Protocatechuate decarboxylase

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In enzymology, a protocatechuate decarboxylase (EC 4.1.1.63) is an enzyme that catalyzes the chemical reaction

3,4-dihydroxybenzoate catechol + CO₂

Hence, this enzyme has one substrate, 3,4-dihydroxybenzoate, and two products, catechol and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3,4-dihydroxybenzoate carboxy-lyase (catechol-forming). Other names in common use include 3,4-dihydrobenzoate decarboxylase, and protocatechuate carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation.

[edit] References

• IUBMB entry for 4.1.1.63
• BRENDA references for 4.1.1.63 (Recommended.)
• PubMed references for 4.1.1.63
• PubMed Central references for 4.1.1.63
• Google Scholar references for 4.1.1.63
• Grant DJW and Patel JC (1969). "Non-oxidative decarboxylation of p-hydroxybenzoic acid, gentisic acid, protocatechuic acid, and gallic acid by Klebsiella aerogenes (Aerobacter aerogenes)". J. Microbiol. Serol. 35: 325–343. 

[edit] External links

The CAS registry number for this enzyme class is 37290-55-4.

• IUBMB entry for 4.1.1.63

• KEGG entry for 4.1.1.63

• BRENDA entry for 4.1.1.63

• NiceZyme view of 4.1.1.63

• EC2PDB: PDB structures for 4.1.1.63

• PRIAM entry for 4.1.1.63

• PUMA2 entry for 4.1.1.63

• IntEnz: Integrated Enzyme entry for 4.1.1.63

• MetaCyc entry for 4.1.1.63

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050223: protocatechuate decarboxylase

• AMIGO entry for GO code 0050223: protocatechuate decarboxylase