Proguanil
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Proguanil
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| Systematic (IUPAC) name | |
| 1-(4-chlorophenyl)-2-(N'-propan-2-ylcarbamimidoyl) guanidine | |
| Identifiers | |
| CAS number | |
| ATC code | P01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C11H16ClN5 |
| Mol. mass | 253.731 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ~20 h |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Proguanil (proguanil hydrochloride) is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Proguanil is effective against sporozoites.
Proguanil is usually taken in combination with another anti-malarial drug such as atovaquone (e.g., in the drug Malarone) or chloroquine. Malarone has fewer side effects than mefloquine, but can be more expensive because it's taken daily. Proguanil is taken with Atovaquone for chloroquine-resistant and multidrug resistant strains of P. falciparum and P. vivax.
Proguanil also known as Paludrine (AstraZeneca). It is sometimes combined with atovaquone, which is sold under the tradename Malarone (GlaxoSmithKline)
General precaution regarding Proguanil involves watching out for feelings of sullenness and anxiety to a level that is outside the ordinary, when taking over a period of several months. These may come on gradually and may not be immediately attributable to anything in particular.
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