Prohibitin

From Wikipedia, the free encyclopedia

Prohibitin

Identifiers

External IDs

OMIM: 176705 MGI: 97572 HomoloGene: 1980

Gene ontology
Molecular Function:	• protein binding • transcription activator activity • transcription repressor activity
Cellular Component:	• nucleus • nucleoplasm • mitochondrion • mitochondrial inner membrane • integral to plasma membrane • membrane
Biological Process:	• regulation of progression through cell cycle • DNA replication • signal transduction • negative regulation of cell proliferation • negative regulation of transcription • histone deacetylation • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002634 (mRNA)
NP_002625 (protein)

NM_008831 (mRNA)
NP_032857 (protein)

Location

Chr 17: 44.84 - 44.85 Mb

n/a

Pubmed search

[1]

[2]

Prohibitin, also known as PHB, is a human gene.^[1]

Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.^[1]

[edit] References

^ ^a ^b Entrez Gene: PHB prohibitin.

[edit] Further reading

McClung JK, Jupe ER, Liu XT, Dell'Orco RT (1996). "Prohibitin: potential role in senescence, development, and tumor suppression.". Exp. Gerontol. 30 (2): 99–124. PMID 8591812.
Dell'Orco RT, McClung JK, Jupe ER, Liu XT (1996). "Prohibitin and the senescent phenotype.". Exp. Gerontol. 31 (1-2): 245–52. PMID 8706794.
Mishra S, Murphy LC, Nyomba BL, Murphy LJ (2005). "Prohibitin: a potential target for new therapeutics.". Trends in molecular medicine 11 (4): 192–7. doi:10.1016/j.molmed.2005.02.004. PMID 15823758.
Rajalingam K, Rudel T (2007). "Ras-Raf signaling needs prohibitin.". Cell Cycle 4 (11): 1503–5. PMID 16294014.
Sato T, Saito H, Swensen J, et al. (1992). "The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.". Cancer Res. 52 (6): 1643–6. PMID 1540973.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.
White JJ, Ledbetter DH, Eddy RL, et al. (1992). "Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism.". Genomics 11 (1): 228–30. PMID 1684951.
Altus MS, Wood CM, Stewart DA, et al. (1995). "Regions of evolutionary conservation between the rat and human prohibitin-encoding genes.". Gene 158 (2): 291–4. PMID 7607556.
Ikonen E, Fiedler K, Parton RG, Simons K (1995). "Prohibitin, an antiproliferative protein, is localized to mitochondria.". FEBS Lett. 358 (3): 273–7. PMID 7843414.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Sato T, Sakamoto T, Takita K, et al. (1993). "The human prohibitin (PHB) gene family and its somatic mutations in human tumors.". Genomics 17 (3): 762–4. PMID 8244394.
Jupe ER, Liu XT, Kiehlbauch JL, et al. (1996). "The 3' untranslated region of prohibitin and cellular immortalization.". Exp. Cell Res. 224 (1): 128–35. doi:10.1006/excr.1996.0120. PMID 8612677.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Rasmussen RK, Ji H, Eddes JS, et al. (1998). "Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins.". Electrophoresis 19 (5): 809–17. doi:10.1002/elps.1150190535. PMID 9629920.
Wang S, Nath N, Adlam M, Chellappan S (1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function.". Oncogene 18 (23): 3501–10. doi:10.1038/sj.onc.1202684. PMID 10376528.
Wang S, Nath N, Fusaro G, Chellappan S (1999). "Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals.". Mol. Cell. Biol. 19 (11): 7447–60. PMID 10523633.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Coates PJ, Nenutil R, McGregor A, et al. (2001). "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence.". Exp. Cell Res. 265 (2): 262–73. doi:10.1006/excr.2001.5166. PMID 11302691.