Protein unc-119 homolog

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Unc-119 homolog (C. elegans)
Identifiers
Symbol(s) UNC119; HRG4
External IDs OMIM: 604011 MGI: 1328357 HomoloGene: 3778
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9094 22248
Ensembl ENSG00000109103 ENSMUSG00000002058
Uniprot Q13432 Q5SYM3
Refseq NM_005148 (mRNA)
NP_005139 (protein)		 XM_001004307 (mRNA)
XP_001004307 (protein)
Location Chr 17: 23.9 - 23.9 Mb Chr 11: 78.16 - 78.17 Mb
Pubmed search [1] [2]

Unc-119 homolog (C. elegans), also known as UNC119, is a human gene.[1]

This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: UNC119 unc-119 homolog (C. elegans).

[edit] Further reading

  • Higashide T, Murakami A, McLaren MJ, Inana G (1996). "Cloning of the cDNA for a novel photoreceptor protein.". J. Biol. Chem. 271 (3): 1797–804. PMID 8576185. 
  • Higashide T, McLaren MJ, Inana G (1998). "Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse.". Invest. Ophthalmol. Vis. Sci. 39 (5): 690–8. PMID 9538874. 
  • Swanson DA, Chang JT, Campochiaro PA, et al. (1998). "Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors.". Invest. Ophthalmol. Vis. Sci. 39 (11): 2085–94. PMID 9761287. 
  • Higashide T, Inana G (1999). "Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to unc-119.". Genomics 57 (3): 446–50. doi:10.1006/geno.1999.5791. PMID 10329014. 
  • Van Valkenburgh H, Shern JF, Sharer JD, et al. (2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cen O, Gorska MM, Stafford SJ, et al. (2003). "Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.". J. Biol. Chem. 278 (10): 8837–45. doi:10.1074/jbc.M208261200. PMID 12496276. 
  • Kobayashi A, Kubota S, Mori N, et al. (2004). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain.". FEBS Lett. 534 (1-3): 26–32. PMID 12527357. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gorska MM, Stafford SJ, Cen O, et al. (2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem. 20030589. PMID 14757743. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Vepachedu R, Gorska MM, Singhania N, et al. (2007). "Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway.". J. Immunol. 179 (1): 682–90. PMID 17579091. 
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