Proline racemase

From Wikipedia, the free encyclopedia

In enzymology, a proline racemase (EC 5.1.1.4) is an enzyme that catalyzes the chemical reaction

L-proline D-proline

Hence, this enzyme has one substrate, L-proline, and one product, D-proline.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is proline racemase. This enzyme participates in arginine and proline metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1TM0, 1W61, and 1W62.

[edit] References

• IUBMB entry for 5.1.1.4
• BRENDA references for 5.1.1.4 (Recommended.)
• PubMed references for 5.1.1.4
• PubMed Central references for 5.1.1.4
• Google Scholar references for 5.1.1.4
• [1] Stadtman TC and Elliott P (1957). "Studies on the enzymic reduction of amino acids. II. Purification and properties of a D-proline reductase and a proline racemase from Clostridium sticklandii". J. Biol. Chem. 228: 983–997. 
• [2] Stenta M, Calvaresi M, Altoè P, Spinelli D, Garavelli M and Bottoni A (2008). "The Catalytic Activity of Proline Racemase: A Quantum Mechanical/Molecular Mechanical Study". J. Chem. Phys. B 112 (4): 1057–1059. 

[edit] External links

The CAS registry number for this enzyme class is 9024-09-3.

• IUBMB entry for 5.1.1.4

• KEGG entry for 5.1.1.4

• BRENDA entry for 5.1.1.4

• NiceZyme view of 5.1.1.4

• EC2PDB: PDB structures for 5.1.1.4

• PRIAM entry for 5.1.1.4

• PUMA2 entry for 5.1.1.4

• IntEnz: Integrated Enzyme entry for 5.1.1.4

• MetaCyc entry for 5.1.1.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018112: proline racemase

• AMIGO entry for GO code 0018112: proline racemase