Talk:Progesterone

From Wikipedia, the free encyclopedia

This is the talk page for discussing improvements to the Progesterone article.
Please sign and date your posts by typing four tildes (~~~~). Put new text under old text. Click here to start a new topic. New to Wikipedia? Welcome! Ask questions, get answers. This is not a forum for general discussion about the article's subject.	Be polite Assume good faith No personal attacks Be welcoming	Article policies No original research Neutral point of view Verifiability

This article is within the scope of the following WikiProjects:

WikiProject Medicine (Rated B-Class) This article is within the scope of WikiProject Medicine. Please visit the project page for details or ask questions at the doctor's mess. B This page has been rated as B-Class on the quality assessment scale High This article has been rated as High-importance on the importance assessment scale WikiProject Pharmacology (Rated B-Class) Progesterone is part of WikiProject Pharmacology, a project to improve all Pharmacology-related articles. If you would like to help improve this and other pharmacology articles, please join the project. All interested editors are welcome. B This article has been rated as B-Class on the quality scale. High This article has been rated as high-importance for this Project's importance scale. WikiProject Chemicals (Rated B-Class) Chemistry Portal Progesterone is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project. Core This is a core article in the WikiProject Chemicals worklist B This article has been rated as B-Class on the quality scale. High This article has been rated as high-importance on the importance scale. Article Grading: The article has been rated for quality and/or importance but has no comments yet. If appropriate, please review the article and then leave comments here to identify the strengths and weaknesses of the article and what work it will need.

Contents 1 The 2 It's 3 Synthesis: Conflicting Information With Testosterone Article 4 Clearer wording needed 5 "necessary to be suspicious..." deleted 6 multiple sclerosis and (not natural )progestagenes 7 membrane progesterone receptors 8 parental behavior and progesterone levels 9 Reference for the Bioavailability section? 10 Annually?

[edit] The

The Princeton Review MCAT course/workbook has a question asking if the Adrenal gland produces bost estradiol and progesterone. It only lists the corpus luteum and placenta as correct answers and shows the adrenal medulla as being wrong. I am not an advanced level doctor (trying to get into medical school)....The article states progesterone is made in the adrenal glands...is this the case but only in small amounts? (Same question for estrogen also... Yakob32 03:19, 30 August 2007 (UTC)Jacob Yakob32 03:20, 30 August 2007 (UTC)

[edit] It's

It's not clear to me why levonorgestrel redirects here. Is levonorgestrel just synthetic progesterone or is it an isomer or just similar in effect? Matt 18:13, 23 Dec 2004 (UTC)

--Levonorgestrel is a synthetic progesterone receptor agonist (aka progestin).

[edit] Synthesis: Conflicting Information With Testosterone Article

In Progesterone article: Progesterone, like all other steroid hormones, is synthesized from pregnenolone, a derivative of cholesterol.

In Testosterone article: Testosterone is synthesized from progesterone, the precursor of all steroid hormones and a derivative of cholesterol.

These appear to me to be conflicting or at least confusingly incomplete.

Progesterone is not a precursor of all steroid hormones and conflicting information seems to have been clarified.Ekem 03:28, 7 June 2006 (UTC)

[edit] Clearer wording needed

"Progesterone is thermogenic, raising the core temperature."

Could someone clarify what this is the core temperature of? It's probably referring to the body's temperature but that should be made explicit in the article. --Molimo 00:44, 12 December 2005 (UTC)

There should be a discussion on this page about the difference between biodentical human progesterone, horse progesterone, and drugs that are similar to progesterone but are not progesterone.

[edit] "necessary to be suspicious..." deleted

could have been reworded to be less subjective, but would still have been misleading. distinction between exogenous/endogenous progesterone could be made viz safety testing, with care to note major distinctions amongst exogenous progestins, i.e., 19 carbon/21 carbon (all of which carry degree of warning as carcinogens). but. as far as i know, there has been no "safety" testing on endogenous progesterone... Cindery 02:24, 13 August 2006 (UTC)

[edit] multiple sclerosis and (not natural )progestagenes

I have a feeling that worsening of my MS coincides with starting my period; which means dropping of my progestagene levels"?

There also are leads with cholesterols and multiple sclerosis, so are cholesterol and progestagene connected (synthesis). Is there a connection between low progestagenes (or relative lows on progestagenes as compared to estragens?) Why do twice as many women suffer from multiple sclerosis as do men? Does this give as a clue?

[edit] membrane progesterone receptors

A recent article about membrane progesterone receptors: "Two unrelated putative membrane-bound progestin receptors, progesterone membrane receptor component 1 (PGMRC1) and membrane progestin receptor (mPR) beta, are expressed in the rainbow trout oocyte and exhibit similar ovarian expression patterns". --JWSchmidt 05:49, 5 November 2006 (UTC)

[edit] parental behavior and progesterone levels

There is a relationships between progesterone levels and paternal/maternal care in some animals. I'm wondering if anyone has any information which could be added?Mechasam 16:55, 6 March 2007 (UTC)

[edit] Reference for the Bioavailability section?

There is currently no reference for the Bioavailability section of this article.

The Bioavailability section states: "Natural progesterone" products derived from yams, do not require a prescription. Wild yams contain a plant steroid called diosgenin, which the human body cannot metabolize into progesterone. Diosgenin can only be chemically processed into progesterone in labs."

The author (John Lee) of What Your Dr. May Not Tell You About Menopause, and the manufacturers of Serenity: Natural Progesterone cream assert that natural progesterone cream can be absorbed by the body as progesterone. The ingredients of Serinity as listed as: Purified Water, Organic Aloe Vera Gel 200:1 Concentrate (Aloe Barbadenis), Vegetable Glycerin, Natural Progesterone USP (2.25%), Vegepure (Complex, Stabilized Vegetable Oil), Natural Vitamin E, Glyceryl Stearate (from plant), Stearic Acid (from plant), Cetyl Alcohol (from plant), PEG-20 Methyl Glucose Sesquistearate (from plant), Methyl Glucose Sesquistearate (from plant), Hyaluronic Acid (Natural Skin Moisturizer), NaPCA (Natural Skin Humectant), Xanthan Gum, Citrus Seed Extract (a natural preservative).

The product claims to contain natural progesterone USP, but makes no mention of yams.

I was hoping the information from which the Bioavailability section of this article was derived could clarify whether there are other "natural progesterone" products in addition to yam-based progesterone products.

The wording of the final sentence "Diosgenin can only be chemically processed into progesterone in labs." leaves me wondering if manufactures are chemically processing diosgenin into progesterone and adding it to the cream. Or whether the article intends to assert that chemically processed progesterone can not be delivered via cream.

Any/all feedback welcomed.

Thanks,

Marimara (talk) 05:44, 12 March 2008 (UTC)marimara

I have added a two citations to the bioavailability section in which demonstrate no increase in progesterone levels after treatment with diosgenin. Furthermore this reference suggests that phytoprogestins (plant derived substances with progestin mimicing effects) are if anything antagonists (which block the effects of progestins). Finally the chemical conversion of diosgenin into progesterone is somewhat involved (six chemical steps) and I seriously doubt that cream manufactures are converting diosgenin into progesterone, and if they were, they would be in serious trouble with the FDA. Cheers. Boghog2 (talk) 18:06, 12 March 2008 (UTC)

[edit] Annually?

The final section in the article quotes: "Eventually, this could become a standard treatment for the many people suffering traumatic brain injuries annually." Do we mean here that it may be used for people who sustain at least one TBI per year? I imagine the inclusion of the word "annually" is an unnecessary reference to the fact that statistics are often compiled annually. If so, it should be removed. —Preceding unsigned comment added by 69.233.26.244 (talk) 06:18, 3 May 2008 (UTC)

I agree that the use of annually here did not make any sense. I have revised the section and included citations which document the neuroprotective effects of progesterone in traumatic brain injury. Cheers. Boghog2 (talk) 10:58, 4 May 2008 (UTC)