Proteasome ATPase

From Wikipedia, the free encyclopedia

In enzymology, a proteasome ATPase (EC 3.6.4.8) is an enzyme that catalyzes the chemical reaction

ATP + H₂O ADP + phosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (polypeptide-degrading).

[edit] References

• IUBMB entry for 3.6.4.8
• BRENDA references for 3.6.4.8 (Recommended.)
• PubMed references for 3.6.4.8
• PubMed Central references for 3.6.4.8
• Google Scholar references for 3.6.4.8
• Rivett AJ, Mason GG, Murray RZ, Reidlinger J (1997). "Regulation of proteasome structure and function". Mol. Biol. Rep. 24: 99–102. PMID 9228289. 
• Mason GG, Murray RZ, Pappin D, Rivett AJ (1998). "Phosphorylation of ATPase subunits of the 26S proteasome". FEBS. Lett. 430: 269–74. PMID 9688553. 

[edit] External links

• IUBMB entry for 3.6.4.8

• KEGG entry for 3.6.4.8

• BRENDA entry for 3.6.4.8

• NiceZyme view of 3.6.4.8

• EC2PDB: PDB structures for 3.6.4.8

• PRIAM entry for 3.6.4.8

• PUMA2 entry for 3.6.4.8

• IntEnz: Integrated Enzyme entry for 3.6.4.8

• MetaCyc entry for 3.6.4.8

• Atomic-resolution structures of enzymes belonging to this class