Propacetamol

From Wikipedia, the free encyclopedia

Propacetamol
Systematic (IUPAC) name
(4-acetamidophenyl) 2-diethylaminoacetate
Identifiers
CAS number  ?
ATC code N02BE05
PubChem 68865
Chemical data
Formula C14H2N2O3 
Mol. mass 264.3202 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 2.4 hours [1]
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes IV[1][2]

Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid Diethylglycin. This has the advantage of making it more water soluble. It is used in post-operative care and is delivered by I.V.. [2] It is given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicated. The onset of analgaesia from propacetamol is more rapid than paracetamol is given orally.[3] 2g of propacetamol are equivalent to 1g of paracetamol. [4]


[edit] References

  1. ^ a b Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A (1992). "Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol". Br J Clin Pharmacol 34 (1): 79–81. PMID 1633071. 
  2. ^ a b Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P (2004). "Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]". BMC Anesthesiol 4 (1): 6. doi:10.1186/1471-2253-4-6. PMID 15367329. 
  3. ^ Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA (2005). "Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery". Br J Anaesth 94 (5): 642–8. doi:10.1093/bja/aei109. PMID 15790675. 
  4. ^ Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A (2004). "Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects". Int J Clin Pharmacol Ther 42 (1): 50–7. PMID 14756388. 


v • d • e
Analgesic products (N02A, N02B)
Opioids
See also: Opioids template
Salicylic acid and derivatives
Aspirin (Acetylsalicylic Acid) · Benorylate · Diflunisal · Ethenzamide · Magnesium Salicylate · Salicin · Salicylamide · Salsalate · See also: NSAIDs
Pyrazolones
Cannabinoids
Anilides
Non-Salicylate Non-Steroidal
Anti-Inflammatories
See also: NSAIDs template
Propionic Acid NSAIDs
Oxicam NSAIDs
Acetic Acid NSAIDs
COX-2 NSAIDs
Anthranilic Acid
(Fenamate) NSAIDS

Meclofenamate  · Mefenamic acid
Other NSAIDS
Atypical, Adjunct
& Miscellaneous
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
Languages