Protein farnesyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a protein farnesyltransferase (EC 2.5.1.58) is an enzyme that catalyzes the chemical reaction

farnesyl diphosphate + protein-cysteine S-farnesyl protein + diphosphate

Thus, the two substrates of this enzyme are farnesyl diphosphate and protein-cysteine, whereas its two products are S-farnesyl protein and diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is farnesyl-diphosphate:protein-cysteine farnesyltransferase. This enzyme is also called FTase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes 1S63, 1S64, 1SA4, 1SA5, 1TN6, 1TN7, 1TN8, 1X81, 2BED, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, and 2IEJ.

[edit] References

• IUBMB entry for 2.5.1.58
• BRENDA references for 2.5.1.58 (Recommended.)
• PubMed references for 2.5.1.58
• PubMed Central references for 2.5.1.58
• Google Scholar references for 2.5.1.58
• Furfine ES, Leban JJ, Landavazo A, Moomaw JF, Casey PJ (1995). "Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release". Biochemistry. 34: 6857–62. doi:10.1021/bi00020a032. PMID 7756316. 
• Casey PJ, Seabra MC (1996). "Protein prenyltransferases". J. Biol. Chem. 271: 5289–92. doi:10.1074/jbc.271.10.5289. PMID 8621375. 
• Long SB, Casey PJ, Beese LS (1998). "Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate". Biochemistry. 37: 9612–8. doi:10.1021/bi980708e. PMID 9657673. 
• Micali E, Chehade KA, Isaacs RJ, Andres DA, Spielmann HP (2001). "Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups". Biochemistry. 40: 12254–65. doi:10.1021/bi011133f. PMID 11591144. 
• Long SB, Casey PJ, Beese LS (2002). "Reaction path of protein farnesyltransferase at atomic resolution". Nature. 419: 645–50. doi:10.1038/nature00986. PMID 12374986. 
• Sinnott, M. (Ed.), Comprehensive Biological Catalysis. A Mechanistic Reference, vol. 1, Academic Press, San Diego, CA, 1998, p. 31-118.

[edit] External links

• IUBMB entry for 2.5.1.58

• KEGG entry for 2.5.1.58

• BRENDA entry for 2.5.1.58

• NiceZyme view of 2.5.1.58

• EC2PDB: PDB structures for 2.5.1.58

• PRIAM entry for 2.5.1.58

• PUMA2 entry for 2.5.1.58

• IntEnz: Integrated Enzyme entry for 2.5.1.58

• MetaCyc entry for 2.5.1.58

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004660: protein farnesyltransferase

• AMIGO entry for GO code 0004660: protein farnesyltransferase