Prostaglandin-D synthase

From Wikipedia, the free encyclopedia

In enzymology, a prostaglandin-D synthase (EC 5.3.99.2) is an enzyme that catalyzes the chemical reaction

(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- dienoate $\rightleftharpoons$ (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate

Thus, the two substrates of this enzyme are (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- and dienoate, whereas its product is (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.

This enzyme belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductases. The systematic name of this enzyme class is (5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase. Other names in common use include prostaglandin-H2 Delta-isomerase, prostaglandin-R-prostaglandin D isomerase, and PGH-PGD isomerase. This enzyme participates in arachidonic acid metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1IYH, 1IYI, 1PD2, 1V40, 2CZT, 2CZU, and 2E4J.

[edit] References

IUBMB entry for 5.3.99.2
BRENDA references for 5.3.99.2 (Recommended.)
PubMed references for 5.3.99.2
PubMed Central references for 5.3.99.2
Google Scholar references for 5.3.99.2
Christ-Hazelhof E, Nugteren DH (1979). "Purification and characterisation of prostaglandin endoperoxide D-isomerase, a cytoplasmic, glutathione-requiring enzyme". Biochim. Biophys. Acta. 572: 43–51. PMID 32914.
Shimizu T, Yamamoto S, Hayaishi O (1979). "Purification and properties of prostaglandin D synthetase from rat brain". J. Biol. Chem. 254: 5222–8. PMID 109431.