Protriptyline

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Protriptyline
Systematic (IUPAC) name
N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
Identifiers
CAS number	438-60-8
ATC code	N06AA11
PubChem	4976
Chemical data
Formula	C19H21N
Mol. mass	263.377 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	54–92 hours
Excretion	Renal, in urine
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	Rx-only (US)
Routes	Oral

Protriptyline (Vivactil) is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for depression and ADHD. Unique among the tricyclics, protriptyline tends to be energizing instead of sedating, and it is sometimes used in narcolepsy to achieve a wakefulness-promoting effect.^{[citation needed]} (The other TCAs tend to be sedating and therefore are often taken in the evening.)

Tricyclics including protriptyline are also used to reduce the incidence of recurring headaches such as migraine, and for other types of chronic pain.

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