Protocatechuate 3,4-dioxygenase

From Wikipedia, the free encyclopedia

In enzymology, a protocatechuate 3,4-dioxygenase (EC 1.13.11.3) is an enzyme that catalyzes the chemical reaction

3,4-dihydroxybenzoate + O₂ $\rightleftharpoons$ 3-carboxy-cis,cis-muconate

Thus, the two substrates of this enzyme are 3,4-dihydroxybenzoate and O₂, whereas its product is 3-carboxy-cis,cis-muconate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is protocatechuate:oxygen 3,4-oxidoreductase (decyclizing). Other names in common use include protocatechuate oxygenase, protocatechuic acid oxidase, protocatechuic 3,4-dioxygenase, and protocatechuic 3,4-oxygenase. This enzyme participates in benzoate degradation via hydroxylation and 2,4-dichlorobenzoate degradation. It employs one cofactor, iron.

1 Structural studies
2 See also
3 References
4 External links
- 4.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 37 structures have been solved for this class of enzymes, with PDB accession codes 1EO2, 1EO9, 1EOA, 1EOB, 1EOC, 1YKK, 1YKL, 1YKM, 1YKN, 1YKO, 1YKP, 2BUM, 2BUQ, 2BUR, 2BUT, 2BUU, 2BUV, 2BUW, 2BUX, 2BUY, 2BUZ, 2BV0, 2PCD, 3PCA, 3PCB, 3PCC, 3PCD, 3PCE, 3PCF, 3PCG, 3PCH, 3PCI, 3PCJ, 3PCK, 3PCL, 3PCM, and 3PCN.

[edit] See also

protocatechuic acid

[edit] References

IUBMB entry for 1.13.11.3
BRENDA references for 1.13.11.3 (Recommended.)
PubMed references for 1.13.11.3
PubMed Central references for 1.13.11.3
Google Scholar references for 1.13.11.3
Fujisawa H, Hayaishi O (1968). "Protocatechuate 3,4-dioxygenase. I. Crystallization and characterization". J. Biol. Chem. 243: 2673–81. PMID 4967959.
GROSS SR, GAFFORD RD, TATUM EL (1956). "The metabolism of protocatechuic acid by Neurospora". J. Biol. Chem. 219: 781–96. PMID 13319299.
Stanier RY and Ingraham JL (1954). "Protocatechuic acid oxidase". J. Biol. Chem. 210: 799–820.