Protein inhibitor of activated STAT2

From Wikipedia, the free encyclopedia

Protein inhibitor of activated STAT, 2

Identifiers

PIAS2; MGC102682; MIZ1; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4; miz

External IDs

OMIM: 603567 MGI: 1096566 HomoloGene: 20979

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity • transcription coactivator activity • protein binding • zinc ion binding • SUMO ligase activity • metal ion binding • androgen receptor binding
Cellular Component:	• nucleus
Biological Process:	• ubiquitin cycle • protein sumoylation • androgen receptor signaling pathway • positive regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001129747 (mRNA)
XP_001129747 (protein)

XM_990156 (mRNA)
XP_995250 (protein)

Location

Chr 18: 42.65 - 42.75 Mb

Chr 18: 77.3 - 77.36 Mb

Pubmed search

[1]

[2]

Protein inhibitor of activated STAT, 2, also known as PIAS2, is a human gene.^[1]

[edit] References

^ Entrez Gene: PIAS2 protein inhibitor of activated STAT, 2.

[edit] Further reading

Cookson MR (2003). "Pathways to Parkinsonism.". Neuron 37 (1): 7-10. PMID 12526767.
Wu L, Wu H, Ma L, et al. (1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA.". Mech. Dev. 65 (1-2): 3-17. PMID 9256341.
Liu B, Liao J, Rao X, et al. (1998). "Inhibition of Stat1-mediated gene activation by PIAS1.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10626-31. PMID 9724754.
Moilanen AM, Karvonen U, Poukka H, et al. (1999). "A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins.". J. Biol. Chem. 274 (6): 3700-4. PMID 9920921.
Minty A, Dumont X, Kaghad M, Caput D (2000). "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.". J. Biol. Chem. 275 (46): 36316-23. doi:10.1074/jbc.M004293200. PMID 10961991.
Kotaja N, Aittomäki S, Silvennoinen O, et al. (2001). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.". Mol. Endocrinol. 14 (12): 1986-2000. PMID 11117529.
Gross M, Liu B, Tan J, et al. (2001). "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.". Oncogene 20 (29): 3880-7. doi:10.1038/sj.onc.1204489. PMID 11439351.
Takahashi K, Taira T, Niki T, et al. (2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.". J. Biol. Chem. 276 (40): 37556-63. doi:10.1074/jbc.M101730200. PMID 11477070.
Schmidt D, Müller S (2002). "Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity.". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2872-7. doi:10.1073/pnas.052559499. PMID 11867732.
Tan JA, Hall SH, Hamil KG, et al. (2002). "Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators.". J. Biol. Chem. 277 (19): 16993-7001. doi:10.1074/jbc.M109217200. PMID 11877418.
Nishida T, Yasuda H (2003). "PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription.". J. Biol. Chem. 277 (44): 41311-7. doi:10.1074/jbc.M206741200. PMID 12177000.
Tussie-Luna MI, Michel B, Hakre S, Roy AL (2003). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I.". J. Biol. Chem. 277 (45): 43185-93. doi:10.1074/jbc.M207635200. PMID 12193603.
Tussié-Luna MI, Bayarsaihan D, Seto E, et al. (2002). "Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12807-12. doi:10.1073/pnas.192464499. PMID 12239342.
Miyauchi Y, Yogosawa S, Honda R, et al. (2003). "Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes.". J. Biol. Chem. 277 (51): 50131-6. doi:10.1074/jbc.M208319200. PMID 12393906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Arora T, Liu B, He H, et al. (2003). "PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4.". J. Biol. Chem. 278 (24): 21327-30. doi:10.1074/jbc.C300119200. PMID 12716907.
Ohshima T, Shimotohno K (2004). "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4.". J. Biol. Chem. 278 (51): 50833-42. doi:10.1074/jbc.M307533200. PMID 14514699.
Lee BH, Yoshimatsu K, Maeda A, et al. (2004). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules.". Virus Res. 98 (1): 83-91. PMID 14609633.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.