Propionate-CoA ligase

From Wikipedia, the free encyclopedia

In enzymology, a propionate-CoA ligase (EC 6.2.1.17) is an enzyme that catalyzes the chemical reaction

ATP + propanoate + CoA AMP + diphosphate + propanoyl-CoA

The 3 substrates of this enzyme are ATP, propanoate, and CoA, whereas its 3 products are AMP, diphosphate, and propanoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is propanoate:CoA ligase (AMP-forming). This enzyme is also called propionyl-CoA synthetase. This enzyme participates in propanoate metabolism.

[edit] References

• IUBMB entry for 6.2.1.17
• BRENDA references for 6.2.1.17 (Recommended.)
• PubMed references for 6.2.1.17
• PubMed Central references for 6.2.1.17
• Google Scholar references for 6.2.1.17
• Ricks CA, Cook RM (1981). "Regulation of volatile fatty acid uptake by mitochondrial acyl CoA synthetases of bovine liver". J. Dairy. Sci. 64: 2324–35. PMID 7341659. 

[edit] External links

The CAS registry number for this enzyme class is 55326-49-3.

• IUBMB entry for 6.2.1.17

• KEGG entry for 6.2.1.17

• BRENDA entry for 6.2.1.17

• NiceZyme view of 6.2.1.17

• EC2PDB: PDB structures for 6.2.1.17

• PRIAM entry for 6.2.1.17

• PUMA2 entry for 6.2.1.17

• IntEnz: Integrated Enzyme entry for 6.2.1.17

• MetaCyc entry for 6.2.1.17

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050218: propionate-CoA ligase

• AMIGO entry for GO code 0050218: propionate-CoA ligase