Promazine

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Promazine
Systematic (IUPAC) name
N,N-dimethyl-3-(10H-phenothiazin-10-yl) propan-1-amine
Identifiers
CAS number	58-40-2
ATC code	N05AA03
PubChem	4926
DrugBank	APRD00358
Chemical data
Formula	C17H20N2S
Mol. mass	284.42 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	94%
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Promazine (marketed as Sparine) is a medication that belongs to the phenothiazine class of antipsychotics. An older medication used to treat schizophrenia, its use has largely been replaced by newer agents such as olanzapine and quetiapine.

It has predominantly anticholinergic side effects, though extrapyramidal side effects are not uncommon either.

v • d • e Psycholeptics: antipsychotics (N05A) Phenothiazine typical antipsychotics Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine • Triflupromazine Other typical antipsychotics Indoles (Molindone) Butyrophenones (Azaperone, Benperidol, Bromperidol, Droperidol, Haloperidol, Trifluperidol) Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) other (Loxapine) Atypical antipsychotics Butyrophenones (Melperone) Indoles (Sertindole, Ziprasidone) Benzamides (Sulpiride, Remoxipride, Amisulpride) diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine)