Propanediol dehydratase

From Wikipedia, the free encyclopedia

In enzymology, a propanediol dehydratase (EC 4.2.1.28) is an enzyme that catalyzes the chemical reaction

propane-1,2-diol $\rightleftharpoons$ propanal + H₂O

Hence, this enzyme has one substrate, 1,2-propanediol, and two products, propanal and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is propane-1,2-diol hydro-lyase (propanal-forming). Other names in common use include meso-2,3-butanediol dehydrase, diol dehydratase, DL-1,2-propanediol hydro-lyase, diol dehydrase, adenosylcobalamin-dependent diol dehydratase, propanediol dehydrase, coenzyme B12-dependent diol dehydrase, 1,2-propanediol dehydratase, dioldehydratase, and propane-1,2-diol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobamide.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1DIO, 1EEX, 1EGM, 1EGV, 1IWB, 1UC4, and 1UC5.

[edit] References

IUBMB entry for 4.2.1.28
BRENDA references for 4.2.1.28 (Recommended.)
PubMed references for 4.2.1.28
PubMed Central references for 4.2.1.28
Google Scholar references for 4.2.1.28
ABELES RH, LEE HA Jr (1961). "An intramolecular oxidation-reduction requiring a cobamide coenzyme". J. Biol. Chem. 236: 2347–50. PMID 13680987.
Forage RG, Foster MA (1982). "Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases". J. Bacteriol. 149: 413–9. PMID 7035429.
LEE HA Jr, ABELES RH (1963). "Purification and properties of dioldehydrase, and enzyme requiring a cobamide coenzyme". J. Biol. Chem. 238: 2367–73. PMID 13929077.