Protein-histidine pros-kinase

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In enzymology, a protein-histidine pros-kinase (EC 2.7.13.1) is an enzyme that catalyzes the chemical reaction

ATP + protein L-histidine $\rightleftharpoons$ ADP + protein Npi-phospho-L-histidine

Thus, the two substrates of this enzyme are ATP and protein L-histidine, whereas its two products are ADP and protein Npi-phospho-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain of histidine residues in proteins (protein-histidine kinases). The systematic name of this enzyme class is ATP:protein-L-histidine Npi-phosphotransferase. Other names in common use include ATP:protein-L-histidine N-pros-phosphotransferase, histidine kinase (ambiguous), histidine protein kinase (ambiguous), protein histidine kinase (ambiguous), protein kinase (histidine) (ambiguous), and HK2.

[edit] References

IUBMB entry for 2.7.13.1
BRENDA references for 2.7.13.1 (Recommended.)
PubMed references for 2.7.13.1
PubMed Central references for 2.7.13.1
Google Scholar references for 2.7.13.1
Fujitaki JM, Fung G, Oh EY, Smith RA (1981). "Characterization of chemical and enzymatic acid-labile phosphorylation of histone H4 using phosphorus-31 nuclear magnetic resonance". Biochemistry. 20: 3658–64. doi:10.1021/bi00515a055. PMID 7196259.
Huebner VD, Matthews HR (1985). "Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia". J. Biol. Chem. 260: 16106–13. PMID 4066704.