Prostaglandin-I synthase

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In enzymology, a prostaglandin-I synthase (EC 5.3.99.4) is an enzyme that catalyzes the chemical reaction

(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- dienoate $\rightleftharpoons$ (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13- dienoate

Thus, the two substrates of this enzyme are (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- and dienoate, whereas its two products are (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13- and dienoate.

This enzyme belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductases. The systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoat e 6-isomerase. Other names in common use include prostacyclin synthase, prostacycline synthetase, prostagladin I2 synthetase, PGI2 synthase, and PGI2 synthetase. This enzyme participates in arachidonic acid metabolism. It employs one cofactor, heme.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2IAG.

[edit] References

IUBMB entry for 5.3.99.4
BRENDA references for 5.3.99.4 (Recommended.)
PubMed references for 5.3.99.4
PubMed Central references for 5.3.99.4
Google Scholar references for 5.3.99.4
DeWitt DL, Smith WL (1983). "Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein". J. Biol. Chem. 258: 3285–93. PMID 6338016.
Ullrich V, Castle L, Weber P (1981). "Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase". Biochem. Pharmacol. 30: 2033–6. doi:10.1016/0006-2952(81)90218-5. PMID 7023490.