| Hs_RefseqProtein = NP_001954
| Hs_RefseqmRNA = NM_001963
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 111053499
| Hs_GenLoc_end = 111152860
| Hs_Uniprot = P01133
| Mm_EntrezGene = 13645
| Mm_Ensembl = ENSMUSG00000028017
| Mm_RefseqmRNA = NM_010113
| Mm_RefseqProtein = NP_034243
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 129669600
| Mm_GenLoc_end = 129747338
| Mm_Uniprot = Q3UWD7
}}
}}
'''Epidermal growth factor (beta-urogastrone)''', also known as '''EGF''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Epidermal growth factor has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide.<ref>{{cite web | title = Entrez Gene: EGF epidermal growth factor (beta-urogastrone)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1950| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Boonstra J, Rijken P, Humbel B, ''et al.'' |title=The epidermal growth factor. |journal=Cell Biol. Int. |volume=19 |issue= 5 |pages= 413-30 |year= 1995 |pmid= 7640657 |doi= }}
*{{cite journal | author=Dvorak B |title=Epidermal growth factor and necrotizing enterocolitis. |journal=Clinics in perinatology |volume=31 |issue= 1 |pages= 183-92 |year= 2004 |pmid= 15183666 |doi= 10.1016/j.clp.2004.03.015 }}
*{{cite journal | author=Howell WM |title=Epidermal growth factor gene polymorphism and development of cutaneous melanoma. |journal=J. Invest. Dermatol. |volume=123 |issue= 4 |pages= xx-xxi |year= 2004 |pmid= 15373802 |doi= 10.1111/j.0022-202X.2004.23308.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FGFR1... {November 1, 2007 12:59:36 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:00:39 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:01:07 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FGFR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1agw.
| PDB = {{PDB2|1agw}}, {{PDB2|1cvs}}, {{PDB2|1evt}}, {{PDB2|1fgi}}, {{PDB2|1fgk}}, {{PDB2|1fq9}}, {{PDB2|2ckn}}, {{PDB2|2cr3}}, {{PDB2|2fgi}}
| Name = Fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
| HGNCid = 3688
| Symbol = FGFR1
| AltSymbols =; BFGFR; CD331; CEK; FGFBR; FLG; FLT2; HBGFR; KAL2; N-SAM
| OMIM = 136350
| ECnumber =
| Homologene = 69065
| MGIid = 95522
| GeneAtlas_image1 = PBB_GE_FGFR1_211535_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FGFR1_207937_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005007 |text = fibroblast growth factor receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000165 |text = MAPKKK cascade}} {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001759 |text = induction of an organ}} {{GNF_GO|id=GO:0002053 |text = positive regulation of mesenchymal cell proliferation}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0007435 |text = salivary gland morphogenesis}} {{GNF_GO|id=GO:0008543 |text = fibroblast growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0016049 |text = cell growth}} {{GNF_GO|id=GO:0030324 |text = lung development}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0042472 |text = inner ear morphogenesis}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}} {{GNF_GO|id=GO:0048469 |text = cell maturation}} {{GNF_GO|id=GO:0048754 |text = branching morphogenesis of a tube}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2260
| Hs_Ensembl = ENSG00000077782
| Hs_RefseqProtein = NP_056934
| Hs_RefseqmRNA = NM_015850
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 38389406
| Hs_GenLoc_end = 38445296
| Hs_Uniprot = P11362
| Mm_EntrezGene = 14182
| Mm_Ensembl = ENSMUSG00000031565
| Mm_RefseqmRNA = NM_001079908
| Mm_RefseqProtein = NP_001073377
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 26997826
| Mm_GenLoc_end = 27039466
| Mm_Uniprot = Q3TJ05
}}
}}
'''Fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)''', also known as '''FGFR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.<ref>{{cite web | title = Entrez Gene: FGFR1 fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2260| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Johnson DE, Williams LT |title=Structural and functional diversity in the FGF receptor multigene family. |journal=Adv. Cancer Res. |volume=60 |issue= |pages= 1-41 |year= 1993 |pmid= 8417497 |doi= }}
*{{cite journal | author=Macdonald D, Reiter A, Cross NC |title=The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. |journal=Acta Haematol. |volume=107 |issue= 2 |pages= 101-7 |year= 2002 |pmid= 11919391 |doi= }}
*{{cite journal | author=Groth C, Lardelli M |title=The structure and function of vertebrate fibroblast growth factor receptor 1. |journal=Int. J. Dev. Biol. |volume=46 |issue= 4 |pages= 393-400 |year= 2003 |pmid= 12141425 |doi= }}
*{{cite journal | author=Wilkie AO |title=Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations. |journal=Cytokine Growth Factor Rev. |volume=16 |issue= 2 |pages= 187-203 |year= 2005 |pmid= 15863034 |doi= 10.1016/j.cytogfr.2005.03.001 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HBA1... {November 1, 2007 1:01:07 PM PDT}
- SEARCH REDIRECT: Control Box Found: HBA1 {November 1, 2007 1:01:30 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 1, 2007 1:01:31 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 1, 2007 1:01:31 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 1, 2007 1:01:31 PM PDT}
- UPDATED: Updated protein page: HBA1 {November 1, 2007 1:01:38 PM PDT}
- INFO: Beginning work on IGF2... {November 1, 2007 1:01:38 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:02:58 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:03:15 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IGF2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1igl.
| PDB = {{PDB2|1igl}}
| Name = Insulin-like growth factor 2 (somatomedin A)
| HGNCid = 5466
| Symbol = IGF2
| AltSymbols =; C11orf43; FLJ22066; FLJ44734; INSIGF; pp9974
| OMIM = 147470
| ECnumber =
| Homologene = 510
| MGIid = 96434
| GeneAtlas_image1 = PBB_GE_IGF2_202409_at_tn.png
| GeneAtlas_image2 = PBB_GE_IGF2_202410_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_IGF2_210881_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005159 |text = insulin-like growth factor receptor binding}} {{GNF_GO|id=GO:0005179 |text = hormone activity}} {{GNF_GO|id=GO:0005520 |text = insulin-like growth factor binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0018445 |text = prothoracicotrophic hormone activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006349 |text = imprinting}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008286 |text = insulin receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3481
| Hs_Ensembl = ENSG00000167244
| Hs_RefseqProtein = NP_000603
| Hs_RefseqmRNA = NM_000612
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 2106918
| Hs_GenLoc_end = 2125616
| Hs_Uniprot = P01344
| Mm_EntrezGene = 16002
| Mm_Ensembl = ENSMUSG00000048583
| Mm_RefseqmRNA = NM_010514
| Mm_RefseqProtein = NP_034644
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 142460158
| Mm_GenLoc_end = 142468879
| Mm_Uniprot = P09535
}}
}}
'''Insulin-like growth factor 2 (somatomedin A)''', also known as '''IGF2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: IGF2 insulin-like growth factor 2 (somatomedin A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3481| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=O'Dell SD, Day IN |title=Insulin-like growth factor II (IGF-II). |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 7 |pages= 767-71 |year= 1998 |pmid= 9722981 |doi= }}
*{{cite journal | author=Butler AA, Yakar S, Gewolb IH, ''et al.'' |title=Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. |journal=Comp. Biochem. Physiol. B, Biochem. Mol. Biol. |volume=121 |issue= 1 |pages= 19-26 |year= 1999 |pmid= 9972281 |doi= }}
*{{cite journal | author=Kalli KR, Conover CA |title=The insulin-like growth factor/insulin system in epithelial ovarian cancer. |journal=Front. Biosci. |volume=8 |issue= |pages= d714-22 |year= 2004 |pmid= 12700030 |doi= }}
*{{cite journal | author=Wood AW, Duan C, Bern HA |title=Insulin-like growth factor signaling in fish. |journal=Int. Rev. Cytol. |volume=243 |issue= |pages= 215-85 |year= 2005 |pmid= 15797461 |doi= 10.1016/S0074-7696(05)43004-1 }}
*{{cite journal | author=Fowden AL, Sibley C, Reik W, Constancia M |title=Imprinted genes, placental development and fetal growth. |journal=Horm. Res. |volume=65 Suppl 3 |issue= |pages= 50-8 |year= 2006 |pmid= 16612114 |doi= 10.1159/000091506 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ITGA2B... {November 1, 2007 1:03:15 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:04:33 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:04:54 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ITGA2B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1txv.
| PDB = {{PDB2|1txv}}, {{PDB2|1ty3}}, {{PDB2|1ty5}}, {{PDB2|1ty6}}, {{PDB2|1ty7}}, {{PDB2|1tye}}
| Name = Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
| HGNCid = 6138
| Symbol = ITGA2B
| AltSymbols =; GTA; CD41; CD41B; GP2B; GPIIb; HPA3
| OMIM = 607759
| ECnumber =
| Homologene = 37304
| MGIid = 96601
| GeneAtlas_image1 = PBB_GE_ITGA2B_206493_at_tn.png
| GeneAtlas_image2 = PBB_GE_ITGA2B_206494_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ITGA2B_216956_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0050840 |text = extracellular matrix binding}}
| Component = {{GNF_GO|id=GO:0005925 |text = focal adhesion}} {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3674
| Hs_Ensembl = ENSG00000005961
| Hs_RefseqProtein = NP_000410
| Hs_RefseqmRNA = NM_000419
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 39805076
| Hs_GenLoc_end = 39822399
| Hs_Uniprot = P08514
| Mm_EntrezGene = 16399
| Mm_Ensembl = ENSMUSG00000034664
| Mm_RefseqmRNA = NM_010575
| Mm_RefseqProtein = NP_034705
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 102269387
| Mm_GenLoc_end = 102285973
| Mm_Uniprot = Q3U3R7
}}
}}
'''Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)''', also known as '''ITGA2B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.<ref>{{cite web | title = Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3674| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bray PF |title=Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization. |journal=Thromb. Haemost. |volume=72 |issue= 4 |pages= 492-502 |year= 1995 |pmid= 7878622 |doi= }}
*{{cite journal | author=Naik UP, Parise LV |title=Structure and function of platelet alpha IIb beta 3. |journal=Curr. Opin. Hematol. |volume=4 |issue= 5 |pages= 317-22 |year= 1997 |pmid= 9288464 |doi= }}
*{{cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390-6 |year= 1999 |pmid= 9789327 |doi= }}
*{{cite journal | author=Lincoff AM |title=Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization. |journal=Am. J. Cardiol. |volume=82 |issue= 8B |pages= 36P-42P |year= 1998 |pmid= 9809890 |doi= }}
*{{cite journal | author=Bennett JS |title=Platelet-fibrinogen interactions. |journal=Ann. N. Y. Acad. Sci. |volume=936 |issue= |pages= 340-54 |year= 2001 |pmid= 11460491 |doi= }}
*{{cite journal | author=Plow EF, Cierniewski CS, Xiao Z, ''et al.'' |title=AlphaIIbbeta3 and its antagonism at the new millennium. |journal=Thromb. Haemost. |volume=86 |issue= 1 |pages= 34-40 |year= 2002 |pmid= 11487023 |doi= }}
*{{cite journal | author=Quinn MJ, Byzova TV, Qin J, ''et al.'' |title=Integrin alphaIIbbeta3 and its antagonism. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 6 |pages= 945-52 |year= 2004 |pmid= 12637342 |doi= 10.1161/01.ATV.0000066686.46338.F1 }}
*{{cite journal | author=Fullard JF |title=The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis. |journal=Curr. Pharm. Des. |volume=10 |issue= 14 |pages= 1567-76 |year= 2004 |pmid= 15134555 |doi= }}
*{{cite journal | author=Watson SP, Auger JM, McCarty OJ, Pearce AC |title=GPVI and integrin alphaIIb beta3 signaling in platelets. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1752-62 |year= 2005 |pmid= 16102042 |doi= 10.1111/j.1538-7836.2005.01429.x }}
*{{cite journal | author=Bennett JS |title=Structure and function of the platelet integrin alphaIIbbeta3. |journal=J. Clin. Invest. |volume=115 |issue= 12 |pages= 3363-9 |year= 2006 |pmid= 16322781 |doi= 10.1172/JCI26989 }}
*{{cite journal | author=Ma YQ, Qin J, Plow EF |title=Platelet integrin alpha(IIb)beta(3): activation mechanisms. |journal=J. Thromb. Haemost. |volume=5 |issue= 7 |pages= 1345-52 |year= 2007 |pmid= 17635696 |doi= 10.1111/j.1538-7836.2007.02537.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MMP3... {November 1, 2007 1:04:54 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:05:29 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:06:11 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MMP3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b3d.
| PDB = {{PDB2|1b3d}}, {{PDB2|1b8y}}, {{PDB2|1biw}}, {{PDB2|1bm6}}, {{PDB2|1bqo}}, {{PDB2|1c3i}}, {{PDB2|1c8t}}, {{PDB2|1caq}}, {{PDB2|1ciz}}, {{PDB2|1cqr}}, {{PDB2|1d5j}}, {{PDB2|1d7x}}, {{PDB2|1d8f}}, {{PDB2|1d8m}}, {{PDB2|1g05}}, {{PDB2|1g49}}, {{PDB2|1g4k}}, {{PDB2|1hfs}}, {{PDB2|1hy7}}, {{PDB2|1oo9}}, {{PDB2|1qia}}, {{PDB2|1qic}}, {{PDB2|1slm}}, {{PDB2|1sln}}, {{PDB2|1uea}}, {{PDB2|1ums}}, {{PDB2|1umt}}, {{PDB2|1usn}}, {{PDB2|2d1o}}, {{PDB2|2srt}}, {{PDB2|2usn}}, {{PDB2|3usn}}
| Name = Matrix metallopeptidase 3 (stromelysin 1, progelatinase)
| HGNCid = 7173
| Symbol = MMP3
| AltSymbols =; MGC126102; MGC126103; MGC126104; MMP-3; SL-1; STMY; STMY1; STR1
| OMIM = 185250
| ECnumber =
| Homologene = 20545
| MGIid = 97010
| GeneAtlas_image1 = PBB_GE_MMP3_205828_at_tn.png
| Function = {{GNF_GO|id=GO:0004248 |text = stromelysin 1 activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0000270 |text = peptidoglycan metabolic process}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0030574 |text = collagen catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4314
| Hs_Ensembl = ENSG00000149968
| Hs_RefseqProtein = NP_002413
| Hs_RefseqmRNA = NM_002422
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 102211738
| Hs_GenLoc_end = 102219552
| Hs_Uniprot = P08254
| Mm_EntrezGene = 17392
| Mm_Ensembl = ENSMUSG00000043613
| Mm_RefseqmRNA = NM_010809
| Mm_RefseqProtein = NP_034939
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 7445822
| Mm_GenLoc_end = 7455975
| Mm_Uniprot = Q3UFJ0
}}
}}
'''Matrix metallopeptidase 3 (stromelysin 1, progelatinase)''', also known as '''MMP3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.<ref>{{cite web | title = Entrez Gene: MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4314| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Massova I, Kotra LP, Fridman R, Mobashery S |title=Matrix metalloproteinases: structures, evolution, and diversification. |journal=FASEB J. |volume=12 |issue= 12 |pages= 1075-95 |year= 1998 |pmid= 9737711 |doi= }}
*{{cite journal | author=Nagase H, Woessner JF |title=Matrix metalloproteinases. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21491-4 |year= 1999 |pmid= 10419448 |doi= }}
*{{cite journal | author=Lijnen HR |title=Matrix metalloproteinases and cellular fibrinolytic activity. |journal=Biochemistry Mosc. |volume=67 |issue= 1 |pages= 92-8 |year= 2002 |pmid= 11841344 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PAH... {November 1, 2007 1:06:11 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:07:11 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:07:24 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PAH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dmw.
| PDB = {{PDB2|1dmw}}, {{PDB2|1j8t}}, {{PDB2|1j8u}}, {{PDB2|1kw0}}, {{PDB2|1lrm}}, {{PDB2|1mmk}}, {{PDB2|1mmt}}, {{PDB2|1pah}}, {{PDB2|1phz}}, {{PDB2|1tdw}}, {{PDB2|1tg2}}, {{PDB2|2pah}}, {{PDB2|2phm}}, {{PDB2|3pah}}, {{PDB2|4pah}}, {{PDB2|5pah}}, {{PDB2|6pah}}
| Name = Phenylalanine hydroxylase
| HGNCid = 8582
| Symbol = PAH
| AltSymbols =; PKU; PKU1
| OMIM = 261600
| ECnumber =
| Homologene = 234
| MGIid = 97473
| GeneAtlas_image1 = PBB_GE_PAH_205719_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PAH_217583_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0004505 |text = phenylalanine 4-monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016597 |text = amino acid binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006559 |text = L-phenylalanine catabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008652 |text = amino acid biosynthetic process}} {{GNF_GO|id=GO:0009072 |text = aromatic amino acid family metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5053
| Hs_Ensembl = ENSG00000171759
| Hs_RefseqProtein = NP_000268
| Hs_RefseqmRNA = NM_000277
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 101756234
| Hs_GenLoc_end = 101835511
| Hs_Uniprot = P00439
| Mm_EntrezGene = 18478
| Mm_Ensembl = ENSMUSG00000020051
| Mm_RefseqmRNA = NM_008777
| Mm_RefseqProtein = NP_032803
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 86951736
| Mm_GenLoc_end = 87013930
| Mm_Uniprot = Q3UEH8
}}
}}
'''Phenylalanine hydroxylase''', also known as '''PAH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = PAH encodes the enzyme phenylalanine hydroxylase that is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria.<ref>{{cite web | title = Entrez Gene: PAH phenylalanine hydroxylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5053| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Eisensmith RC, Woo SL |title=Molecular basis of phenylketonuria and related hyperphenylalaninemias: mutations and polymorphisms in the human phenylalanine hydroxylase gene. |journal=Hum. Mutat. |volume=1 |issue= 1 |pages= 13-23 |year= 1993 |pmid= 1301187 |doi= 10.1002/humu.1380010104 }}
*{{cite journal | author=Konecki DS, Lichter-Konecki U |title=The phenylketonuria locus: current knowledge about alleles and mutations of the phenylalanine hydroxylase gene in various populations. |journal=Hum. Genet. |volume=87 |issue= 4 |pages= 377-88 |year= 1991 |pmid= 1679029 |doi= }}
*{{cite journal | author=Cotton RG |title=Heterogeneity of phenylketonuria at the clinical, protein and DNA levels. |journal=J. Inherit. Metab. Dis. |volume=13 |issue= 5 |pages= 739-50 |year= 1991 |pmid= 2246858 |doi= }}
*{{cite journal | author=Erlandsen H, Fusetti F, Martinez A, ''et al.'' |title=Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria. |journal=Nat. Struct. Biol. |volume=4 |issue= 12 |pages= 995-1000 |year= 1998 |pmid= 9406548 |doi= }}
*{{cite journal | author=Waters PJ, Parniak MA, Nowacki P, Scriver CR |title=In vitro expression analysis of mutations in phenylalanine hydroxylase: linking genotype to phenotype and structure to function. |journal=Hum. Mutat. |volume=11 |issue= 1 |pages= 4-17 |year= 1998 |pmid= 9450897 |doi= 10.1002/(SICI)1098-1004(1998)11:1<4::AID-HUMU2>3.0.CO;2-L }}
*{{cite journal | author=Waters PJ |title=How PAH gene mutations cause hyper-phenylalaninemia and why mechanism matters: insights from in vitro expression. |journal=Hum. Mutat. |volume=21 |issue= 4 |pages= 357-69 |year= 2003 |pmid= 12655545 |doi= 10.1002/humu.10197 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PARK2... {November 1, 2007 1:07:24 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:08:06 PM PDT}
- CREATE: Found no pages, creating new page. {November 1, 2007 1:08:29 PM PDT}
- CREATED: Created new protein page: PARK2 {November 1, 2007 1:08:39 PM PDT}
- INFO: Beginning work on PLAT... {November 1, 2007 1:08:39 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:09:14 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:10:57 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PLAT_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a5h.
| PDB = {{PDB2|1a5h}}, {{PDB2|1bda}}, {{PDB2|1pk2}}, {{PDB2|1pml}}, {{PDB2|1rtf}}, {{PDB2|1tpg}}, {{PDB2|1tpk}}, {{PDB2|1tpm}}, {{PDB2|1tpn}}
| Name = Plasminogen activator, tissue
| HGNCid = 9051
| Symbol = PLAT
| AltSymbols =; DKFZp686I03148; T-PA; TPA
| OMIM = 173370
| ECnumber =
| Homologene = 717
| MGIid = 97610
| GeneAtlas_image1 = PBB_GE_PLAT_201860_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008233 |text = peptidase activity}} {{GNF_GO|id=GO:0008243 |text = plasminogen activator activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0030141 |text = secretory granule}} {{GNF_GO|id=GO:0045177 |text = apical part of cell}}
| Process = {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0048008 |text = platelet-derived growth factor receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5327
| Hs_Ensembl = ENSG00000104368
| Hs_RefseqProtein = NP_000921
| Hs_RefseqmRNA = NM_000930
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 42151912
| Hs_GenLoc_end = 42184351
| Hs_Uniprot = P00750
| Mm_EntrezGene = 18791
| Mm_Ensembl = ENSMUSG00000031538
| Mm_RefseqmRNA = NM_008872
| Mm_RefseqProtein = NP_032898
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 24223292
| Mm_GenLoc_end = 24248389
| Mm_Uniprot = Q6P7U0
}}
}}
'''Plasminogen activator, tissue''', also known as '''PLAT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: PLAT plasminogen activator, tissue| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5327| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rijken DC |title=Relationships between structure and function of tissue-type plasminogen activator. |journal=Klin. Wochenschr. |volume=66 Suppl 12 |issue= |pages= 33-9 |year= 1988 |pmid= 3126346 |doi= }}
*{{cite journal | author=Bode W, Renatus M |title=Tissue-type plasminogen activator: variants and crystal/solution structures demarcate structural determinants of function. |journal=Curr. Opin. Struct. Biol. |volume=7 |issue= 6 |pages= 865-72 |year= 1998 |pmid= 9434908 |doi= }}
*{{cite journal | author=Anglés-Cano E, Rojas G |title=Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site. |journal=Biol. Chem. |volume=383 |issue= 1 |pages= 93-9 |year= 2003 |pmid= 11928826 |doi= }}
*{{cite journal | author=Ny T, Wahlberg P, Brändström IJ |title=Matrix remodeling in the ovary: regulation and functional role of the plasminogen activator and matrix metalloproteinase systems. |journal=Mol. Cell. Endocrinol. |volume=187 |issue= 1-2 |pages= 29-38 |year= 2003 |pmid= 11988309 |doi= }}
*{{cite journal | author=Teesalu T, Kulla A, Asser T, ''et al.'' |title=Tissue plasminogen activator as a key effector in neurobiology and neuropathology. |journal=Biochem. Soc. Trans. |volume=30 |issue= 2 |pages= 183-9 |year= 2002 |pmid= 12023848 |doi= 10.1042/ }}
*{{cite journal | author=Pang PT, Lu B |title=Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF. |journal=Ageing Res. Rev. |volume=3 |issue= 4 |pages= 407-30 |year= 2005 |pmid= 15541709 |doi= 10.1016/j.arr.2004.07.002 }}
*{{cite journal | author=Sheehan JJ, Tsirka SE |title=Fibrin-modifying serine proteases thrombin, tPA, and plasmin in ischemic stroke: a review. |journal=Glia |volume=50 |issue= 4 |pages= 340-50 |year= 2005 |pmid= 15846799 |doi= 10.1002/glia.20150 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPARA... {November 1, 2007 1:10:57 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:12:05 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:12:25 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PPARA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1i7g.
| PDB = {{PDB2|1i7g}}, {{PDB2|1k7l}}, {{PDB2|1kkq}}, {{PDB2|2p54}}
| Name = Peroxisome proliferator-activated receptor alpha
| HGNCid = 9232
| Symbol = PPARA
| AltSymbols =; MGC2237; MGC2452; NR1C1; PPAR; hPPAR
| OMIM = 170998
| ECnumber =
| Homologene = 21047
| MGIid = 104740
| GeneAtlas_image1 = PBB_GE_PPARA_206870_at_tn.png
| GeneAtlas_image2 = PBB_GE_PPARA_gnf1h00859_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004879 |text = ligand-dependent nuclear receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0015908 |text = fatty acid transport}} {{GNF_GO|id=GO:0019217 |text = regulation of fatty acid metabolic process}} {{GNF_GO|id=GO:0032000 |text = positive regulation of fatty acid beta-oxidation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5465
| Hs_Ensembl = ENSG00000186951
| Hs_RefseqProtein = NP_001001929
| Hs_RefseqmRNA = NM_001001929
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 44925163
| Hs_GenLoc_end = 45018317
| Hs_Uniprot = Q07869
| Mm_EntrezGene = 19013
| Mm_Ensembl = ENSMUSG00000022383
| Mm_RefseqmRNA = NM_011144
| Mm_RefseqProtein = NP_035274
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 85605326
| Mm_GenLoc_end = 85629024
| Mm_Uniprot = Q542P9
}}
}}
'''Peroxisome proliferator-activated receptor alpha''', also known as '''PPARA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.<ref>{{cite web | title = Entrez Gene: PPARA peroxisome proliferator-activated receptor alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5465| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Berger J, Moller DE |title=The mechanisms of action of PPARs. |journal=Annu. Rev. Med. |volume=53 |issue= |pages= 409-35 |year= 2002 |pmid= 11818483 |doi= 10.1146/annurev.med.53.082901.104018 }}
*{{cite journal | author=Kuenzli S, Saurat JH |title=Peroxisome proliferator-activated receptors in cutaneous biology. |journal=Br. J. Dermatol. |volume=149 |issue= 2 |pages= 229-36 |year= 2003 |pmid= 12932225 |doi= }}
*{{cite journal | author=Mandard S, Müller M, Kersten S |title=Peroxisome proliferator-activated receptor alpha target genes. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 4 |pages= 393-416 |year= 2004 |pmid= 14999402 |doi= 10.1007/s00018-003-3216-3 }}
*{{cite journal | author=van Raalte DH, Li M, Pritchard PH, Wasan KM |title=Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future. |journal=Pharm. Res. |volume=21 |issue= 9 |pages= 1531-8 |year= 2005 |pmid= 15497675 |doi= }}
*{{cite journal | author=Lefebvre P, Chinetti G, Fruchart JC, Staels B |title=Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. |journal=J. Clin. Invest. |volume=116 |issue= 3 |pages= 571-80 |year= 2006 |pmid= 16511589 |doi= 10.1172/JCI27989 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRKDC... {November 1, 2007 1:12:25 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:12:49 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein kinase, DNA-activated, catalytic polypeptide
| HGNCid = 9413
| Symbol = PRKDC
| AltSymbols =; DNAPK; DNPK1; HYRC; HYRC1; XRCC7; p350
| OMIM = 600899
| ECnumber =
| Homologene = 5037
| MGIid = 104779
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004677 |text = DNA-dependent protein kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000723 |text = telomere maintenance}} {{GNF_GO|id=GO:0001756 |text = somitogenesis}} {{GNF_GO|id=GO:0006303 |text = double-strand break repair via nonhomologous end joining}} {{GNF_GO|id=GO:0006310 |text = DNA recombination}} {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0007507 |text = heart development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5591
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001075109
| Hs_RefseqmRNA = NM_001081640
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 19090
| Mm_Ensembl = ENSMUSG00000022672
| Mm_RefseqmRNA = NM_011159
| Mm_RefseqProtein = NP_035289
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 15551467
| Mm_GenLoc_end = 15755813
| Mm_Uniprot = Q91UZ3
}}
}}
'''Protein kinase, DNA-activated, catalytic polypeptide''', also known as '''PRKDC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PRKDC protein kinase, DNA-activated, catalytic polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5591| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Giaccia AJ, Kastan MB |title=The complexity of p53 modulation: emerging patterns from divergent signals. |journal=Genes Dev. |volume=12 |issue= 19 |pages= 2973-83 |year= 1998 |pmid= 9765199 |doi= }}
*{{cite journal | author=Collis SJ, DeWeese TL, Jeggo PA, Parker AR |title=The life and death of DNA-PK. |journal=Oncogene |volume=24 |issue= 6 |pages= 949-61 |year= 2005 |pmid= 15592499 |doi= 10.1038/sj.onc.1208332 }}
*{{cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26-43 |year= 2005 |pmid= 15875659 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PROC... {November 1, 2007 1:12:49 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:13:24 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:13:36 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PROC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aut.
| PDB = {{PDB2|1aut}}, {{PDB2|1lqv}}
| Name = Protein C (inactivator of coagulation factors Va and VIIIa)
| HGNCid = 9451
| Symbol = PROC
| AltSymbols =; PROC1
| OMIM = 176860
| ECnumber =
| Homologene = 37288
| MGIid = 97771
| GeneAtlas_image1 = PBB_GE_PROC_206259_at_tn.png
| Function = {{GNF_GO|id=GO:0003808 |text = protein C (activated) activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0030195 |text = negative regulation of blood coagulation}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5624
| Hs_Ensembl = ENSG00000115718
| Hs_RefseqProtein = NP_000303
| Hs_RefseqmRNA = NM_000312
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 127892486
| Hs_GenLoc_end = 127903288
| Hs_Uniprot = P04070
| Mm_EntrezGene = 19123
| Mm_Ensembl = ENSMUSG00000024386
| Mm_RefseqmRNA = XM_984063
| Mm_RefseqProtein = XP_989157
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 32266137
| Mm_GenLoc_end = 32281209
| Mm_Uniprot = P33587
}}
}}
'''Protein C (inactivator of coagulation factors Va and VIIIa)''', also known as '''PROC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reitsma PH, Poort SR, Bernardi F, ''et al.'' |title=Protein C deficiency: a database of mutations. For the Protein C & S Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. |journal=Thromb. Haemost. |volume=69 |issue= 1 |pages= 77-84 |year= 1993 |pmid= 8446940 |doi= }}
*{{cite journal | author=Winegrad S |title=Cardiac myosin binding protein C. |journal=Circ. Res. |volume=84 |issue= 10 |pages= 1117-26 |year= 1999 |pmid= 10347086 |doi= }}
*{{cite journal | author=Witt I |title=[Molecular biological basis and diagnosis of hereditary defect of antithrombin III, protein c and protein S] |journal=Hamostaseologie |volume=22 |issue= 2 |pages= 14-24 |year= 2002 |pmid= 12193972 |doi= 10.1267/Hamo02020057 }}
*{{cite journal | author=Petäjä J, Manco-Johnson MJ |title=Protein C pathway in infants and children. |journal=Semin. Thromb. Hemost. |volume=29 |issue= 4 |pages= 349-62 |year= 2004 |pmid= 14517747 |doi= 10.1055/s-2003-42586 }}
*{{cite journal | author=Dahlbäck B |title=Progress in the understanding of the protein C anticoagulant pathway. |journal=Int. J. Hematol. |volume=79 |issue= 2 |pages= 109-16 |year= 2004 |pmid= 15005336 |doi= }}
*{{cite journal | author=Van de Wouwer M, Collen D, Conway EM |title=Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 8 |pages= 1374-83 |year= 2005 |pmid= 15178554 |doi= 10.1161/01.ATV.0000134298.25489.92 }}
*{{cite journal | author=Dahlbäck B, Villoutreix BO |title=Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=25 |issue= 7 |pages= 1311-20 |year= 2005 |pmid= 15860736 |doi= 10.1161/01.ATV.0000168421.13467.82 }}
*{{cite journal | author=O'Brien LA, Gupta A, Grinnell BW |title=Activated protein C and sepsis. |journal=Front. Biosci. |volume=11 |issue= |pages= 676-98 |year= 2006 |pmid= 16146761 |doi= }}
*{{cite journal | author=Hoshi S, Hijikata M, Togashi Y, ''et al.'' |title=Protein C deficiency in a family with thromboembolism and identified gene mutations. |journal=Intern. Med. |volume=46 |issue= 13 |pages= 997-1003 |year= 2007 |pmid= 17603240 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RXRA... {November 1, 2007 1:13:36 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:14:31 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:14:49 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RXRA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1by4.
| PDB = {{PDB2|1by4}}, {{PDB2|1dkf}}, {{PDB2|1dsz}}, {{PDB2|1fby}}, {{PDB2|1fm6}}, {{PDB2|1fm9}}, {{PDB2|1g1u}}, {{PDB2|1g5y}}, {{PDB2|1k74}}, {{PDB2|1lbd}}, {{PDB2|1mv9}}, {{PDB2|1mvc}}, {{PDB2|1mzn}}, {{PDB2|1r0n}}, {{PDB2|1rdt}}, {{PDB2|1rxr}}, {{PDB2|1xdk}}, {{PDB2|1xls}}, {{PDB2|1xv9}}, {{PDB2|1xvp}}, {{PDB2|1ynw}}, {{PDB2|2acl}}, {{PDB2|2nll}}
| Name = Retinoid X receptor, alpha
| HGNCid = 10477
| Symbol = RXRA
| AltSymbols =; FLJ16020; FLJ16733; MGC102720; NR2B1
| OMIM = 180245
| ECnumber =
| Homologene = 2220
| MGIid = 98214
| GeneAtlas_image1 = PBB_GE_RXRA_202449_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RXRA_202426_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003706 |text = ligand-regulated transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004886 |text = retinoid-X receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006766 |text = vitamin metabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6256
| Hs_Ensembl = ENSG00000186350
| Hs_RefseqProtein = NP_002948
| Hs_RefseqmRNA = NM_002957
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 136358137
| Hs_GenLoc_end = 136472250
| Hs_Uniprot = P19793
| Mm_EntrezGene = 20181
| Mm_Ensembl = ENSMUSG00000015846
| Mm_RefseqmRNA = XM_976705
| Mm_RefseqProtein = XP_981799
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 27499210
| Mm_GenLoc_end = 27585328
| Mm_Uniprot = Q3UMU4
}}
}}
'''Retinoid X receptor, alpha''', also known as '''RXRA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.<ref>{{cite web | title = Entrez Gene: RXRA retinoid X receptor, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6256| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Szanto A, Narkar V, Shen Q, ''et al.'' |title=Retinoid X receptors: X-ploring their (patho)physiological functions. |journal=Cell Death Differ. |volume=11 Suppl 2 |issue= |pages= S126-43 |year= 2005 |pmid= 15608692 |doi= 10.1038/sj.cdd.4401533 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC4A1... {November 1, 2007 1:14:49 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:15:28 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:16:10 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SLC4A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bh7.
| PDB = {{PDB2|1bh7}}, {{PDB2|1bzk}}, {{PDB2|1hyn}}
| Name = Solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
| HGNCid = 11027
| Symbol = SLC4A1
| AltSymbols =; WD; AE1; BND3; CD233; DI; EMPB3; EPB3; FR; MGC116750; MGC116753; MGC126619; MGC126623; RTA1A; SW; WD1; WR
| OMIM = 109270
| ECnumber =
| Homologene = 37290
| MGIid = 109393
| GeneAtlas_image1 = PBB_GE_SLC4A1_205592_at_tn.png
| Function = {{GNF_GO|id=GO:0005452 |text = inorganic anion exchanger activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008509 |text = anion transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030863 |text = cortical cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006820 |text = anion transport}} {{GNF_GO|id=GO:0006873 |text = cell ion homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6521
| Hs_Ensembl = ENSG00000004939
| Hs_RefseqProtein = NP_000333
| Hs_RefseqmRNA = NM_000342
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 39682566
| Hs_GenLoc_end = 39700993
| Hs_Uniprot = P02730
| Mm_EntrezGene = 20533
| Mm_Ensembl = ENSMUSG00000006574
| Mm_RefseqmRNA = NM_011403
| Mm_RefseqProtein = NP_035533
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 102164917
| Mm_GenLoc_end = 102181211
| Mm_Uniprot = Q3TA19
}}
}}
'''Solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)''', also known as '''SLC4A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The CD233 gene is located on chromosome 17q21-q22 and is part of the anion exchanger (AE) family. CD233 is expressed in the erythrocyte plasma membrane where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. CD233 associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of CD233. CD233 is predominantly dimeric but forms tetramers in the presence of ankyrin. Many CD233 mutations are known in man and these mutations can lead to two types of disease; destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other CD233 mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the CD233 protein and is common in areas where Plasmodium falciparum malaria is endemic. One CD233 null human is known also with very severe anemia and nephrocalcinosis.<ref>{{cite web | title = Entrez Gene: SLC4A1 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6521| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tanner MJ |title=Molecular and cellular biology of the erythrocyte anion exchanger (AE1). |journal=Semin. Hematol. |volume=30 |issue= 1 |pages= 34-57 |year= 1993 |pmid= 8434259 |doi= }}
*{{cite journal | author=Chambers EJ, Askin D, Bloomberg GB, ''et al.'' |title=Studies on the structure of a transmembrane region and a cytoplasmic loop of the human red cell anion exchanger (band 3, AE1). |journal=Biochem. Soc. Trans. |volume=26 |issue= 3 |pages= 516-20 |year= 1998 |pmid= 9765907 |doi= }}
*{{cite journal | author=Inaba M |title=[Band 3: expanding knowledge on its functions] |journal=Seikagaku |volume=73 |issue= 12 |pages= 1431-5 |year= 2002 |pmid= 11831035 |doi= }}
*{{cite journal | author=Tanner MJ |title=Band 3 anion exchanger and its involvement in erythrocyte and kidney disorders. |journal=Curr. Opin. Hematol. |volume=9 |issue= 2 |pages= 133-9 |year= 2002 |pmid= 11844997 |doi= }}
*{{cite journal | author=Shayakul C, Alper SL |title=Defects in processing and trafficking of the AE1 Cl-/HCO3- exchanger associated with inherited distal renal tubular acidosis. |journal=Clin. Exp. Nephrol. |volume=8 |issue= 1 |pages= 1-11 |year= 2004 |pmid= 15067510 |doi= 10.1007/s10157-003-0271-x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SOD2... {November 1, 2007 1:16:10 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:17:04 PM PDT}
- CREATE: Found no pages, creating new page. {November 1, 2007 1:17:18 PM PDT}
- CREATED: Created new protein page: SOD2 {November 1, 2007 1:18:20 PM PDT}
- INFO: Beginning work on THBS1... {November 1, 2007 1:18:21 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:20:07 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:20:22 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_THBS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lsl.
| PDB = {{PDB2|1lsl}}, {{PDB2|1ux6}}, {{PDB2|1z78}}, {{PDB2|1za4}}, {{PDB2|2erf}}, {{PDB2|2es3}}
| Name = Thrombospondin 1
| HGNCid = 11785
| Symbol = THBS1
| AltSymbols =; THBS; TSP; TSP1
| OMIM = 188060
| ECnumber =
| Homologene = 31142
| MGIid = 98737
| GeneAtlas_image1 = PBB_GE_THBS1_201110_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_THBS1_201107_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_THBS1_201108_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004866 |text = endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0016525 |text = negative regulation of angiogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7057
| Hs_Ensembl = ENSG00000137801
| Hs_RefseqProtein = NP_003237
| Hs_RefseqmRNA = NM_003246
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 37660572
| Hs_GenLoc_end = 37676957
| Hs_Uniprot = P07996
| Mm_EntrezGene = 21825
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011580
| Mm_RefseqProtein = NP_035710
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Thrombospondin 1''', also known as '''THBS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.<ref>{{cite web | title = Entrez Gene: THBS1 thrombospondin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7057| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Roberts DD |title=Regulation of tumor growth and metastasis by thrombospondin-1. |journal=FASEB J. |volume=10 |issue= 10 |pages= 1183-91 |year= 1996 |pmid= 8751720 |doi= }}
*{{cite journal | author=Adams JC |title=Thrombospondin-1. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 6 |pages= 861-5 |year= 1997 |pmid= 9304800 |doi= }}
*{{cite journal | author=Sargiannidou I, Qiu C, Tuszynski GP |title=Mechanisms of thrombospondin-1-mediated metastasis and angiogenesis. |journal=Semin. Thromb. Hemost. |volume=30 |issue= 1 |pages= 127-36 |year= 2004 |pmid= 15034804 |doi= 10.1055/s-2004-822977 }}
*{{cite journal | author=Esemuede N, Lee T, Pierre-Paul D, ''et al.'' |title=The role of thrombospondin-1 in human disease. |journal=J. Surg. Res. |volume=122 |issue= 1 |pages= 135-42 |year= 2004 |pmid= 15522326 |doi= 10.1016/j.jss.2004.05.015 }}
*{{cite journal | author=Li Z, Wang C, Prendergast GC, Pestell RG |title=Cyclin D1 functions in cell migration. |journal=Cell Cycle |volume=5 |issue= 21 |pages= 2440-2 |year= 2007 |pmid= 17106256 |doi= }}
*{{cite journal | author=Roberts DD, Isenberg JS, Ridnour LA, Wink DA |title=Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis. |journal=Clin. Cancer Res. |volume=13 |issue= 3 |pages= 795-8 |year= 2007 |pmid= 17289869 |doi= 10.1158/1078-0432.CCR-06-1758 }}
*{{cite journal | author=Kaczorowski DJ, Billiar TR |title=Targeting CD47: NO limit on therapeutic potential. |journal=Circ. Res. |volume=100 |issue= 5 |pages= 602-3 |year= 2007 |pmid= 17363705 |doi= 10.1161/01.RES.0000261609.44977.25 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TP73L... {November 1, 2007 1:22:45 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:24:41 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:25:17 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TP73L_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rg6.
| PDB = {{PDB2|1rg6}}
| Name = Tumor protein p73-like
| HGNCid = 13473
| Symbol = TP73L
| AltSymbols =; p63; B(p51A); B(p51B); EEC3; KET; LMS; OFC8; RHS; SHFM4; TP63; p51; p73H; p73L
| OMIM = 603273
| ECnumber =
| Homologene = 31189
| MGIid = 1330810
| GeneAtlas_image1 = PBB_GE_TP73L_209863_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TP73L_211194_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TP73L_211195_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001736 |text = establishment of planar polarity}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007389 |text = pattern specification process}} {{GNF_GO|id=GO:0007499 |text = ectoderm and mesoderm interaction}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}} {{GNF_GO|id=GO:0030859 |text = polarized epithelial cell differentiation}} {{GNF_GO|id=GO:0031069 |text = hair follicle morphogenesis}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0045747 |text = positive regulation of Notch signaling pathway}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0051289 |text = protein homotetramerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8626
| Hs_Ensembl = ENSG00000073282
| Hs_RefseqProtein = NP_003713
| Hs_RefseqmRNA = NM_003722
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 190831910
| Hs_GenLoc_end = 191097731
| Hs_Uniprot = Q9H3D4
| Mm_EntrezGene = 22061
| Mm_Ensembl = ENSMUSG00000022510
| Mm_RefseqmRNA = NM_011641
| Mm_RefseqProtein = NP_035771
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 25599639
| Mm_GenLoc_end = 25807431
| Mm_Uniprot = O88898
}}
}}
'''Tumor protein p73-like''', also known as '''TP73L''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Little NA, Jochemsen AG |title=p63. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 1 |pages= 6-9 |year= 2002 |pmid= 11733180 |doi= }}
*{{cite journal | author=van Bokhoven H, McKeon F |title=Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans. |journal=Trends in molecular medicine |volume=8 |issue= 3 |pages= 133-9 |year= 2002 |pmid= 11879774 |doi= }}
*{{cite journal | author=van Bokhoven H, Brunner HG |title=Splitting p63. |journal=Am. J. Hum. Genet. |volume=71 |issue= 1 |pages= 1-13 |year= 2002 |pmid= 12037717 |doi= }}
*{{cite journal | author=Brunner HG, Hamel BC, Bokhoven Hv H |title=P63 gene mutations and human developmental syndromes. |journal=Am. J. Med. Genet. |volume=112 |issue= 3 |pages= 284-90 |year= 2003 |pmid= 12357472 |doi= 10.1002/ajmg.10778 }}
*{{cite journal | author=Jacobs WB, Walsh GS, Miller FD |title=Neuronal survival and p73/p63/p53: a family affair. |journal=The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry |volume=10 |issue= 5 |pages= 443-55 |year= 2005 |pmid= 15359011 |doi= 10.1177/1073858404263456 }}
*{{cite journal | author=Zusman I |title=The soluble p51 protein in cancer diagnosis, prevention and therapy. |journal=In Vivo |volume=19 |issue= 3 |pages= 591-8 |year= 2005 |pmid= 15875781 |doi= }}
*{{cite journal | author=Morasso MI, Radoja N |title=Dlx genes, p63, and ectodermal dysplasias. |journal=Birth Defects Res. C Embryo Today |volume=75 |issue= 3 |pages= 163-71 |year= 2005 |pmid= 16187309 |doi= 10.1002/bdrc.20047 }}
*{{cite journal | author=Barbieri CE, Pietenpol JA |title=p63 and epithelial biology. |journal=Exp. Cell Res. |volume=312 |issue= 6 |pages= 695-706 |year= 2006 |pmid= 16406339 |doi= 10.1016/j.yexcr.2005.11.028 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRAF2... {November 1, 2007 1:20:22 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:21:08 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:21:24 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TRAF2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ca4.
| PDB = {{PDB2|1ca4}}, {{PDB2|1ca9}}, {{PDB2|1czy}}, {{PDB2|1czz}}, {{PDB2|1d00}}, {{PDB2|1d01}}, {{PDB2|1d0a}}, {{PDB2|1d0j}}, {{PDB2|1f3v}}, {{PDB2|1qsc}}
| Name = TNF receptor-associated factor 2
| HGNCid = 12032
| Symbol = TRAF2
| AltSymbols =; TRAP; MGC:45012; TRAP3
| OMIM = 601895
| ECnumber =
| Homologene = 22520
| MGIid = 101835
| GeneAtlas_image1 = PBB_GE_TRAF2_204413_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0002726 |text = positive regulation of T cell cytokine production}} {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007250 |text = activation of NF-kappaB-inducing kinase}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0050870 |text = positive regulation of T cell activation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7186
| Hs_Ensembl = ENSG00000127191
| Hs_RefseqProtein = NP_066961
| Hs_RefseqmRNA = NM_021138
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 138900786
| Hs_GenLoc_end = 138940887
| Hs_Uniprot = Q12933
| Mm_EntrezGene = 22030
| Mm_Ensembl = ENSMUSG00000026942
| Mm_RefseqmRNA = NM_009422
| Mm_RefseqProtein = NP_033448
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 25339991
| Mm_GenLoc_end = 25368903
| Mm_Uniprot = Q3TWR1
}}
}}
'''TNF receptor-associated factor 2''', also known as '''TRAF2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.<ref>{{cite web | title = Entrez Gene: TRAF2 TNF receptor-associated factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7186| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wajant H, Henkler F, Scheurich P |title=The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. |journal=Cell. Signal. |volume=13 |issue= 6 |pages= 389-400 |year= 2001 |pmid= 11384837 |doi= }}
*{{cite journal | author=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs). |journal=Oncogene |volume=20 |issue= 44 |pages= 6482-91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on WT1... {November 1, 2007 1:21:24 PM PDT}
- UPLOAD: Added new Image to wiki:
{November 1, 2007 1:22:28 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {November 1, 2007 1:22:45 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_WT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xf7.
| PDB = {{PDB2|1xf7}}
| Name = Wilms tumor 1
| HGNCid = 12796
| Symbol = WT1
| AltSymbols =; WAGR; GUD; WIT-2; WT33
| OMIM = 607102
| ECnumber =
| Homologene = 11536
| MGIid = 98968
| GeneAtlas_image1 = PBB_GE_WT1_206067_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_WT1_216953_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001570 |text = vasculogenesis}} {{GNF_GO|id=GO:0001656 |text = metanephros development}} {{GNF_GO|id=GO:0001823 |text = mesonephros development}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007281 |text = germ cell development}} {{GNF_GO|id=GO:0008584 |text = male gonad development}} {{GNF_GO|id=GO:0009888 |text = tissue development}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7490
| Hs_Ensembl = ENSG00000184937
| Hs_RefseqProtein = NP_000369
| Hs_RefseqmRNA = NM_000378
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 32365901
| Hs_GenLoc_end = 32413663
| Hs_Uniprot = P19544
| Mm_EntrezGene = 22431
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001001558
| Mm_RefseqProtein = XP_001001558
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Wilms tumor 1''', also known as '''WT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms.<ref>{{cite web | title = Entrez Gene: WT1 Wilms tumor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7490| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Haber DA, Buckler AJ |title=WT1: a novel tumor suppressor gene inactivated in Wilms' tumor. |journal=New Biol. |volume=4 |issue= 2 |pages= 97-106 |year= 1992 |pmid= 1313285 |doi= }}
*{{cite journal | author=Rauscher FJ |title=The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor. |journal=FASEB J. |volume=7 |issue= 10 |pages= 896-903 |year= 1993 |pmid= 8393820 |doi= }}
*{{cite journal | author=Lee SB, Haber DA |title=Wilms tumor and the WT1 gene. |journal=Exp. Cell Res. |volume=264 |issue= 1 |pages= 74-99 |year= 2001 |pmid= 11237525 |doi= 10.1006/excr.2000.5131 }}
*{{cite journal | author=Scharnhorst V, van der Eb AJ, Jochemsen AG |title=WT1 proteins: functions in growth and differentiation. |journal=Gene |volume=273 |issue= 2 |pages= 141-61 |year= 2001 |pmid= 11595161 |doi= }}
*{{cite journal | author=Lim HN, Hughes IA, Hawkins JR |title=Clinical and molecular evidence for the role of androgens and WT1 in testis descent. |journal=Mol. Cell. Endocrinol. |volume=185 |issue= 1-2 |pages= 43-50 |year= 2003 |pmid= 11738793 |doi= }}
*{{cite journal | author=Heathcott RW, Morison IM, Gubler MC, ''et al.'' |title=A review of the phenotypic variation due to the Denys-Drash syndrome-associated germline WT1 mutation R362X. |journal=Hum. Mutat. |volume=19 |issue= 4 |pages= 462 |year= 2002 |pmid= 11933209 |doi= 10.1002/humu.9031 }}
*{{cite journal | author=Wagner KD, Wagner N, Schedl A |title=The complex life of WT1. |journal=J. Cell. Sci. |volume=116 |issue= Pt 9 |pages= 1653-8 |year= 2004 |pmid= 12665546 |doi= }}
*{{cite journal | author=Niaudet P, Gubler MC |title=WT1 and glomerular diseases. |journal=Pediatr. Nephrol. |volume=21 |issue= 11 |pages= 1653-60 |year= 2007 |pmid= 16927106 |doi= 10.1007/s00467-006-0208-1 }}
*{{cite journal | author=Hohenstein P, Hastie ND |title=The many facets of the Wilms' tumour gene, WT1. |journal=Hum. Mol. Genet. |volume=15 Spec No 2 |issue= |pages= R196-201 |year= 2006 |pmid= 16987884 |doi= 10.1093/hmg/ddl196 }}
}}
{{refend}}
{{protein-stub}}
end log.
