Protein-arginine deiminase

From Wikipedia, the free encyclopedia

In enzymology, a protein-arginine deiminase (EC 3.5.3.15) is an enzyme that catalyzes the chemical reaction

protein L-arginine + H₂O protein L-citrulline + NH₃

Thus, the two substrates of this enzyme are protein L-arginine and H₂O, whereas its two products are protein L-citrulline and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is protein-L-arginine iminohydrolase. This enzyme is also called peptidylarginine deiminase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1WD8, 1WD9, 1WDA, 2DEW, 2DEX, 2DEY, and 2DW5.

[edit] References

• IUBMB entry for 3.5.3.15
• BRENDA references for 3.5.3.15 (Recommended.)
• PubMed references for 3.5.3.15
• PubMed Central references for 3.5.3.15
• Google Scholar references for 3.5.3.15
• Fujisaki M, Sugawara K (Tokyo). "Properties of peptidylarginine deiminase from the epidermis of newborn rats". J. Biochem.: 257–63. PMID 7217033. 

[edit] External links

The CAS registry number for this enzyme class is 75536-80-0.

• IUBMB entry for 3.5.3.15

• KEGG entry for 3.5.3.15

• BRENDA entry for 3.5.3.15

• NiceZyme view of 3.5.3.15

• EC2PDB: PDB structures for 3.5.3.15

• PRIAM entry for 3.5.3.15

• PUMA2 entry for 3.5.3.15

• IntEnz: Integrated Enzyme entry for 3.5.3.15

• MetaCyc entry for 3.5.3.15

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004668: protein-arginine deiminase

• AMIGO entry for GO code 0004668: protein-arginine deiminase