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Proprotein convertase 2 (PC2) is a serine protease and proprotein convertase It is also referred to as "prohormone convertase 2". PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin. PC2 plays only a minor role in insulin biosynthesis, but a greater role in glucagon biosynthesis compared to PC1. PC2 binds to the small acidic pan-neuroendocrine protein 7B2, and if this protein is not present, proPC2 cannot become an enzymatically active form.
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