Progesterone monooxygenase

From Wikipedia, the free encyclopedia

In enzymology, a progesterone monooxygenase (EC 1.14.99.4) is an enzyme that catalyzes the chemical reaction

progesterone + AH₂ + O₂ testosterone acetate + A + H₂O

The 3 substrates of this enzyme are progesterone, AH2, and O₂, whereas its 3 products are testosterone acetate, A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating). This enzyme is also called progesterone hydroxylase.

[edit] References

• IUBMB entry for 1.14.99.4
• BRENDA references for 1.14.99.4 (Recommended.)
• PubMed references for 1.14.99.4
• PubMed Central references for 1.14.99.4
• Google Scholar references for 1.14.99.4
• Rahim MA and Sih CJ (1966). "Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain". J. Biol. Chem. 241: 3615–3623. 

[edit] External links

The CAS registry number for this enzyme class is 37256-85-2.

• IUBMB entry for 1.14.99.4

• KEGG entry for 1.14.99.4

• BRENDA entry for 1.14.99.4

• NiceZyme view of 1.14.99.4

• EC2PDB: PDB structures for 1.14.99.4

• PRIAM entry for 1.14.99.4

• PUMA2 entry for 1.14.99.4

• IntEnz: Integrated Enzyme entry for 1.14.99.4

• MetaCyc entry for 1.14.99.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050214: progesterone monooxygenase

• AMIGO entry for GO code 0050214: progesterone monooxygenase