Protocatechuic acid
From Wikipedia, the free encyclopedia
| Protocatechuic acid | |
|---|---|
 |
|
| IUPAC name | 3,4-Dihydroxybenzoic acid |
| Identifiers | |
| CAS number | [99-50-3] |
| PubChem | |
| SMILES | C1=CC(=C(C=C1C(=O)O)O)O |
| Properties | |
| Molecular formula | C7H6O4 |
| Molar mass | 154.12014 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
|
Protocatechuic acid (PCA) is an polyphenol antioxidant found in roselle. Data on the biological activity of PCA are contradictory with both anti-tumor and tumor-promoting effects observed in in vitro studies. For example, PCA has been shown to induce apoptosis of human leukemia cells, as well as malignant HSG1 cells taken from human oral cavities.[1] However, PCA enhances tumor promotion in mouse skin cells.[2]
[edit] References
- ^ Babich H, Sedletcaia A, Kenigsberg B (November 2002). "In vitro cytotoxicity of protocatechuic acid to cultured human cells from oral tissue: involvement in oxidative stress". Pharmacol. Toxicol. 91 (5): 245–53. PMID 12570031.
- ^ Nakamura Y, Torikai K, Ohto Y, Murakami A, Tanaka T, Ohigashi H (October 2000). "A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase". Carcinogenesis 21 (10): 1899–907. PMID 11023549.
