Talk:Progeria

From Wikipedia, the free encyclopedia

This is the talk page for discussing improvements to the Progeria article.
Please sign and date your posts by typing four tildes (~~~~). Put new text under old text. Click here to start a new topic. New to Wikipedia? Welcome! Ask questions, get answers. This is not a forum for general discussion about the article's subject.	Be polite Assume good faith No personal attacks Be welcoming	Article policies No original research Neutral point of view Verifiability

	This article is supported by the WikiProject on Medical Genetics, which gives a central approach to Medical genetics and related subjects on Wikipedia. Please participate by editing the article Progeria, or visit the project page for more details on the projects.
B	This article has been rated as B-Class on the quality scale.

To-do list for Progeria:	edit · history · watch · refresh
Strike through when completed Expand Infobox Sections: (arranged per MEDMOS) See WP:MEDMOS for style suggestions
Priority 4

	This article is within the scope of WikiProject Medicine. Please visit the project page for details or ask questions at the doctor's mess.
Start	This page has been rated as Start-Class on the quality assessment scale
Mid	This article has been rated as Mid-importance on the importance assessment scale

Contents 1 Progeria and hormones 2 Inconsistency 3 pictures 4 Found some pictures 5 References 6 Symptoms 7 More Inconsistency 8 Jargon 9 Living people

[edit] Progeria and hormones

Hi. I just wondered if people who suffer from Progeria's hormone cycle is the same as people not suffering from it. For example, do progeria girls' menstrual cycles start prematurely?

Jchillerup 21:17, 13 July 2005 (UTC)

Progeria in itself is just premature aging and forms a heterogenic group of diseases which can be inherited in different ways. E.g. classic (Hutchinson-Gilford) progeria is autosomal dominant, later onset (werner syndrome) progeria is autosomal recessive. --WS 23:40, 13 February 2006 (UTC)

Btw. it is more complicated than that, for a discussion of the inheritance of H-G progeria see Online 'Mendelian Inheritance in Man' (OMIM) 176670. --WS 23:57, 13 February 2006 (UTC)

To avoid confusion, it would probably be a good idea to move this page to Hutchinson-Gilford progeria syndrome, the name that is usually used in medical literature, and give a more general overview of progeria and different syndromes here. --WS 23:47, 13 February 2006 (UTC)

But a link 'Progeria' (perhpas on a disambiguation page if 'progeria' can refer to more than just Hutchinson-Gilford progeria) should be maintained, as 'progeria' is the commonly-used lay-term for the syndrome - Jim Witte —The preceding unsigned comment was added by 216.9.143.221 (talk) 17:41, 24 January 2007 (UTC).

[edit] Inconsistency

The first part of the article states: "Unlike most other "accelerated aging diseases" (like Werner's syndrome), progeria is not caused by defective DNA repair."

Under cause, the article then states: "New evidence suggests that, as in other aging syndromes, the cause of HGPS is due to a defect in the DNA repair via the homologous recombination pathway."

It cannot be both. Though the first part of the article seems definitive when it says that HPGS is not caused by defective DNA repair.

hi dumdum I just did a search of PUB MED and I see no sign of recent evidence suggesting a DNA repair defect causing HGPS. [1]

I think that the evidence is pretty convincing that HPGS is caused by LMNA mutations and not DNA repair defects. The paragraph suggesting DNA repair as a cause of HPGS was added on February 10 by User:212.128.162.184 who has made no other contributions to Wikipedia. Until evidence is provided for a role of DNA repair in HGPS I think the paragraph should be deleted, and I will now do so. --Ben Best 17:47, 7 March 2006 (UTC)

[edit] pictures

I need some pictures for a visual aid... other then people who have the disease. That is all there is on google images and all the sites I've been to.

[edit] Found some pictures

I had to have pictures for my project, so I thought this might help. If someone wants to move either or these into the arcticle thats good, but I don't know enough to do it myself. http://img125.imageshack.us/img125/1314/progeriacells0yi.jpg http://img125.imageshack.us/img125/1717/progeria6ay.jpg

The one in spanish I used a free Spanish to English translator on. Sorry for any inaccuracies! The one with the picture of the child with progeria: The first cell is a normal healthy cell and the second is a cell from someone with progeria. —Preceding unsigned comment added by 68.37.51.204 (talk)

Can you say where these images come from, if you own the copyright and whether you are willing to release the copyright? --apers0n 12:07, 22 September 2006 (UTC)

I added a picture of John Tucket, after reading an interview with him when he was in 8th grade at school. Emperor Jackal 19:41, 9 May 2007 (UTC)

[edit] References

I added internal Wiki-links for the terms 'CAAX box' and 'C-termius' under the Cause section. It seems to me that basic terms like this should be defined somewhere, as should other terms for general DNA structures such as 'forkhead box', 'winged helix' - I assume these are general structures (I am not a geneticist) The referencing articles do not exist yet. - Jim Witte—The preceding unsigned comment was added by 216.9.143.221 (talk) 17:37, 24 January 2007 (UTC).

[edit] Symptoms

FYI, I removed the first sentence of the symptoms section - i.e. "Symptoms generally begin appearing around 18-24 months of age.". Progeria diagnosises have actually occurred within the first 5 months of life and certain symptoms can be witnessed at birth or shortly thereafter (i.e. FTT and a specific skin abnormalities).

Want to modify the list to include other common symptoms (i.e. lack of subcutaneous fat causing prominent veins on the head, atrophy of lower legs etc.)

Yelirmac 03:00, 17 June 2007 (UTC)

[edit] More Inconsistency

"Currently, there are 51 known cases in the world."

"Around 100 cases have been identified since then."

Am I missing something? --68.100.13.86 18:16, 27 July 2007 (UTC)

There are around 50 living "progerians" worldwide -- there have been over 100 diagnoses since the disease was first classified. Yelirmac 21:28, 6 August 2007 (UTC)

== Another Possible Inconsistency == therre is no cure for the dieseaese

The article speaks of a few million reported cases, but later, says only about 100 cases have been identified. Is the one sentence referring to general accelerated aging diseases, and the other sentence referring only to HGPS? That's the only explanation I can think of. --Iritscen (talk) 15:09, 4 January 2008 (UTC)

[edit] Jargon

There's a lot of jargon in the overview section, particular the paragraph that starts with "Prelamin A...". It's unreadable to the layman. So I've tagged it in hopes of a cleanup or revision. (Darthveda (talk) 13:19, 6 February 2008 (UTC))

[edit] Living people

Do we really want to include the names of living people with this condition? If you were a child with this condition, would you necessarily want the entire world to know your family's name, town, and medical history? I'm inclined to remove the family names and leave just a general location (region or country). WhatamIdoing (talk) 21:05, 31 May 2008 (UTC)

Leslie Gordon encouraged media coverage of her son Sam, and other families encouraged media coverage of their children, because they believed that it would draw attention to their case and encourage research. This strategy was successful.

Their names were public because they chose to disclose them. If the families think it is to their advantage to disclose their names, I think we should follow their wishes.

If you don't identify families by name, and you read about 2 families, you don't know whether you're reading about 2 families reported twice, or 2 different families. It makes a big difference (statistically and epidemiologically) whethere there is only 1 reported family with inherited progeria, or more than 1. Nbauman (talk) 15:26, 1 June 2008 (UTC)