Progesterone 5alpha-reductase

From Wikipedia, the free encyclopedia

In enzymology, a progesterone 5alpha-reductase (EC 1.3.1.30) is an enzyme that catalyzes the chemical reaction

5alpha-pregnan-3,20-dione + NADP⁺ progesterone + NADPH + H⁺

Thus, the two substrates of this enzyme are 5alpha-pregnan-3,20-dione and NADP⁺, whereas its 3 products are progesterone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase. Other names in common use include steroid 5-alpha-reductase, and Delta4-steroid 5alpha-reductase (progesterone). This enzyme participates in c21-steroid hormone metabolism.

[edit] References

• IUBMB entry for 1.3.1.30
• BRENDA references for 1.3.1.30 (Recommended.)
• PubMed references for 1.3.1.30
• PubMed Central references for 1.3.1.30
• Google Scholar references for 1.3.1.30
• Cheng YJ, Karavolas HJ (1975). "Subcellular distribution and properties of progesterone (delta4-steroid) 5alpha-reductase in rat medial basal hypothalamus". J. Biol. Chem. 250: 7997–8003. PMID 240847. 
• Cheng YJ, Karavolas HJ (1975). "Properties and subcellular distribution of delta4-steroid (progesterone) 5alpha-reductase in rat anterior pituitary". Steroids. 26: 57–71. doi:10.1016/0039-128X(75)90006-9. PMID 1166484. 

[edit] External links

The CAS registry number for this enzyme class is 72412-84-1.

• IUBMB entry for 1.3.1.30

• KEGG entry for 1.3.1.30

• BRENDA entry for 1.3.1.30

• NiceZyme view of 1.3.1.30

• EC2PDB: PDB structures for 1.3.1.30

• PRIAM entry for 1.3.1.30

• PUMA2 entry for 1.3.1.30

• IntEnz: Integrated Enzyme entry for 1.3.1.30

• MetaCyc entry for 1.3.1.30

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050213: progesterone 5-alpha-reductase

• AMIGO entry for GO code 0050213: progesterone 5-alpha-reductase